三阴性乳腺癌和68Ga-Trivehexin：一瞥希望。

IF 9.6 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Clinical Nuclear Medicine Pub Date : 2025-05-15 DOI:10.1097/RLU.0000000000005963

Fahad Marafi, Taibah Alahmad, Mahmoud Alfeeli, Alyaa Sadeq

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引用次数: 0

摘要

αvβ6整合素是一种异二聚体跨膜细胞粘附受体，介导细胞-基质粘附，与包括乳腺癌在内的多种恶性肿瘤的侵袭性相关，可降低无进展生存期。该整合素促进肿瘤侵袭，抑制细胞凋亡，调节基质金属蛋白酶的表达，激活TGF-β。因此，它可以作为一种预后指标，用于跟踪侵袭前肿瘤的进展，监测靶向αvβ6-整合素的放射性药物的治疗变化，以及其作为治疗药物的潜在作用。我们的病例证明了68Ga-Trivehexin PET示踪剂在组织病理学证实的三阴性乳腺癌中的可行性。

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Triple Negative Breast Cancer and 68Ga-Trivehexin: A Glance of Hope.

αvβ6 integrin is a heterodimeric transmembrane cell adhesive receptors that mediate cell-substratum adhesion and has been correlated to aggressiveness of various malignancies including breast cancer, with reduced progression-free survival. This integrin was found to facilitate tumor invasion, inhibit apoptosis, regulate expression of matrix metalloproteases, and activate TGF-β. Therefore, it could serve as a prognostic prob for tracking preinvasive tumor progression and monitoring the treatment variety of radiopharmaceuticals that target αvβ6-integrin, as well as its potential role as theranostic agent. Our case demonstrates the viability of 68Ga-Trivehexin PET tracer in a case of histopathologically proven triple-negative breast cancer.

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来源期刊

Clinical Nuclear Medicine 医学-核医学

CiteScore

2.90

自引率

31.10%

发文量

1113

审稿时长

2 months

期刊介绍： Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty. Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.