Yang-Yun Chen, Yong-Rong Zhou, Zhen-Peng Jiang, Shu-Xia Wang, Dan Shao
{"title":"A Case of 99mTc-Pyrophosphate Myocardial Scintigraphy Positivity in Fabry Disease.","authors":"Yang-Yun Chen, Yong-Rong Zhou, Zhen-Peng Jiang, Shu-Xia Wang, Dan Shao","doi":"10.1097/RLU.0000000000005972","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005972","url":null,"abstract":"<p><p>A 62-year-old man with echocardiographic findings suggestive of cardiac amyloidosis and positive 99mTc-pyrophosphate (99mTc-PYP) scintigraphy was ultimately diagnosed with Fabry disease confirmed by genetic testing. This case highlights myocardial 99mTc-PYP uptake in Fabry cardiomyopathy, expanding the differential diagnosis of non-amyloid cardiomyopathies associated with myocardial radiotracer retention.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chenxi Wu, Julia W Foster, Shahein Tajmir, Hardik Shah, Mihir M Shah, Saima Muzahir
{"title":"False-positive Uptake in Splenic Hamartoma on 68Ga-DOTATATE PET/CT.","authors":"Chenxi Wu, Julia W Foster, Shahein Tajmir, Hardik Shah, Mihir M Shah, Saima Muzahir","doi":"10.1097/RLU.0000000000005947","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005947","url":null,"abstract":"<p><p>68Ga-DOTATATE is not completely specific for neuroendocrine tumors, and a wide range of benign and malignant tumors may reveal high uptake of 68Ga-DOTATATE on PET scan. Spleen hamartoma is a rare benign solid lesion of the spleen, composed of a mixture of normal splenic structures. Here we present a case of a 49-year-old woman who underwent a 68Ga-DOTATATE PET/CT scan for complete staging of a duodenal neuroendocrine tumor, and it incidentally demonstrated intense radiotracer uptake in a splenic lesion, with surgical pathology demonstrating a splenic hamartoma.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Léo Morin, Héléna Pencroffi, Lucas Jallet, Clément Drouet
{"title":"Low FDG Uptake of a Mass Initially Suspected of Being a Nasopharyngeal Carcinoma: MRI and FDG PET/CT Reveal a Clivus Chordoma.","authors":"Léo Morin, Héléna Pencroffi, Lucas Jallet, Clément Drouet","doi":"10.1097/RLU.0000000000005959","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005959","url":null,"abstract":"<p><p>This case illustrates an atypical clinical presentation of a nasopharyngeal invasive process in a 56-year-old woman, which corresponded to a chordoma, a rare malignant primary bone tumor with unfavorable prognosis, derived from remnants of the notochord.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of the Therapeutic Response and Recurrence by 18F-FLT PET in a Case of Central Nervous System-Lymphomatoid Granulomatosis.","authors":"Katsuya Mitamura, Takashi Norikane, Yuri Manabe, Yuka Yamamoto, Keisuke Miyake, Yoshihiro Nishiyama","doi":"10.1097/RLU.0000000000005953","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005953","url":null,"abstract":"<p><p>A 78-year-old man visited our hospital complaining of cognitive decline and gait disturbance. MRI revealed multiple nodular enhancing lesions in the brain. He was pathologically diagnosed with central nervous system-lymphomatoid granulomatosis (CNS-LYG) by brain biopsy. Brain PET examinations using 18F-fluorothymidine (FLT) PET and 11C-methionine (MET) PET were performed. Strong accumulation in the lesions was observed with 18F-FLT PET. After treatment, the accumulation of lesions disappeared, and accumulation was observed again at the time of recurrence. In contrast, 11C-MET PET showed unclear accumulation in the lesions both before therapy and at recurrence. 18F-FLT uptake was likely reflecting the degree of cell infiltration and the disrupted blood-brain barrier. 18F-FLT PET might be a useful tool for evaluating the therapeutic response and recurrence of CNS-LYG.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Moritz B Bastian, Benedikt Wörl, Arne Blickle, Caroline Burgard, Tilman Speicher, Joel Wessendorf, Mark Bartholomä, Andrea Schaefer-Schuler, Stephan Maus, Samer Ezziddin, Florian Rosar
{"title":"PSMA Radioligand Therapy in Advanced Age: Insights From an 85y+ mCRPC Patient Cohort.","authors":"Moritz B Bastian, Benedikt Wörl, Arne Blickle, Caroline Burgard, Tilman Speicher, Joel Wessendorf, Mark Bartholomä, Andrea Schaefer-Schuler, Stephan Maus, Samer Ezziddin, Florian Rosar","doi":"10.1097/RLU.0000000000005968","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005968","url":null,"abstract":"<p><strong>Purpose: </strong>With increasing life expectancy, the number of older patients with metastatic castration-resistant prostate cancer (mCRPC) continues to rise, but this group is currently underrepresented in clinical trials. This study aims to assess the efficacy and safety of prostate-specific membrane antigen (PSMA) targeted radioligand therapy (RLT) in patients over 85 years old with mCRPC.</p><p><strong>Materials and methods: </strong>A retrospective analysis was conducted on 21 mCRPC patients aged 85 years or older receiving PSMA-RLT (range: 85-96 y). The median number of treatment cycles was 4 (range: 1-13 cycles), with a mean cumulative administered activity of 26.9±17.3 GBq (range: 8.0-87.2 GBq) of [177Lu]Lu-PSMA-617. Adverse events, including anemia, thrombocytopenia, leukopenia, renal impairment, fatigue, and xerostomia were classified according to CTCAE version 5.0.</p><p><strong>Results: </strong>The mean best PSA response across the cohort was -37.6±73.3%, with 62% (13 of 21 patients) showing partial remission. Median progression-free survival and overall survival were 4.6 and 14.7 months, respectively. Severe adverse events were rare, occurring in 2 patients: 1 case of grade 3 anemia and 1 of grade 3 thrombocytopenia.</p><p><strong>Conclusions: </strong>The results demonstrate that PSMA-RLT is an effective and well-tolerated treatment for mCRPC patients over 85 years, with clinical outcomes and safety comparable to those observed in studies involving younger populations. This highlights its potential as a valuable therapeutic option for this aging patient group.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ahmad Ghasemifard, Amin Saber Tanha, Faeze Rabani, Amir Behforouz, Emran Askari
{"title":"99mTc-PSMA Scintigraphy in Splenic Hemangioma.","authors":"Ahmad Ghasemifard, Amin Saber Tanha, Faeze Rabani, Amir Behforouz, Emran Askari","doi":"10.1097/RLU.0000000000005969","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005969","url":null,"abstract":"<p><p>A 67-year-old man was referred for initial staging of prostate adenocarcinoma (Gleason score 4+3, 7/12 cores positive). A 99mTc-PSMA scintigraphy revealed localized uptake in the right prostate lobe (miTNM: T2mN0M0, and PRIMARY score: 5) and increased uptake in a hypo-dense splenic lesion (PSMA-RADS-3C), which was subsequently confirmed as a hemangioma on further evaluations. This case underscores the potential for false-positive 99mTc-PSMA uptake in splenic hemangiomas, highlighting the importance of considering this possibility in clinical practice.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparable Diagnostic Value of 99mTc-FAPI-46 SPECT/CT and 18F-FDG PET/CT in Cholangiocarcinoma: A Case Report.","authors":"Nasrin Raeisi, Amin Saber Tanha, Mitra Ghahraman, Kamran Aryana, Atena Aghaee","doi":"10.1097/RLU.0000000000005877","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005877","url":null,"abstract":"<p><p>We describe a 51-year-old man with cholangiocarcinoma of the common bile duct. Initially deemed nonmetastatic, he was a candidate for curative surgery and liver transplantation. However, during laparotomy, peritoneal seeding was discovered, necessitating omentectomy and lesion resection. Following chemotherapy, the patient underwent 18F-FDG PET/CT for re-staging, revealing uptake in the primary tumor and a right iliac bone metastasis. Subsequently, FAPI-based scintigraphy using 99mTc-FAPI-46 as a novel conventional imaging agent demonstrated comparable uptake in both lesions. This case highlights the diagnostic potential of 99mTc-FAPI-46 SPECT/CT as an alternative to 18F-FDG PET/CT and 68Ga-FAPI in cholangiocarcinoma, particularly in resource-limited settings.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hye In Kim, Boram Kim, Jiyeon Hyeon, Nak Gyeong Ko, Mihyeon Jin, Jung Hwan Cho, Ji Min Han, Sunghwan Suh, Ji Cheol Bae, Man Ki Chung, Jun-Ho Choe, Sun Wook Kim, Jae Hoon Chung, Young Lyun Oh, Kyunga Kim, Tae Hyuk Kim, Joon Young Choi
{"title":"Impact of Therapeutic Radioactive Iodine on the Recurrence of Papillary Thyroid Cancer With Extranodal Extension in Metastatic Lymph Nodes: A Propensity Score-matched Analysis.","authors":"Hye In Kim, Boram Kim, Jiyeon Hyeon, Nak Gyeong Ko, Mihyeon Jin, Jung Hwan Cho, Ji Min Han, Sunghwan Suh, Ji Cheol Bae, Man Ki Chung, Jun-Ho Choe, Sun Wook Kim, Jae Hoon Chung, Young Lyun Oh, Kyunga Kim, Tae Hyuk Kim, Joon Young Choi","doi":"10.1097/RLU.0000000000005940","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005940","url":null,"abstract":"<p><strong>Purpose: </strong>Radioactive iodine therapy (RAI) ≥100 mCi (3.7 GBq) is commonly recommended for papillary thyroid cancer (PTC) patients with extranodal extension (ENE). However, no study has evaluated whether RAI ≥100 mCi is effective in reducing the recurrence of PTC with ENE.</p><p><strong>Methods: </strong>This retrospective cohort study enrolled 191 PTC patients with ENE who underwent total thyroidectomy and RAI. Recurrence according to RAI activity (<100 vs. ≥100 mCi) was compared before and after propensity score matching (PSM) (1:2) using Kaplan-Meier curves and Cox proportional hazards regression models. Subgroup analyses according to mass size (<4 and ≥4 cm), gender, blood vessel invasion, lymph node (LN) number (≤5 and >5), and stimulated Tg (sTg) level (<10 and ≥10 ng/mL) before and after PSM were performed.</p><p><strong>Results: </strong>During about 116 months, 5 (12.5%) and 19 (12.6%) before PSM, five (12.5%) and 3 (3.8%) after PSM recorded recurrence in <100 and ≥100 mCi groups, respectively. The impact of RAI ≥100 mCi on reducing recurrence was not significant before [log-rank P = 0.915, adjusted hazard ratio (HR) 0.49 (0.12-1.85); P = 0.294) and after PSM (log-rank P = 0.077). Subgroup analysis after PSM demonstrated the impact of RAI ≥100 mCi on lowering recurrence only in ENE patients with mass size ≥4 cm (log-rank P = 0.008), LN >5 (log-rank P = 0.007), and sTg ≥10 ng/mL (log-rank P = 0.039).</p><p><strong>Conclusions: </strong>In PTC patients with ENE, mass size ≥4 cm, LN >5, or sTg ≥10 ng/mL had a benefit from RAI ≥100 mCi compared with RAI <100 mCi.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Solitary Radius Metastasis as the First Presentation of Renal Cell Carcinoma Revealed by Bone Scintigraphy.","authors":"Huan Liang, Yanbin Bai, Wenjun Bao, Lingge Wei, Peng Xie","doi":"10.1097/RLU.0000000000005951","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005951","url":null,"abstract":"<p><p>Solitary radius metastasis as the initial presentation of renal cell carcinoma is extremely rare. Here we present the bone scintigraphy findings of a 72-year-old man who complained of left wrist pain for 6 months. The 99mTc-MDP bone scintigraphy demonstrated intense ring-like MDP uptake in the distal left radius. Finally, solitary radius metastasis from renal cell carcinoma was confirmed.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Application of 99mTc-FAPI-46 SPECT/CT in Evaluation of Idiopathic Retroperitoneal Fibrosis: Case Report of a Novel Promising Experience.","authors":"Nasrin Raeisi, Amin Saber Tanha, Ehsan Soltani, Kamran Aryana, Atena Aghaee","doi":"10.1097/RLU.0000000000005875","DOIUrl":"https://doi.org/10.1097/RLU.0000000000005875","url":null,"abstract":"<p><p>This case report describes a 59-year-old man with fatigue and bilateral lower limb edema, diagnosed with retroperitoneal fibrosis (RPF). Laboratory tests showed elevated serum creatinine, ESR, and CRP levels, while imaging revealed left hydroureteronephrosis and a pelvic mass encasing the iliac vessels. A biopsy indicated fibrotic changes without malignancy, confirming RPF. This experience of using 99mTc-FAPI-46 as a novel agent for conventional imaging demonstrated a high target-to-background ratio in the RPF, suggesting its utility in diagnosis and assessing disease activity, also aiding in ruling out the distant malignant neoplasms, especially where PET/CT is not available.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}