Clinical Medicine Insights. Case Reports最新文献

{"title":"Splenic Sequestration and Suspected Transient Aplastic Crisis in Sickle-Cell SC/Hemoglobin-G Disease in an Adult: A Case Report.","authors":"Evani Patel, Simon Gunter, Lee Hartner","doi":"10.1177/11795476261470569","DOIUrl":"10.1177/11795476261470569","url":null,"abstract":"<p><p>Acute Splenic Sequestration Crisis (ASSC) and Transient Aplastic Crisis (TAC) are severe, but distinct, hematologic complications of sickle cell disease (SCD). ASSC typically presents with acute splenomegaly and anemia due to red blood cell (RBC) pooling, while TAC, often secondary to Parvovirus B19 infection, results in a sudden halt in erythropoiesis and reticulocytopenia. The concurrence of these two conditions is rare, particularly in adults and non-Hb-SS genotypes. We describe a 36-year-old woman with Hb-SC and Hb-G Philadelphia variant SCD who presented with non-specific symptoms who was found to have marked splenomegaly and laboratory findings of severe anemia (hemoglobin 3.8 g/dL), thrombocytopenia, and reticulocytopenia. These combined findings raised concern for ASSC with suspected TAC, especially in light of her positive Parvovirus B19 IgM antibodies. We describe the importance of having a structured and precise diagnostic work-up to elucidate differences between the two conditions in the absence of a bone marrow biopsy, and the rarity of concurrent ASSC with presumed TAC in a patient with Hb-SC SCD. Our case highlights that early recognition of overlapping sickle cell complications despite a bone marrow biopsy is critical as it led to timely diagnosis, optimized management strategies, and reduced morbidity.</p>","PeriodicalId":10357,"journal":{"name":"Clinical Medicine Insights. Case Reports","volume":"19 ","pages":"11795476261470569"},"PeriodicalIF":0.6,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13583269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148988507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Suspected Rupture of a Papillary Thyroid Tumor in a Patient With Graves' Disease Who Experienced Airway Narrowing Without Respiratory Distress.","authors":"Daniel Goodman, Samuel Bosco, Bradford Davison Smith","doi":"10.1177/11795476261486750","DOIUrl":"10.1177/11795476261486750","url":null,"abstract":"<p><p>This case report describes a 55-year-old woman presenting with acute dysphagia and neck swelling after a \"popping\" sensation in her neck. CT and MRI revealed a large retropharyngeal cystic mass and a left thyroid lobe mass, causing airway displacement. Despite significant effacement of the oropharyngeal and supraglottic airway on flexible nasopharyngolaryngoscopy, the patient remained asymptomatic regarding respiratory distress. Subsequent ultrasound-guided fine needle aspiration biopsy diagnosed malignant papillary thyroid carcinoma. Concurrently, previously undiagnosed Graves' disease was identified. The clinical presentation was attributed to suspected rupture or hemorrhage of the malignant thyroid tumor, leading to a serosanguineous fluid collection and inflammatory edema. The patient was managed with high-dose steroids and intravenous antibiotics, resulting in improved airway edema. She never developed stridor or dyspnea throughout her hospital course and later underwent a total thyroidectomy with neck dissection. This case highlights the potential for a thyroid malignancy to present with suspected spontaneous rupture or hemorrhage causing airway effacement and raises the question of whether Graves' disease, due to increased vascularity, put patients at additional risk of this presentation.</p>","PeriodicalId":10357,"journal":{"name":"Clinical Medicine Insights. Case Reports","volume":"19 ","pages":"11795476261486750"},"PeriodicalIF":0.6,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13554550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148918814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual Thiol Drug-Induced Insulin Autoimmune Syndrome in a Non-Asian Patient Carrying HLA-DRB1*04:06: A Case Report and Literature Review.","authors":"Mohammad Adi, Doniyor Umarov, Zairullo Oqboyev, Aseel Smerat, Ahmed Ashraf","doi":"10.1177/11795476261485260","DOIUrl":"10.1177/11795476261485260","url":null,"abstract":"<p><strong>Introduction: </strong>Insulin autoimmune syndrome (IAS, Hirata's disease) is a rare cause of endogenous hyperinsulinemic hypoglycemia classically linked to high-titer insulin autoantibodies and exposure to sulfhydryl (-SH)-containing drugs. IAS is strongly HLA-associated and is most frequently reported in East Asian populations. We report a case in which simultaneous exposure to two thiol-containing agents unmasked IAS in a non-Asian patient carrying HLA-DRB1*04:06.</p><p><strong>Case presentation: </strong>A 60-year-old woman developed recurrent autonomic and neuroglycopenic episodes 2-4 hours after meals. Home medications included captopril and over-the-counter α-lipoic acid (ALA). During a symptomatic episode her plasma glucose was 38 mg/dL with markedly elevated serum insulin, C-peptide and proinsulin; mixed-meal testing reproduced a postprandial glucose peak followed by profound hypoglycemia accompanied by paradoxical hyperinsulinemia. Insulin autoantibodies were strongly positive (>150 U/mL) and HLA genotyping revealed DRB1*04:06. A supervised fast was non-diagnostic for insulinoma. Management comprised immediate discontinuation of both captopril and ALA (captopril replaced with losartan) and dietary measures (frequent small low-carbohydrate meals). Hypoglycemic episodes abated within two weeks and resolved by six weeks; fasting glucose, insulin and IAA titers had substantially improved by three months.</p><p><strong>Conclusion: </strong>To our knowledge, this is the first reported case of IAS temporally associated with concurrent captopril and ALA exposure in a non-Asian carrier of HLA-DRB1*04:06. The case highlights the need to review both prescription drugs and supplements when investigating hyperinsulinemic hypoglycemia, that IAS can occur outside typical ethnic groups when permissive HLA alleles are present, and that prompt withdrawal of offending agents with conservative measures often leads to spontaneous remission.</p>","PeriodicalId":10357,"journal":{"name":"Clinical Medicine Insights. Case Reports","volume":"19 ","pages":"11795476261485260"},"PeriodicalIF":0.6,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13547792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148905177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paraneoplastic Pemphigus Associated With Renal Cell Carcinoma. Rare Case Report and Literature Review.","authors":"Halkawt Babarasul Ahmed, Hawnaz Atta Karim, Othman Abdulrahman Mohammed, Jeza Muhamad Abdul Aziz, Mohammed Kaka Bra Salih, Parshal Bhandari","doi":"10.1177/11795476261486498","DOIUrl":"10.1177/11795476261486498","url":null,"abstract":"<p><strong>Introduction: </strong>Paraneoplastic pemphigus (PNP) is an uncommon autoimmune blistering disorder frequently associated with underlying malignancies. Renal cell carcinoma (RCC) is the most common primary renal cancer. It is associated with a wide range of paraneoplastic syndromes, but occasionally presents as a dermatological finding.</p><p><strong>Case presentation: </strong>A 56-year-old woman with severe oral and cutaneous lesions was diagnosed with PNP associated with renal cell carcinoma (RCC). The patient was treated with 1 g of rituximab as an infusion, and after two weeks, another dose of 1 g of rituximab was administered in combination with steroids (prednisolone 0.5 mg/kg) until control, then gradually decreasing by 25% each month, until we reached 5 mg/day. The patient achieved complete clinical remission at 6 months; however, long-term outcomes remain unknown because she was subsequently lost to follow-up.</p><p><strong>Conclusion: </strong>A comprehensive workup is crucial for diagnosing the underlying tumor associated with this phenomenon. Rituximab- and steroid-based therapies may be effective in controlling PNP symptoms.</p>","PeriodicalId":10357,"journal":{"name":"Clinical Medicine Insights. Case Reports","volume":"19 ","pages":"11795476261486498"},"PeriodicalIF":0.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13535019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148879448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thyrotoxic Periodic Paralysis Following a 75-g Oral Glucose Load Revealing Previously Undiagnosed Graves' Disease: A Case Report.","authors":"Amogh Verma, Sourav Sudan, Mudit Singla, Tarun Kumar Suvvari, Tweheyo Ronald, Shubham Kumar","doi":"10.1177/11795476261486902","DOIUrl":"10.1177/11795476261486902","url":null,"abstract":"<p><strong>Introduction: </strong>Thyrotoxic periodic paralysis (TPP) is an uncommon endocrine emergency caused by rapid intracellular potassium redistribution during thyrotoxicosis. Carbohydrate exposure is a recognized precipitant, but direct observation of a first paralytic attack developing during supervised diagnostic glucose testing is unusual.</p><p><strong>Case presentation: </strong>A 29-year-old Indian man underwent a supervised oral glucose tolerance test (OGTT) for borderline fasting dysglycemia and episodic postprandial tremulousness. He had also experienced recent weight loss, heat intolerance, and palpitations but had no previous weakness. During the late phase of testing, progressive thigh heaviness evolved into symmetrical flaccid quadriparesis with lower-limb predominance, reduced reflexes, preserved sensation, and no respiratory involvement. Serial samples demonstrated a rapid transition from normal baseline potassium to severe hypokalemia, accompanied by hypophosphatemia and a marked insulin response. Normal acid-base status and suppressed urinary potassium excretion supported transcellular redistribution. Thyroid testing and antibody studies established previously undiagnosed Graves' disease. Limited potassium replacement, magnesium supplementation, and propranolol produced complete neurological recovery without rebound hyperkalemia. Carbimazole therapy achieved progressive biochemical control, with no recurrent paralysis during 24 weeks of follow-up.</p><p><strong>Discussion: </strong>Standardized glucose exposure and serial sampling documented the metabolic transition from normal potassium to paralytic hypokalemia. The episode supports an interaction between endogenous insulin stimulation and thyrotoxic skeletal-muscle susceptibility rather than hyperinsulinemia as an isolated cause.</p><p><strong>Conclusion: </strong>Unrecognized thyrotoxicosis should be considered before carbohydrate provocation testing in patients with unexplained hyperadrenergic symptoms.</p>","PeriodicalId":10357,"journal":{"name":"Clinical Medicine Insights. Case Reports","volume":"19 ","pages":"11795476261486902"},"PeriodicalIF":0.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13535033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148879419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent Bilateral Anesthesia Mumps after Cesarean Section Under Spinal Anesthesia, Rare Case Report and Literature Review.","authors":"Paxshan Ashraf Mohammed, Rawand Othman Ali, Shnow Hussain Abdullah, Sumaya Omer Hama Morad, Harun Mohammed Ahmed, Jeza Muhamad Abdul Aziz, Parshal Bhandari","doi":"10.1177/11795476261485263","DOIUrl":"10.1177/11795476261485263","url":null,"abstract":"<p><p>Anesthesia mumps, also known as acute postoperative sialadenitis, is a rare complication that can occur following general or regional anesthesia. The prevalence of this condition ranges from 0.16% to 0.2%. This case report presents a patient with recurrent bilateral parotid swelling after cesarean section (CS) under spinal anesthesia and its management. A 42-year-old G5P4 woman with gestational diabetes mellitus and antiphospholipid syndrome presented for elective cesarean delivery at 39 weeks and two days of gestation under spinal anesthesia. The patient developed bilateral facial swelling after five hours, which was more evident on the right parotid site. A review by an otolaryngologist confirmed the diagnosis of anesthesia mumps. Anesthesia mumps typically presents as painless swelling of the salivary glands. Salivary duct obstruction and hyperemia are believed to be common causes. This case highlights that anesthesia-induced mumps is a reversible and transient complication that may occur after short surgical procedures, such as cesarean sections. Early recovery was achieved following supportive conservative management, with hydration and analgesia.</p>","PeriodicalId":10357,"journal":{"name":"Clinical Medicine Insights. Case Reports","volume":"19 ","pages":"11795476261485263"},"PeriodicalIF":0.6,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13530503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148873151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasmacytomas in Extramedullary Manifestation of Multiple Myeloma: A Case Report.","authors":"Jawad Hmayed, Doha Fadel, Anthony Albayeh, Chris Jreij, Karam Karam, Lamita El Sett, Charbel Fares","doi":"10.1177/11795476261485712","DOIUrl":"10.1177/11795476261485712","url":null,"abstract":"<p><p>Extramedullary plasmacytomas are an uncommon manifestation of multiple myeloma (MM) and may involve a wide range of soft-tissue sites. Superficial involvement of the back is particularly rare and may be mistaken for benign soft-tissue lesions. We report the case of a 59-year-old man with MM diagnosed in April 2024 who was treated with four cycles of bortezomib, cyclophosphamide, and dexamethasone (VCD), achieving remission with disappearance of serum and urine M-protein on immunofixation. In October 2025, the disease relapsed, with early progression despite treatment with daratumumab, prompting initiation of teclistamab therapy. During the course of his disease, he developed two progressively enlarging, painless indurations over the left upper and lower back. Ultrasound demonstrated well-circumscribed heterogeneous hypoechoic subcutaneous masses with internal arterial vascularity on Doppler imaging. Ultrasound-guided core biopsy revealed diffuse infiltration by monoclonal plasma cells expressing CD138 with lambda light-chain restriction, confirming secondary extramedullary plasmacytoma. This case highlights the importance of considering extramedullary plasmacytoma in the differential diagnosis of new superficial soft-tissue masses in patients with MM and underscores the complementary role of ultrasound and histopathological examination in establishing the diagnosis.</p>","PeriodicalId":10357,"journal":{"name":"Clinical Medicine Insights. Case Reports","volume":"19 ","pages":"11795476261485712"},"PeriodicalIF":0.6,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525268/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148856872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Reversal of Tamoxifen-Associated Weight Gain and Metabolic Dysfunction with Liraglutide in a Breast Cancer Survivor: A Case Report.","authors":"Masharibov Anvarbek, Doniyor Umarov, Zarina Khalbayeva, Aseel Smerat, Mohammad Adi, Ahmed Ashraf","doi":"10.1177/11795476261485623","DOIUrl":"10.1177/11795476261485623","url":null,"abstract":"<p><p><b>Introduction:</b> Adjuvant endocrine therapy for breast cancer - particularly tamoxifen - is commonly associated with weight gain, increased adiposity, and metabolic dysfunction. Lifestyle measures often fail to reverse these effects. Evidence regarding glucagon-like peptide-1 (GLP-1) receptor agonists in this specific context remains limited. Reversal of tamoxifen-associated weight gain with liraglutide has been rarely reported. <b>Case Presentation:</b> A 58-year-old postmenopausal woman with stage IIA, hormone-receptor positive breast cancer experienced marked weight gain after 24 months of tamoxifen therapy, despite diet and exercise. She developed prediabetes, insulin resistance (assessed by Homeostatic Model Assessment of Insulin Resistance [HOMA-IR] 4.9), and dyslipidemia. Liraglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, was initiated and titrated to 3.0 mg/day. Over 12 months, she lost 18.5 kg, and her metabolic parameters, including HOMA-IR and glycated hemoglobin (HbA1c), normalized. Tamoxifen therapy was continued without adverse effects. <b>Conclusion:</b> This case suggests that liraglutide may reverse substantial tamoxifen-associated weight gain and related metabolic derangements in a breast cancer survivor. The observed improvement exceeded what is typically achieved with lifestyle measures alone. Formal studies are needed to define the role of GLP-1 receptor agonists in managing endocrine therapy-related metabolic complications.</p>","PeriodicalId":10357,"journal":{"name":"Clinical Medicine Insights. Case Reports","volume":"19 ","pages":"11795476261485623"},"PeriodicalIF":0.6,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148856955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical Orogenital Lichen Planus in a Young Male: A Case Report.","authors":"Ammar Al-Subh, Haya Asaad, Mohammad Adi","doi":"10.1177/11795476261479467","DOIUrl":"10.1177/11795476261479467","url":null,"abstract":"<p><strong>Introduction: </strong>Lichen planus is a chronic inflammatory ailment with a wide range of symptoms that can mimic other dermatological and sexually transmitted conditions, especially when affecting the genitalia. Such overlap might make diagnosis difficult, particularly in uncommon circumstances.</p><p><strong>Case presentation: </strong>We present a 21-year-old Middle Eastern male with a one-year history of progressive papular lesions that started in the glans penis and advanced to the oral mucosa, where they extended to the gingiva. The lesions were non-ulcerated, well-defined, dome-shaped papules ranging from pink to skin-colored, with some hypertrophic and pigmented characteristics. Clinically, it was misconstrued as a sexually transmitted disease, leading to a diagnostic dilemma. The patient complained of burning oral pain and paresthesia described as electric-like sensations in the genitals, which were accompanied by serious psychological distress and sexual discomfort. Histopathological confirmation was not obtained due to the patient's refusal based on sociocultural concerns. The patient did not respond to topical corticosteroids but did improve slightly with topical tacrolimus 0.1%.</p><p><strong>Conclusion: </strong>This case demonstrates a unique presentation of lichen planus in a young male, with genital-to-oral development and diagnostic confusion in the absence of biopsy. It highlights the need for clinically identifying non-venereal dermatoses in genital lesions and the impact of psychological factors on treatment and diagnosis choices.</p>","PeriodicalId":10357,"journal":{"name":"Clinical Medicine Insights. Case Reports","volume":"19 ","pages":"11795476261479467"},"PeriodicalIF":0.6,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13494330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148789000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent Primary Intracranial Ewing Sarcoma With Parietal Bone Involvement: A Case Report.","authors":"Junaid Imran, Sadiq Ur Rehman, Muhammad Osama, Hania Kalsoom, Pawan Kumar Thada","doi":"10.1177/11795476261476941","DOIUrl":"10.1177/11795476261476941","url":null,"abstract":"<p><strong>Introduction: </strong>Ewing sarcoma is a rare, aggressive malignancy of small round blue cells that typically arises from bone or soft tissue. Primary intracranial involvement is exceedingly uncommon, particularly in adults, and is associated with diagnostic challenges, high recurrence rates, and poor prognosis. Limited data exist regarding optimal management strategies for recurrent intracranial Ewing sarcoma in adult patients.</p><p><strong>Case summary: </strong>We report the case of a 24-year-old pregnant female who presented with progressive headaches, vomiting, and left parietal swelling. MRI revealed a ring-enhancing lesion in the left parietal region with surrounding edema. She underwent surgical resection, and histopathology demonstrated sheets of small round blue cells with strong CD99 positivity. Fluorescence in situ hybridization using an EWSR1 break-apart probe confirmed EWSR1 gene rearrangement; however, fusion partner identification was not available. Based on the morphologic and immunohistochemical features in conjunction with EWSR1 rearrangement, a diagnosis of EWSR1-rearranged round cell sarcoma consistent with Ewing sarcoma was made. Adjuvant therapy was delayed due to pregnancy. Despite subsequent multimodal treatment including surgery, VAC-IE chemotherapy, and radiotherapy, the patient developed local recurrence involving the parietal bone within one year and died four months after recurrence.</p><p><strong>Conclusion: </strong>This case highlights the aggressive nature and high recurrence risk of primary intracranial Ewing sarcoma in adults. Diagnostic confirmation requires histopathological and molecular analysis, as radiological findings may mimic other central nervous system tumors. Early diagnosis, timely multimodal therapy, and close surveillance are critical; however, outcomes remain poor, underscoring the need for improved and individualized treatment strategies for adult intracranial Ewing sarcoma.</p>","PeriodicalId":10357,"journal":{"name":"Clinical Medicine Insights. Case Reports","volume":"19 ","pages":"11795476261476941"},"PeriodicalIF":0.6,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13477540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148757526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}