Detection of Recurrent Parathyroid Cancer Using 68Ga-Trivehexin PET/CT.

IF 9.6 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Clinical Nuclear Medicine Pub Date : 2025-05-15 DOI:10.1097/RLU.0000000000005735

Dilara Denizmen Zorba, Serkan Kuyumcu, Ayse Kubat Uzum, Emine Goknur Isik, Yasemin Sanli

引用次数: 0

Abstract

A 53-year-old woman with a history of multiple surgeries due to recurrent parathyroid carcinoma (rPTC) presented with elevated serum parathyroid hormone (PTH) and ionized calcium (Ca) levels. While 18F-FDG PET/CT showed no pathologic uptake and 99mTc-MIBI SPECT/CT showed a suspicious uptake, 68Ga-Trivehexin PET/CT revealed intense activity in the recurrent lesion, as well as mild activity in one of the newly detected, widespread lesions in both lungs, which was assessed as metastatic. This is the first case report demonstrating the potential role of 68Ga-Trivehexin PET/CT in detecting recurrent PTC, highlighting the possibility of false-negative results with 18F-FDG PET/CT and 99mTc-MIBI scintigraphy.

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68Ga-Trivehexin PET/CT检测复发性甲状旁腺癌。

一位53岁女性，因复发性甲状旁腺癌（rPTC）多次手术，表现为血清甲状旁腺激素（PTH）和离子钙（Ca）水平升高。18F-FDG PET/CT未显示病理性摄取，99mTc-MIBI SPECT/CT显示可疑摄取，68Ga-Trivehexin PET/CT显示复发病灶有强烈活性，其中一个新发现的双肺广泛病灶有轻度活性，评估为转移。这是第一个证明68Ga-Trivehexin PET/CT在检测复发性PTC中的潜在作用的病例报告，强调了18F-FDG PET/CT和99mTc-MIBI显像假阴性结果的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Nuclear Medicine 医学-核医学

CiteScore

2.90

自引率

31.10%

发文量

1113

审稿时长

2 months

期刊介绍： Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty. Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.