Pharmacological Research - Natural Products最新文献

{"title":"Phytochemical study and biological activity of Morettia philaeana (Delile) DC","authors":"Amel H.I. Elfaky ,&nbsp;Gihan O.M. El hassan ,&nbsp;Saad M. Howladar ,&nbsp;Sakina Yagi","doi":"10.1016/j.prenap.2024.100127","DOIUrl":"10.1016/j.prenap.2024.100127","url":null,"abstract":"<div><div><em>Morettia phillaeana</em> (Delile) DC. (family Brassicaceae) is used in Sudan traditionally to treat some skin and digestive tract diseases. The aim of this study was to investigate the chemical profile of the root, stem, leaf, flower and fruit of <em>M. phillaeana</em> and to evaluate their cytotoxicity, antibacterial, antigiardial, antimalarial and antioxidant activities. Extracts were prepared by sequential maceration of powder of each organ in acetone and methanol. Cytotoxicity was tested against normal Vero cell line. Antibacterial activity was determined by the disc diffusion method. Antimalarial and antigiardial activities were determined by microplate assay against the K1 parasite strain of <em>Plasmodium falciparum</em> and <em>Giardia duodenalis</em> respectively. The DPPH and ABTS assays were adopted to evaluate the antioxidant activity. Phytochemical analysis revealed the presence of alkaloids, flavonoids, tannins, steroids, terpenes and saponins as metabolites. The stem, fruit and leaf accumulated the highest total phenolic (3903.85 GAE mg/g), flavonoids (1078.37 mg QE/g) and tannins (1009.05 TAE mg/g) contents respectively. Results of biological activity revealed that the plant possessed mainly significant antigiardial and antibacterial activities. The highest antigiardial effect was recorded from the acetone and ethanol extracts of the leaf (IC₅₀ 4.40 and 4.49 and µg/mL, <em>p</em> ≥ 0.05) and the highest antibacterial activity was obtained against <em>Escherichia coli</em> from the ethanolic extracts of leaf (inhibition zone = 23.2 mm). The acetone extract of the fruit displayed moderate ABTS radical scavenging activity (66.7 %). All organs’ extracts exerted weak antimalaria activity (IC₅₀ 172.2–238.5 µg/mL). All extracts, except the acetone extract of the stem (IC₅₀ 43.48 µg/mL), were not toxic (IC₅₀ ≥ 222.09 µg/mL). In conclusion, it is worth mentioning that the present study demonstrates for the first time the cytotoxicity, antigiardial and antimalarial properties of <em>M. phillaeana</em> and the results obtained partly supported its traditional uses. The plant could be a promising source of bioactive molecules for different pharmaceutical applications.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"5 ","pages":"Article 100127"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142756803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the effect of milk casein on the pharmacokinetics of rutin","authors":"Ravindra Semwal ,&nbsp;Ankit Kumar ,&nbsp;Ruchi Badoni Semwal ,&nbsp;Ashutosh Chauhan ,&nbsp;Sunil Kumar Joshi ,&nbsp;Kumud Upadhyaya ,&nbsp;Deepak Kumar Semwal","doi":"10.1016/j.prenap.2024.100130","DOIUrl":"10.1016/j.prenap.2024.100130","url":null,"abstract":"<div><div>Rutin, often referred to as vitamin P, possesses numerous pharmaceutical applications, yet its market availability is restricted due to poor bioavailability. Recent interest has focused on exploiting rutin's therapeutic potential, prompting efforts to enhance its bioavailability. This study aimed to enhance the bioavailability of rutin by formulating tablet dosage forms using cow milk casein as a matrix-forming agent. Tablet formulations containing rutin and milk casein were prepared, and their physicochemical properties were evaluated through in vitro tests, including hardness, friability, and dissolution. Pharmacokinetic studies were conducted using Wistar rat models, analyzing plasma drug concentrations and urine excretion. Stability studies were also performed to assess the tablets' shelf life under various conditions. The results of the study revealed that the incorporation of milk casein significantly improved the bioavailability of rutin, both in vitro and in vivo. Physicochemical evaluations demonstrated satisfactory tablet properties, while pharmacokinetic studies indicated enhanced plasma drug concentrations and reduced urine excretion of rutin with milk casein formulations. Stability studies further supported the suitability of the formulated tablets for long-term storage. In conclusion, milk casein proved effective as a matrix-forming agent for improving the bioavailability of rutin. The formulated tablets exhibited favorable physicochemical properties and enhanced drug absorption characteristics, suggesting the potential utility of milk casein in enhancing the therapeutic efficacy of rutin formulations.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"5 ","pages":"Article 100130"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142759048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allium cepa bioactive phytochemicals as potent ALK (Anaplastic lymphoma kinase) inhibitors and therapeutic agents against non-small cell lung cancer (NSCLC): A computational study","authors":"Md. Sakib Al Hasan ,&nbsp;Emon Mia ,&nbsp;Noshin Tasnim Yana ,&nbsp;Imam Hossen Rakib ,&nbsp;Md. Shimul Bhuia ,&nbsp;Raihan Chowdhury ,&nbsp;Salehin Sheikh ,&nbsp;Muhammad Torequl Islam","doi":"10.1016/j.prenap.2024.100124","DOIUrl":"10.1016/j.prenap.2024.100124","url":null,"abstract":"<div><div>Anaplastic lymphoma kinase (ALK) inhibitors go after and stop the ALK protein, which is very important for cancer growth, especially in ALK-positive cancers like non-small cell lung cancer (NSCLC). Lung cancer, particularly ALK-positive NSCLC prone to metastasis, is treated with ALK inhibitors targeting the cancer-driving ALK protein. This study explored the potential of onion (<em>Allium cepa</em>) phytochemicals as inhibitors of ALK for NSCLC treatment using computational methods. The <em>in silico</em> study evaluated the binding affinity of all phytochemicals of <em>A. cepa</em> and also predicted pharmacokinetics, ADMET parameters, drug-likeness, anti-carcinogenic properties, and acute toxicity prediction to find reliable and safe ALK inhibitor agents for the treatment of NSCLC. The findings revealed that three phytochemicals, fisetin, quercetin, and tricetin demonstrated promising results with favorable drug-likeness profiles and strong binding affinities for the ALK receptors. Specifically, their binding affinities were –7.6, –7.7, and –7.8 kcal/mol for the 4ANQ receptor; –7.6, –7.6, and –8.0 kcal/mol for the 4ANS receptor, and –7.7, –7.6, and –7.7 kcal/mol for the 6MX8 receptor, respectively. Additionally, these compounds showed hydrogen bond formation, which is crucial for drug discovery against ALK and is comparable to the known ALK inhibitors crizotinib and alectinib. These findings also suggest their potential as therapeutic agents. Further, <em>in vitro</em> and <em>in vivo</em> studies are warranted to validate these results and elucidate their mechanisms of action. This study highlights the potential of natural compounds from <em>A. cepa</em> for the development of novel NSCLC therapies.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"5 ","pages":"Article 100124"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142744213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reconnoitring antiepileptic and anxiolytic effects of Indian herbs: Findings from zebrafish behavioral research","authors":"Srijan Bhattacharya ,&nbsp;Debarpan Chatterjee ,&nbsp;Rajdip Goswami ,&nbsp;Bhaskar Pal ,&nbsp;Susanta Paul ,&nbsp;Nilanjan Sarkar ,&nbsp;Mainak Chakraborty","doi":"10.1016/j.prenap.2024.100125","DOIUrl":"10.1016/j.prenap.2024.100125","url":null,"abstract":"<div><h3>Introduction</h3><div>In the 21st century, neuropsychological disorders such as anxiety, insomnia, and epilepsy have become increasingly prevalent due to irregular lifestyles, unhealthy food habits, and work pressure. These disorders significantly impact individuals' emotional, mental, and physical well-being, leading to decreased functionality and potential long-term health complications.</div></div><div><h3>Materials and methods</h3><div>The research project utilized zebrafish behavioral studies to investigate the effects of herbal extracts on anxiety-like behavior and stress levels. Specifically, the study focused on four herbal plants, <em>Withania somnifera</em>, <em>Adiantumcapillus-veneris</em>, <em>Marsileaq uadrifolia Linn.</em> and <em>Nardostachys jatamansi,</em> to assess their potential in managing neuropsychological disorders. The zebrafish were exposed to solutions or extracts of these plants, and standard doses of pentylenetetrazol (PTZ) were administered to induce seizures for anti-seizure tests. Additionally, six behavioural studies, including the Novel Tank Test and Open Field Test, were conducted to evaluate anxiety-like behaviour. The methods employed in this study aimed to provide insights into the potential anxiolytic and stress-reducing properties of the herbal extracts.</div></div><div><h3>Results</h3><div>The findings reveal that <em>Withania somnifera and Marsilea quadrifolia Linn.</em>, demonstrate promising effects in reducing anxiety-like behaviour and stress levels in zebrafish compared to<em>Adiantumcapillus-veneris and Nardostachys jatamansi</em>. These results also show the potential to improve explorative behavior and reduce time spent in dark areas, indicating anxiolytic properties.</div></div><div><h3>Conclusion</h3><div>The study highlights the potential of herbal therapy in managing neuropsychological disorders and emphasizes the importance of exploring alternative treatment approaches. The results provide valuable insights into the potential use of <em>Withania somnifera</em> and <em>Marsilea quadrifolia Linn</em> extracts in alleviating anxiety and stress-related behaviours and mitigating seizures, paving the way for further research and potential therapeutic applications.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"5 ","pages":"Article 100125"},"PeriodicalIF":0.0,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142698204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethnobotanical knowledge and practices of pastoralist communities on plants used as repellents and/or insecticides against insect vectors in the Korahaye zone of the Somali Regional State, Eastern Ethiopia","authors":"Getu Alemayehu ,&nbsp;Araya Gebresilassie ,&nbsp;Desta Woldetsadik ,&nbsp;Shushay Hagos ,&nbsp;Moa Megersa ,&nbsp;Patrick Van Damme ,&nbsp;Solomon Yared","doi":"10.1016/j.prenap.2024.100122","DOIUrl":"10.1016/j.prenap.2024.100122","url":null,"abstract":"<div><h3>Background</h3><div>Combined efforts to combat both outdoor and indoor transmission of malaria parasites are hampered by emerging vector resistance in a wide range of endemic malaria settings in Ethiopia and the rest of the world, stressing the need to develop and implement alternative control measures. This study aimed to document indigenous pastoralist knowledge on the use of repellent and insecticidal plant species against insect vectors in a number of kebeles in the Somali Regional State, eastern Ethiopia.</div></div><div><h3>Methods</h3><div>Data were collected by interviewing a total of 120 participants (105 men and 15 women) through face-to-face interviews guided by a semi-structured questionnaire, observing information on the preparation method, and performing a guided field walk with a guide to collect plant specimens. The ethnobotanical survey was carried out from 5 May 2018–12 April 2019. Medicinal plant specimens were collected following a standard approach, and voucher specimens were deposited in the National Herbarium, Addis Ababa University. The data were analyzed using descriptive statistics, preference rankings, paired comparisons and direct matrix rankings.</div></div><div><h3>Results</h3><div>A total of 52 voucher specimens belonging to 47 genera and 31 families were obtained. Of these, 42 were reported to be repellents against mosquitoes or insects in general. Among the plant families recorded, Fabaceae had the highest number of plant species, at 6 (11.5 %). The most represented life forms were herbs (21, 40.38 %), followed by shrubs (17, 32.69 %). Leaves were the most commonly used plant part for remedy preparation and accounted for 14 (26.92 %) of the total plants. Among the repellent plant species documented, 57.68 % were reported to be burned to produce in-house smoke, 20.37 % were mashed, and the paste was applied on the human skin to repel insects. The plants that were commonly mentioned by respondents were <em>Amaranthus sparganiocephalus</em> (27, 22.5 %), <em>Phytolacca dodecandra</em> (18, 15 %), and <em>Commiphora rostrata</em> (26, 21.66 %) for repellent, insecticidal, and both repellent and insecticidal uses, respectively.</div></div><div><h3>Conclusions</h3><div>The present study showed that pastoralist communities have valuable indigenous knowledge and practices related to the use of plants as repellents. This knowledge should be validated and confirmed experimentally and possibly promoted as a sustainable and ecosystem-friendly insect vector control tool<em>.</em></div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"5 ","pages":"Article 100122"},"PeriodicalIF":0.0,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142650824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical compositions, antioxidant, anticholinesterase, and antibacterial properties of Clerodendrum thomsoniae Balf.f. leaves: In vitro and in silico analyses","authors":"Shubham Bhattacharyya ,&nbsp;Sovan Samanta ,&nbsp;Mayukh Hore ,&nbsp;Samir Barai ,&nbsp;Sandeep Kumar Dash ,&nbsp;Subhrajyoti Roy","doi":"10.1016/j.prenap.2024.100121","DOIUrl":"10.1016/j.prenap.2024.100121","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Clerodendrum thomsoniae</em> Balf.f. (Family: Lamiaceae) is an ornamental plant with a high polyphenol content that has been extensively studied in traditional medicinal systems of several countries for a variety of important pharmacological properties. Present study is aimed to investigate the chemical constituents, and antioxidant, anticholinesterase, and antibacterial properties of methanolic leaf extract of <em>Clerodendrum thomsoniae</em> (MECT) using <em>in vitro</em> and <em>in silico</em> methods.</div></div><div><h3>Methods</h3><div>The phytochemical characterization of the crude methanolic leaves extract of <em>Clerodendrum thomsoniae</em> (MECT) was investigated using FT-IR and GC-MS studies. The biological evaluation of MECT was conducted using DPPH and β-carotene bleaching assays, acetyl- and butyrylcholinesterase inhibitory properties. The antibacterial effectiveness of the MECT was assessed against <em>E. coli</em> and <em>S. aureus</em> using MIC, MBC, and disc agar diffusion techniques. The bioactive compounds that were identified by GC-MS were subjected to docking studies with several proteins associated with antioxidants, anticholinesterase, and antibacterial properties.</div></div><div><h3>Result</h3><div>DPPH radical scavenging and β-carotene bleaching assays demonstrated significant antioxidant activities (IC₅₀ values: 162.2±2.8 μg/mL and 179.7±5.1 μg/mL, respectively). The anticholinesterase activity of MECT was demonstrated by its efficient acetylcholinesterase- (132.8±2.3 μg/mL) and butyrylcholinesterase inhibitory (157.6±6.6 μg/mL) activities. MECT is also found to contain significant amounts of phenolics and flavonoids. Results also showed significant antibacterial capacity of MECT against both Gram-negative (<em>E. coli</em>) and Gram-positive (<em>S. aureus</em>) stains. FT-IR and GC-MS analyses revealed the presence of different functional groups with seven phytocompounds which were further used to evaluate the <em>in silico</em> properties of MECT. Molecular docking analysis revealed that 2,4-bis(1,1-dimethylethyl)-phenol has the highest binding affinities with different proteins. ADMET study including toxicity prediction analysis confirmed that most of the phytochemicals were non-toxic.</div></div><div><h3>Conclusion</h3><div>In conclusion, the findings of the present study suggest that MECT possesses potential antioxidant, anticholinesterase and antibacterial properties and may further be investigated as a therapeutic candidate against microbial infections and oxidative stress mediated neurodegenerative conditions.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"5 ","pages":"Article 100121"},"PeriodicalIF":0.0,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142586390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical characterization and therapeutic potential of leaf of Emilia sonchifolia (L.) DC.: A comprehensive study on functional groups and bioactive compounds.","authors":"Mahantesh Banni ,&nbsp;M. Jayaraj","doi":"10.1016/j.prenap.2024.100120","DOIUrl":"10.1016/j.prenap.2024.100120","url":null,"abstract":"<div><h3>Background</h3><div>Emilia sonchifolia (L.) DC is an annual herbaceous plant used in the Ayurveda and Unani therapeutic systems. It treats various conditions such as diarrhea, sore throat, night blindness, rashes, fever, measles, earache, eye inflammation, ophthalmia, asthma, malaria, stomach tumors, chest pain, liver diseases, cuts, and wounds.</div></div><div><h3>Purpose</h3><div>This study aimed to assess the functional groups and bioactive compounds present in the leaves of E. sonchifolia using FT-IR and GC-MS analyses and explore their antioxidant, antidiabetic and anticancer effects.</div></div><div><h3>Materials and methods</h3><div>Different leaf extracts of E. sonchifolia were subjected to Fourier transform infrared (FT-IR) and gas chromatography-mass spectrometry (GC-MS) analyses to determine the presence of functional groups and for chemical characterization. Biological evaluations such as antioxidant (DPPH and ABTS assays) and antidiabetic (α-amylase enzyme inhibition and glucose uptake using yeast cell assays) and anticancer (HepG2 cell lines) potentials were also analyzed.</div></div><div><h3>Results</h3><div>FT-IR analysis revealed the presence of various functional groups such as amines, alcohols, alkanes, alkenes, halo compounds, aldehydes, sulfates, esters, phenols, and carboxylic acids. GC-MS analysis revealed the presence of 32 bioactive compounds in different leaf extracts. Among the extracts, petroleum ether (16) contained the highest number of chemical compounds, followed by ethanol (14), chloroform (9), and acetone (4). Lanosterol was the most significant compound in petroleum ether extract, whereas phytol (44.05 %) in the acetone extract and 1,2-benzenedicarboxylic acid in the chloroform (82.47 %) and ethanol (50.49 %) extracts. The ethanol leaf extract showed the highest antioxidant potential in DPPH (63.38±0.46 µg/mL) and ABTS (60.74±0.59 µg/mL) assays. It also showed better results in antidiabetic activity in both α-amylase enzyme inhibition (135.69±2.08 µg/mL) and glucose uptake using yeast cell (114.37±1.71 µg/mL) assays. Ethanol leaf extract exhibits good anticancer activity with 59.52±0.76 µg/mL against HepG2 cell line.</div></div><div><h3>Conclusion</h3><div>FTIR and GC-MS analyses confirmed the presence of bioactive functional groups and phytoconstituents. These results justify the leaves as a traditional remedy in Ayurveda and Unani therapeutic systems. Antioxidant, antidiabetic and anticancer assays suggested that <em>E. sonchifolia</em> leaves have good antioxidant, antidiabetic and anticancer potential compared to standards. Further studies are required to identify the chemical compounds responsible for these activities.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"5 ","pages":"Article 100120"},"PeriodicalIF":0.0,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142650821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ameliorative effect of Ferula Asafoetida oleo-gum-resin (Asafin) against cisplatin induced functional dyspepsia condition","authors":"Svenia P. Jose ,&nbsp;Ratheesh M ,&nbsp;Sheethal S ,&nbsp;Sony Rajan ,&nbsp;Krishnakumar IM ,&nbsp;Sandya S","doi":"10.1016/j.prenap.2024.100117","DOIUrl":"10.1016/j.prenap.2024.100117","url":null,"abstract":"<div><h3>Background</h3><div>Functional dyspepsia (FD), affecting over 30 % of the global population, manifests with symptoms like fullness, bloating, epigastric pain, early satiety, and gastric motility issues. In the current study, we investigated the efficacy and mechanism of action of a water-soluble powder formulation of Ferula Asafoetida oleo-gum-resin (Asafin) in an animal model of Cisplatin-induced (CP) FD.</div></div><div><h3>Methods</h3><div>The animals were divided into four groups: Group I - Normal, Group II - Cisplatin control, Group III - Cisplatin + Standard drug, and Group IV - Cisplatin + Asafin. Various parameters including body weight, food intake, hematological markers, biochemical markers, and histopathology were analyzed during and after a 30-day study period.</div></div><div><h3>Results</h3><div>It was observed that CP-treated animals exhibited a marked reduction in food intake and body weight, which significantly improved or reversed when treated with Asafin. Further analysis of gut peptide hormones (Leptin, Ghrelin, GLP-1) and their gene expressions confirmed delayed gastric emptying and impaired gastric motility in CP rats. However, co-administration of Asafin with CP showed a significant improvement in these markers, indicating the normalization of the symptoms. These results were also consistent with the observed gene expressions of appetite-regulating GI peptide hormones CCK, POMC, MTL, NPY, and CART, which returned to normal levels. Histopathology results further supported the significant improvement provided by Asafin in CP rats</div></div><div><h3>Conclusions</h3><div>Our findings suggest that Asafin may mitigate FD risk by modulating the gut-brain axis via gut peptide hormones and neurotransmitters.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"5 ","pages":"Article 100117"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacodynamic approaches of phytoconstitutents in wound healing mechanisms","authors":"Divyanshi Agrawal ,&nbsp;Manish Pal Singh ,&nbsp;Gyanendra Kumar Sharma","doi":"10.1016/j.prenap.2024.100119","DOIUrl":"10.1016/j.prenap.2024.100119","url":null,"abstract":"<div><div>The present review aims to provide the comprehensive study of pharmacodynamic actions of various phytoconstitutents that promote wound healing. Various medicinal plants have been used from centuries for treating various kinds of wounds. Different plants contain particular phytoconstitutents with an antioxidant, anti-inflammatory, immunostimulant and collagen synthesis activity on the wound. Many patents were filed on herbs that are frequently used in wound healing. Plants contain flavonoids, saponins, polysaacharides, alkaloids, volatile oil and terpenoids, etc and their active constituents such as eugenol, rutin, quercetin, kampferol, curcumin, α- terpineol, etc act on different phases of wound healing that helps to reduce inflammation, have scavenging activity and provide relief from pain. In conclusion, phytoconstitutents shows their promising effect on wound healing.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"5 ","pages":"Article 100119"},"PeriodicalIF":0.0,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142650819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “Efficacy and safety of a Unani polyherbal formulation compared with Telmisartan in stage-2 essential hypertension: An open label, randomized, standard controlled clinical study” [Pharmacol. Res. - Nat. Prod. 4 (2024) 100083]","authors":"Nazneen Aiman Siddiqui ,&nbsp;Rais ur Rahman ,&nbsp;Yasmeen Shamsi","doi":"10.1016/j.prenap.2024.100111","DOIUrl":"10.1016/j.prenap.2024.100111","url":null,"abstract":"","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"5 ","pages":"Article 100111"},"PeriodicalIF":0.0,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142539760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}