黄柏的神经药理活性Hassk。在阿尔茨海默病和帕金森病的背景下:一个小回顾

Abir Biswas , Ragupathi Abirami , Anitha Rathinam , Kesavan Swaminathan Jayachandran , Muthuswamy Anusuyadevi
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引用次数: 0

摘要

神经退行性疾病,如阿尔茨海默病和帕金森病,其特征是神经元和/或其功能的逐渐丧失,导致认知和运动障碍。阿尔茨海默病是痴呆症最常见的病因,而帕金森氏症主要影响运动。目前,治疗选择有限,没有一种可以预防或逆转疾病进展。植物是传统医学的基石,由于其对疾病病理过程中涉及的关键代谢过程具有多靶点作用,因此仍然是潜在补救措施的来源。这使它们成为阻止甚至治愈这些疾病的有希望的候选者。其中一种植物是黄花(Eclipta alba)。Hassk。本文综述了黄月牙(Eclipta alba, L.)的传统用途和实验证据。Hassk。在治疗阿尔茨海默病和帕金森病方面,研究了潜在的机制和神经药理学成分,并检查了其毒理学特征,强调了进一步研究临床应用的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neuropharmacological activities of Eclipta alba (L.) Hassk. in the context of Alzheimer's and Parkinson's diseases: A mini review
Neurodegenerative disorders, such as Alzheimer's and Parkinson's diseases, are characterized by the progressive loss of neurons and/or their functions, leading to cognitive and motor impairments. Alzheimer's disease is the most common cause of dementia, while Parkinson's primarily affects movement. Currently, there are limited therapeutic options, and none can prevent or reverse disease progression. Plants, a cornerstone of traditional medicine, remain a source of potential remedies due to their multi-target effects on key metabolic processes involved in disease pathologies. This makes them promising candidates for halting or even curing these disorders. One such plant is Eclipta alba (L.) Hassk. This review highlights the traditional uses and experimental evidence of Eclipta alba (L.) Hassk. in treating Alzheimer’s and Parkinson’s diseases, explores the underlying mechanisms and neuropharmacological constituents, and examines its toxicological profile, emphasizing the need for further research into clinical applications.
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