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A Scoring System Based on [ 18 F]PFPN PET and Clinical Features for Predicting Prognosis in Patients With Mucosal Melanoma. 基于[18F]PFPN PET和临床特征的评分系统预测粘膜黑色素瘤患者预后
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2025-11-01 Epub Date: 2025-09-10 DOI: 10.1097/RLU.0000000000006117
Zhi Lin, Cheng Tang, Yuan Feng, Weiwei Ruan, Fan Hu, Yongkang Gai, Xiao Zhang, Xiaoli Lan
{"title":"A Scoring System Based on [ 18 F]PFPN PET and Clinical Features for Predicting Prognosis in Patients With Mucosal Melanoma.","authors":"Zhi Lin, Cheng Tang, Yuan Feng, Weiwei Ruan, Fan Hu, Yongkang Gai, Xiao Zhang, Xiaoli Lan","doi":"10.1097/RLU.0000000000006117","DOIUrl":"10.1097/RLU.0000000000006117","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to establish a prognostic prediction system for mucosal melanoma patients by integrating melanocyte-targeting PET with clinical parameters.</p><p><strong>Patients and methods: </strong>A retrospective study was conducted on primary mucosal melanoma patients who underwent [ 18 F]PFPN PET scans between January 2021 and April 2024. Researchers manually delineated all lesions on the [ 18 F]PFPN PET images and recorded the imaging features. Kaplan-Meier survival analysis, Cox regression, and stepwise regression were used to analyze prognosis and construct the prediction model.</p><p><strong>Results: </strong>Fifty patients (mean age 60.5±8.8 y) were included, with a median follow-up of 13 months (1-39 mo) and an average survival of 14.62 months. Multivariate analysis showed that lower Whole-body Melanotic Tumor Volume (WBMTV), earlier stage, younger age, immunotherapy, and head and neck or vulvar subtypes were associated with longer overall survival (OS, P <0.05). A simplified prognostic scoring system was developed based on 5 variables: stage (not detected or I/II/III/IV: 0/5/10/15 points), age (<60/≥60: 0/10), WBMTV (<1.52/≥1.52: 0/10), immunotherapy (yes/no: 0/5), and subtype (head and neck or vulva/others: 0/10). Patients were stratified into low (0-19), intermediate (20-29), and high-risk (30-50) groups. The model's concordance index was 0.85, outperforming the clinical staging (0.76). OS declined progressively from low-risk to high-risk groups, with 1-year survival from 100% to 74.6% and 3-year survival from 100% to 0%.</p><p><strong>Conclusions: </strong>[ 18 F]PFPN PET provides an accurate assessment of mucosal melanoma burden, and a prognostic model combining [ 18 F]PFPN PET features and clinical data offers reliable stratification of patient outcomes.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"1016-1023"},"PeriodicalIF":9.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to the Letter to the Editor Concerning Metabolic and Pharmacological Interactions of 131 I-MIBG. 对有关 131I-MIBG 代谢和药理作用的致编辑信的回复。
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2025-11-01 Epub Date: 2024-10-10 DOI: 10.1097/RLU.0000000000005532
Ruaa Al Ward, Steven G Waguespack, Jeena Varghese, Yang Lu, Camilo Jimenez
{"title":"Reply to the Letter to the Editor Concerning Metabolic and Pharmacological Interactions of 131 I-MIBG.","authors":"Ruaa Al Ward, Steven G Waguespack, Jeena Varghese, Yang Lu, Camilo Jimenez","doi":"10.1097/RLU.0000000000005532","DOIUrl":"10.1097/RLU.0000000000005532","url":null,"abstract":"","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"1106-1107"},"PeriodicalIF":9.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142399655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
68 Ga-Exendin-4 PET/CT Enables Identification of Multiple and Ectopic Insulinoma in a Patient With Multiple Endocrine Neoplasia 1. 68Ga-Exendin-4 PET/CT能够鉴别多发性内分泌肿瘤患者的多发和异位胰岛素瘤1。
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2025-11-01 Epub Date: 2025-06-16 DOI: 10.1097/RLU.0000000000006032
Hongzhe Zhang, Qingqing Pan, Silu Liu, Jie Feng, Yaping Luo
{"title":"68 Ga-Exendin-4 PET/CT Enables Identification of Multiple and Ectopic Insulinoma in a Patient With Multiple Endocrine Neoplasia 1.","authors":"Hongzhe Zhang, Qingqing Pan, Silu Liu, Jie Feng, Yaping Luo","doi":"10.1097/RLU.0000000000006032","DOIUrl":"10.1097/RLU.0000000000006032","url":null,"abstract":"<p><p>A 53-year-old woman with hyperinsulinemic hypoglycemia was diagnosed with multiple insulinomas as determined by contrast-enhanced CT. Genetic test confirmed the presence of multiple endocrine neoplasia type 1 (MEN1). 68 Ga-exendin-4 PET/CT revealed multiple lesions with intense uptake in the tail and uncinate process of the pancreas, with an additional lesion in the gastric wall on the lesser curvature. These lesions were subsequently confirmed to be insulinomas by histopathologic examination after surgery. This case illustrates the benefits of 68 Ga-exendin-4 PET/CT in detecting multiple and ectopic insulinomas in patients with a MEN1 background.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"1093-1094"},"PeriodicalIF":9.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Atypical Lymphoid Hyperplasia of the Liver on FDG PET/CT. FDG PET/CT显示肝脏非典型淋巴样增生。
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2025-11-01 Epub Date: 2025-06-05 DOI: 10.1097/RLU.0000000000006002
Xiaoxue Tan, Yuegao Liu, Yanli Wang, Yuzhao Zhu
{"title":"Atypical Lymphoid Hyperplasia of the Liver on FDG PET/CT.","authors":"Xiaoxue Tan, Yuegao Liu, Yanli Wang, Yuzhao Zhu","doi":"10.1097/RLU.0000000000006002","DOIUrl":"10.1097/RLU.0000000000006002","url":null,"abstract":"<p><p>Hepatic atypical lymphoid hyperplasia is a rare borderline lymphoproliferative lesion. Unlike benign reactive lymphoid hyperplasia, atypical lymphoid hyperplasia has the potential to transform into lymphoma. We describe MRI and FDG PET/CT findings in a case of hepatic atypical lymphoid hyperplasia. The hepatic lesion appeared as a small solid mass with central necrosis and low-grade enhancement on MRI and showed intense FDG uptake with SUV max of 8.2, mimicking malignancy. This case suggests that hepatic atypical lymphoid hyperplasia should be considered as a rare differential diagnosis in patients with focal hypermetabolic hepatic lesions.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"1099-1101"},"PeriodicalIF":9.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[ 18 F]FDG PET/CT is Superior to [ 68 Ga]Ga-FAPI PET/CT for Lesion Detection in Extranodal NK/T-cell Lymphoma, Nasal Type. [18F]FDG PET/CT对鼻型结外NK/ t细胞淋巴瘤病变的检测优于[68Ga]Ga-FAPI PET/CT。
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2025-11-01 Epub Date: 2025-07-29 DOI: 10.1097/RLU.0000000000006082
Hengyu Su, Minggang Su, Ming Jiang, Liqun Zou, Chong Jiang, Rong Tian
{"title":"[ 18 F]FDG PET/CT is Superior to [ 68 Ga]Ga-FAPI PET/CT for Lesion Detection in Extranodal NK/T-cell Lymphoma, Nasal Type.","authors":"Hengyu Su, Minggang Su, Ming Jiang, Liqun Zou, Chong Jiang, Rong Tian","doi":"10.1097/RLU.0000000000006082","DOIUrl":"10.1097/RLU.0000000000006082","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to assess the feasibility of [ 68 Ga]Ga-FAPI PET/CT for detecting lesions in extranodal NK/T-cell lymphoma, nasal type (ENKTL-NT), and to compare its diagnostic performance with [ 18 F]FDG PET/CT in clinical practice.</p><p><strong>Patients and methods: </strong>Between December 2022 and December 2023, 19 patients with pathologically confirmed ENKTL-NT at West China Hospital underwent baseline [ 68 Ga]Ga-FAPI and [ 18 F]FDG PET/CT. Lesions were documented by each modality, and detection rates compared at both patient and lesion levels.</p><p><strong>Results: </strong>Among the 19 patients, a total of 117 lesions were identified (66 nodal and 51 extranodal). At the patient level, the detection rate was 94.7% (18/19) for [ 68 Ga]Ga-FAPI versus 100% (19/19) for [ 18 F]FDG. At the lesion level, rates were 54.7% (64/117) versus 99.1% (116/117), respectively.</p><p><strong>Conclusions: </strong>[ 68 Ga]Ga-FAPI PET/CT is less effective than [ 18 F]FDG PET/CT in detecting ENKTL-NT lesions.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"992-997"},"PeriodicalIF":9.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on "Prognostic Value of Baseline Tumor Burden and Tumor Dissemination Extracted From 18 F-FDG PET/CT in a Cohort of Adult Patients With Early or Advanced Hodgkin Lymphoma". 关于 "18F-FDG PET/CT 对成人早期或晚期霍奇金淋巴瘤患者基线肿瘤负荷和肿瘤扩散的预后价值 "的评论
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2025-11-01 Epub Date: 2024-08-02 DOI: 10.1097/RLU.0000000000005401
Wenjue Tang, Yinlin Tang
{"title":"Comment on \"Prognostic Value of Baseline Tumor Burden and Tumor Dissemination Extracted From 18 F-FDG PET/CT in a Cohort of Adult Patients With Early or Advanced Hodgkin Lymphoma\".","authors":"Wenjue Tang, Yinlin Tang","doi":"10.1097/RLU.0000000000005401","DOIUrl":"10.1097/RLU.0000000000005401","url":null,"abstract":"","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"1104-1105"},"PeriodicalIF":9.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141874371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional Imaging in 2 Rare Cases of Struma Ovarii With Contrasting Features. 2例卵巢甲状腺肿的功能影像学对比分析。
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2025-11-01 Epub Date: 2025-03-17 DOI: 10.1097/RLU.0000000000005855
Yeshwanth Edamadaka, Gaurav Malhotra, Jugal V Gada, Abraham A Kodiatte, Priyanka Verma, Nikhil M Bhagwat, Premlata K Varthakavi
{"title":"Functional Imaging in 2 Rare Cases of Struma Ovarii With Contrasting Features.","authors":"Yeshwanth Edamadaka, Gaurav Malhotra, Jugal V Gada, Abraham A Kodiatte, Priyanka Verma, Nikhil M Bhagwat, Premlata K Varthakavi","doi":"10.1097/RLU.0000000000005855","DOIUrl":"10.1097/RLU.0000000000005855","url":null,"abstract":"<p><p>We present 2 cases, one with benign struma ovarii that was diagnosed preoperatively on Tc- 99 m and I-131 scans and another of malignant struma ovarii with peritoneal metastases that were detected postoperatively on 18 F-FDG PET/CT and post-radioiodine (I-131) therapy scans. Benign struma ovarri had a rare occurrence of coexisting Graves' disease, while malignant struma ovarii demonstrated rare peritoneal involvement on functional imaging. Even though rare, struma ovarii can present with contrasting features and may require extensive workup, including functional scans and radioiodine therapy as shown in these cases.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e659-e660"},"PeriodicalIF":9.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FDG PET/CT in Two Patients With Isolated Splenic Metastasis From Colorectal Cancer. 2例结直肠癌脾转移的FDG PET/CT分析。
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2025-11-01 Epub Date: 2025-04-30 DOI: 10.1097/RLU.0000000000005876
Xia Ji, Aisheng Dong
{"title":"FDG PET/CT in Two Patients With Isolated Splenic Metastasis From Colorectal Cancer.","authors":"Xia Ji, Aisheng Dong","doi":"10.1097/RLU.0000000000005876","DOIUrl":"10.1097/RLU.0000000000005876","url":null,"abstract":"<p><p>Splenic metastasis from colorectal cancer is rare. Isolated splenic metastasis from colorectal cancer is even rarer. We describe FDG PET/CT findings in 2 patients with solitary isolated splenic metastasis from colorectal cancer. FDG PET/CT showed intense activity of the splenic tumors, mimicking the primary splenic tumor. Careful correlation with the patient's history, serum tumor marker level, and anatomic imaging findings is helpful for the diagnosis.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"1080-1082"},"PeriodicalIF":9.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of Terbium-161 [ 161 Tb]Tb-DOTATATE in Recurrent Paraganglioma. 铽-161 [161Tb]Tb-DOTATATE在复发性副神经节瘤中的应用。
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2025-11-01 Epub Date: 2025-05-16 DOI: 10.1097/RLU.0000000000005897
Nihaad Jacobs, Tariq Solomon, Olumayowa Kolade, Khanyisile Hlongwa, Stuart More
{"title":"Use of Terbium-161 [ 161 Tb]Tb-DOTATATE in Recurrent Paraganglioma.","authors":"Nihaad Jacobs, Tariq Solomon, Olumayowa Kolade, Khanyisile Hlongwa, Stuart More","doi":"10.1097/RLU.0000000000005897","DOIUrl":"10.1097/RLU.0000000000005897","url":null,"abstract":"<p><p>This report explores the application of terbium-161 [( 161 Tb)Tb] DOTATATE in the case of a 31-year-old man with recurrent paraganglioma. Due to liver metastases and inoperable nodal disease, he was treated with lutetium-177 [( 177 Lu)Lu] DOTATATE, resulting in decreased chromogranin A levels and stable disease. Logistical challenges with lutetium-177 acquisition resulted in treatment with [ 161 Tb]Tb-DOTATATE, demonstrating prominent lesion uptake, further reduction in chromogranin A levels, and no adverse effects. He maintains an excellent functional status and 19 months of progression-free survival after 3 total cycles of [ 177 Lu]Lu and [ 161 Tb]Tb-DOTATATE, suggesting [ 161 Tb]Tb-DOTATATE as a promising alternative radionuclide therapy for advanced neuroendocrine tumors.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"1076-1077"},"PeriodicalIF":9.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insights and Recommendations on the Study of HSA- 131 I-MIBG Treatment for Advanced Pheochromocytoma and Paraganglioma. 关于 HSA-131I-MIBG 治疗晚期嗜铬细胞瘤和副神经节瘤研究的见解和建议。
IF 9.6 3区 医学
Clinical Nuclear Medicine Pub Date : 2025-11-01 Epub Date: 2024-10-17 DOI: 10.1097/RLU.0000000000005569
Lianwei Zhou, Manling Li, Wenbo Li
{"title":"Insights and Recommendations on the Study of HSA- 131 I-MIBG Treatment for Advanced Pheochromocytoma and Paraganglioma.","authors":"Lianwei Zhou, Manling Li, Wenbo Li","doi":"10.1097/RLU.0000000000005569","DOIUrl":"10.1097/RLU.0000000000005569","url":null,"abstract":"","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"1105-1106"},"PeriodicalIF":9.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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