18F-FDG PET/CT在胸腔NUT癌中的表现。

IF 9.6 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Clinical Nuclear Medicine Pub Date : 2025-11-01 Epub Date: 2025-04-30 DOI:10.1097/RLU.0000000000005872

Anselm Johannes Schlemmer, Gregor Gorkiewicz, Martin Michael Uggowitzer, Spela Salamon, Philipp Jost, Emina Talakic

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引用次数: 0

摘要

NUT癌（NUTc）是一种罕见的侵袭性癌症，其特征是染色体15q14上的NUTM1基因重排。我们报告一例32岁男性，持续咳嗽，一般情况下降，B症状2个月。CT显示右肺高度可疑肿块，浸润肺门结构和纵隔。18F-FDG PET/CT分期显示肿瘤内病理的18F-FDG摄取。组织学、免疫组织化学和分子分析证实为肺NUTc。代谢成像模式可能在NUTc患者的分期、再分期和评估治疗反应中发挥关键作用。

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18 F-FDG PET/CT in NUT Carcinoma of the Thorax.

NUT carcinoma (NUTc) is a rare, aggressive cancer characterized by rearrangement of the NUTM1 gene on chromosome 15q14. We present the case of a 32-year-old man with a persisting cough, reduced general condition, and B symptoms for 2 months. CT imaging revealed a highly suspicious mass in the right lung, infiltrating hilar structures, and the mediastinum. Staging with 18 F-FDG PET/CT demonstrated pathologic 18 F-FDG uptake within the tumor. Histology, immunohistochemistry, and molecular analysis confirmed NUTc of the lung. Metabolic imaging modalities may play a key role in staging, restaging, and assessing treatment response in patients with NUTc.

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来源期刊

Clinical Nuclear Medicine 医学-核医学

CiteScore

2.90

自引率

31.10%

发文量

1113

审稿时长

2 months

期刊介绍： Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty. Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.