Hossein Jadvar, Kai Chen, Passant Mohamed, Donya S Jadvar, Andre Luis Abreu
{"title":"18F-FMAU PET/CT辅助mpMRI在疑似前列腺癌影像引导活检中的细胞增殖成像","authors":"Hossein Jadvar, Kai Chen, Passant Mohamed, Donya S Jadvar, Andre Luis Abreu","doi":"10.1097/RLU.0000000000005702","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>We evaluated the potential diagnostic utility of PET with the cellular proliferation biomarker, 2'-deoxyl-2'-[ 18 F]fluoro-5-methyl-1-beta-D-arabinofuranosyluracil ( 18 F-FMAU), as an adjunct to multiparametric MRI (mpMRI), in localization of sites for image-guided biopsy in men with suspected prostate cancer.</p><p><strong>Patients and materials: </strong>Seventeen men with clinically suspected prostate cancer underwent standard mpMRI and investigational PET/CT with 18 F-FMAU.</p><p><strong>Results: </strong>Tissue samples obtained from 22 image-guided biopsies were examined histologically. There were 11 benign, 6 ISUP grade 1, and 5 ISUP grade 2 tumors. The sensitivity for detection of ISUP 1 and ISUP 2 prostate cancer was 16.7% and 100% for mpMRI, and 50% and 60% for 18 F-FMAU PET/CT, respectively.</p><p><strong>Conclusions: </strong>18 F-FMAU PET/CT may be a useful adjunct to mpMRI in image-guided prostate biopsy.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e340-e343"},"PeriodicalIF":9.6000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052491/pdf/","citationCount":"0","resultStr":"{\"title\":\"Cellular Proliferation Imaging With 18 F-FMAU PET/CT as Adjunct to mpMRI in Image-Guided Biopsy of Suspected Prostate Cancer.\",\"authors\":\"Hossein Jadvar, Kai Chen, Passant Mohamed, Donya S Jadvar, Andre Luis Abreu\",\"doi\":\"10.1097/RLU.0000000000005702\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>We evaluated the potential diagnostic utility of PET with the cellular proliferation biomarker, 2'-deoxyl-2'-[ 18 F]fluoro-5-methyl-1-beta-D-arabinofuranosyluracil ( 18 F-FMAU), as an adjunct to multiparametric MRI (mpMRI), in localization of sites for image-guided biopsy in men with suspected prostate cancer.</p><p><strong>Patients and materials: </strong>Seventeen men with clinically suspected prostate cancer underwent standard mpMRI and investigational PET/CT with 18 F-FMAU.</p><p><strong>Results: </strong>Tissue samples obtained from 22 image-guided biopsies were examined histologically. There were 11 benign, 6 ISUP grade 1, and 5 ISUP grade 2 tumors. The sensitivity for detection of ISUP 1 and ISUP 2 prostate cancer was 16.7% and 100% for mpMRI, and 50% and 60% for 18 F-FMAU PET/CT, respectively.</p><p><strong>Conclusions: </strong>18 F-FMAU PET/CT may be a useful adjunct to mpMRI in image-guided prostate biopsy.</p>\",\"PeriodicalId\":10692,\"journal\":{\"name\":\"Clinical Nuclear Medicine\",\"volume\":\" \",\"pages\":\"e340-e343\"},\"PeriodicalIF\":9.6000,\"publicationDate\":\"2025-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052491/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Nuclear Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1097/RLU.0000000000005702\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/2/10 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Nuclear Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/RLU.0000000000005702","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/10 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Cellular Proliferation Imaging With 18 F-FMAU PET/CT as Adjunct to mpMRI in Image-Guided Biopsy of Suspected Prostate Cancer.
Purpose: We evaluated the potential diagnostic utility of PET with the cellular proliferation biomarker, 2'-deoxyl-2'-[ 18 F]fluoro-5-methyl-1-beta-D-arabinofuranosyluracil ( 18 F-FMAU), as an adjunct to multiparametric MRI (mpMRI), in localization of sites for image-guided biopsy in men with suspected prostate cancer.
Patients and materials: Seventeen men with clinically suspected prostate cancer underwent standard mpMRI and investigational PET/CT with 18 F-FMAU.
Results: Tissue samples obtained from 22 image-guided biopsies were examined histologically. There were 11 benign, 6 ISUP grade 1, and 5 ISUP grade 2 tumors. The sensitivity for detection of ISUP 1 and ISUP 2 prostate cancer was 16.7% and 100% for mpMRI, and 50% and 60% for 18 F-FMAU PET/CT, respectively.
Conclusions: 18 F-FMAU PET/CT may be a useful adjunct to mpMRI in image-guided prostate biopsy.
期刊介绍：
Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty.
Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.
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