TANDEM Peptide Receptor Radionuclide Therapy Using [ 225 Ac]Ac-/[ 177 Lu]Lu-DOTA-LM3 in a Patient With Parotid Gland Metastasis From Pancreatic Neuroendocrine Neoplasm.

IF 9.6 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Clinical Nuclear Medicine Pub Date : 2025-10-01 Epub Date: 2025-03-07 DOI:10.1097/RLU.0000000000005782

Elisabetta Perrone, Kriti Ghai, Aleksandr Eismant, Richard P Baum

引用次数: 0

Abstract

We present the case of a young 38-year-old woman with metastatic progressive pancreatic neuroendocrine neoplasm (NEN) exhibiting an unusual metastasis to the parotid gland. After previous treatments, including radionuclide therapy with the somatostatin-receptor agonist DOTATOC and parotid metastasectomy, failed, she was referred to TANDEM peptide receptor radionuclide therapy (PRRT) using the somatostatin-receptor antagonist DOTA-LM3 labeled with Actinium-225 and Lutetium-177. Following 2 cycles of TANDEM-PRRT, she achieved partial remission in all metastatic sites, notably in the parotid gland and liver. This is the first reported case of metastatic pancreatic NEN with parotid involvement treated with TANDEM-PRRT.

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[225Ac]Ac-/[177Lu]Lu-DOTA-LM3在胰腺神经内分泌肿瘤腮腺转移患者中的应用

我们提出的情况下，一个年轻的38岁妇女转移性进展胰腺神经内分泌肿瘤（NEN）表现出一个不寻常的转移到腮腺。在之前的治疗，包括使用生长抑素受体激动剂DOTATOC的放射性核素治疗和腮腺转移切除术失败后，她被转到TANDEM肽受体放射性核素治疗（PRRT），使用生长抑素受体拮抗剂DOTA-LM3标记的锕-225和镥-177。经过2个周期的TANDEM-PRRT治疗后，患者的所有转移部位均部分缓解，尤其是腮腺和肝脏。这是首次报道的转移性胰腺NEN伴腮腺受累用TANDEM-PRRT治疗的病例。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Nuclear Medicine 医学-核医学

CiteScore

2.90

自引率

31.10%

发文量

1113

审稿时长

2 months

期刊介绍： Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty. Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.