Clinical Nuclear Medicine最新文献

{"title":"Quantitative Evaluation of 99m Tc-Galactosyl Human Serum Albumin SPECT/CT for the Prediction of Posthepatectomy Liver Failure.","authors":"Yukinori Okajima, Shin Yanagisawa, Akira Yamada, Tsuyoshi Notake, Akira Shimizu, Yuji Soejima, Yasunari Fujinaga","doi":"10.1097/RLU.0000000000005648","DOIUrl":"10.1097/RLU.0000000000005648","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the predictive ability of 99m Tc-galactosyl human serum albumin SPECT/CT quantitative parameters for posthepatectomy liver failure (PHLF).</p><p><strong>Methods: </strong>Sixty-eight patients who underwent 99m Tc-galactosyl human serum albumin scintigraphy as a preoperative examination for hepatectomy between July 2021 and December 2023 were prospectively evaluated. The patients were divided into PHLF and non-PHLF groups. The clearance index (HH15) and receptor index (LHL15) were calculated from planar images. Quantitative parameters for the total liver (SUV max , SUV mean , peak SUV [SUV peak ], functional liver volume [FLV], SUV mean  × FLV), remnant liver (r-SUV max , r-SUV mean , r-SUV peak , r-FLV, and r-SUV mean  × r-FLV), and r-FLV/FLV were calculated from SPECT/CT images. The areas under the curve (AUCs) of parameters from planar images and SPECT/CT parameters of the total and remnant livers were calculated to evaluate the predictive ability of PHLF.</p><p><strong>Results: </strong>PHLF occurred in 9 patients. AUC of r-FLV was significantly higher than that of HH15 (0.93; 95% confidence interval [CI], 0.84-0.99 vs 0.66; 95% CI, 0.46-0.84; P  = 0.026) and LHL15 (0.93; 95% CI, 0.84-0.99 vs 0.72; 95% CI, 0.55-0.86; P  = 0.043). AUC of r-SUV mean  × r-FLV was significantly higher than that of HH15 (0.90; 95% CI, 0.80-0.97 vs 0.66; 95% CI, 0.46-0.84; P  = 0.037). There were no significant differences between the AUC of other SPECT/CT, r-FLV/FLV, and planar image parameters.</p><p><strong>Conclusions: </strong>r-FLV can predict PHLF more accurately than HH15 or LHL15.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"404-409"},"PeriodicalIF":9.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct Characteristics of Suspected Non-Alzheimer Pathophysiology in Relation to Cognitive Status and Cerebrovascular Burden.","authors":"Min Young Chun, Yu Hyun Park, Hee Jin Kim, Duk L Na, Jun Pyo Kim, Sang Won Seo, Hyemin Jang","doi":"10.1097/RLU.0000000000005793","DOIUrl":"10.1097/RLU.0000000000005793","url":null,"abstract":"<p><strong>Purpose of the report: </strong>This study investigated the prevalence and clinical characteristics of suspected non-Alzheimer disease pathophysiology (SNAP) across varying cognitive statuses and cerebral small vessel disease (CSVD) burden.</p><p><strong>Patients and methods: </strong>We included 1992 participants with cognitive status categorized as cognitively unimpaired, mild cognitive impairment, or dementia. β-amyloid (Aβ, A) positivity was assessed by Aβ PET, and neurodegeneration (N) positivity was determined through hippocampal volume. Participants were further divided by the presence or absence of severe CSVD. The clinical and imaging characteristics of A-N+ (SNAP) group were compared with those of the A-N- and A+N+ groups.</p><p><strong>Results: </strong>SNAP participants were older and had more vascular risk factors compared with A-N- and A+N+ in the CSVD(-) cohort. SNAP and A+N+ showed similar cortical thinning. At the dementia stage, SNAP had a cognitive trajectory similar to A+N+ in the CSVD(-) cohort. However, SNAP exhibited less cognitive decline than A+N+ in the CSVD(+) cohort.</p><p><strong>Conclusions: </strong>SNAP is characterized by distinct clinical and imaging characteristics; however, it does not necessarily indicate a benign prognosis, particularly at the dementia stage. These findings highlight the need to assess SNAP in relation to the cognitive stage and CSVD presence to better understand its progression and guide interventions.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"368-380"},"PeriodicalIF":9.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11969373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Below-the-Radar: A Case of Extensive Osseous Metastasis of Prostate Cancer Confined Exclusively to One Lower Limb.","authors":"Jan Heilinger, Dominic Ufton, Uta Drebber, Matthias Schmidt, Alexander Drzezga","doi":"10.1097/RLU.0000000000005756","DOIUrl":"10.1097/RLU.0000000000005756","url":null,"abstract":"<p><p>Osseous metastases are a common finding in prostate cancer, usually affecting the central skeleton. Metastases in the peripheral skeleton are less frequent but can occur as isolated findings as well. Therefore, imaging protocols limited to the trunk may miss such lesions and extended range (total-body) PSMA-PET/CT may be helpful for comprehensive evaluation, especially when peripheral metastases are suspected, for example, due to clinical symptoms.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":"50 5","pages":"421-422"},"PeriodicalIF":9.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11967916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Application of 68 Ga-Pentixafor PET/CT for the Detection of Thymoma: A Pilot Study.","authors":"Rongxi Wang, Xuehan Gao, Xingtong Peng, Jiarou Wang, Jialin Xiang, Linlin Li, Chenhao Jia, Jingci Chen, Xin Du, Chao Guo, Xiaoyun Zhou, Yumin Zheng, Zhaohui Zhu, Yeye Chen, Shanqing Li","doi":"10.1097/RLU.0000000000005770","DOIUrl":"10.1097/RLU.0000000000005770","url":null,"abstract":"<p><strong>Purpose: </strong>This study was designed to evaluate 68 Ga-pentixafor, which targets C-X-C chemokine receptor 4 (CXCR4), in the noninvasive diagnosis of thymomas.</p><p><strong>Patients and methods: </strong>With institutional review board approval and signed informed consent, 32 patients with thymic masses were enrolled in this study, and all patients underwent 68 Ga-pentixafor PET/CT scans.</p><p><strong>Results: </strong>Among the 28 patients included in the analysis, 13 patients were diagnosed with thymomas, 9 patients with cysts, and 6 patients with other anterior mediastinal masses. 68 Ga-pentixafor identified all patients with thymomas (13/13, 100%), and the mean SUV max in all 13 thymomas lesions was 13.96±8.20, which was significantly higher than that in patients with cysts (1.54±0.88) and other anterior mediastinal masses (2.59±1.68), respectively ( P <0.001).</p><p><strong>Conclusions: </strong>The preliminary study indicates the diagnostic utility of 68 Ga-pentixafor in thymomas and the differential diagnostic ability of 68 Ga-pentixafor in thymomas, thymic cysts and other benign anterior mediastinal masses.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"388-393"},"PeriodicalIF":9.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-Stop 68 Ga-FAPI/ 18 F-FDG Total-Body PET/CT Scan : More Theranostics Information Available.","authors":"Huaping Gao, Han Tang, Zhe Zheng, Haojun Yu, Wujian Mao, Yu Lin, Jiefu Zheng, Akram Al-Ibraheem, Yibo He, Wenxin Tang, Runjun Yang, Yunze Xie, Lijie Tan, Hongcheng Shi","doi":"10.1097/RLU.0000000000005673","DOIUrl":"10.1097/RLU.0000000000005673","url":null,"abstract":"<p><strong>Purpose: </strong>This prospective study aims to assess the feasibility of a one-stop imaging protocol using 68 Ga-FAPI-04/ 18 F-FDG dual-radiotracer with dual-low-activity for tumor imaging.</p><p><strong>Patients and methods: </strong>Forty patients underwent one-stop 68 Ga-FAPI-04 PET (PET FAPI ) and dual-radiotracer PET (PET DUAL ) using a total-body PET/CT scanner with a 194-cm axial field of view. After a half-dose (0.925 MBq/kg) 68 Ga-FAPI-04 PET/CT, an additional half-dose (1.85 MBq/kg) of 18 F-FDG was administered for a 60-minute dynamic acquisition. PET DUAL was reconstructed at 10-minute intervals (PET D0-10 , PET D10-20 , PET D20-30 , PET D30-40 , PET D40-50 , and PET D50-60 ). Data of lesion detectability, target-to-background ratios, tumor staging, and total radiation dose were analyzed. A target-to-liver ratio (TLR) ≥ 3 on PET FAPI was considered indicative of sufficient fibroblast activation protein expression.</p><p><strong>Results: </strong>PET D50-60 and PET FAPI showed similar performance in detecting primary tumors (42 vs 41, P  > 0.999). However, significantly more metastatic lesions were identified on PET D50-60 compared with PET FAPI (102 vs 60, P  < 0.001). PET FAPI demonstrated significantly higher TLR, target-to-blood-pool ratio, and target-to-normal-tissue ratio than PET DUAL ( P  < 0.05). Lesion detectability was similar across PET D10-20 , PET D20-30 , PET D30-40 , PET D40-50 , and PET D50-60 (all P 's > 0.05). Notably, PET D30-40 and PET D40-50 detected all lesions identified by PET D50-60 . PET D40-50 showed no significant differences in TLR, target-to-blood-pool ratio, and target-to-normal-tissue ratio compared with PET D50-60 ( P  > 0.05). Up to 94.9% of malignant primary lesions exhibited a TLR ≥ 3 on PET FAPI . The average effective dose was 9.85 ± 2.19 mSv, similar to that of a whole-body 18 F-FDG PET/CT.</p><p><strong>Conclusions: </strong>This one-stop, dual-radiotracer, dual-low-activity imaging protocol combines the strengths of 68 Ga-FAPI-04 and 18 F-FDG, offering a shorter imaging duration and reduced radiation exposure.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e253-e261"},"PeriodicalIF":9.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"99m Tc-FAPI-46 Uptake in Simultaneous Occurrence of Benign Thyroid Nodule and Mixed-Mucinous-Invasive Ductal Breast Carcinoma.","authors":"Nasrin Raeisi, Amin Saber Tanha, Kamran Aryana, Mahsa Akbari Oryani, Somaye Barashki","doi":"10.1097/RLU.0000000000005729","DOIUrl":"10.1097/RLU.0000000000005729","url":null,"abstract":"<p><p>We present a case of a 65-year-old woman diagnosed with mixed mucinous-invasive ductal carcinoma, a rare subtype of breast cancer. Utilizing 99m Tc-FAPI-46 scintigraphy, we observed a high target-to-background ratio in the breast mass and metastatic axillary lymph nodes. Notably, a benign follicular nodule was also detected in the thyroid which showed absent 99m Tc-FAPI uptake. Our findings suggest that 99m Tc-FAPI-46 shares similar characteristics with 68 Ga-FAPI and may outperform 18 F-FDG PET/CT in mucinous breast cancer. This case highlights the potential of FAPI as a predictive biomarker for malignancy and its role in benign findings.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e297-e299"},"PeriodicalIF":9.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"68 Ga-FAPI PET/CT Depicted Non-FDG-Avid Malignant Peritoneal Mesothelioma.","authors":"Puhao Li, Juan Liang, Yue Chen, Haoyuan Ding","doi":"10.1097/RLU.0000000000005676","DOIUrl":"10.1097/RLU.0000000000005676","url":null,"abstract":"<p><strong>Abstract: </strong>Malignant peritoneal mesothelioma (MPM) is a rare and aggressive malignancy of mesothelial cells in the peritoneum. Herein, we describe the 68 Ga-FAPI and 18 F-FDG PET/CT findings of MPM in a 41-year-old man. In the present case, the primary and metastatic tumors showed intense 68 Ga-FAPI accumulation but no significantly increased 18 F-FDG uptake. This case demonstrates that 68 Ga-FAPI PET/CT might be used as a helpful tool for evaluating MPM staging.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"462-463"},"PeriodicalIF":9.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"68 Ga-FAPI PET/CT in a Patient With Multiple Aneurysms Due to Idiopathic Hypereosinophilic Syndrome.","authors":"Puhao Li, Juan Liang, Yue Chen, Haoyuan Ding","doi":"10.1097/RLU.0000000000005704","DOIUrl":"10.1097/RLU.0000000000005704","url":null,"abstract":"<p><strong>Abstract: </strong>Idiopathic hypereosinophilic syndrome is a group of unexplained diseases characterized by a persistent increase in eosinophils with multiple organs damage. Herein, we describe the 68 Ga-FAPI PET/CT findings of idiopathic hypereosinophilic syndrome in a 56-year-old woman. 68 Ga-FAPI PET/CT showed multiple aneurysms with increased FAPI uptake. In addition, myocardial uptake of FAPI was observed.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"431-432"},"PeriodicalIF":9.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"68 Ga-PSMA Uptake of Brain Abscesses in a Patient With Prostate Cancer.","authors":"Ying Huang, Bing Zhang, Dianchao Yue","doi":"10.1097/RLU.0000000000005659","DOIUrl":"10.1097/RLU.0000000000005659","url":null,"abstract":"<p><strong>Abstract: </strong>A 56-year-old man with a history of brain abscess undergoing a 68 Ga-labeled prostate-specific membrane antigen (PSMA) ligand PET/CT scan due to rising prostate-specific antigen levels. Besides the uptake of PSMA in the prostate lesion, the 68 Ga-PSMA PET/CT images showed significant PSMA uptake in the abscesses in the left parietal and left temporal lobes. This highlights the necessity of cautious interpretation of PSMA PET/CT results, considering alternative diagnoses like infections.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"e283-e285"},"PeriodicalIF":9.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FDG-PET/CT Findings in Hemophagocytic Lymphohistiocytosis.","authors":"Debra Ann Dawson, Duncan E K Sutherland","doi":"10.1097/RLU.0000000000005780","DOIUrl":"10.1097/RLU.0000000000005780","url":null,"abstract":"<p><p>A 44-year-old man was admitted to the hospital with fever, pancytopenia, and a new rash. FDG-PET was ordered in light of nonspecific clinical, imaging, and biopsy findings. Findings included diffuse FDG uptake throughout the subcutaneous fat overlying fat stranding/haziness on CT. FDG uptake was associated with scattered subsolid/ground-glass lesions in the lungs. Splenomegaly and increased FDG uptake throughout the bone marrow were seen. Diagnostic considerations included infectious versus lymphomatous processes, and possible sites for biopsy were identified. Biopsy of a highly FDG-avid lung lesion led to a diagnosis of hemophagocytic lymphohistiocytosis secondary to peripheral T-cell lymphoma, not otherwise specified.</p>","PeriodicalId":10692,"journal":{"name":"Clinical Nuclear Medicine","volume":" ","pages":"458-459"},"PeriodicalIF":9.6,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}