Clinical Medicine Insights. Case Reports最新文献

{"title":"<i>Fusarium</i> Species Fungal Prosthetic Joint Infection of the Proximal Interphalangeal Joint After Silicone Arthroplasty: A Case Report.","authors":"Grace Anne Longfellow, Stephen M Himmelberg, Alexander D Jeffs, Reid W Draeger","doi":"10.1177/11795476251377947","DOIUrl":"10.1177/11795476251377947","url":null,"abstract":"<p><strong>Background: </strong>Prosthetic joint infection (PJI) following proximal interphalangeal joint (PIPJ) arthroplasty is rare, with most reported cases involving bacterial organisms. Fungal PJIs comprise <1% of all PJIs, with <i>Fusarium</i> species an exceptionally uncommon cause, particularly in the upper extremity.</p><p><strong>Case presentation: </strong>A 60-year-old female with a history of rheumatoid arthritis on methotrexate and adalimumab underwent right long finger PIPJ silicone arthroplasty. She presented 12 weeks postoperatively with pain, swelling, and radiographic changes concerning for PJI despite normal inflammatory markers. Implant explantation with debridement was performed, and intraoperative cultures grew <i>Fusarium</i> species. Initial oral voriconazole was insufficient, necessitating readmission for intravenous liposomal amphotericin B and oral posaconazole. Thirty-nine days after completing her 6-month antifungal course, she underwent arthrodesis, which later failed, requiring revision with iliac crest autograft and dorsal plate fixation. At latest follow-up, she remained pain-free with radiographic union and no recurrent infection.</p><p><strong>Conclusions: </strong>Based on available literature, this represents the first reported case of <i>Fusarium</i> PJI following silicone arthroplasty of the hand. This underscores the importance of maintaining suspicion for atypical pathogens in immunosuppressed hosts and highlights the complexities managing fungal infections in small joint arthroplasty.</p>","PeriodicalId":10357,"journal":{"name":"Clinical Medicine Insights. Case Reports","volume":"18 ","pages":"11795476251377947"},"PeriodicalIF":0.6,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late-Onset Intracranial Melanotic Schwannoma of the Cerebellopontine Angle: Case Report and Review of the Literature.","authors":"Saverio Nicoletti, Giuseppe Magliulo, Giannicola Iannella, Alessandra Manno, Daniela Messineo, Mara Riminucci, Alessandro Corsi, Annalisa Pace","doi":"10.1177/11795476251346605","DOIUrl":"10.1177/11795476251346605","url":null,"abstract":"<p><p>Melanotic schwannoma is a rare malignant tumor of nerve sheaths characterized by melanin-producing cells. It is mostly localized in the posterior roots of spinal nerves or sympathetic ganglia whereas the intracranial localizations are less common. The aim of this study is to describe a case of sporadic melanotic schwannoma of the right cerebellopontine angle, including a literature review of the topic. This is the case of a 79-year-old woman who presented with right-sided hearing loss and vertigo. Magnetic resonance imaging (MRI) of the brain revealed an 8 × 6 mm lesion at the level of the right cerebellar peduncle, hyperintense on T1-weighted sequences. A gross total resection of the lesion was performed through a retrosigmoid approach. The histological and immunohistochemical exams were consistent with a malignant melanotic schwannoma. Research was conducted using Pubmed and a reference list. Only melanotic schwannomas with intracranial localizations were considered. Twenty-nine articles were included in this review, reporting a total number of 32 cases of intracranial melanotic schwannomas. The treatment of choice is the complete surgical excision of the neoplasm; adjuvant radiotherapy correlates with lower rates of recurrence and metastasis. Our case represents the latest onset of an intracranial melanocytic schwannoma with a clinical course similar to a conventional eighth cranial nerve schwannoma.</p>","PeriodicalId":10357,"journal":{"name":"Clinical Medicine Insights. Case Reports","volume":"18 ","pages":"11795476251346605"},"PeriodicalIF":0.6,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457748/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triple Threat: SLE, APS, and Clotting Factor Abnormalities Leading to Subacute Budd-Chiari Syndrome. A Case Report and Review of the Literature.","authors":"Khadija Malik, Areeb Jawed, Muddassir Syed Saleem, Nidal Bin Kamran, Laiba Shahbaz","doi":"10.1177/11795476251377952","DOIUrl":"10.1177/11795476251377952","url":null,"abstract":"<p><strong>Background: </strong>This report presents a unique case of subacute BCS in a patient with systemic lupus erythematosus (SLE), antiphospholipid syndrome (APS), and multiple inherited thrombophilic disorders No previous history and lack of inciting events meant extensive investigation had to be done to figure out the underlying pathology. The amalgam of thrombophilias presenting initially as Sub-Acute Budd Chiari syndrome is very rare to find in the literature and highlights the importance of early screening and diagnosis to prevent complications of Thrombosis.</p><p><strong>Case presentation: </strong>The patient presented with a 3 months history of progressive abdominal distension, hematemesis, and altered consciousness. The diagnosis made was Sub-Acute Budd Chiari Syndrome. The patient was managed with anticoagulation, diuretics, and symptomatic treatment. After stabilization the patient was discharged for follow-up after 2 weeks.</p><p><strong>Conclusion and key take-away lessons: </strong>This case highlights the diagnostic challenges of BCS, particularly in patients with hereditary hypercoagulability. Early recognition and management are critical in preventing severe complications of thrombosis. Moreover, it underscores the impact of limited healthcare access in rural settings, emphasizing the need for improved screening, awareness, and targeted interventions for thrombophilic disorders with a set diagnostic criteria for sub-acute presentation.</p>","PeriodicalId":10357,"journal":{"name":"Clinical Medicine Insights. Case Reports","volume":"18 ","pages":"11795476251377952"},"PeriodicalIF":0.6,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12446807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145112105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe Diabetic Ketoacidosis With Leukemoid Reaction and Coma in a Toddler: A Case Report.","authors":"Ievgeniia Burlaka, Serhii Babii, Ihor Kovalchuk","doi":"10.1177/11795476251375551","DOIUrl":"10.1177/11795476251375551","url":null,"abstract":"<p><p>We present a case of a 3-year-old girl with previously diagnosed type 1 diabetes mellitus (T1DM) who was admitted in an unconscious state with severe diabetic ketoacidosis (DKA), lactic acidosis, and coma. The condition was complicated by profound dehydration, leukemoid reaction of neutrophilic type, and reactive thrombocytosis. Early intensive care management, mechanical ventilation, and insulin therapy led to stabilization and gradual recovery. This case highlights the critical importance of early recognition, aggressive management, and multidisciplinary care in pediatric patients with complicated DKA.</p>","PeriodicalId":10357,"journal":{"name":"Clinical Medicine Insights. Case Reports","volume":"18 ","pages":"11795476251375551"},"PeriodicalIF":0.6,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12441270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrocele of the Canal of Nuck: A Rare Etiology of Inguino-Labial Swelling in a Young Female: A Case Report.","authors":"Tesfa G Meskel, Mesfin Wubishet, Abraham Teshome","doi":"10.1177/11795476251375634","DOIUrl":"10.1177/11795476251375634","url":null,"abstract":"<p><strong>Background: </strong>Hydrocele of the canal of Nuck is a rare congenital condition in females that often mimics other groin masses, making accurate diagnosis challenging. Limited awareness, particularly among non-surgical clinicians, often leads to unnecessary investigations or delayed treatment. Greater recognition of this entity is crucial for timely diagnosis and appropriate management.</p><p><strong>Case presentation: </strong>We report the case of a 6-year-old girl who presented with a painless swelling in the right inguinal region, persisting for six months. On examination, a firm, non-tender mass measuring 3 × 3 cm was noted. Ultrasonography revealed a well-defined, unilocular cystic lesion measuring 4 × 3 cm, extending through the inguinal canal into the labia majora. Surgical excision was performed, with careful dissection from the round ligament and ligation of the canal of Nuck at the deep inguinal ring. The cyst contained clear serous fluid. The patient's postoperative course was uneventful, and no recurrence was observed at three-month follow-up.</p><p><strong>Conclusion: </strong>Hydrocele of the canal of Nuck is an uncommon and often overlooked condition with limited representation in surgical and gynecological literature, yet it remains an important differential diagnosis for inguino-labial swelling in young females. Early clinical recognition is crucial to avoid unnecessary imaging or invasive procedures. Ultrasonography provides a reliable, non-invasive means of differentiation from other inguino-labial masses, while surgical excision remains the definitive treatment with excellent outcomes. This case underscores the importance of considering this diagnosis in young females presenting with inguino-labial swelling.</p>","PeriodicalId":10357,"journal":{"name":"Clinical Medicine Insights. Case Reports","volume":"18 ","pages":"11795476251375634"},"PeriodicalIF":0.6,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12441254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral Subdural Hematoma Caused by Cervical Traction.","authors":"Tomoo Mano","doi":"10.1177/11795476251376464","DOIUrl":"10.1177/11795476251376464","url":null,"abstract":"<p><p>Cervical traction therapy is commonly used for cervical spondylosis; however, complications, such as subdural hematomas can occur. Possible mechanisms include cerebrospinal fluid (CSF) leakage and bridging vein damage. A 51-year-old Japanese woman developed a persistent headache after 2 weeks of cervical traction therapy. Magnetic resonance imaging revealed bilateral subdural hematomas. Bed rest, oral analgesics, and daily infusion therapy failed to improve symptoms, but 2 epidural blood patches led to recovery. Although no direct CSF leakage was found, a spinal epidural lesion may have contributed. Cervical traction therapy may cause subdural hematomas via intracranial hypotension. Clinicians should consider this risk and conduct thorough diagnostic evaluations in affected patients.</p>","PeriodicalId":10357,"journal":{"name":"Clinical Medicine Insights. Case Reports","volume":"18 ","pages":"11795476251376464"},"PeriodicalIF":0.6,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12441269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the Usual Features-Expanded Dengue Syndrome in Association With Possible Pre-existing Neurological Disease: A Case Report.","authors":"Warda Fatmi, Usha Kumari, Shehroz Shahid, Maria Waseem, Qamar Un Nisa Mukhtar","doi":"10.1177/11795476251359429","DOIUrl":"10.1177/11795476251359429","url":null,"abstract":"<p><p>Dengue virus infection is a significant public health concern, particularly in endemic areas. This case report highlights the difficulties in diagnosing expanded dengue syndrome (EDS) in a dengue-endemic region. This case report emphasizes keeping high suspicion of index for (EDS) among patients presenting with fever and neurological manifestations particularly in regions where dengue is endemic. The atypical neurological symptoms and inconclusive initial investigations underscore the diagnostic challenges associated with (EDS). Prompt recognition and appropriate laboratory testing, such as detecting dengue NS1 antigen, can aid in accurate diagnosis and subsequent management of patients with this condition. Increased awareness among healthcare providers in endemic regions is crucial for timely identification and intervention in case of dengue-associated neurological complications. Therefore, a multidisciplinary approach is required for time-effective management.</p>","PeriodicalId":10357,"journal":{"name":"Clinical Medicine Insights. Case Reports","volume":"18 ","pages":"11795476251359429"},"PeriodicalIF":0.6,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Sutures: Moist Exposed Burn Ointment (MEBO) and Scar Massage for Anatomical Restoration of Penetrating Upper Lip Laceration at the Vermilion-Cutaneous Junction in Primary Care-A Case Report.","authors":"Hana M Abualadas","doi":"10.1177/11795476251370546","DOIUrl":"10.1177/11795476251370546","url":null,"abstract":"<p><strong>Introduction: </strong>Workplace-related traumatic lip injuries, particularly at the vermilion-cutaneous junction, are challenging due to functional impairment and visible scarring. While typically managed in specialized settings, some cases present in primary care clinics. This report details the successful management of a penetrating laceration at this junction using layered closure and MEBO for optimized healing, with postoperative scar massage therapy to enhance recovery.</p><p><strong>Case presentation: </strong>A 19-year-old male construction worker sustained a full-thickness laceration from the vermilion-cutaneous junction to the inner mucosa. The injury was repaired in a primary care clinic, where precise vermilion alignment was essential. Layered closure was performed using absorbable (5-0 Vicryl) sutures for mucosal, muscular, and dermal layers, and nonabsorbable (6-0 Prolene) sutures for the vermilion-cutaneous junction. MEBO, a plant-based ointment primarily used for burns, was applied postoperatively to promote healing, and reduce scarring. Scar massage therapy was initiated after wound healing. Follow-ups at 5 days, 1 week, 6 weeks, and 4 months showed excellent cosmetic outcomes, minimal scarring, and full functional recovery.</p><p><strong>Clinical discussion: </strong>6-0 Prolene was preferred over nylon sutures due to its superior biocompatibility. Simple interrupted sutures ensured tension-free closure for optimal healing. MEBO supported epithelial proliferation, moisture retention, and reduced inflammation-promoting faster tissue repair and superior scar remodeling compared to standard antibiotic ointments, petroleum jelly, or silicone gels. Postoperative scar massage further enhanced collagen remodeling, reduced fibrosis, and improved lip flexibility.</p><p><strong>Conclusion: </strong>This case highlights the feasibility of managing complex lip injuries in a primary care setting and emphasizes the importance of precise anatomical repair, proper suture selection, and novel interventions like MEBO and scar massage. Further research is needed to establish MEBO's role in standard postoperative care for traumatic lip injuries.</p>","PeriodicalId":10357,"journal":{"name":"Clinical Medicine Insights. Case Reports","volume":"18 ","pages":"11795476251370546"},"PeriodicalIF":0.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12402591/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypokalemic Periodic Paralysis in a Patient With Primary Sjögren's Syndrome and Distal Renal Tubular Acidosis: A Case Report.","authors":"Vansh Varma, Ajay Kumar Patel, Nitya Pathak, Abhishek Patel, Shubham Kumar, Shilpa Gaidhane, Sanjit Sah, Prakasini Satapathy, Rachana Mehta, Amogh Verma","doi":"10.1177/11795476251372407","DOIUrl":"10.1177/11795476251372407","url":null,"abstract":"<p><strong>Introduction: </strong>Hypokalemic periodic paralysis (HPP) is a severe yet reversible neuromuscular condition precipitated by profound hypokalemia. Autoimmune disorders can exacerbate renal potassium loss resulting in abrupt muscle weakness. Primary Sjögren's syndrome (pSS), an autoimmune disease characterized by exocrine gland insufficiency, can lead to renal tubular dysfunction and episodes of HPP when distal acidification is compromised.</p><p><strong>Case presentation: </strong>A 40-year-old woman was admitted with rapidly progressive, painless quadriplegia for over 2 days. Laboratory tests revealed critical hypokalemia (1.4 mEq/L), metabolic acidosis, and alkaline urine pH, which was consistent with type 1 distal renal tubular acidosis (dRTA). Serologic studies confirmed pSS. Corrective measures included intravenous potassium chloride and sodium bicarbonate along with immunomodulation with intravenous methylprednisolone, followed by oral prednisolone.</p><p><strong>Discussion: </strong>The patient's presentation illustrates how autoimmune-mediated renal tubular dysfunction can precipitate HPP. Failure of distal acid excretion impairs potassium handling, amplifying the risk of potentially life-threatening neuromuscular collapse. Stabilization requires meticulous electrolyte repletion and treatment of the underlying autoimmunity. Restoration of serum potassium levels, acid-base balance, and targeted immunosuppression resulted in rapid clinical improvement.</p><p><strong>Conclusion: </strong>An accurate diagnosis of HPP secondary to dRTA and Sjögren's syndrome requires high clinical suspicion. Prompt recognition and intervention, including immunotherapy and balanced electrolyte replacement, can prevent profound neuromuscular complications and improve patient outcome.</p>","PeriodicalId":10357,"journal":{"name":"Clinical Medicine Insights. Case Reports","volume":"18 ","pages":"11795476251372407"},"PeriodicalIF":0.6,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12398652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pneumatosis Intestinalis Detected by Point of Care Ultrasound, Case Report.","authors":"Zouheir Ibrahim Bitar, Ossama Sajeh Maadarani, Mohamad Abdelfatah, Bibin Antony","doi":"10.1177/11795476251370547","DOIUrl":"10.1177/11795476251370547","url":null,"abstract":"<p><p>Pneumatosis intestinalis (PI) is characterized by the presence of air within the walls of the small intestine, large intestine, and sometimes the gastric wall. The mechanism and pathogenesis of PI are poorly understood. The discovery of PI can occur in the form of an incidental finding, such as a benign course or a life-threatening condition, such as intestinal ischemia. Point-of-care ultrasonography (POCUS) for pneumatosis intestinalis (PI) is rarely reported in adults, with only 1 previous poster presentation. However, POCUS is well-documented in the pediatric population, particularly for the diagnosis of intussusception. We present a 78-year-old man with longstanding uncorrected severe pulmonary stenosis, right-sided heart failure, atrial fibrillation on dabigatran, diabetes, and cirrhosis who presented with progressive abdominal distension. POCUS and computerized tomography of the abdomen showed ascites, diffusing small-bowel wall thickening with edema, and pneumatosis intestinalis, without portal venous gas or vascular occlusion. Patient was transitioned to palliative care on diuretics, lactulose; follow-up ultrasound showed only mild ascites but persistent small-bowel PI. This case report marks the second instance of POCUS being utilized for PI in an adult population. POCUS can play an essential diagnostic role at the bedside, ruling out serious underlying etiologies and guiding physicians in further diagnostic testing.</p>","PeriodicalId":10357,"journal":{"name":"Clinical Medicine Insights. Case Reports","volume":"18 ","pages":"11795476251370547"},"PeriodicalIF":0.6,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12397599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144944892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}