{"title":"黄柏的神经药理活性Hassk。在阿尔茨海默病和帕金森病的背景下:一个小回顾","authors":"Abir Biswas , Ragupathi Abirami , Anitha Rathinam , Kesavan Swaminathan Jayachandran , Muthuswamy Anusuyadevi","doi":"10.1016/j.prenap.2025.100308","DOIUrl":null,"url":null,"abstract":"<div><div>Neurodegenerative disorders, such as Alzheimer's and Parkinson's diseases, are characterized by the progressive loss of neurons and/or their functions, leading to cognitive and motor impairments. Alzheimer's disease is the most common cause of dementia, while Parkinson's primarily affects movement. Currently, there are limited therapeutic options, and none can prevent or reverse disease progression. Plants, a cornerstone of traditional medicine, remain a source of potential remedies due to their multi-target effects on key metabolic processes involved in disease pathologies. This makes them promising candidates for halting or even curing these disorders. One such plant is <em>Eclipta alba</em> (L.) Hassk. This review highlights the traditional uses and experimental evidence of <em>Eclipta alba</em> (L.) Hassk. in treating Alzheimer’s and Parkinson’s diseases, explores the underlying mechanisms and neuropharmacological constituents, and examines its toxicological profile, emphasizing the need for further research into clinical applications.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100308"},"PeriodicalIF":0.0000,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Neuropharmacological activities of Eclipta alba (L.) Hassk. in the context of Alzheimer's and Parkinson's diseases: A mini review\",\"authors\":\"Abir Biswas , Ragupathi Abirami , Anitha Rathinam , Kesavan Swaminathan Jayachandran , Muthuswamy Anusuyadevi\",\"doi\":\"10.1016/j.prenap.2025.100308\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Neurodegenerative disorders, such as Alzheimer's and Parkinson's diseases, are characterized by the progressive loss of neurons and/or their functions, leading to cognitive and motor impairments. Alzheimer's disease is the most common cause of dementia, while Parkinson's primarily affects movement. Currently, there are limited therapeutic options, and none can prevent or reverse disease progression. Plants, a cornerstone of traditional medicine, remain a source of potential remedies due to their multi-target effects on key metabolic processes involved in disease pathologies. This makes them promising candidates for halting or even curing these disorders. One such plant is <em>Eclipta alba</em> (L.) Hassk. This review highlights the traditional uses and experimental evidence of <em>Eclipta alba</em> (L.) Hassk. in treating Alzheimer’s and Parkinson’s diseases, explores the underlying mechanisms and neuropharmacological constituents, and examines its toxicological profile, emphasizing the need for further research into clinical applications.</div></div>\",\"PeriodicalId\":101014,\"journal\":{\"name\":\"Pharmacological Research - Natural Products\",\"volume\":\"8 \",\"pages\":\"Article 100308\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-07-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pharmacological Research - Natural Products\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2950199725001685\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmacological Research - Natural Products","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2950199725001685","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Neuropharmacological activities of Eclipta alba (L.) Hassk. in the context of Alzheimer's and Parkinson's diseases: A mini review
Neurodegenerative disorders, such as Alzheimer's and Parkinson's diseases, are characterized by the progressive loss of neurons and/or their functions, leading to cognitive and motor impairments. Alzheimer's disease is the most common cause of dementia, while Parkinson's primarily affects movement. Currently, there are limited therapeutic options, and none can prevent or reverse disease progression. Plants, a cornerstone of traditional medicine, remain a source of potential remedies due to their multi-target effects on key metabolic processes involved in disease pathologies. This makes them promising candidates for halting or even curing these disorders. One such plant is Eclipta alba (L.) Hassk. This review highlights the traditional uses and experimental evidence of Eclipta alba (L.) Hassk. in treating Alzheimer’s and Parkinson’s diseases, explores the underlying mechanisms and neuropharmacological constituents, and examines its toxicological profile, emphasizing the need for further research into clinical applications.