Clinical Nuclear Medicine最新文献

{"title":"18 F-FDG PET/CT in NUT Carcinoma of the Thorax.","authors":"Anselm Johannes Schlemmer, Gregor Gorkiewicz, Martin Michael Uggowitzer, Spela Salamon, Philipp Jost, Emina Talakic","doi":"10.1097/RLU.0000000000005872","DOIUrl":"10.1097/RLU.0000000000005872","url":null,"abstract":"<p><p>NUT carcinoma (NUTc) is a rare, aggressive cancer characterized by rearrangement of the NUTM1 gene on chromosome 15q14. We present the case of a 32-year-old man with a persisting cough, reduced general condition, and B symptoms for 2 months. CT imaging revealed a highly suspicious mass in the right lung, infiltrating hilar structures, and the mediastinum. Staging with 18 F-FDG PET/CT demonstrated pathologic 18 F-FDG uptake within the tumor. Histology, immunohistochemistry, and molecular analysis confirmed NUTc of the lung. Metabolic imaging modalities may play a key role in staging, restaging, and assessing treatment response in patients with NUTc.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"1062-1063"},"PeriodicalIF":9.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[ 68 Ga]-DOTATOC PET/CT and Clear Cell Renal Cell Carcinoma Metastasis: Simple False Positive or Potential Staging Imaging?","authors":"Nicolas Jacquet-Francillon, Sibel Isal, Isabelle Morelec, Chawki Ghayor, Mathilde Vergoby, Anthime Flaus","doi":"10.1097/RLU.0000000000005949","DOIUrl":"10.1097/RLU.0000000000005949","url":null,"abstract":"<p><p>Clear cell renal cell carcinoma is the most common type of kidney cancer. Apart of lymph nodes, the frequent metastatic sites are lung, bone and, more rarely, pancreas. These three sites of involvement are also common for NETs. This well-differentiated tumour has a low FDG avidity. We report two clinical cases of pancreatic and pulmonary lesions, suspicious of NET but with a history of clear cell renal cell carcinoma. [68Ga]-DOTATOC PET/CT find strong uptakes but biopsies ultimately revealed metastases of clear cell renal cell carcinoma.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e656-e658"},"PeriodicalIF":9.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sacral Hemangioma Mimicking Bone Metastasis on 18 F-PSMA-1007 PET/CT.","authors":"Xiaojun Man, Changming Dong, Xiandong Song, Aisheng Dong","doi":"10.1097/RLU.0000000000005961","DOIUrl":"10.1097/RLU.0000000000005961","url":null,"abstract":"<p><p>A 74-year-old man with prostate cancer was referred for an 18 F-PSMA-1007 PET/CT scan for restaging due to a progressive rise in serum prostate-specific antigen levels. 18 F-PSMA-1007 PET/CT showed a focal intense activity in the left sacral ala. The sacral lesion corresponded to a hemangioma, which was initially detected on pelvic MRI 6 months ago and remained stable in size. A second 18 F-PSMA-1007 PET/CT performed 8 months after the first PET/CT showed no significant changes in size, density, and activity of the sacral lesion. This case indicates that hemangioma should be included in the differential diagnosis of PSMA-avid sacral lesions.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"1083-1086"},"PeriodicalIF":9.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Case of Retroperitoneal Angiolipoma Mimicking Paraganglioma on Multimodality Imaging.","authors":"Yan Cui, Xiangxiang Ding, Jiangyuan Yu, Nan Li","doi":"10.1097/RLU.0000000000005802","DOIUrl":"10.1097/RLU.0000000000005802","url":null,"abstract":"<p><p>We discuss a patient with a retroperitoneal mass demonstrating marked enhancement on contrast-enhanced CT and heterogeneous uptake of both 18 F-FDG and 68 Ga-DOTATOC on PET/CT. The postoperative pathologic diagnosis revealed an angiolipoma, a benign entity composed of mature adipocytes interspersed with capillaries and containing fibrin thrombi within the vessels. This case underscores the positive uptake of angiolipoma on 18 F-FDG and 68 Ga-DOTATOC PET/CT, which should be recognized as a crucial differential diagnosis.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"1033-1034"},"PeriodicalIF":9.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deficiency of 68 Ga-FAPI-04 PET/CT Compared With 18 F-FDG PET/CT in Staging Metastatic Paraganglioma: A Case Report.","authors":"Yang Liu, Xinfeng Lin, Nina Zhou, Yan Cui, Nan Li","doi":"10.1097/RLU.0000000000006007","DOIUrl":"10.1097/RLU.0000000000006007","url":null,"abstract":"<p><p>A 26-year-old man was incidentally found to have a retroperitoneal mass. 18 F-FDG PET/CT showed intense uptake in the retroperitoneal mass, lymph nodes, and bone lesions. Contrast-enhanced MRI revealed significant and similar enhancement in the retroperitoneal mass, lymph nodes, and the lesion in the L5 vertebral body, supporting the diagnosis of metastases. In contrast, 68 Ga-FAPI-04 PET/CT demonstrated intense uptake in the retroperitoneal mass, but only mild uptake in the L5 vertebral body and negligible uptake in other lesions. Histopathological examination confirmed paraganglioma. This case suggests that 68 Ga-FAPI-04 PET/CT may be less effective than 18 F-FDG PET/CT for staging metastatic paraganglioma.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"1042-1044"},"PeriodicalIF":9.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of MRI, [ 18 F]FDG-PET/CT, and [ 18 F]FDG-PET/MRI for Initial Staging of Multiple Myeloma : A Systematic Review and Meta-analysis.","authors":"Mickael Tordjman, Murat Yuce, Amine Geahchan, Giuseppe Petralia, Roberto C Delgado Bolton, Katherine Wang, Amish H Doshi, Ian Bolger, Xueyan Mei, Laurent Dercle, Himanshu Joshi, Christina Messiou, Dow-Mu Koh, Samir Parekh, Bachir Taouli","doi":"10.1097/RLU.0000000000006048","DOIUrl":"10.1097/RLU.0000000000006048","url":null,"abstract":"<p><strong>Purpose: </strong>This systematic review and meta-analysis compared the diagnostic performance of MRI, [ 18 F]FDG-PET/CT, and [ 18 F]FDG-PET/MRI in detecting focal bone lesions and bone marrow infiltration in the initial staging of patients with multiple myeloma (MM) who underwent both MRI and [ 18 F]FDG-PET/CT or [ 18 F]FDG-PET/MRI studies.</p><p><strong>Patients and methods: </strong>A systematic literature search was conducted across PubMed, Embase, and Cochrane databases, including studies comparing the performance of MRI (WB-MRI or spine/pelvis MRI), [ 18 F]FDG-PET/CT, and/or [ 18 F]FDG-PET/MRI in the same patients for MM initial staging. Pooled sensitivities and concordance between imaging modalities were analyzed using R (package META-R). Heterogeneity and bias were assessed with the QUADAS-C tool.</p><p><strong>Results: </strong>Twenty studies (published between 2007 and 2025) using the international MM diagnostic criteria as a reference standard met the inclusion criteria. Of these, 13 (n=742) compared per-patient sensitivity of [ 18 F]FDG-PET/CT and MRI, and 4 (n=224) compared MRI and [ 18 F]FDG-PET/MRI. Pooled sensitivities were 0.807 (95% CI: 0.74-0.86) for [ 18 F]FDG-PET/CT (with significant heterogeneity) versus 0.914 (95% CI: 0.88-0.94) for MRI (0.906 for spine/pelvis MRI and 0.920 for WB-MRI) ( P <0.001 for meta-regression analysis). Using contingency tables, 83% (599/721) of included patients had concordant [ 18 F]FDG-PET/CT and MRI results, while 14% (101/721) patients had negative [ 18 F]FDG-PET/CT and positive MRI with significant differences between the 2 techniques for the paired sample analysis ( P <0.001). The pooled sensitivity of the 4 studies including [ 18 F]FDG-PET/MRI was 0.944 (95% CI: 0.88-0.98). Consensus definitions for specificity in MM imaging should be standardized across studies.</p><p><strong>Conclusions: </strong>This systematic review and comparative meta-analysis demonstrates superior sensitivity of WB-MRI compared with [ 18 F]FDG-PET/CT for initial staging of MM patients. Future international guidelines might prioritize MRI and [ 18 F]FDG-PET/MRI for staging of MM patients.</p><p><strong>Registration: </strong>PROSPERO CRD42024564937.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"1006-1015"},"PeriodicalIF":9.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144612130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metastasis of Breast Cancer in Myometrium, Detected Exclusively Through 18 F-FDG PET/CT.","authors":"Yeong-Shin Hsiao, Shu-Chane Shen, Shih-Chuan Hsiao","doi":"10.1097/RLU.0000000000006055","DOIUrl":"10.1097/RLU.0000000000006055","url":null,"abstract":"<p><p>We share the case of a 50-year-old woman with isolated myometrial metastasis of recurrent invasive breast ductal carcinoma. Eight years after initial diagnosis at stage IIIC, a hypodense myometrial tumor was spotted in whole-body CT, which was also noted as a lesion with high SUV in 18 F-FDG PET/CT. Myometrial metastatic mammary carcinoma was then pathologically proven after hysterectomy and bilateral oophorectomy. This case warns us to be alert to how easily malignant uterine lesions could be misjudged as benign in traditional imaging and, consequently, how irreplaceable PET/CT is in the early diagnosis and treatment of malignant diseases.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"1095-1096"},"PeriodicalIF":9.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144834361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"18 F-FDG PET/CT in a Patient With Primary Rectal Angiosarcomas and Multiple Bone Metastases.","authors":"Xiaohua Ma, Shanshan Xia, Zichan Long, Xulong Zhao, Zhanli Fu","doi":"10.1097/RLU.0000000000005670","DOIUrl":"10.1097/RLU.0000000000005670","url":null,"abstract":"<p><strong>Abstract: </strong>A 54-year-old man presented with a 1-month history of pain and numbness in the right lower limb. Lumbar spine MRI revealed bone metastases. 18 F-FDG PET/CT showed a soft tissue mass with increased 18 F-FDG uptake in the rectum, accompanied by multiple hypermetabolic lesions in the bilateral ribs, spine, pelvis, and upper right femur. A colonoscopy biopsy of the submucosal rectal mass confirmed the diagnosis of epithelioid angiosarcoma.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e596-e598"},"PeriodicalIF":9.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unilateral Nodular Adrenal Hyperplasia Mimicking Endometrial Cancer Metastasis on 18 F-FDG PET/CT After Immunochemotherapy.","authors":"Hui Li, Le Song, Meng Wang, Kai Yang, Yan Wan","doi":"10.1097/RLU.0000000000005892","DOIUrl":"10.1097/RLU.0000000000005892","url":null,"abstract":"<p><p>Unilateral nodular adrenal hyperplasia after immunochemotherapy is extremely rare. We reported a 70-year-old woman with endometrial cancer who underwent 18 F-FDG PET/CT to evaluate the immunochemotherapy response. Compared with the baseline, follow-up PET/CT revealed a newly hypermetabolic nodule in the left adrenal gland, initially suspected to be metastatic. However, surgical resection and pathology confirmed it as adrenal hyperplasia. This case highlights the importance of recognizing unilateral nodular adrenal hyperplasia as a rare imaging finding mimicking metastasis following immunochemotherapy, which should be considered in the differential diagnosis.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"956-957"},"PeriodicalIF":9.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urethral Diverticulum Mimicking Metastatic Prostate Cancer on 68 Ga-PSMA-11 PET/CT.","authors":"Xiaojun Man, Changming Dong, Xiandong Song, Aisheng Dong","doi":"10.1097/RLU.0000000000005739","DOIUrl":"10.1097/RLU.0000000000005739","url":null,"abstract":"<p><p>Urethral diverticulum rarely occurs in a man. A 57-year-old man who underwent radical prostatectomy for prostate adenocarcinoma 9 years ago was referred for 68 Ga-PSMA-11 PET/CT scan for restating due to elevated serum total prostate-specific antigen level. 68 Ga-PSMA-11 PET/CT showed multiple PSMA-avid bone metastases and a focal intense activity in the anterior penis. The PSMA-avid penil lesion corresponded to a urethral diverticulum, which was initially detected on pelvic MRI 8 years ago. This case indicates that the urethral diverticulum should be included in the differential diagnosis of PSMA-avid penile lesions.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"941-942"},"PeriodicalIF":9.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}