Pharmacological Research - Natural Products最新文献

{"title":"Herbal pharmacopeias: Bridging ancient traditions, nanotechnological innovation, and global regulatory cohesion for equitable healthcare","authors":"Kushagra Sharma","doi":"10.1016/j.prenap.2025.100301","DOIUrl":"10.1016/j.prenap.2025.100301","url":null,"abstract":"<div><div>This review examines the role of herbal pharmacopeias in integrating ancient healing traditions, nanotechnology-driven innovations, and global regulatory frameworks to advance equitable healthcare. It addresses critical challenges such as low bioavailability, inconsistent quality control, and fragmented regulations hindering the integration of herbal medicines into mainstream healthcare systems. By synthesizing ethnobotanical knowledge, nanotechnology applications, and regulatory science, this review evaluates advancements such as nanocarriers (e.g., liposomes, phytosomes) and Traditional Chinese Medicine (TCM) supermolecules (e.g., berberine-rhein complexes). Regional case studies from China, Brazil, and Africa are analyzed to highlight contributions like genomic databases, biodiversity-driven innovations, and standardized monographs. Key findings demonstrate nanotechnology’s potential to enhance solubility, targeted delivery, and therapeutic efficacy of herbal compounds. Regional initiatives, such as China’s genomic resources and Africa’s pharmacopeial monographs, underscore diverse contributions. Persistent challenges include herb-drug interactions, variable raw material quality, and inadequate pharmacovigilance systems. Harmonized regulations (e.g., European Pharmacopeia, World Health Organization (WHO) initiatives) and AI-driven safety monitoring are identified as pivotal solutions. The integration of ethnobotanical wisdom, nanotechnology, and global regulatory cohesion is essential to unlock the full potential of herbal medicines. Interdisciplinary collaboration, ethical benefit-sharing frameworks (e.g., Nagoya Protocol), and robust pharmacovigilance are critical for achieving scalable, equitable healthcare solutions. Herbal pharmacopeias must evolve as interconnected systems, balancing tradition with innovation to address 21st-century health disparities.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100301"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144572021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effect of morin hydrate against chronic unpredictable mild stress-induced depression in mice","authors":"Deepak ,&nbsp;Dinesh Dhingra","doi":"10.1016/j.prenap.2025.100302","DOIUrl":"10.1016/j.prenap.2025.100302","url":null,"abstract":"<div><div>Morin flavonoid has been reported to possess anti-stress, anti-anxiety, nootropic, anti-oxidant, and neuroprotective properties. In the present study, morin hydrate was evaluated for antidepressant-like activity in unstressed and stressed Swiss young male albino mice. The mice were subjected to chronic unpredictable mild stress (CUMS) for 21 successive days. Morin hydrate (10, 20, and 40 mg/kg, p.o.) and fluoxetine (20 mg/kg, p.o.) <em>per se</em> were administered for 21 successive days to separate groups of unstressed and stressed mice. Tail suspension test (TST) and sucrose preference test were used to evaluate the effect of Morin on depression-like behavior in mice. During the study, the effect of Morin on lipid peroxidation, reduced glutathione, catalase, nitrite, corticosterone, and MAO-A activity was estimated. All the results were analyzed by analysis of variance (ANOVA) followed by the Tukey–Kramer multiple comparison test using Graph Pad Instat (GPIS) package, version 3.05. Morin (20 and 40 mg/kg, p.o.) <em>per se</em> administered for 21 successive days significantly decreased the immobility period of stressed mice in the tail suspension test as compared to vehicle-treated stressed mice, indicating significant antidepressant-like activity. Morin significantly restored the reduced sucrose preference (%) in stressed mice as compared to vehicle-treated stressed mice. Further, morin significantly reversed the stress-induced increase in brain thiobarbituric acid-reactive substances (TBARS), plasma nitrite, and corticosterone levels, and increased the stress-induced decrease in brain catalase levels. The highest dose (40 mg/kg) of morin hydrate significantly inhibited brain MAO-A activity in stressed mice. Thus, morin hydrate showed significant antidepressant-like activity in mice subjected to CUMS, probably through inhibition of brain MAO-A activity, decrease in plasma nitrite and corticosterone levels, and due to its antioxidant activity.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100302"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144581368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticancer activity of reserpine: A comprehensive review of mechanisms, chemistry and botanical sources","authors":"Md. Sakib Al Hasan ,&nbsp;Noshin Tasnim Yana ,&nbsp;Emon Mia ,&nbsp;Md. Shimul Bhuia ,&nbsp;Raihan Chowdhury ,&nbsp;Md. Shadin ,&nbsp;Muhammad Torequl Islam","doi":"10.1016/j.prenap.2025.100303","DOIUrl":"10.1016/j.prenap.2025.100303","url":null,"abstract":"<div><div>Reserpine (RSP), an alkaloid derived from <em>Rauvolfia</em> species. It is a well-established antipsychotic and antihypertensive drug which has demonstrated promising anticancer properties across various studies. This study aims to provide a short, comprehensive overview of RSP’s anticancer properties. A literature review was conducted, searching database, such as PubMed, Springer Link, Scopus up to February 15, 2025. The review included studies that reported RSP’s activity on various <em>in vitro</em> cancer cell lines and in vivo models, excluding those with data duplication or lacking full text. RSP demonstrated potent anticancer activity across multiple cancer types, such as lung, breast, prostate, and skin cancers, through mechanisms like increased reactive oxygen species (ROS) generation, apoptosis induction, and inhibition of DNA synthesis. These findings suggest RSP’s potential as an anticancer agent, though further research is needed to fully understand its therapeutic capabilities.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100303"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144581370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuropharmacological activities of Eclipta alba (L.) Hassk. in the context of Alzheimer's and Parkinson's diseases: A mini review","authors":"Abir Biswas ,&nbsp;Ragupathi Abirami ,&nbsp;Anitha Rathinam ,&nbsp;Kesavan Swaminathan Jayachandran ,&nbsp;Muthuswamy Anusuyadevi","doi":"10.1016/j.prenap.2025.100308","DOIUrl":"10.1016/j.prenap.2025.100308","url":null,"abstract":"<div><div>Neurodegenerative disorders, such as Alzheimer's and Parkinson's diseases, are characterized by the progressive loss of neurons and/or their functions, leading to cognitive and motor impairments. Alzheimer's disease is the most common cause of dementia, while Parkinson's primarily affects movement. Currently, there are limited therapeutic options, and none can prevent or reverse disease progression. Plants, a cornerstone of traditional medicine, remain a source of potential remedies due to their multi-target effects on key metabolic processes involved in disease pathologies. This makes them promising candidates for halting or even curing these disorders. One such plant is <em>Eclipta alba</em> (L.) Hassk. This review highlights the traditional uses and experimental evidence of <em>Eclipta alba</em> (L.) Hassk. in treating Alzheimer’s and Parkinson’s diseases, explores the underlying mechanisms and neuropharmacological constituents, and examines its toxicological profile, emphasizing the need for further research into clinical applications.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100308"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing the phenolic composition and exploring the antioxidant, anti-cancer, and anti-inflammatory potential of medicinal plant infusions","authors":"Cláudia Botelho ,&nbsp;Diana Ferreira-Sousa ,&nbsp;Javier Quero ,&nbsp;Augusto Costa-Barbosa ,&nbsp;Catarina Teixeira-Guedes ,&nbsp;Paula Sampaio ,&nbsp;María Jesús Rodríguez-Yoldi ,&nbsp;Pedro Ferreira-Santos","doi":"10.1016/j.prenap.2025.100304","DOIUrl":"10.1016/j.prenap.2025.100304","url":null,"abstract":"<div><div>Natural products and their derivatives have played important roles in various fields, including nutrition, medicine and cosmetics. In this study, different formulated plant infusions, namely Purifying Body (PB), Boost Training (BT), Calm Night I Spirit (CN), and Boost Energy (BE) were analyzed regarding their phenolic composition and biological properties such as antioxidant, anti-inflammatory, and its influence on a different type of tumoral and non-tumoral cells. Nineteen phenolic compounds across six groups were identified, being cinnamic acid the most prevalent in all infusions. BE infusions exhibited the highest total phenolic content (5 g GAE/L), while BT had the lowest (2 g GAE/L). BE demonstrated superior antioxidant activity, correlating with its high phenolic content. The impact of plant infusions on cell metabolic activity revealing a concentration-dependent behaviour for three used cell lines [human embryonic kidney (HEK293t), normal mouse fibroblast (L929), and human colorectal adenocarcinoma (Caco-2)]. IC₅₀ values indicated low toxicity on non-tumoral cells and higher inhibition on the metabolic activity of colon cancer Caco-2 cells. These effects can be due to the induction of cell cycle arrest and apoptosis. All plant infusions significantly prevented reactive oxygen species formation (oxidative stress regulation), and present anti-inflammatory capacity with a decrease of pro-inflammatory (IL-1β) and an increase of anti-inflammatory (IL-10) cytokines.</div><div>Overall, the formulated infusions have antioxidant and anti-inflammatory properties and a notable impact on colon cancer cells. This study revealed the potential of the tested infusions in various medical applications, such as preventive care, as well as in the nutraceutical field.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100304"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144571584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the pharmacological effect of cardiac glycosides against hepatocellular carcinoma using network pharmacology","authors":"Yatendra Singh ,&nbsp;Arun Kumar Jajoriya ,&nbsp;Sanjeev Kanojiya","doi":"10.1016/j.prenap.2025.100307","DOIUrl":"10.1016/j.prenap.2025.100307","url":null,"abstract":"<div><div>Hepatocellular carcinoma (HCC) is the most common form of liver cancer and the third leading cause of cancer-related deaths worldwide. Currently, treatment options for patients with advanced HCC remain limited. Cardiac glycosides (CGs), traditionally used for their cardiac effects, have recently garnered attention for their potential anti-cancer properties. This study aimed to explore the pharmacological effects of CGs against HCC using network pharmacology. Our previous research identified 36 CGs, of which 16 were selected for further analysis based on oral bioavailability, drug-likeness, and toxicity, and were considered active compounds. We retrieved protein targets for these active CGs and HCC-related genes from various databases. The intersection of CGs and HCC-related genes revealed 258 potential therapeutic targets for HCC treatment. The pharmacological mechanisms of CGs were investigated through enrichment analysis of Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, using the ShinyGO 0.80 bioinformatics platform. GO analysis indicated that the targets of active CGs are involved in key biological processes, such as protein phosphorylation, membrane rafts, protein kinase activity, and ATP binding. Enriched KEGG pathway analysis revealed that the therapeutic effects of CGs against HCC are associated with several critical pathways, including EGFR tyrosine kinase inhibitor resistance, glioma, ErbB signaling, MicroRNAs in cancer, hepatitis B, Rap1 signaling, Kaposi sarcoma-associated herpesvirus infection, focal adhesion, proteoglycans in cancer, MAPK signaling, Ras signaling, and PI3K-Akt signaling. This study utilized network pharmacology to identify potential biomarkers for HCC and lay a foundation for future experimental validation and development of novel anti-HCC drugs using CGs.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100307"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144597058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crude alkaloids from Phyllanthus fraternus, Webster: Antibacterial, time-kill kinetics and resistance modulation studies","authors":"Samuel Asiamah Obiri ,&nbsp;Denzel Opoku-Kwabi ,&nbsp;Yaw Opoku-Boahen ,&nbsp;Francis Ackah Armah ,&nbsp;Malcolm Patrick Fynn ,&nbsp;Lawrence Sheringham Borquaye ,&nbsp;Isaac Asiamah","doi":"10.1016/j.prenap.2025.100312","DOIUrl":"10.1016/j.prenap.2025.100312","url":null,"abstract":"<div><div>Antimicrobial resistance (AMR) continues to rise, making a growing number of infectious diseases difficult to cure. Millions of people worldwide die from infections with medication resistance. According to the World Health Organization (WHO), a resistant variant has a 64 % higher chance of killing an infected victim than a non-resistant variant. As a result, scientists continue to focus research attention on finding novel chemotypes that could have different modes of action. Combination therapy has the potential to overcome AMR since the therapeutic components work together to suppress the etiological microorganism. In the current study, we investigated the antibacterial properties of crude alkaloidal extract of <em>Phyllanthus fraternus</em> (AEPF) using high-throughput spot culture growth inhibition (HT-SPOTi) assay. We performed time-kill kinetic assays to assess the interactions between the crude alkaloids and test microbial strains. The ability of the crude alkaloids to alter the antimicrobial action of standard tetracycline was evaluated by modulation study. Our findings indicate that <em>P. fraternus</em> alkaloids effectively suppress majority of clinically significant pathogenic strains <em>in vitro.</em> Bactericidal effect was shown by time-kill kinetics against <em>S. aureus</em>, <em>E. coli</em> (ATCC 43888), and <em>E. coli</em> (ATCC 10455). Tetracycline was successfully potentiated against <em>Shigella sp.</em> by the alkaloidal extract. The crude alkaloid extract of <em>P. fraternus</em> included two known alkaloids, epibubbialine and ent-norsecurinine, according to LC-ESI-MS analysis. Taken together, the antibiotic activity of <em>P. fraternus</em> is primarily due to its alkaloids and that the potential exists to develop isolated alkaloids as drug candidates for use in combination therapies against antimicrobial resistance.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100312"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144623620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive analysis of the phytochemicals, antioxidant, antibacterial and mosquitocidal activities in Canthium coromandelicum (Burm.f.) Alston","authors":"Murugaiyan Annathurai,&nbsp;Sabapathy Vijayakumar,&nbsp;Palanivel Vanishree,&nbsp;Shanmugasundaram Somu","doi":"10.1016/j.prenap.2025.100309","DOIUrl":"10.1016/j.prenap.2025.100309","url":null,"abstract":"<div><div>Plants have been integral to human health and medicine since ancient times. This study investigates the therapeutic potential of <em>Canthium coromandelicum</em> (Burm.f.) Alston through comprehensive phytochemical analysis, evaluation of antioxidant properties, mosquitocidal and assessment of antibacterial activities. The plant extract was subjected to qualitative and quantitative phytochemical analyses to identify and quantify its bioactive compounds. Antioxidant activity was assessed using various solvent based various assays including 2,2-diphenyl-1-picrylhydrazyl free radical scavenging, 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) assay, Ferric reducing antioxidant power assay, Nitric oxide assay and Super oxide assays, while antibacterial efficacy was evaluated against selected bacterial strains through disc diffusion determination. Finally different solvent of <em>C. coromandelicum</em> against dengue vector <em>Aedes aegypti</em>. Results revealed a rich phytochemical profile including flavonoids, phenols, tannins and terpenoids. Flavonoids were rich in presented the methanol (131.23 ± 3.13 mg RUE/g extract) extract compared with other solvent extracts. In GCMS analysis we have observed 19 phytocomponents were presented in the ethyl acetate extract, 27 phytocomponents from hexane extract, 13 phytocomponents from methanol and 19 phytocomponents from aqueous extract, respectively. The major dominant bioactive compounds are Squalene (53.93 %), 2-Pyrrolidinethione, 1-phenyl (57.08 %), Isoquinoline (59 %), 2H-Pyrazol-3-ol, 5-furan-2-yl- (22.56 %), 3-Pyridinecarboxamide (22.31 %) and 2-Imino-3-ethylbenzothiazoline (16.74 %) respectively. The extract exhibited significant antioxidant potential, indicative of its free radical scavenging ability and reducing power. Furthermore, notable antibacterial activities were observed against both Gram-positive and Gram-negative bacteria, suggesting promising therapeutic applications. Finally, in mosquitocidal assay the methanol extract having significant mortality were observed in lower concentration compared to another solvent, the LC₅₀ values ranged 209.752 µg/mL (2nd instar) and 267.735 µg/mL (3rd instar) in methanol extract. These findings underscore <em>C. coromandelicum</em> potential as a source of natural antioxidants, mosquitocidal and antibacterial agents, warranting further exploration for pharmaceutical and health-promoting purposes. However, widespread study is necessary to screen the role of recorded phytochemicals through <em>in vivo</em> studies to support its use in traditional medicine.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100309"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144581369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of CB2 cannabinoid receptors in the ameliorative effects of curcumin on BCG-induced depression in mice: Insights into peripheral inflammation and central NF-κB signaling","authors":"Kartik T. Nakhate ,&nbsp;Rucha Deore ,&nbsp;Sanjay N. Awathale,&nbsp;Rashid Ansari,&nbsp;Sameer N. Goyal,&nbsp;Pradip Bawane","doi":"10.1016/j.prenap.2025.100310","DOIUrl":"10.1016/j.prenap.2025.100310","url":null,"abstract":"<div><div>Elevated peripheral inflammatory markers are associated with the development of several neurological disorders. Curcumin, a strong natural anti-inflammatory agent, has recently been identified as a potent agonist of the CB2 cannabinoid receptor. Since the function of CB2 receptors in neuropsychiatric illnesses is gaining increasing attention, the present study aimed to elucidate their involvement in the effects of curcumin on depressive phenotypes. The mice were inoculated with BCG and allowed 7 days to induce depression-like behavior. The animals were then administered curcumin alone or concomitantly with CB2 receptor agonist JWH133 or antagonist AM630, daily for 7 days, and subjected to the sucrose preference test, open field test, tail suspension test, and splash test. Further, the blood samples were analyzed for the TNF-α and IL-6 contents, and the brains were processed to estimate NF-κB and serotonin levels using the ELISA and HPLC techniques. The results showed a significant reversal of depressive episodes by curcumin in BCG-inoculated mice. The elevated plasma levels of TNF-α and IL-6 in depressed animals were associated with higher NF-κB and lower serotonin contents in the brain. The concentrations of these biochemical parameters were restored by curcumin treatment. Moreover, pre-treatment with JWH133 potentiated the effects of curcumin on behavioral and biochemical parameters, whereas AM630 attenuated the same. We suggest that curcumin, through its interaction with the CB2 receptor, may inhibit BCG-evoked activation of peripheral TNF-α and IL-6, which could prevent the stimulation of NF-κB in the brain, potentially leading to increased serotonin contents and alleviation of depressive phenotypes.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100310"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144597059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting the gut microbiome dynamics and treatment strategies in acute pancreatitis","authors":"Prachi Mehta ,&nbsp;Dipankar Saha ,&nbsp;Trishna Das ,&nbsp;Bhrigu Kumar Das","doi":"10.1016/j.prenap.2025.100306","DOIUrl":"10.1016/j.prenap.2025.100306","url":null,"abstract":"<div><h3>Background</h3><div>Acute pancreatitis (AP) is a severe inflammatory condition characterized by sudden abdominal pain that may escalate to systemic inflammation and organ failure. Alterations in the gut microbiome, including overgrowth of pathogenic bacteria like <em>Enterobacteriaceae</em> and reduced levels of <em>Bifidobacterium</em>, have been linked to increased oxidative stress, bacterial translocation, and compromised intestinal barrier function, exacerbating systemic inflammation and disease severity. Recent research highlights the potential of phytoconstituents and microbiome modulation in regulating AP-associated inflammatory pathways.</div></div><div><h3>Objective</h3><div>This review examines the roles of the gut microbiome and phytochemicals in AP regulation and evaluates the impact of nutritional interventions, probiotics, and Ringer's lactate solution on AP management.</div></div><div><h3>Method</h3><div>A comprehensive literature search was conducted across multiple databases for studies published in English up to October 2024, using keywords like 'acute pancreatitis', 'gut microbiome', 'phytochemicals', and 'nutritional management'.</div></div><div><h3>Results</h3><div>Key phytochemicals, such as Quercetin, Rhein, and Kaempferol, effectively regulate lipase and amylase levels in AP patients. Controlled trials indicated that nutritional regulation and nano-curcumin supplementation significantly alleviated pain and improved clinical outcomes. The gut microbiome also modulated critical metabolic pathways related to AP, influencing inflammation and disease progression.</div></div><div><h3>Conclusion</h3><div>The gut microbiome significantly impacts pancreatic inflammation, enzyme regulation, and AP progression. Addressing oxidative stress and gut dysbiosis through phytomedicines, microbiome-targeted therapies, and nutritional strategies presents promising avenues for AP management. Further research is necessary to elucidate these interventions' mechanisms and potential clinical applications.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100306"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}