68 Ga-Exendin-4 PET/CT Enables Identification of Multiple and Ectopic Insulinoma in a Patient With Multiple Endocrine Neoplasia 1.

IF 9.6 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Clinical Nuclear Medicine Pub Date : 2025-11-01 Epub Date: 2025-06-16 DOI:10.1097/RLU.0000000000006032

Hongzhe Zhang, Qingqing Pan, Silu Liu, Jie Feng, Yaping Luo

引用次数: 0

Abstract

A 53-year-old woman with hyperinsulinemic hypoglycemia was diagnosed with multiple insulinomas as determined by contrast-enhanced CT. Genetic test confirmed the presence of multiple endocrine neoplasia type 1 (MEN1). 68 Ga-exendin-4 PET/CT revealed multiple lesions with intense uptake in the tail and uncinate process of the pancreas, with an additional lesion in the gastric wall on the lesser curvature. These lesions were subsequently confirmed to be insulinomas by histopathologic examination after surgery. This case illustrates the benefits of 68 Ga-exendin-4 PET/CT in detecting multiple and ectopic insulinomas in patients with a MEN1 background.

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68Ga-Exendin-4 PET/CT能够鉴别多发性内分泌肿瘤患者的多发和异位胰岛素瘤1。

一位53岁女性，患有高胰岛素血症性低血糖症，经增强CT诊断为多发胰岛素瘤。基因检测证实多发性内分泌肿瘤1型（MEN1）。68Ga-exendin-4 PET/CT显示胰腺尾部和棘突多发病变，有强烈摄取，胃壁小弯处有附加病变。这些病变随后被手术后的组织病理学检查证实为胰岛素瘤。该病例说明了68Ga-exendin-4 PET/CT在MEN1背景患者中检测多发和异位胰岛素瘤的益处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Nuclear Medicine 医学-核医学

CiteScore

2.90

自引率

31.10%

发文量

1113

审稿时长

2 months

期刊介绍： Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty. Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.