Clinical Medicine Insights. Case Reports最新文献

{"title":"Dual Case Report: Symptomatic Myocardial Bridging Managed with Calcium Channel Blockers.","authors":"Osman Farah Dahir, Said Abdirahman Ahmed, Ahmed Shafie Aden, Ishak Ahmed Abdi, Mohamud Mire Waberi, Abdullahi Mohamed Hassan Fujeyra, Mohammed A M Ahmed","doi":"10.1177/11795476261430037","DOIUrl":"10.1177/11795476261430037","url":null,"abstract":"<p><strong>Background: </strong>Myocardial bridging (MB) is a congenital coronary artery anomaly in which a segment of an epicardial coronary artery, most commonly the left anterior descending (LAD) artery, courses intramyocardially, and undergoes systolic compression. Although historically regarded as a benign anatomical variant, myocardial bridging has increasingly been recognized as a potential cause of myocardial ischemia, exertional chest pain, and other cardiac symptoms, particularly in patients without obstructive coronary artery disease. Awareness of this condition is important, as its diagnosis and management differ from those of atherosclerotic coronary disease.</p><p><strong>Case presentation: </strong>We report 2 cases of symptomatic myocardial bridging involving the mid-segment of the LAD artery. The first case involved a 35-year-old male with a 2-month history of exertional chest pain and no cardiovascular risk factors. Initial evaluation, including electrocardiography, cardiac biomarkers, and transthoracic echocardiography, was unremarkable. Coronary angiography demonstrated a myocardial bridge in the mid-LAD with systolic compression and normal diastolic filling, without evidence of obstructive coronary artery disease. The patient was treated with diltiazem, resulting in complete symptom resolution at 1-month follow-up. The second case involved a 48-year-old male with a history of smoking and well-controlled hypertension who presented with exertional chest pain radiating to the left arm, accompanied by palpitations. Laboratory investigations, electrocardiography, and echocardiography were normal. Coronary angiography again revealed myocardial bridging of the mid-LAD without obstructive lesions. Treatment with diltiazem led to complete symptom resolution, and the patient remained clinically stable at 2-month follow-up.</p><p><strong>Discussion: </strong>These cases highlight the clinical significance of myocardial bridging as a cause of angina-like symptoms in patients with non-obstructive coronary arteries. The pathophysiology is multifactorial and includes dynamic systolic compression, delayed diastolic relaxation, endothelial dysfunction, and increased susceptibility to ischemia during tachycardia. Medical therapy aimed at reducing heart rate and myocardial contractility, particularly with non-dihydropyridine calcium channel blockers, remains the cornerstone of management.</p><p><strong>Conclusion: </strong>Myocardial bridging should be considered in the differential diagnosis of chest pain in patients with normal coronary arteries. Early recognition and appropriate medical therapy can result in effective symptom control and may prevent unnecessary invasive interventions.</p>","PeriodicalId":10357,"journal":{"name":"Clinical Medicine Insights. Case Reports","volume":"19 ","pages":"11795476261430037"},"PeriodicalIF":0.6,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13009864/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147510038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ruptured Pulmonary Hydatid Cyst Complicated by Tension Pneumothorax: A Rare Case Report.","authors":"Mohammad Alaa Aldakak, Nawwar Fallouh, Bassel Ibrahim, Raneem Ahmad, Wasfi Sahloul, Bassam Darwish","doi":"10.1177/11795476261429283","DOIUrl":"10.1177/11795476261429283","url":null,"abstract":"<p><strong>Background: </strong>Cystic echinococcosis (CE), or hydatid disease, is a zoonotic parasitic infection caused by Echinococcus granulosus. Although primarily hepatic, pulmonary involvement accounts for 10% to 30% of cases. Rupture of pulmonary hydatid cysts can lead to life-threatening complications such as pneumothorax and anaphylaxis.</p><p><strong>Case presentation: </strong>We report the case of a 20-year-old female from Syria who presented with sudden-onset dyspnea, pleuritic chest pain, palpitations, and dry cough. Imaging revealed a massive right-sided pneumothorax with a ruptured hydatid cyst in the right middle lobe, evidenced by the presence of a Water Lily sign. Emergency decompression and chest tube insertion were performed, followed by definitive surgical intervention with cyst excision and capitonnage. The postoperative course was uneventful, and the patient achieved full radiological and clinical recovery.</p><p><strong>Discussion: </strong>Pulmonary hydatid cysts are often asymptomatic but may become acutely symptomatic upon rupture. Diagnosis relies on imaging, particularly CT, and can be supported by serology. While medical therapy is reserved for select cases, surgery remains the mainstay of treatment, especially in complicated or large cysts. Intraoperative precautions are crucial to avoid recurrence.</p><p><strong>Conclusion: </strong>This case highlights the importance of early recognition and multidisciplinary management of ruptured pulmonary hydatid cysts. Prompt surgical intervention following stabilization can lead to favorable outcomes even in cases complicated by tension pneumothorax.</p>","PeriodicalId":10357,"journal":{"name":"Clinical Medicine Insights. Case Reports","volume":"19 ","pages":"11795476261429283"},"PeriodicalIF":0.6,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12988266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147466768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric Mesenteric Inflammatory Myofibroblastic Tumor Presenting as a Diagnostic Challenge: A Case Report and Literature Review.","authors":"Mesfin Wubishet Gurmu, Samuel Negash, Solomon Gelaye Yinges, Netsanet Mengesha, Esubalew Mezgebu, Liyat Kebede","doi":"10.1177/11795476261425831","DOIUrl":"10.1177/11795476261425831","url":null,"abstract":"<p><strong>Background: </strong>Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal neoplasm of intermediate malignant potential that predominantly affects children and young adults. Although pulmonary involvement is most frequently reported, mesenteric IMT is uncommon in pediatric patients. Its diagnosis remains challenging due to nonspecific clinical manifestations and significant radiologic and histopathologic overlap with other mesenchymal tumors.</p><p><strong>Case presentation: </strong>We describe the case of a 5-year-old girl who presented with a three-month history of progressive abdominal distension, anorexia, and weight loss. Radiologic evaluation revealed a calcified mesenteric mass initially suggestive of a calcified fibrous tumor. The patient subsequently underwent exploratory laparotomy with complete surgical excision of the lesion. Histopathologic examination, supported by immunohistochemical analysis, established the diagnosis of inflammatory myofibroblastic tumor. The postoperative course was uneventful, and no evidence of recurrence was observed at the six-month follow-up.</p><p><strong>Conclusion: </strong>Although rare, pediatric mesenteric IMT should be considered in the differential diagnosis of abdominal masses in children. The absence of distinctive clinical and radiologic features frequently limits accurate preoperative diagnosis, highlighting the importance of a multidisciplinary approach. Definitive diagnosis relies on histopathologic evaluation and immunohistochemical studies, including anaplastic lymphoma kinase (ALK) assessment. Complete surgical excision remains the cornerstone of management and is generally associated with favorable outcomes. This case emphasizes the need for heightened clinical suspicion and underscores the critical role of immunohistochemistry in establishing an accurate diagnosis and guiding appropriate management.</p>","PeriodicalId":10357,"journal":{"name":"Clinical Medicine Insights. Case Reports","volume":"19 ","pages":"11795476261425831"},"PeriodicalIF":0.6,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12988309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147466690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunoglobulin A Nephropathy With Associated Thrombotic Microangiopathy: Biopsy and Clinical Case Series.","authors":"Ryan Fekrat, Arif Nihat Demirci, Caroline Gee, Sohrab Kharabaf, Mina Tadros, Matthew Nguyen, Dao Le, Omid Vadpey, Jonathan Zuckerman, Ramy Hanna","doi":"10.1177/11795476261427772","DOIUrl":"10.1177/11795476261427772","url":null,"abstract":"<p><strong>Introduction: </strong>IgA nephropathy (IgAN) with concurrent thrombotic microangiopathy (TMA) is an unusual combination of pathological findings that is associated with severe hypertension, proteinuria, and lower estimated glomerular filtration rate (eGFR). This series presents 7 patients with kidney biopsies demonstrating IgAN and concomitant TMA and presents a link by way of complement disorder.</p><p><strong>Case presentation: </strong>Seven patients all presented as IgAN with associated TMA coinciding with hypertension, proteinuria, and low eGFR. Six patients showed tubular atrophy or interstitial fibrosis and 5 of those 6 showed >50% of renal cortex containing tubular atrophy or interstitial fibrosis. Variations of low serum C3, high serum C4, elevated IgA or IgM proteins, and elevated CH50 were found in 6 of the 7 patients.</p><p><strong>Conclusions: </strong>Chronic changes seen like interstitial fibrosis and tubular atrophy appear to show a subacute or chronic nature of IgAN with TMA. The low serum C3, high C4, elevated CH50, suggests complement activation in endothelial and mesangial from IgG-IgA complexes known to occur in IgAN. This phenotype of IgAN with TMA may represent a more unique IgAN phenotype with a more severe clinical course and be indicative of underlying complement dysregulation.</p>","PeriodicalId":10357,"journal":{"name":"Clinical Medicine Insights. Case Reports","volume":"19 ","pages":"11795476261427772"},"PeriodicalIF":0.6,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12957606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147364124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Q Fever Presenting with Severe Cholestatic Jaundice and Acute Kidney Injury in the Absence of Classic Exposure: A Rare Case Report.","authors":"Karim Zodeh, Tya Youssef, Philippe Attieh, Mahmoud Othman","doi":"10.1177/11795476261424306","DOIUrl":"10.1177/11795476261424306","url":null,"abstract":"<p><p>Q fever, caused by <i>Coxiella burnetii</i>, is a zoonotic infection with highly variable clinical manifestations, often leading to diagnostic delays. Although typically associated with livestock exposure and presenting with nonspecific febrile illness or hepatitis, its clinical spectrum is broad. We report an unusual case of a 53-year-old previously healthy male who presented with high-grade fever, epigastric pain radiating to both upper quadrants, marked jaundice, severe acute kidney injury, and dark urine. Initial imaging revealed bilateral perinephric and periureteral stranding, gallbladder wall edema, and absence of biliary obstruction, raising concern for urinary and hepatobiliary pathology. Serologic testing for viral hepatitis and multiple bacterial pathogens was negative. Persistent cholestatic abnormalities and systemic symptoms prompted an expanded infectious workup, which revealed positive <i>Coxiella burnetii</i> IgG and IgM. Doxycycline therapy resulted in rapid clinical improvement and progressive normalization of renal and hepatic parameters, confirming acute Q fever based on compatible clinical presentation, positive serology, exclusion of alternative diagnoses, and response to doxycycline. This case is notable for the coexistence of cholestatic jaundice, severe renal dysfunction, and urinary symptoms without pulmonary or classical hepatitic features, illustrating a rare phenotype of acute Q fever. Additionally, the absence of identifiable exposure risks underscores ongoing under recognition of this infection outside traditional high-risk settings. The patient's favorable response to timely doxycycline treatment highlights the importance of considering Q fever in the differential diagnosis of febrile jaundice with multiorgan involvement. This report reinforces the value of broad infectious evaluation in atypical presentations and contributes to expanding clinical awareness of Q fever's diverse manifestations.</p>","PeriodicalId":10357,"journal":{"name":"Clinical Medicine Insights. Case Reports","volume":"19 ","pages":"11795476261424306"},"PeriodicalIF":0.6,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12925016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147276003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hiccups as Rare Presentation of Bilateral Pulmonary Embolism: Case Report.","authors":"Mohamed Elshafei, Haidar Barjas, Abdelnasser Elzouki","doi":"10.1177/11795476261424305","DOIUrl":"10.1177/11795476261424305","url":null,"abstract":"<p><strong>Background: </strong>Pulmonary embolism is considered a life-threatening condition, with a variable spectrum of clinical presentations. Dyspnea, hemoptysis, and chest pain are the classical symptoms; however, atypical presentations may delay the diagnosis. Persistent hiccups as the sole presentation of pulmonary embolism are rarely reported, posing a diagnostic challenge. Identifying this rare presentation is paramount for early diagnosis and improving patient outcomes.</p><p><strong>Case presentation: </strong>A 76-year-old Egyptian man was admitted with persistent, daily hiccups lasting ~2 months, refractory to conservative and pharmacologic measures. He denied chest pain, dyspnea, or any respiratory or gastrointestinal symptoms. On admission, physical examination was unremarkable, while laboratory testing revealed an elevated D-dimer level. On hospital day 1, lower limb Doppler ultrasound demonstrated acute deep vein thrombosis in the right lower extremity. Subsequently, CT pulmonary angiography confirmed bilateral pulmonary embolism.</p><p><strong>Conclusions: </strong>This case highlights persistent hiccups as the sole manifestation of pulmonary embolism. Clinicians should maintain a high index of suspicion for pulmonary embolism in elderly patients presenting with persistent, unexplained hiccups particularly after common causes of hiccups have been excluded. Early diagnosis and timely treatment are crucial to reducing morbidity and improving patient outcomes in such atypical presentations.</p>","PeriodicalId":10357,"journal":{"name":"Clinical Medicine Insights. Case Reports","volume":"19 ","pages":"11795476261424305"},"PeriodicalIF":0.6,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12924915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147275494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DIP-like Adenocarcinoma Presenting as a Part-Solid Nodule: A Case Report.","authors":"Natalia Brar, Robert Hsu, William D Wallace, Ching-Fei Chang","doi":"10.1177/11795476261416241","DOIUrl":"10.1177/11795476261416241","url":null,"abstract":"<p><p>Pure ground-glass and part-solid lung nodules are becoming increasingly appreciated as harbingers of malignancy. However, occasionally diagnostic biopsies can demonstrate unexpected findings that may lead to a misleading diagnosis and clinical confusion. Here we present the case of a 70-year-old Taiwanese man with a light smoking history (10-20 pack years), emphysema, and childhood-treated tuberculosis who presented with a part-solid nodule that was diagnosed as a very rare case of adenocarcinoma of the lung with <i>desquamative interstitial pneumonia</i> (DIP)-like microscopic morphology. DIP is a non-neoplastic interstitial lung disease which presents as a diffuse and bilateral process and primarily occurs in smokers. When the morphologic pattern of DIP presents as a focal process, usually around bronchioles, it is labeled <i>respiratory bronchiolitis</i>. (RB)- a very common entity and almost universal in patients with significant smoking history. We describe this case to help educate and guide pathologists on the existence of this very rare entity and to consider performing lung cancer immunohistochemical markers whenever faced with this unexpected histological pattern in a pulmonary nodule.</p>","PeriodicalId":10357,"journal":{"name":"Clinical Medicine Insights. Case Reports","volume":"19 ","pages":"11795476261416241"},"PeriodicalIF":0.6,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12923932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147269937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late Onset of Congenital TTP: Case Presentation and Review of the Literature.","authors":"Athanasios Chatzisfetkos, Carsten Bergmann, Ulf Janssen","doi":"10.1177/11795476261421638","DOIUrl":"10.1177/11795476261421638","url":null,"abstract":"<p><strong>Background: </strong>Congential thrombotic thrombocytopenic purpura (cTTP) is a ultrarare genetic disorder caused by reduced or absent ADAMTS13 enzyme activity. In contrast to the acquired form of TTP, which results from inhibitory autoantibodies against ADAMTS13, cTTP arises due to mutations in the ADAMTS13 gene and lacks such inhibitors. cTTP commonly manifests during infancy through recurrent episodes of hemolytic anemia and signs of microvascular damage. Episodes are often precipitated by infections or physical stressors.</p><p><strong>Case presentation: </strong>A 23-year-old female patient presented to the emergency department with microangiopathic hemolytic anemia (MAHA), a reduced platelet count and acute kidney injury stage 3 (AKI 3). Three days before she had suffered a knee injury, which was treated with fentanyl. The peripheral-blood smear showed many schistocytes. A thrombotic microangiopathy was suspected and therapeutic plasma exchange (TPE) was initiated. ADAMTS13 activity on admission was 4% without a detectable inhibitory antibody and an inherited ADAMTS13 deficiency was suspected. Genetic testing revealed 2 presumably compound heterozygous variants in the ADAMTS13 gene, confirming the diagnosis of cTTP. After 3 TPE platelet count raised significantly with improvement of renal function. Thereafter the patient received prophylactic plasma infusions every 2 to 3 weeks. At 1-year follow-up she had a normal renal function and no recurrence of hemolytic anemia.</p><p><strong>Conclusion: </strong>The present case of cTTP is notable for its late onset at first presentation, with unusual severe renal impairment. Rapid diagnosis and timely initiation of treatment are critical. Differential diagnoses such as malignant hypertension, sepsis, and autoimmune diseases like systemic lupus erythematosus must be excluded.</p>","PeriodicalId":10357,"journal":{"name":"Clinical Medicine Insights. Case Reports","volume":"19 ","pages":"11795476261421638"},"PeriodicalIF":0.6,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12921173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147269951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reversible Atrial Fibrillation and Cardiogenic Shock Following Acute Aluminum Phosphide Poisoning: A Case Report and Literature Review.","authors":"Chernet T Mengistie, Biruk T Mengistie, Ruth S Belachew, Mikiyas G Teferi, Zayed H Tesfaye, Ezikel A Eneyew","doi":"10.1177/11795476251410403","DOIUrl":"10.1177/11795476251410403","url":null,"abstract":"<p><strong>Background: </strong>Aluminum phosphide (ALP) is a highly toxic pesticide widely used as a grain fumigant, especially in low- and middle-income countries. Ingestion of ALP releases phosphine gas, causing cellular oxidative damage and profound mitochondrial dysfunction. The cardiovascular system is particularly affected, typically resulting in refractory hypotension and dysrhythmias. There is no specific antidote, so management is entirely supportive. We report a case of intentional ALP ingestion leading to new-onset atrial fibrillation with rapid ventricular response and mild left ventricular dysfunction.</p><p><strong>Case presentation: </strong>A 32-year-old Black African man presented 4 hours after ingesting 4 ALP tablets. He developed hypotension, tachycardia, and metabolic acidosis. Six hours into intensive care unit (ICU) care, he acutely developed atrial fibrillation with rapid ventricular response (heart rate ~140/minute) and persistent hypotension. Laboratory troponin remained normal, but echocardiography showed mild global left ventricular systolic dysfunction.</p><p><strong>Management and outcome: </strong>The patient received aggressive supportive care, including intravenous fluids, vasopressors, corticosteroids, and repeated magnesium sulfate and electrolyte repletion. Amiodarone infusion was used for rate control (to avoid negative inotropic effects). No invasive therapies were needed. The atrial fibrillation reverted to sinus rhythm within 18 hours. Hemodynamics normalized over 24 to 48 hours, and the patient fully recovered without neurologic sequelae. On follow-up, cardiac function and electrocardiogram (ECG) were normal.</p><p><strong>Conclusion: </strong>This case highlights that surviving ALP-induced cardiotoxicity is possible with prompt aggressive supportive therapy. Key learning points include recognition of ALP ingestion in shock, vigilance for life-threatening arrhythmias, and tailored management (eg, use of amiodarone and careful fluid and pressor support). The patient's full recovery underscores that even severe ALP cardiotoxicity can be reversible with appropriate care.</p>","PeriodicalId":10357,"journal":{"name":"Clinical Medicine Insights. Case Reports","volume":"19 ","pages":"11795476251410403"},"PeriodicalIF":0.6,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12868594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146123253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidentally Found Olfactory Schwannoma: A Rare Case Report.","authors":"Mahdi Mohsenzadeh, Fatemeh Pouladkhay","doi":"10.1177/11795476251407356","DOIUrl":"10.1177/11795476251407356","url":null,"abstract":"<p><strong>Background: </strong>Olfactory nerve schwannomas are sporadic, benign neurogenic tumors arising from Schwann cells within the olfactory pathway. Their clinical presentation is typically nonspecific, and diagnosis often requires careful radiologic and histopathologic evaluation.</p><p><strong>Case presentation: </strong>We describe a 19-year-old male patient with an olfactory schwannoma that was incidentally discovered during evaluation for head trauma. The patient was asymptomatic, with preserved olfactory function.</p><p><strong>Management and results: </strong>The patient underwent complete surgical excision via bifrontal craniotomy. Immunohistochemical staining demonstrated positivity for S100, CD34, and Bcl-2, and negativity for GFAP and EMA, confirming the diagnosis of schwannoma. The postoperative course was uneventful, with full preservation of olfactory nerve function, and the patient was discharged in stable condition on postoperative day 7.</p><p><strong>Conclusion: </strong>This case highlights the clinical significance of recognizing olfactory schwannomas, which may be discovered incidentally. Comprehensive imaging and histopathological evaluation are crucial for accurate diagnosis. Early detection and total resection contribute to favorable neurological outcomes in asymptomatic patients.</p>","PeriodicalId":10357,"journal":{"name":"Clinical Medicine Insights. Case Reports","volume":"19 ","pages":"11795476251407356"},"PeriodicalIF":0.6,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12852575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146104383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}