早期灌注FP-CIT SPECT成像与360度CZT相机在痴呆伴路易体中的应用。

IF 9.6 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Clinical Nuclear Medicine Pub Date : 2025-05-01 Epub Date: 2025-02-26 DOI:10.1097/RLU.0000000000005764

Antoine Verger, Laetitia Imbert, Diego Cecchin

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引用次数: 0

摘要

路易体痴呆（Dementia with Lewy bodies， DLB）可通过结合临床标准、突触前[123I]FP-CIT SPECT多巴胺能成像中多巴胺能神经元末端的缺失以及弥漫性[18F]FDG PET低代谢（通常也影响视觉皮层）来诊断。与传统的SPECT系统相比，360度CZT SPECT系统在计数灵敏度、灌注和多巴胺能成像的对比度和能量分辨率方面具有优势。与PET成像方案一样，对疑似DLB患者使用了双时间窗方案和CZT SPECT成像，以捕获灌注和多巴胺能状态。

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Early Perfusion [ 123 I]FP-CIT SPECT Imaging With a 360-degree CZT Camera in Dementia With Lewy Bodies.

Dementia with Lewy bodies (DLB) can be diagnosed through a combination of clinical criteria, the loss of dopaminergic neuron terminals in presynaptic [ 123 I]FP-CIT SPECT dopaminergic imaging, and diffuse [ 18 F]FDG PET hypometabolism, which typically affects also the visual cortex. A 360-degree CZT SPECT systems offer advantages in terms of count sensitivity, and both contrast and energy resolution for perfusion and dopaminergic imaging as compared with conventional SPECT systems. As it happens for PET imaging protocols, a dual-time-window protocol with CZT SPECT imaging was used for a suspected DLB patient to capture both perfusion and dopaminergic states.

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来源期刊

Clinical Nuclear Medicine 医学-核医学

CiteScore

2.90

自引率

31.10%

发文量

1113

审稿时长

2 months

期刊介绍： Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty. Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.