{"title":"从根到药:探索萝卜的药理学和纳米医学潜力","authors":"Dinesh Kumar , Devesh Kumar , Vaibhav Kumar , Sushil Kumar , Vidhan Chand Bala , Thakur Gurjeet Singh , Mohit Kumar","doi":"10.1016/j.prenap.2025.100380","DOIUrl":null,"url":null,"abstract":"<div><div><em>Raphanus sativus</em> (<em>R. sativus</em>), commonly known as radish, has been widely utilised in traditional medicine, particularly in Traditional Chinese Medicine (TCM), due to its numerous medicinal properties. This study thoroughly analyses the pharmacological and therapeutic potential of <em>R. sativus</em>, highlighting its bioactive components, such as glucosinolates, flavonoids, phenolic acids, and isothiocyanates. These phytochemicals have shown various pharmacological actions, including antioxidant, anti-inflammatory, anticancer, antidiabetic, and antibacterial properties. Recent breakthroughs in nanotechnology-based drug delivery systems have enhanced the solubility, stability, and bioavailability of bioactive substances, thereby improved their therapeutic effectiveness and broadened their potential uses in contemporary medicine. However, several challenges remain, including variability in phytochemical composition, a lack of comprehensive clinical studies, and the absence of standardized extraction and formulation protocols. Future investigations should focus on the isolation and characterization of novel bioactive compounds, elucidation of their mechanisms of action, and assessment of their potential synergistic effects with existing pharmaceuticals or medicinal plants. Integrating modern pharmacological approaches with traditional medicinal knowledge holds significant potential for the development of innovative natural therapeutics derived from <em>Raphanus sativus</em>, thereby contributing to the advancement of evidence-based herbal medicine.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"9 ","pages":"Article 100380"},"PeriodicalIF":0.0000,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"From root to remedy: Exploring the pharmacological and nanomedical potential of Raphanus sativus\",\"authors\":\"Dinesh Kumar , Devesh Kumar , Vaibhav Kumar , Sushil Kumar , Vidhan Chand Bala , Thakur Gurjeet Singh , Mohit Kumar\",\"doi\":\"10.1016/j.prenap.2025.100380\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div><em>Raphanus sativus</em> (<em>R. sativus</em>), commonly known as radish, has been widely utilised in traditional medicine, particularly in Traditional Chinese Medicine (TCM), due to its numerous medicinal properties. This study thoroughly analyses the pharmacological and therapeutic potential of <em>R. sativus</em>, highlighting its bioactive components, such as glucosinolates, flavonoids, phenolic acids, and isothiocyanates. These phytochemicals have shown various pharmacological actions, including antioxidant, anti-inflammatory, anticancer, antidiabetic, and antibacterial properties. Recent breakthroughs in nanotechnology-based drug delivery systems have enhanced the solubility, stability, and bioavailability of bioactive substances, thereby improved their therapeutic effectiveness and broadened their potential uses in contemporary medicine. However, several challenges remain, including variability in phytochemical composition, a lack of comprehensive clinical studies, and the absence of standardized extraction and formulation protocols. Future investigations should focus on the isolation and characterization of novel bioactive compounds, elucidation of their mechanisms of action, and assessment of their potential synergistic effects with existing pharmaceuticals or medicinal plants. Integrating modern pharmacological approaches with traditional medicinal knowledge holds significant potential for the development of innovative natural therapeutics derived from <em>Raphanus sativus</em>, thereby contributing to the advancement of evidence-based herbal medicine.</div></div>\",\"PeriodicalId\":101014,\"journal\":{\"name\":\"Pharmacological Research - Natural Products\",\"volume\":\"9 \",\"pages\":\"Article 100380\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-09-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmacological Research - Natural Products\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S295019972500240X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacological Research - Natural Products","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S295019972500240X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
萝卜(Raphanus sativus, R. sativus),俗称萝卜,由于其众多的药用特性,在传统医学中,特别是在中医(TCM)中被广泛应用。本研究深入分析了红花的药理和治疗潜力,重点介绍了其生物活性成分,如硫代葡萄糖苷、类黄酮、酚酸和异硫氰酸酯。这些植物化学物质已显示出各种药理作用,包括抗氧化、抗炎、抗癌、抗糖尿病和抗菌特性。基于纳米技术的药物传递系统的最新突破提高了生物活性物质的溶解度、稳定性和生物利用度,从而提高了它们的治疗效果,扩大了它们在当代医学中的潜在用途。然而,仍然存在一些挑战,包括植物化学成分的可变性,缺乏全面的临床研究,以及缺乏标准化的提取和配方方案。未来的研究应集中在分离和表征新的生物活性化合物,阐明其作用机制,并评估其与现有药物或药用植物的潜在协同作用。将现代药理学方法与传统医学知识相结合,对于开发从莴苣中提取的创新天然疗法具有重大潜力,从而促进循证草药的发展。
From root to remedy: Exploring the pharmacological and nanomedical potential of Raphanus sativus
Raphanus sativus (R. sativus), commonly known as radish, has been widely utilised in traditional medicine, particularly in Traditional Chinese Medicine (TCM), due to its numerous medicinal properties. This study thoroughly analyses the pharmacological and therapeutic potential of R. sativus, highlighting its bioactive components, such as glucosinolates, flavonoids, phenolic acids, and isothiocyanates. These phytochemicals have shown various pharmacological actions, including antioxidant, anti-inflammatory, anticancer, antidiabetic, and antibacterial properties. Recent breakthroughs in nanotechnology-based drug delivery systems have enhanced the solubility, stability, and bioavailability of bioactive substances, thereby improved their therapeutic effectiveness and broadened their potential uses in contemporary medicine. However, several challenges remain, including variability in phytochemical composition, a lack of comprehensive clinical studies, and the absence of standardized extraction and formulation protocols. Future investigations should focus on the isolation and characterization of novel bioactive compounds, elucidation of their mechanisms of action, and assessment of their potential synergistic effects with existing pharmaceuticals or medicinal plants. Integrating modern pharmacological approaches with traditional medicinal knowledge holds significant potential for the development of innovative natural therapeutics derived from Raphanus sativus, thereby contributing to the advancement of evidence-based herbal medicine.