[ 18 F]FDG PET/CT is Superior to [ 68 Ga]Ga-FAPI PET/CT for Lesion Detection in Extranodal NK/T-cell Lymphoma, Nasal Type.

IF 9.6 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Clinical Nuclear Medicine Pub Date : 2025-11-01 Epub Date: 2025-07-29 DOI:10.1097/RLU.0000000000006082

Hengyu Su, Minggang Su, Ming Jiang, Liqun Zou, Chong Jiang, Rong Tian

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引用次数: 0

Abstract

Background: This study aimed to assess the feasibility of [ 68 Ga]Ga-FAPI PET/CT for detecting lesions in extranodal NK/T-cell lymphoma, nasal type (ENKTL-NT), and to compare its diagnostic performance with [ 18 F]FDG PET/CT in clinical practice.

Patients and methods: Between December 2022 and December 2023, 19 patients with pathologically confirmed ENKTL-NT at West China Hospital underwent baseline [ 68 Ga]Ga-FAPI and [ 18 F]FDG PET/CT. Lesions were documented by each modality, and detection rates compared at both patient and lesion levels.

Results: Among the 19 patients, a total of 117 lesions were identified (66 nodal and 51 extranodal). At the patient level, the detection rate was 94.7% (18/19) for [ 68 Ga]Ga-FAPI versus 100% (19/19) for [ 18 F]FDG. At the lesion level, rates were 54.7% (64/117) versus 99.1% (116/117), respectively.

Conclusions: [ 68 Ga]Ga-FAPI PET/CT is less effective than [ 18 F]FDG PET/CT in detecting ENKTL-NT lesions.

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[18F]FDG PET/CT对鼻型结外NK/ t细胞淋巴瘤病变的检测优于[68Ga]Ga-FAPI PET/CT。

背景：本研究旨在评估[68Ga]Ga-FAPI PET/CT检测结外NK/ t细胞淋巴瘤鼻型（ENKTL-NT）病变的可行性，并比较其与[18F]FDG PET/CT在临床中的诊断性能。患者和方法：2022年12月至2023年12月，华西医院19例病理证实的ENKTL-NT患者接受了基线[68Ga]Ga-FAPI和[18F]FDG PET/CT检查。病变按每种模式记录，并在患者和病变水平上比较检出率。结果：19例患者共发现病变117处（淋巴结66处，结外51处）。在患者水平，[68Ga]Ga-FAPI的检出率为94.7%(18/19)，而[18F]FDG的检出率为100%（19/19）。在病变水平，发生率分别为54.7%（64/117）和99.1%（116/117）。结论：[68Ga]Ga-FAPI PET/CT对ENKTL-NT病变的检测效果低于[18F]FDG PET/CT。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Nuclear Medicine 医学-核医学

CiteScore

2.90

自引率

31.10%

发文量

1113

审稿时长

2 months

期刊介绍： Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty. Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.