99mTc-PYP和99mTc-MDP在罕见的apoa - 1型心脏淀粉样变性合并骨Paget病中的显像分析

IF 9.6 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Clinical Nuclear Medicine Pub Date : 2025-10-01 Epub Date: 2025-07-07 DOI:10.1097/RLU.0000000000005879

Naoko Okada, Yoichi Otomi, Takayoshi Shinya, Shoichiro Takao, Hideki Otsuka

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引用次数: 0

摘要

一名70岁男性，有20年心力衰竭病史，并发心房颤动，接受了心脏起搏器植入；然而，他的心力衰竭继续恶化。99mTc-PYP显像显示心肌和右侧骨盆骨明显摄取。同样，99mtc -二膦酸亚甲基闪烁成像显示在两个区域都有积极的吸收。心肌活检证实心脏淀粉样变性，质谱鉴定为apoa - 1淀粉样变性。此外，右髂翼骨活检导致病理诊断为骨Paget病。

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99m Tc-PYP and 99m Tc-MDP Scintigraphy in a Rare Case of Combined ApoA-I Cardiac Amyloidosis and Paget Disease of the Bone.

A 70-year-old man with a 20-year history of heart failure developed atrial fibrillation and underwent pacemaker implantation; however, his heart failure continued to worsen. Imaging with 99m Tc-PYP scintigraphy revealed significant uptake in the myocardium and the right pelvic bone. Similarly, 99m Tc-methylene diphosphonate scintigraphy demonstrated positive uptake in both regions. A myocardial biopsy confirmed cardiac amyloidosis, and mass spectrometry identified ApoA-I amyloidosis. In addition, a bone biopsy of the right iliac wing resulted in a pathologic diagnosis of Paget disease of bone.

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来源期刊

Clinical Nuclear Medicine 医学-核医学

CiteScore

2.90

自引率

31.10%

发文量

1113

审稿时长

2 months

期刊介绍： Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty. Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.