Pharmacological Research - Natural Products最新文献

{"title":"Cytotoxic effects of herbal medicine: An overview of mechanistic pathways and clinical relevance","authors":"Deepika Bairagee ,&nbsp;Pankaj S. Patel ,&nbsp;Johee Pradhan ,&nbsp;Sunita Panchawat","doi":"10.1016/j.prenap.2025.100259","DOIUrl":"10.1016/j.prenap.2025.100259","url":null,"abstract":"<div><div>Herbal medicines have been used for centuries for their therapeutic benefits. However, the potential cytotoxic effects of certain herbal compounds pose significant safety concerns. This review explores the mechanistic pathways underlying the cytotoxicity of herbal medicines, the factors influencing these effects, and their clinical relevance. It also examines current research on identifying and mitigating these risks to improve the safety and efficacy of herbal therapeutics. The article highlights the need for comprehensive toxicological assessments and regulatory frameworks to balance the benefits and risks of traditional herbal products.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"7 ","pages":"Article 100259"},"PeriodicalIF":0.0,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lecaniodiscus cupanioides leaf extract attenuates Plasmodium berghei-induced malaria infection in albino mice via modulation of serum biochemical and hematological markers","authors":"Aderonke A. Aderinola ,&nbsp;Jane I. Ejiofor ,&nbsp;Luqman O. Ogunjimi ,&nbsp;Abdullahi A. Murtala ,&nbsp;Oyinloye E. Oladapo ,&nbsp;Farouk A. Oladoja","doi":"10.1016/j.prenap.2025.100257","DOIUrl":"10.1016/j.prenap.2025.100257","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Malaria has been among the predominant reasons for hospitalization and death in numerous tropical and/or subtropical African territories due to treatment failure resulting from the development of drug-resistant species of &lt;em&gt;Plasmodium falciparum&lt;/em&gt;, highlighting the need for alternative therapeutic approaches.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;The intent of this research was to explore the antiplasmodial efficacy of ethanol extract of the leaf of &lt;em&gt;Lecaniodiscus cupanioides&lt;/em&gt; in mice infected with &lt;em&gt;Plasmodium berghei&lt;/em&gt; having altered biochemical and/or hematological markers.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Method&lt;/h3&gt;&lt;div&gt;An acute toxicity study (LD50) of &lt;em&gt;Lecaniodiscus cupanioides&lt;/em&gt; leaf extracted with ethanol was conducted in 12 mice using Lorke’s methodology. Screening for phytochemicals and HPLC study of the leaf extract were also conducted. The leaf extract’s &lt;em&gt;in-vivo&lt;/em&gt; antimalarial activity against &lt;em&gt;Plasmodium berghei&lt;/em&gt; (NK65) strain was tested through a 4-day suppressive study, prophylactic test and curative test at 200, 400 and 800 mg/kg dosages.&lt;/div&gt;&lt;div&gt;Following a 7-day treatment period, five mice from the curative group were sacrificed under light ether, and their serum was utilized to evaluate liver enzymes, hematological markers, and inflammatory biomarkers associated with malaria severity.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;No deaths were observed at the maximum extract dose of 5000 mg/kg. Preliminary phytochemical screening and HPLC study of the leaf extract indicated the availability of biological constituents of pharmacological importance. The extract at all tested doses of 200, 400 and 800 mg/kg showed significant (&lt;em&gt;P ≤ 0.05&lt;/em&gt;) dose-dependent chemosuppressive effect, with percentage (%) chemosuppression of 73.79 % at 200 mg/kg, 81.55 % at 400 mg/kg and notable efficacy (84.65 %) at the 800 mg/kg dose in the Peters 4-day suppressive test. A significant (&lt;em&gt;P ≤ 0.05&lt;/em&gt;) dose-dependent reduction in the parasitaemia levels of the treated mice, with the 800 mg/kg dose displaying the highest antimalarial activity was produced in the curative study. The extract displayed dose-dependent prophylactic activity against the &lt;em&gt;P. berghei-&lt;/em&gt;induced parasitaemia in the mice, making 45.22 % and 61.34 % at 200 and 400 mg/kg, and the 800 mg/kg dose showing a highly significant effect (75.59 %). The group treated with chloroquine exhibited superior percentage (%) chemosuppression of 100 % in the suppressive, curative and prophylactic studies compared to the groups treated with &lt;em&gt;Lecaniodiscus cupanioides&lt;/em&gt; extract. For every administered dose, the extract successfully normalized aberrations in hematological markers, reduced elevated liver enzymes and mitigated inflammatory biomarkers induced by an infection &lt;em&gt;wi&lt;/em&gt;th &lt;em&gt;Plasmodium berghei&lt;/em&gt; in the mice.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;Results of this study validated the traditional usage of &lt;em&gt;Lecaniodis","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"7 ","pages":"Article 100257"},"PeriodicalIF":0.0,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the potential of herbal bioactives to treat acne: A perspective review","authors":"Pratibha Dhiwar ,&nbsp;Trilochan Satapathy ,&nbsp;Arun Kumar Sahu ,&nbsp;Nikita Patel","doi":"10.1016/j.prenap.2025.100260","DOIUrl":"10.1016/j.prenap.2025.100260","url":null,"abstract":"<div><div>Millions of individuals worldwide suffer from acne, a common skin ailment that is frequently caused by hormonal imbalance, bacterial infections, inflammation, and excessive sebum production. Despite their effectiveness, conventional therapies can result in antibiotic resistance and adverse consequences. The potential of herbal bioactive substances as an alternate therapeutic strategy for acne treatment is examined in this review. Numerous medicinal herbs those are high in antibacterial, anti-inflammatory, and antioxidant compounds have demonstrated potential in minimizing the symptoms of acne. Important bioactive from plants like tea tree, Aloe vera, and neem, containing flavonoids, alkaloids, and essential oils, have demonstrated strong anti-acne effects by regulating sebum production, preventing Propionibacterium acnes, and accelerating skin healing. In this review, the authors tried to explore the safety profile and therapeutic applications of potent herbal bioactives for the treatment of acne. The authors also expect that, the information containing in this review will pave the way and helpful for the researchers engaged in the field of acne and associated skin disorders.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"7 ","pages":"Article 100260"},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143942057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonanal inhibits growth and virulence factors in Candida albicans","authors":"Sayali A. Chougule ,&nbsp;Tanjila C. Gavandi ,&nbsp;Shivani B. Patil ,&nbsp;Sargun T. Basrani ,&nbsp;Deepak Sawant ,&nbsp;Shivanand R. Yankanchi ,&nbsp;Ashwini K. Jadhav ,&nbsp;Sankunny M. Karuppayil","doi":"10.1016/j.prenap.2025.100256","DOIUrl":"10.1016/j.prenap.2025.100256","url":null,"abstract":"<div><div>The recent surge in fungal infections, particularly caused by <em>Candida albicans</em>, is an important public health concern, especially among immunocompromised individuals. The current study aims to elucidate antifungal activity of nonanal against <em>C. albicans</em> (ATCC 90028) and clinical isolates. A range of quantitative methods was employed, including minimum inhibitory concentration (MIC) determination, cell cycle analysis, biofilm assays, microscopic observation of yeast to hyphal transitions, scanning electron microscopy of biofilms, and assessments of ergosterol inhibition and cell membrane damage. The results demonstrated that nonanal effectively inhibits the growth, morphogenesis, and biofilm formation at concentrations of 63 µg/ml, 125 µg/ml, and 16 µg/ml, respectively for <em>C. albicans</em> ATCC 90028, and at 125 µg/ml, 500 µg/ml, and 63 µg/ml, respectively for C1 and C2. Nonanal was able to induce cell cycle arrest and increase the reactive oxygen species (ROS) level in all strains of <em>C. albicans</em>. qRT-PCR analysis showed the downregulation of expression of key genes <em>RAS1, BCY1, ECE1, CEK1</em>, and <em>HWP1</em> in ATCC 90028 and C1 isolte, while the negative regulator <em>TUP1</em> was significantly upregulated ATCC 90028. Nonanal also affected the ergosterol synthesis and cell membrane in all the tested strains. Moreover, nonanal exhibited <em>in vivo</em> antifungal efficacy in silkworm animal model. These findings advance our understanding of nonanal as a novel potential antifungal agent, laying the groundwork for future antifungal strategies.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"7 ","pages":"Article 100256"},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144068549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antidiabetic properties of Cymbopogon spp.: Bridging preclinical findings with therapeutic applications in diabetes","authors":"Ailton Santos Sena-Júnior ,&nbsp;Francielly Lima da Fonseca ,&nbsp;Daiane Caroline Santos Teles ,&nbsp;Luiz André da Silva Santos ,&nbsp;Weslley Gabriel Dias Silva ,&nbsp;Ênio Pereira Telles ,&nbsp;Felipe J. Aidar ,&nbsp;Bárbara Melo Santos do Nascimento ,&nbsp;Lysandro Pinto Borges ,&nbsp;Divaldo Pereira de Lyra ,&nbsp;Lucindo José Quintans-Júnior ,&nbsp;Rogéria de Souza Nunes ,&nbsp;Paulo Ricardo Martins-Filho ,&nbsp;Ana Amélia Moreira Lira","doi":"10.1016/j.prenap.2025.100255","DOIUrl":"10.1016/j.prenap.2025.100255","url":null,"abstract":"<div><h3>Background</h3><div>Diabetes mellitus (DM) is a significant global health challenge with increasing prevalence. Conventional treatments often have side effects that impact patient compliance. This has stimulated interest in alternative therapies, including the use of medicinal plants such as <em>Cymbopogon spp</em>., known for their hypoglycemic properties.</div></div><div><h3>Objective</h3><div>This scoping review aims to assess the scientific evidence supporting the antidiabetic effects of <em>Cymbopogon spp</em>., focusing on its use in managing both Type 1 and Type 2 diabetes.</div></div><div><h3>Methods</h3><div>Following PRISMA guidelines, we conducted a comprehensive search across PubMed/Medline, Scopus, Web of Science, EMBASE, and LILACS from September 2023 to June 2024. Studies involving the use of <em>Cymbopogon</em> extracts and essential oils in mammals with DM were included. The selection criteria, structured around the PICO framework (Population, Intervention, Comparison, Outcome), guided our systematic evaluation of the studies, with data subsequently analyzed through descriptive methods.</div></div><div><h3>Results</h3><div>Our search yielded 172 articles, of which 11 met the inclusion criteria after screening and assessments. These studies, primarily preclinical, consistently demonstrated significant reductions in blood glucose levels and improvements in lipid profiles among diabetic models treated with <em>Cymbopogon spp</em>. Additionally, antioxidant and anti-inflammatory effects were noted, indicating broader therapeutic potential.</div></div><div><h3>Conclusions</h3><div>The findings suggest that <em>Cymbopogon spp</em>. may offer beneficial effects in diabetes management, improving glycemic control and metabolic outcomes. However, further clinical studies are required to validate these effects in human populations and to explore the mechanisms of action, optimal dosages, and long-term safety of <em>Cymbopogon spp</em>.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"7 ","pages":"Article 100255"},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143941954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flavonoids as bioenhancers: A critical review on their potential to improve drug delivery and therapeutic outcomes","authors":"Rakesh Mishra ,&nbsp;Jitendra Hiwarkar ,&nbsp;Abhishek Nikam ,&nbsp;Tanaji Nandgude ,&nbsp;Vivekanand Chatap ,&nbsp;Abhishek Jha","doi":"10.1016/j.prenap.2025.100251","DOIUrl":"10.1016/j.prenap.2025.100251","url":null,"abstract":"<div><h3>Purpose</h3><div>The purpose of this review is to explore how flavonoids can enhance the bioavailability and effectiveness of various medicinal substances as bioenhancers. The focus is on examining the interactions of flavonoids with medications, enzymes, and biological barriers to improve therapeutic outcomes. The main aim is to demonstrate the potential benefits of incorporating flavonoids as additives in pharmaceutical formulations to enhance drug delivery and improve health outcomes.</div></div><div><h3>Methods</h3><div>Comprehensive literature search was undertaken, covering research from early developments to current findings, using online search tools (PubMed, Google Scholar, Science Direct and Scopus).</div></div><div><h3>Results</h3><div>The review findings suggest that flavonoids have significant potential as bioenhancers, playing a crucial role in increasing the bioavailability and efficacy of different medicinal compounds. Through synergistic interactions with medications and biological systems, flavonoids contribute to improving treatment outcomes. Additionally, the review also pointed the pathways that underlie flavonoid-mediated bio-enhancement, and synergistic actions illuminating their potential use in pharmaceutical formulations for enhanced clinical efficacy and optimised drug delivery.</div></div><div><h3>Conclusion</h3><div>This review underscores the significant role of flavonoids as bioenhancers, highlighting their ability to synergistically improve the bioavailability and efficacy of pharmaceutical compounds. By elucidating the underlying mechanisms of flavonoid-drug interactions, this study provides valuable insights for leveraging flavonoids in drug delivery strategies mainly in the area of cancer and antibiotic therapy<em><strong>.</strong></em></div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"7 ","pages":"Article 100251"},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144068548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxicological profile and therapeutic potentials of Impatiens chinensis leaf extract: Exploring antibacterial, antioxidant, antidiabetic and insecticidal properties","authors":"Dharmalingam Kirubakaran ,&nbsp;Venugopal Krishnan","doi":"10.1016/j.prenap.2025.100238","DOIUrl":"10.1016/j.prenap.2025.100238","url":null,"abstract":"<div><div><em>Impatiens chinensis</em>, a plant known for its traditional medicinal applications, has not been thoroughly investigated for its biological activities. This research delves into the chemical composition and biological effects of its methanolic leaf extract, focusing on its antibacterial, antioxidant, antidiabetic, molecular docking, larvicidal and insecticidal properties. The extract is rich in phenols and flavonoids, containing 20 compounds identified through GC-MS analysis. The primary components include Hexadecanoic acid (29.31 %). FTIR analysis revealed the presence of functional groups such as alcohols, alkenes and amides. The extract demonstrated strong antibacterial activity, especially against <em>Staphylococcus aureus</em> and exhibited significant Antioxidant effects, achieving 60.27 % inhibition in the DPPH assay and 65.20 % inhibition in the ABTS assay. It also showed considerable Antidiabetic potential, inhibiting α-amylase (66.50 %) and α-glucosidase (61.12 %). Molecular docking studies with antidiabetic proteins (5NN8, 3W37) indicated promising interactions, suggesting potential therapeutic applications for diabetes. Additionally, the extract exhibited potent larvicidal and insecticidal properties. Overall, the leaf extract of <em>I. chinensis</em> showcases diverse biological activities, highlighting its potential as a valuable resource in medicinal research.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"7 ","pages":"Article 100238"},"PeriodicalIF":0.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143928935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the global landscape of in vitro antioxidant assays for natural product research: A bibliometric perspective","authors":"Aisyah Jaafar ,&nbsp;Nurul Alimah Abdul Nasir ,&nbsp;Aisyah Hasyila Jahidin ,&nbsp;Fazleen Haslinda Mohd Hatta ,&nbsp;Mizaton Hazizul Hasan","doi":"10.1016/j.prenap.2025.100248","DOIUrl":"10.1016/j.prenap.2025.100248","url":null,"abstract":"<div><div>In vitro antioxidant assays (IVAA) are effective tools for evaluating the antioxidant properties of natural products, which are thought to contribute to their medicinal effects. However, the landscape of global interest in this topic has not been thoroughly examined. This study is the first to evaluate the bibliometric trends on the use of IVAA in natural product research focusing on the publication trends by year and country, top-cited articles, authors, journals, primary subject areas, and co-occurrences of authors' keywords. A total of 2856 Scopus-indexed publications from 1995 to 2024 were analysed using Scopus’s “Analyse Results” feature and VOSviewer v1.6.20 for keyword co-occurrence visualizations. Our findings revealed a steady increase in relevant publications from 2008 to 2024, with English as the dominant language. India and China emerged as the leading countries. Food Chemistry was the top publishing journal. A review article published by the Saudi Pharmaceutical Journal in 2013 was the most cited. Gokhan Zengin from Selcuk University, Turkey, was the topmost influential researcher. Agricultural and Biological Sciences, along with Pharmacology, Toxicology, and Pharmaceutics, were the primary research subjects. Network visualisation identified six keyword clusters, with the red cluster being the most significant, featuring nine keywords including “antioxidant,” “anti-inflammatory,” “antimicrobial” and “phytochemical” among others. Recent impactful keywords include “antidiabetic” and “molecular docking.” Our in-depth analysis illustrated the key aspects of global research trend of IVAA impacting the natural product research. The use of computational tools is encouraged to complement IVAA while global collaborations are expected to promote natural product research.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"7 ","pages":"Article 100248"},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143929003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of oral treatment with quercetin on inflammatory and oxidative stress markers in patients with chronic obstructive pulmonary disease","authors":"Shivani Patel ,&nbsp;Nathaniel Marchetti ,&nbsp;Haleh Ganjian ,&nbsp;Daohai Yu ,&nbsp;Steven G. Kelsen ,&nbsp;Gerard J. Criner ,&nbsp;Umadevi S. Sajjan","doi":"10.1016/j.prenap.2025.100252","DOIUrl":"10.1016/j.prenap.2025.100252","url":null,"abstract":"<div><h3>Background</h3><div>Airway inflammation plays a major role in the development and progression of chronic obstructive pulmonary disease (COPD). Quercetin, which has potent antioxidant and anti-inflammatory properties reduces lung inflammation in mice displaying COPD-like lung disease. Previously we showed that quercetin was safely tolerated up to 2000 mg/day. We conducted a pilot Phase II clinical trial to examine the effects of quercetin on inflammation in COPD patients.</div></div><div><h3>Methods</h3><div>Fourteen COPD patients with ≥ 10 pack-year smoking history and CRP &gt; 3.0 mg/L were randomized in 1:2 ratio to either placebo or quercetin 2000 mg/day for 6 months. Blood and bronchoalveolar lavage fluid (BALF) were collected at baseline and 6 months post-treatment. The reduction of inflammatory and oxidative stress biomarkers in BALF and blood were expressed as change from baseline. Safety of quercetin was assessed based on FEV₁ and blood tests.</div></div><div><h3>Results</h3><div>Plasma quercetin levels significantly increased after treatment in only quercetin group. The levels of IL-8, IL-1β, and 8-isoprostane in the BAL and serum SP-D were significantly different from baseline in patients treated with quercetin, but not placebo. The patient-reported disease symptoms showed lowering trend in quercetin-treated group. No study drug-related adverse events were observed as assessed by comprehensive metabolic panel and FEV₁.</div></div><div><h3>Conclusions</h3><div>Oral treatment with quercetin was safely and well-tolerated by COPD patients. Quercetin treatment reduced some lung and serum inflammatory biomarkers in COPD. Further prospective studies are necessary to confirm the anti-inflammatory and antioxidant effects of quercetin in COPD patients and to determine if quercetin offers any clinical benefit.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"7 ","pages":"Article 100252"},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nano-formulation of phytochemicals to combat neurodegenerative diseases: Current and thorough strategies","authors":"Sailee Chowdhury ,&nbsp;Garima Kumari ,&nbsp;Tanmay Jit","doi":"10.1016/j.prenap.2025.100249","DOIUrl":"10.1016/j.prenap.2025.100249","url":null,"abstract":"<div><div>Nanoparticles have established potential in enhancing medication pharmacokinetics, biodegradability, and therapeutic efficacy, while decreasing adverse effects. By breaching the blood-brain barrier, they have the ability to modulate disturbed processes in neurodegenerative illnesses, including inflammatory processes, oxidative stress, apoptosis, and protein aggregation. Nanoparticle-based formulations targeting pathways contribute to mental and neurological illnesses, including Parkinson's disease, Amyotrophic Lateral Sclerosis, Alzheimer’s disease, Multiple sclerosis, and Huntington's syndrome. Various phytochemicals have shown potential for producing nano-formulations to treat Alzheimer's disease. Integrative medicine, combining Western and traditional medicine, has shown promising results in treating neurological problems. Various nano-formulations with bioactive phytochemicals have shown promising outcomes in treating various neuro-degenerative diseases through diverse ways. This review combines recent advancements in nanotechnology with neurodegenerative disease treatments, highlighting innovative approaches that focus on specific, lesser-explored phytochemicals or their novel combinations.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"7 ","pages":"Article 100249"},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143921659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}