Clinical Medicine Insights. Case Reports最新文献

{"title":"Silent Gastroesophageal Reflux Disease Presenting With Acute Cough and Poor Response to Antitussives: A Case Report.","authors":"Hussein Mussa Muafa","doi":"10.1177/11795476261446356","DOIUrl":"https://doi.org/10.1177/11795476261446356","url":null,"abstract":"<p><p>Silent gastroesophageal reflux disease (GERD) is an atypical form of reflux disease in which patients present predominantly with extra-esophageal manifestations rather than classic symptoms such as heartburn or acid regurgitation. In this form, gastric refluxate may reach the upper aerodigestive tract, leading to laryngeal or respiratory symptoms that are frequently misattributed to infectious or allergic conditions. The absence of typical gastrointestinal complaints often results in delayed diagnosis and repeated ineffective treatments. We report the case of a 27-year-old male who presented with acute dry cough and progressive hoarseness without gastrointestinal symptoms. After excluding infectious and allergic etiologies, and noting a poor response to antitussive and bronchodilator therapies, a presumptive clinical diagnosis was established. Recognition of dietary triggers and rapid symptom resolution following a 4-week empirical trial of proton pump inhibitor therapy-along with symptom recurrence upon temporary discontinuation-supported the diagnosis of silent GERD. This case highlights the importance of considering reflux-related etiologies in patients with unexplained cough and laryngeal symptoms to avoid diagnostic delays and unnecessary empirical treatments.</p>","PeriodicalId":10357,"journal":{"name":"Clinical Medicine Insights. Case Reports","volume":"19 ","pages":"11795476261446356"},"PeriodicalIF":0.6,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13133487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When Hiccups Speak Louder Than Cough: A Case Report of An Unusual Presentation of Lung Abscess.","authors":"Antonio Al Hazzouri, Philippe Attieh, Karam Karam, Ihab I El Hajj, Said G Farhat, Elias Fiani","doi":"10.1177/11795476261443093","DOIUrl":"https://doi.org/10.1177/11795476261443093","url":null,"abstract":"<p><p>Hiccups are commonly benign, self-limiting events often triggered by transient gastrointestinal or central nervous system irritants. However, when persistent, they may indicate underlying pathology involving the thoracic, gastrointestinal, or neurological systems. We report the case of a 65-year-old male smoker who presented with a 4-day history of persistent hiccups. He denied fever, chest pain, hemoptysis, or other systemic symptoms. Physical examination was largely unremarkable except for decreased air entry in the right middle and lower lung zones. Initial investigations, including gastroscopy and tumor markers, ruled out gastrointestinal causes. CT scan of the chest revealed a right lower lobe consolidation and cavitation with air fluid level and adjacent ground-glass opacities, along with enlarged subcarinal lymph nodes. Differential diagnoses included lung abscess, pneumonia, and tuberculosis cavitation. The patient was admitted for suspected lung abscess and received antibiotics. Bronchoscopy with bronchoalveolar lavage revealed no endobronchial lesions, and PCR testing and culture of the fluid was negative for tuberculosis but positive for klebsiella pneumonia. Despite radiologic regression of pneumonia, the cavitary lesion and lymphadenopathy persisted initially, but later started to regress. This case highlights an unusual presentation of lung abscess manifesting solely as persistent hiccups, without classic respiratory or systemic signs. We aim to emphasize the need to consider thoracic causes in patients with otherwise unexplained persistent hiccups, and undergo further evaluation in such cases.</p>","PeriodicalId":10357,"journal":{"name":"Clinical Medicine Insights. Case Reports","volume":"19 ","pages":"11795476261443093"},"PeriodicalIF":0.6,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13133434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147812003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual Antithyroid Drug-Induced Agranulocytosis in Graves' Disease With Decompensated Heart Failure: A Multidisciplinary Approach.","authors":"Amarildo Voci, Liri Seraj, Mario Shehu, Asfloral Haxhiu","doi":"10.1177/11795476261446355","DOIUrl":"https://doi.org/10.1177/11795476261446355","url":null,"abstract":"<p><p>Antithyroid drug-induced agranulocytosis is a rare but potentially life-threatening complication, particularly in patients with limited therapeutic options. This case illustrates the complexity of managing uncontrolled thyrotoxicosis in the context of a patient with decompensated heart failure, chronic obstructive pulmonary disease (COPD), and adverse reactions to both methimazole and propylthiouracil. A 54-year-old male patient with a 2-year history of Graves' disease presented with worsening dyspnea and tachycardia in the setting of thyrotoxicosis with a TSH of 0.0007 mIU/L. He had previously developed agranulocytosis (ANC 180 cells/µL) subsequent to treatment with methimazole, and subsequently developed febrile agranulocytosis (ANC 190 cells/µL) upon initiation of propylthiouracil, thereby exhausting all antithyroid drug options. A bridging therapy of Lugol's iodine and granulocyte colony-stimulating factor (G-CSF) was utilized, which enabled successful total thyroidectomy. Right heart catheterization confirmed the patient's suitability for surgery despite a left ventricular ejection fraction of 35%. This case highlights the importance of interdisciplinary collaboration in managing complex endocrine-cardiac-hematology presentations.</p>","PeriodicalId":10357,"journal":{"name":"Clinical Medicine Insights. Case Reports","volume":"19 ","pages":"11795476261446355"},"PeriodicalIF":0.6,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13133480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic Ultrasound-Guided Transoesophageal Biopsy in a Mediastinal Tumour: A Case Report.","authors":"Roberto Antonio Alvarado-Hernández, Yoeli Marisa Escandón-Espinoza, Katia Daniela López-García","doi":"10.1177/11795476261440723","DOIUrl":"https://doi.org/10.1177/11795476261440723","url":null,"abstract":"<p><p>Endoscopic ultrasound-guided transoesophageal biopsy (EUS-FNA/FNB) is a minimally invasive and highly accurate diagnostic technique for evaluating mediastinal lesions, particularly in centres where surgical approaches or endobronchial ultrasound are unavailable. We report the case of a 79-year-old woman with multiple comorbidities who presented with non-specific abdominal pain and a 5 kg weight loss over 1 month. Imaging revealed a 50% left pleural effusion and mediastinal and retroperitoneal lymphadenopathy. Endoscopic ultrasound demonstrated hilar, retroperitoneal and interaortocaval lymph nodes, prompting a transoesophageal fine-needle biopsy using a 22G needle and fanning technique, which was performed without complications. Initial histopathology suggested a lymphoproliferative process, and a subsequent excisional lymph node biopsy confirmed classical mixed-cellularity Hodgkin lymphoma associated with Epstein-Barr virus. This case highlights the diagnostic value of EUS-FNA/FNB in mediastinal lesions that are difficult to access using traditional techniques. Although its diagnostic yield is high, lymphomas-particularly Hodgkin lymphoma-may require additional tissue sampling to preserve architectural detail. Procedure success depends on sample adequacy, needle selection and operator expertise. Integrating EUS-guided biopsy into a multidisciplinary diagnostic pathway enables safe, effective and timely evaluation of mediastinal pathology, especially in resource-limited settings or in patients with significant comorbidities.</p>","PeriodicalId":10357,"journal":{"name":"Clinical Medicine Insights. Case Reports","volume":"19 ","pages":"11795476261440723"},"PeriodicalIF":0.6,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13129358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sydenham's Chorea as the Sole Presenting Symptom of Acute Rheumatic Fever in a 14-Year-Old Boy: A Case Report.","authors":"Omar Nashwan, Ziad W Elmezayen, Bassel Alrabadi, Natalie Bandak, Mohammad Adi","doi":"10.1177/11795476261437634","DOIUrl":"https://doi.org/10.1177/11795476261437634","url":null,"abstract":"<p><strong>Background: </strong>Rheumatic chorea is an uncommon but time-honored neurological manifestation of acute rheumatic fever that usually presents weeks to months after an untreated streptococcal pharyngitis. When it presents alone, that is, without other manifestations of the disease, it could easily be overlooked or delayed in its diagnosis. In such a scenario, it is uniquely presented as an isolated primary presentation of rheumatic fever, which underscores the challenge of diagnosis and the importance of early recognition.</p><p><strong>Case presentation: </strong>A 14-year-old boy presented with automatic, aimless, and arrhythmic movements of his limbs and face. There was no fever, rash, or joint pain in the preceding weeks. Neurological examination demonstrated choreiform movements typical of Sydenham's chorea, and serology suggested a recent Group A streptococcal infection. Transthoracic echocardiography revealed mild mitral valve leaflet thickening with mild mitral regurgitation consistent with subclinical rheumatic carditis. The patient was treated with benzathine penicillin for eradication and long-term prophylaxis, and valproic acid for symptomatic control. Symptoms improved over weeks and follow-up assessments showed near resolution of valvular changes without development of clinically significant rheumatic heart disease.</p><p><strong>Conclusion: </strong>This case highlights that rheumatic chorea may occur as an isolated type of acute rheumatic fever. Recognition of such a presentation is important in making early diagnosis and treatment, which are essential to prevent long-term effects such as rheumatic heart disease.</p>","PeriodicalId":10357,"journal":{"name":"Clinical Medicine Insights. Case Reports","volume":"19 ","pages":"11795476261437634"},"PeriodicalIF":0.6,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13111883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147763986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic Epinephrine Toxicity Following Topical Anesthetic Gel on Mucosal Surfaces: A Case Report and Literature Review.","authors":"Ziad W Elmezayen, Zeina Zakarya Marzouk, Mohammad Adi","doi":"10.1177/11795476261437585","DOIUrl":"https://doi.org/10.1177/11795476261437585","url":null,"abstract":"<p><strong>Introduction: </strong>Systemic toxicity from topical epinephrine is rare because dermal and mucosal absorption is typically limited. However, application to highly vascular mucosa, particularly under occlusion, may result in clinically significant systemic absorption.</p><p><strong>Case presentation: </strong>A 42-year-old woman developed severe headache, palpitations, tremor, and marked hypertension shortly after a compounded 2.5% lidocaine with epinephrine (1:2000; 0.5 mg/mL) gel was applied to the labial mucosa under occlusion during a cosmetic procedure. An estimated 0.5 to 1.5 mg of epinephrine was applied. Symptoms began within 10 minutes and persisted until gel removal approximately 25 minutes later. On EMS arrival, heart rate was 145 bpm and blood pressure 210/110 mmHg. In the emergency department, ECG showed sinus tachycardia without ischemic changes; laboratory studies were unremarkable except for mild respiratory alkalosis, and serial high-sensitivity troponin I was negative. Management included prompt removal of the topical agent, supportive care, and cardiac monitoring. Symptoms resolved spontaneously without pharmacologic intervention, and the patient was discharged after 4 hours of observation.</p><p><strong>Conclusion: </strong>Topical epinephrine applied to highly vascular mucosal surfaces-especially under occlusion-can rarely cause systemic sympathomimetic toxicity characterized by hypertension, tachycardia, tremor, and anxiety. Although it may resemble local anesthetic systemic toxicity, it is clinically distinct. Careful dosing, avoidance of occlusive dressings, close monitoring, and immediate removal of the agent at the first sign of systemic effects are essential to prevent complications.</p>","PeriodicalId":10357,"journal":{"name":"Clinical Medicine Insights. Case Reports","volume":"19 ","pages":"11795476261437585"},"PeriodicalIF":0.6,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13111853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatic Fascioliasis Masquerading as Acute Appendicitis in a Child: A Case Report.","authors":"Bisrat Abate Bekele, Mikiyas G Teferi, Muluken Bekele Wondimagegnehu, Rebecca Haile Tesfay, Alem Mekete Ayalew, Biniam Girma Tsega, Taye Jemberu Robele","doi":"10.1177/11795476261438872","DOIUrl":"https://doi.org/10.1177/11795476261438872","url":null,"abstract":"<p><strong>Background: </strong>Fascioliasis is a neglected tropical disease caused by <i>Fasciola species</i> that can present with nonspecific abdominal symptoms and mimic surgical emergencies.</p><p><strong>Case presentation: </strong>We report a 12-year-old Ethiopian boy who presented with right-sided abdominal pain, fever, and marked eosinophilia and was initially suspected to have acute appendicitis. Diagnostic laparoscopy revealed hepatic rather than appendiceal pathology. Imaging demonstrated subcapsular hepatic tracks, and serologic testing confirmed <i>Fasciola species</i> infection (most probably <i>Fasciola gigantica</i> in the Ethiopian context). Histopathology showed eosinophil-rich granulomatous hepatitis with helminthic structures. The patient was treated with triclabendazole and recovered completely.</p><p><strong>Conclusion: </strong>This case highlights the importance of considering parasitic infections such as fascioliasis in children presenting with atypical acute abdominal pain in endemic regions. Early use of imaging and serologic testing may prevent unnecessary surgical interventions and allow timely curative therapy.</p>","PeriodicalId":10357,"journal":{"name":"Clinical Medicine Insights. Case Reports","volume":"19 ","pages":"11795476261438872"},"PeriodicalIF":0.6,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13110278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-streptococcal Glomerulonephritis Presenting With Acute Pulmonary Edema and Critical Hyperkalemia: A Rare Pediatric Case Report From Yemen.","authors":"Ali Abdu Abdelbaky Mohamed, Mansoor Khalid Mansoor Ayish, Hussein Mussa Muafa","doi":"10.1177/11795476261444444","DOIUrl":"https://doi.org/10.1177/11795476261444444","url":null,"abstract":"<p><strong>Background: </strong>Post-streptococcal glomerulonephritis (PSGN) is a common cause of acute nephritic syndrome in children. Rarely, it may result in life-threatening complications, including acute pulmonary edema and critical hyperkalemia.</p><p><strong>Case presentation: </strong>We report a 10-year-old Yemeni girl (25 kg) presenting with severe respiratory distress, irritability, and generalized pitting edema. Laboratory tests confirmed PSGN with markedly reduced complement C3 (42.2 mg/dL) and nephritic urine sediment containing numerous red blood cells and casts. The patient developed critical hyperkalemia (7.0 mmol/L) and acute pulmonary edema, requiring urgent intubation and mechanical ventilation using pressure-controlled mandatory ventilation (P-CMV).</p><p><strong>Management: </strong>Aggressive fluid mobilization and electrolyte stabilization were initiated. High-dose intravenous furosemide (4 mg/kg/day) and low-dose dopamine (per local institutional protocols) were applied. Despite critical hyperkalemia, standard protocols (calcium, insulin-glucose) were unavailable; thus, potassium-lowering relied on continuous salbutamol and rapid diuresis. Appropriate adjunctive sedation was utilized briefly to facilitate mechanical ventilation. The patient produced 1700 mL urine in 17 hours, demonstrating a strong diuretic response. Continuous cardiac monitoring was maintained throughout the acute phase to mitigate arrhythmic complications.</p><p><strong>Conclusion: </strong>Early recognition of severe extra-renal complications in PSGN is critical. Intensive supportive care-including mechanical ventilation, meticulous fluid and electrolyte management, and appropriate sedation-is essential for survival in cases of acute pulmonary edema and critical hyperkalemia.</p>","PeriodicalId":10357,"journal":{"name":"Clinical Medicine Insights. Case Reports","volume":"19 ","pages":"11795476261444444"},"PeriodicalIF":0.6,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13110295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Management of Tyrosine Kinase Inhibitor-Induced Bone Marrow Aplasia in Chronic Phase Chronic Myeloid Leukemia with Ponatinib: A Case Report and Literature Review.","authors":"Rola Ghasoub, Laila Shafei, Ruba Y Taha, Dina Soliman, Hesham Elsabah, Maria Benkharda, Afaf Albattah, Halima Elomri","doi":"10.1177/11795476261436608","DOIUrl":"https://doi.org/10.1177/11795476261436608","url":null,"abstract":"<p><strong>Background: </strong>Tyrosine kinase inhibitors (TKIs) represent the standard of care for chronic myeloid leukemia (CML). Although cytopenias are frequent, severe and persistent bone marrow aplasia is exceedingly rare, with limited evidence to guide management in non-transplant candidates.</p><p><strong>Case presentation: </strong>A 35-year-old man with chronic-phase CML developed persistent bone marrow aplasia after sequential treatment with imatinib and dasatinib. Despite dose reductions and supportive measures, profound pancytopenia persisted, leading to treatment cessation. In the absence of a matched donor and response (<i>BCR::ABL1</i>: 25% IS), ponatinib was initiated at 45 mg daily and later reduced to 15 mg. Remarkably, hematologic recovery occurred, with normalization of peripheral blood counts, without recurrence of aplasia, and the patient achieved a sustained complete cytogenetic response within 15 months (<i>BCR::ABL1</i> < 1% IS).</p><p><strong>Discussion: </strong>TKI-associated bone marrow aplasia has been reported with agents such as imatinib, dasatinib, and nilotinib. Proposed mechanisms include off-target inhibition of hematopoietic kinases (eg, c-KIT, PDGFR) and suppression of malignant clones preceding normal marrow recovery. Management typically involves discontinuation, transfusion support, immunosuppressive therapy, or transplantation. In this case, ponatinib proved effective and tolerable as salvage therapy after previous TKI-induced marrow aplasia.</p><p><strong>Conclusion: </strong>TKI-induced bone marrow aplasia is an uncommon but serious toxicity in CML. This case supports the potential role of ponatinib as an effective salvage option following severe TKI-related marrow toxicity, particularly in patients who are not candidates for allogeneic transplantation. Further clinical experience and larger studies are needed to better define optimal management strategies for this rare but serious complication.</p>","PeriodicalId":10357,"journal":{"name":"Clinical Medicine Insights. Case Reports","volume":"19 ","pages":"11795476261436608"},"PeriodicalIF":0.6,"publicationDate":"2026-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13103490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Cutaneous Rosai-Dorfman Disease With Typical Immunophenotype But Lacking Emperipolesis: A Case Report.","authors":"Lina Al-Soufi, Aya Marashli, Razan Younis, Areeb Saeed Alkasem, Firas Hussein, Zuheir Al-Shehabi","doi":"10.1177/11795476261438660","DOIUrl":"https://doi.org/10.1177/11795476261438660","url":null,"abstract":"<p><strong>Background: </strong>Cutaneous Rosai-Dorfman disease (CRDD) is a rare extranodal histiocytosis that can mimic other dermatoses, particularly when hallmark emperipolesis is absent.</p><p><strong>Case presentation: </strong>A 50-year-old man presented with 5 months of intensely pruritic lesions affecting the palms, soles, flexures, and limbs. Skin biopsy revealed a nodular infiltrate of foamy histiocytes extending into the subcutis. Immunohistochemistry showed S100⁺, CD68⁺, CD1a⁻, while emperipolesis was not identified. Systemic evaluation was unremarkable. He was treated with oral prednisone, which was discontinued due to steroid-induced hyperglycemia, and methotrexate 15 mg/week, achieving approximately 60% improvement of symptoms at 6 months.</p><p><strong>Conclusion: </strong>CRDD may present atypically, and the absence of emperipolesis does not exclude the diagnosis. Careful clinicopathologic correlation and immunohistochemical analysis are essential for accurate diagnosis and guiding individualized therapy.</p>","PeriodicalId":10357,"journal":{"name":"Clinical Medicine Insights. Case Reports","volume":"19 ","pages":"11795476261438660"},"PeriodicalIF":0.6,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13096700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}