Pharmacological Research - Natural Products最新文献

{"title":"Immunomodulatory role of royal jelly in managing PCOS and associated comorbidities: A critical review","authors":"Divya ,&nbsp;Ankita Thakur ,&nbsp;Younis Ahmad Hajam ,&nbsp;Rajesh Kumar","doi":"10.1016/j.prenap.2025.100278","DOIUrl":"10.1016/j.prenap.2025.100278","url":null,"abstract":"<div><div>Polycystic ovarian syndrome (PCOS), a complex, multifactorial &amp; widespread endocrine-metabolic disorder, has become major cause of female sterility with characteristic symptoms of hormonal imbalance, menstrual abnormalities, and chronic anovulation. This condition is not only associated with significant reproductive challenges, but it has also developed a threat to long-term chronic health conditions like cardiovascular diseases, type 2 diabetes, and other metabolic dysfunctions. The conventional treatments for polycystic ovarian syndrome (PCOS) like hormonal therapy, aromatic agonists and insulin-sensitizing agents are typically associated with significant repercussions, including mood swings, weight gain, and long-term metabolic concerns. Instead of treating the pathophysiology of the problem, these pharmacological therapies mainly focus on symptom management, which may result in a cycle of reliance without enhancing the overall health. This emphasizes the shift towards the use of alternative and complementary medicine, which has drawn attention to the natural products which can be used in the mitigation of PCOS and associated metabolic dysfunctions. Royal jelly, bee products has drawn scientific attention due to its efficacy and potential health benefits in reproductive physiology. The diverse chemical make-up of royal jelly (lipids, proteins, and bioactive compounds like 10-hydroxy-2-decenoic acid), has been found to have various immunomodulatory effects which may contribute to its potential benefits in PCOS management. This systematic literature survey was conducted on scientific and digital databases, such as Science Direct, Elsevier, Wiley online library, Google Scholar, and PubMed published from 2005 to 2024. Therefore, present review aims to construct a systematic study on PCOS and its various aspects, such as pathogenicity, and immunogenicity with emphasis on the therapeutic efficacy of royal jelly.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100278"},"PeriodicalIF":0.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144271445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-silico Pharmacokinetic study of phytoconstituents present in Tulipa gesneriana L.","authors":"Jill Kavaiya,&nbsp;Bhavinkumar Gayakvad,&nbsp;Dignesh Khunt,&nbsp;Ravi Patel,&nbsp;Sanjay Chauhan","doi":"10.1016/j.prenap.2025.100279","DOIUrl":"10.1016/j.prenap.2025.100279","url":null,"abstract":"<div><div>Recently, tulip flower (Tulipa gesneriana L.) culinary and medicinal uses have grown in popularity. Tulip blooms include bioactive substances such tuliposides and tulipalins, which are antibacterial and antifungal. Additionally, these flowers contain high levels of flavonoids, which have been researched for their antioxidant, anti-inflammatory, and various therapeutic effects. This study examines the <em>in-silico</em> evaluation of the ADME (Absorption, Distribution, Metabolism, and Excretion) properties of 31 phytocompounds sourced from Tulipa gesneriana L., employing the SwissADME computational tool. SwissADME was selected for its free accessibility, intuitive interface, and extensive range of predictive models, including iLOGP and the BOILED-Egg, facilitating thorough assessment of pharmacokinetics, drug-likeness, and medicinal chemistry properties appropriate for both expert and non-expert users. Numerous compounds showed favourable gastrointestinal absorption and bioavailability, with quercetin showing promise for drug development due to its favourable physicochemical properties and pharmacokinetic profile. Coumarin can cross the blood-brain barrier, improving its therapeutic potential. Whole tulip flower extracts may be therapeutic, even though some compounds raise drug-likeness concerns, according to the study. The study emphasizes the importance of computational tools in drug discovery for phytochemical screening and analysis, as well as the need to study whole extracts and individual compounds to improve therapeutic outcomes. However, the study is limited by its reliance on i<em>n-silico</em> predictions, and future experimental validation through <em>in-vitro</em> and <em>in-vivo</em> studies is essential to confirm the pharmacokinetic behaviours and therapeutic potentials of the identified compounds.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100279"},"PeriodicalIF":0.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144271447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural remedies for post-inflammatory hyperpigmentation: Antibacterial and anti-melanogenesis properties of Thai herbs","authors":"Soontari Komkonekaew ,&nbsp;Wichuta Kamphuan ,&nbsp;Phattaraporn Paobthong ,&nbsp;Warinporn Anukoonrajchathon ,&nbsp;Pacharaporn Putthangkul ,&nbsp;Sarocha Sapcharoen ,&nbsp;Chanikan Sonklin ,&nbsp;Wiwat Klankaew ,&nbsp;Kanyanat Khongrin ,&nbsp;Kiattawee Choowongkomon ,&nbsp;Saranya Sedthananan ,&nbsp;Lueacha Tabtimmai","doi":"10.1016/j.prenap.2025.100280","DOIUrl":"10.1016/j.prenap.2025.100280","url":null,"abstract":"<div><div>Post-inflammatory hyperpigmentation (PIH) occurs when excess melanin is produced in response to skin irritation or injury, resulting in uneven pigmentation. This study evaluates the cosmeceutical potential of ethanolic extracts from eight Thai herbs—<em>Curcuma xanthorrhiza</em> (CX), <em>Quercus infectoria</em> (QI), <em>Calophyllum inophyllum</em> (CI), <em>Caesalpinia sappan</em>(CS), <em>Garcinia hanburyi</em> (GH), <em>Punica granatum</em> (PG), <em>Cotylelobium lanceolatum</em> (CL), and <em>Strychnos nux-vomica</em> (SN)—to treat PIH through antioxidant, anti-inflammatory, antibacterial, and anti-melanogenesis properties. Phytochemical analysis revealed that CX and QI contained high levels of phenolics and flavonoids, correlating with their strong antioxidant activity. CX also protected against hydrogen peroxide (H₂O₂)-induced oxidative stress in a yeast-based model and prevented DNA damage in vitro, helping to mitigate cellular injury that can lead to melanin overproduction. Anti-inflammatory assays showed that both CX and QI significantly reduced nitric oxide and interleukin-6 (IL-6) levels without causing cytotoxicity, supporting their role in treating inflammation-related PIH. The extracts also demonstrated selective antibacterial activity against <em>Staphylococcus aureus</em> (MSSA and MRSA) and <em>Cutibacterium acnes</em>, while sparing <em>Staphylococcus epidermidis</em>, an important member of the skin microbiome. CI and CX significantly inhibited <em>C. acnes</em>, a key contributor to acne-induced PIH. Finally, anti-melanogenesis assays revealed that QI and SN effectively inhibited α-MSH-induced melanin production. These findings suggest that CX, QI, and CI are promising natural cosmeceutical agents for addressing PIH by modulating oxidative stress, inflammation, microbial imbalance, and melanin overproduction, while maintaining skin microbiota integrity.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100280"},"PeriodicalIF":0.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144271932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The latest progress on the pharmacological effects of single components of traditional Chinese medicine in in vitro models of cervical cancer","authors":"Min Zhao ,&nbsp;Liuxiang Feng ,&nbsp;Wenhua Li","doi":"10.1016/j.prenap.2025.100272","DOIUrl":"10.1016/j.prenap.2025.100272","url":null,"abstract":"<div><h3>Objective</h3><div>This article attempts to comprehensively review all literature on traditional Chinese medicine monomers for the treatment of cervical cancer(CC) to date, with a focus on exploring their mechanisms of action and future prospects in the prevention and treatment of cervical cancer.</div></div><div><h3>Method</h3><div>A computer was used to search for relevant literature from databases such as PubMed, Medline, and CNKI up to now. The search keywords were \"cervical cancer, traditional Chinese medicine monomers (TCM) and mechanisms\". Literature that matched this article was selected for sorting, summarizing, and summarizing.</div></div><div><h3>Result and conclusion</h3><div>The development and transfer of CC is a complex process involving many signaling pathways. Although significant progress has been made in the treatment of CC, there are still some adverse reactions, including infection, bone marrow suppression, and hematotoxicity. Therefore, there is an urgent need to develop new, effective, safe, and affordable anti CC drugs. Traditional Chinese medicine monomers have attracted increasing attention in the field of anti CC research due to their advantages such as easy extraction, safety, low toxicity, and minimal side effects. Traditional Chinese medicine monomers act on multiple targets through various mechanisms, not only inhibiting the growth, proliferation, invasion, and migration of CC cells, but also promoting their apoptosis.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100272"},"PeriodicalIF":0.0,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144271446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LC-HRMS metabolomics, isolation, network pharmacology, and molecular docking based evaluation of anti-cancer potential of compounds of Glycyrrhiza glabra L.","authors":"Sanheeta Chakrabarty ,&nbsp;Hitesh Harsukhbhai Chandpa ,&nbsp;Nancy Tripathi ,&nbsp;Sagar Singh Shyamal ,&nbsp;Anindita Bhattacharjee ,&nbsp;Sanjay Kumar ,&nbsp;Bharat Goel ,&nbsp;Sanju Kumari ,&nbsp;Jairam Meena ,&nbsp;Venkatnarayan Ramanathan ,&nbsp;Sanjeev Kumar ,&nbsp;Shreyans K. Jain","doi":"10.1016/j.prenap.2025.100271","DOIUrl":"10.1016/j.prenap.2025.100271","url":null,"abstract":"<div><div>Network pharmacology plays a crucial role in drug discovery by identifying target genes and elucidating underlying mechanisms. In the present work, <em>Glycyrrhiza glabra</em> hydroalcoholic extract (GGHE) was subjected to LC-MS phytochemical profiling, followed by in-silico ADME analysis of identified compounds. Various databases like GeneCards, SEA databases, PharmMapper, DisGeNet, SwissTargetPrediction, and STRING were used to find information on target genes, and a network was created using CytoScape. The combination synergy study was done by constructing hierarchical networks. In the LC-MS study, 16 compounds were identified, with 12 passing ADME screening. Enrichment analysis revealed the involvement of various pathways linked to cancer, including EGFR TKI resistance, MAPK, PD-L1/PD-1, proteoglycans, PI3K-Akt, ErbB, and RAS pathways. Synergy studies highlighted mTOR and CHUK gene targets for two compounds. Besides, secondary metabolites were isolated using chromatographic techniques, characterized by NMR, and evaluated for cytotoxicity in human cancer cell lines by MTT assay. Six compounds <em>viz</em> hispaglabridin A, glabrol, isoliquiritin apioside, formononetin, glycyrrhizin, and glabridin were isolated, and most of these were subjected to cytotoxic evaluation. Glabridin showed the highest potency against breast cancer cell lines (MDA-MB-231 and MCF-7) and Network pharmacology suggests Glabrene and Glyinflanin A possesses anti-cancer potential. Thus, the study demonstrates GGHE or its compounds have potential against breast, prostate, and pancreatic cancer.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"7 ","pages":"Article 100271"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144240734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticancer activity and chemical composition of dry extract from Moroccan chamomile (Matricaria chamomilla L.)","authors":"Amina El Mihyaoui ,&nbsp;Saoulajan Charfi ,&nbsp;El Hadi Erbiai ,&nbsp;Mariana Pereira ,&nbsp;Diana Duarte ,&nbsp;Nuno Vale ,&nbsp;María Emilia Requena Candela ,&nbsp;Ahmed Lamarti ,&nbsp;Joaquim C.G. Esteves da Silva ,&nbsp;Marino B. Arnao","doi":"10.1016/j.prenap.2025.100270","DOIUrl":"10.1016/j.prenap.2025.100270","url":null,"abstract":"<div><div>Breast cancer is one of the leading causes of cancer-related fatalities among women. Recently, the role of phytochemicals in the prevention and treatment of cancer has received increasing attention. The medicinal plant <em>Matricaria chamomilla</em> L. is well known for its use in traditional medicine to treat a variety of illnesses, due to the presence of diverse phytochemicals with remarkable biological properties. Herein, this study aimed to explore the anticancer property and chemical composition of four parts of <em>M. chamomilla</em> (roots, stems, leaves, and flowers) growing in northern Morocco. The anticancer activity of methanolic extracts were determined <em>in vitro</em> against PC-3 prostate cancer cells, MCF-7 breast cancer cells, and non-tumoral MRC-5 cells, applying the MTT test and microscopic visualization, while the phytochemicals composition was characterized by HPLC-MS and GC-MS techniques. Our results indicated that the plant extracts possess cytotoxicity activity on PC-3 and MCF-7 cells, with the strongest effect obtained with the flower extract, which induced a cell inhibition of around 60 %. In addition, the extracts showed an acceptable biosafety profile against normal cells when used at a concentration below 500 µg/mL. The HPLC-MS analysis of the extracts allowed the identification of 22 phenolic compounds in the flowers and roots, and 23 in the leaves and stems. Furthermore, the GC-MS chromatograms of <em>M. chamomilla</em> flower, leaf, stem, and root extracts revealed the presence of 55, 52, 48, and 44 components, respectively. The identified biomolecules can be mainly divided into fatty acids, terpenoids, esters, amino acids, organic acids, vitamins, and other groups. The most abundant group was fatty acids in the flower (56.00 %), leaves (55.08 %), and stems (48.27 %), while vitamin (18.01 %) was found to be the major biomolecule group in roots. These findings showed that <em>M. chamomilla</em> extracts revealed promising antitumor properties provided by their phytochemical composition.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"7 ","pages":"Article 100270"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144240735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrinsic Apoptosis Induction by Codariocalyx motorius: A Natural Hepatoprotective Strategy against HepG2 Cell Proliferation","authors":"Anju Rani George,&nbsp;Sradha Sajeev,&nbsp;Kavimani Thangasamy,&nbsp;Geetha Natesan","doi":"10.1016/j.prenap.2025.100273","DOIUrl":"10.1016/j.prenap.2025.100273","url":null,"abstract":"<div><h3><em>Background</em></h3><div>Globally, liver cancer or hepatocellular carcinoma cases are rising alarmingly and chemotherapeutic agents are used for treatment, they often cause side effects. <em>Codariyocalyx motorius</em> (Houtt.) H. Ohashi, a plant from the Fabaceae family, is traditionally used in Thailand, India and China to treat ailments including cancer-like symptoms. However, this claim lacks scientific validation.</div></div><div><h3>Aim</h3><div>This study aimed to investigate the effect of aqueous leaf extract of <em>Codariyocaly motorius</em> (ALCM) on liver cancer cells (HepG2) to study its possible mechanism of action for suppressing cell proliferation through activation of intrinsic apoptotic pathway.</div></div><div><h3>Methodology</h3><div>Qualitative estimation of the component profiling through HPLC and apoptosis induction on HepG2 cell lines was assessed using MTT assay, cellular morphology analysis with AO/EtBr, DAPI stain, ROS generation, quantification of cellular apoptosis by flow cytometry and expression of apoptotic and anti-apoptotic genes by RT-PCR were studied.</div></div><div><h3>Results</h3><div>During HPLC analysis, four phytocompounds such as gallic acid, rutin, camptothecin and luteolin were quantified. The ALCM exhibited significant anti-proliferative property against HepG2 cancer cell lines with an IC₅₀ of 24.6 µg/mL and reduced their clonogenic potential in a concentration-dependent manner. Furthermore the ALCM showed no adverse toxic effect on Human Embryonic Normal Kidney cells (HEK293). Apoptosis was confirmed through cytometric analysis and microscopic examination of AO/EtBr, DAPI and Annexin V/IP stained cells. Biochemical evidences of apoptosis came from elevating the intracellular ROS level and cell cycle arrest at S and G0/G1 phase. RT-PCR analysis showed that ALCM induced mitochondrial apoptosis in HepG2 cells revealed a concentration-dependent up-regulation of apoptotic genes (Bax and caspase-3) and down regulation of non-apoptotic gene (Bcl-2).</div></div><div><h3>Conclusion</h3><div>Thus, the present study suggest the remarkable potential of active metabolites in ALCM for the initiation of cell apoptosis through the activation of intrinsic apoptotic pathway in HepG2 cells and thereby serve as promising therapeutic agent for the treatment and management of HCC.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"7 ","pages":"Article 100273"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144263366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chitosan from Labeo rohita fish scales and its effects on ameliorating high-carbohydrate-high-fat diet-induced metabolic dysfunction by modulating mRNA expression of LDL-R in obese rats","authors":"Md. Sultan Mahmud Rony,&nbsp;Nuraya Yeasmin Bristy,&nbsp;Pritam Sarkar,&nbsp;Prottoy Kumar Debnath,&nbsp;Jamil Ahmad Shilpi,&nbsp;Shaikh Jamal Uddin","doi":"10.1016/j.prenap.2025.100269","DOIUrl":"10.1016/j.prenap.2025.100269","url":null,"abstract":"<div><h3>Background</h3><div>Chitosan, a natural biopolymer that is widely used in the food industry, offers various pharmacological benefits. Most pharmacological research focuses on non-fish sources of chitosan, but in this study, chitosan was extracted from <em>Labeo rohita</em> scales to evaluate its potential to reduce obesity and related metabolic disorders. This approach repurposes fish waste into a valuable resource and provides an eco-friendly alternative source of pharmaceutical raw materials.</div></div><div><h3>Methods</h3><div>Chitosan was extracted using an established method, followed by characterization and evaluation of its physical properties. Pharmacological effects were studied in Wistar rats divided into six groups: Control, HCHF, HCHF + atorvastatin, HCHF + chitosan (150 mg/kg), HCHF + chitosan (300 mg/kg), and HCHF + chitosan (500 mg/kg). The study measured glucose tolerance, food intake, body and organ weights, liver damage markers, lipid profiles, oxidative stress markers, and mRNA expression to explore underlying mechanisms.</div></div><div><h3>Results</h3><div>Infrared spectrum analysis confirmed the successful extraction of chitosan, with physical properties similar to commercial chitosan. Chitosan supplementation significantly (p &lt; 0.05) reduced weight gain and improved glucose tolerance in a dose-dependent manner. It also improved lipid profiles, bringing the atherogenic coefficient into the normal range. This effect was achieved due to increased LDL-R mRNA expression in chitosan-supplemented rats, which enhanced cholesterol clearance. Chitosan restored ALT, AST, and ALP levels to normal and also increased antioxidant enzyme levels (GSH, SOD, CAT) in a dose-dependent manner.</div></div><div><h3>Conclusion</h3><div>Our data shows that Chitosan from <em>Labeo rohita</em> scales effectively mitigates HCHF diet-induced obesity and metabolic dysfunction.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"7 ","pages":"Article 100269"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144230971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical profiling and synergistic antifungal activity of essential oils from Moroccan aromatic plants against peanut-associated fungi","authors":"Narjisse Mokhtari ,&nbsp;Hammadi El Farissi ,&nbsp;Haiat Essalmani ,&nbsp;El Touhami Ouazzani Tayebi ,&nbsp;Mariam El Idrissi El Berkani ,&nbsp;Yousra Mdarhri ,&nbsp;Oussama Chauiyakh ,&nbsp;Abderrahman Bouassab ,&nbsp;Mohamed Chabbi","doi":"10.1016/j.prenap.2025.100277","DOIUrl":"10.1016/j.prenap.2025.100277","url":null,"abstract":"<div><div>As part of the valorization of Aromatic and Medicinal Plants (AMP) in Morocco, we evaluated the chemical composition and the antifungal activity of Four Essential Oils (Eos) from Northern Morocco, including: <em>Origanum compactum, Mentha pulegium, Lavandula officinalis and Myrtus communis</em>. After extraction of the Eos by hydro-distillation process, the study of their chemical composition was carried out by GC/MS (gas chromatography- mass spectrometry). Additionally, the evaluation of individual and combined antifungal activity was assessed against <em>Aspergilus flavus (A.flavus)</em> and other fungi species isolated from peanuts, including <em>Aspergillus niger</em>, Penicillium <em>sp</em>, <em>Rhizopus sp</em>, <em>Fusarium sp</em> and <em>Alternaria sp</em>. The yields after extraction by hydro-distillation were 2,7 %, 3.2 %, 2.65 % and 0.6 % for <em>Origanum compactum, Mentha pulegium, Lavandula officinalis and Myrtus communis</em> respectively. The binary combinations demonstrated strong antifungal activity across a broad spectrum of fungi compared to the individual antifungal assay. Additionally, these combinations were effective in inhibiting aflatoxin B₁ (AFB₁) production. This bioactivity is primarily attributed to the interactions among the components of the various Eos, including thymol, carvacrol, linalool, pulegone, and eucalyptol. The current investigation appears to be unique as it combines various Eos and assesses their binary antifungal efficacy against fungi isolated from peanuts, which has not been extensively documented in existing literature.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"7 ","pages":"Article 100277"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144240733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diverse bioactivity of traditional herb Achyranthes aspera in ethnomedicine","authors":"Yuvaraj Dinakarkumar ,&nbsp;Gnanasekaran Ramakrishnan ,&nbsp;Ponmozhi Marimuthu ,&nbsp;Santhan Velayudham Priya ,&nbsp;Sharmila Kumar ,&nbsp;Vaagdevi Mukkavilli","doi":"10.1016/j.prenap.2025.100268","DOIUrl":"10.1016/j.prenap.2025.100268","url":null,"abstract":"<div><div>A popular ethnomedical herb, <em>Achyranthes aspera</em> has a long history in traditional medicine because of its many medicinal uses. Tannins, alkaloids, flavonoids, and saponins are among the many bioactive substances that have been found through phytochemical studies and contribute to its therapeutic qualities. This herb has been thoroughly investigated in contemporary pharmacology, revealing its anti-inflammatory, antimicrobial, and cardiovascular-modulating properties despite having strong roots in traditional treatments. It is important for treating oxidative stress-related conditions like degenerative and chronic inflammatory diseases because of its strong antioxidant activity. According to scientific research, the plant's anti-inflammatory qualities effectively lower inflammation by modifying pro-inflammatory cytokines. It has the potential to treat diseases naturally because of its antibacterial action, which has been shown against a variety of pathogens. Its pharmacological relevance is further expanded by its cardiovascular-modulating activities, which include antihypertensive and cardioprotective properties. Furthermore, <em>Achyranthes aspera</em>'s antioxidant qualities are essential in the fight against oxidative stress, which is connected to a number of chronic illnesses, such as cancer, diabetes, and neurological diseases. This review highlights the plant's potential to aid in the creation of innovative medicinal substances and as sources of novel drug development since it combines traditional medical practices with contemporary pharmacological understanding.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"7 ","pages":"Article 100268"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144205262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}