Pharmacological Research - Natural Products最新文献

{"title":"Quercetin ameliorates depressive-like phenotypes and memory deficits in hypoxia-induced murine model of stress","authors":"Lily O. Otomewo ,&nbsp;Anthony T. Eduviere ,&nbsp;Olusegun A. Adeoluwa ,&nbsp;Emuesiri G. Moke ,&nbsp;Gladys O. Adeoluwa","doi":"10.1016/j.prenap.2024.100104","DOIUrl":"10.1016/j.prenap.2024.100104","url":null,"abstract":"<div><h3>Background</h3><div>Hypoxia is believed to induce a form of stress that contributes to the exacerbation of certain disease conditions such as heart diseases. Most of these conditions revolve around the central nervous system (CNS) since the brain consumes a significant percentage of oxygen.</div></div><div><h3>Purpose</h3><div>This study aims to determine the specific effect of hypoxia on mood and cognitive behaviours using behavioural assessment and histological methods in mice. Additionally, this study investigated the counter effect of quercetin (QCN) on the hypoxia-induced changes.</div></div><div><h3>Methods</h3><div>A total of thirty (30) mice were equally divided into five (5) groups. Group 1 and 2 received 5 % DMSO while only the latter was subjected to the hypoxia protocol. Groups 3–5 received graded doses of quercetin (10, 20 and 40 mg/kg), respectively. Approximately 24 h after a consecutive seven-day treatment, the mice were tested for depressive-like symptoms as well as dysfunctional memory function using recognized pharmacological tests. Afterwards, histology of specific brain regions was conducted. Finally, the data were analysed by one-way ANOVA and statistical significance was set at p&lt;0.05.</div></div><div><h3>Results</h3><div>In comparison with the normal control, mice of the model control group scored significantly (p&lt;0.05) higher in the tests that assess depression and significantly (p&lt;0.05) lower in the tests that assessed memory function, both indicators of adverse effects of hypoxia. Also, the contributing brain regions were also negatively affected by hypoxia. However, a significant attenuation of these effects was observed in the groups that received quercetin.</div></div><div><h3>Conclusion</h3><div>In conclusion, quercetin is a nutritional flavonoid that possesses the ability to improve behaviour and cognition in individuals regularly exposed to hypoxia or suffering from conditions that affect oxygen delivery within the body.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"5 ","pages":"Article 100104"},"PeriodicalIF":0.0,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142422651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the medicinal potential of Euonymus alatus (Thunb.) siebold: From traditional knowledge to mechanistic understanding","authors":"Acharya Balkrishna ,&nbsp;Pardeep Kaur ,&nbsp;Deepika Srivastava ,&nbsp;Priyanka Chaudhary ,&nbsp;Nidhi Sharma ,&nbsp;Vedpriya Arya","doi":"10.1016/j.prenap.2024.100102","DOIUrl":"10.1016/j.prenap.2024.100102","url":null,"abstract":"<div><div><em>Euonymus alatus</em> is an evergreen shrub of the Celastraceae family. It has been used in Asia for more than 2000 years, primarily in China, Japan, and Korea, to treat a variety of ailments including rheumatism, wounds, dysentery, pain, sores, gastrointestinal problems, skin problems, etc., and also kill insects. Web search engines such as PubMed, Science Direct Google Scholar, have been extensively searched using different keywords such as <em>Euonymus alatus</em>, ethnomedicinal, chemicals, etc. Some books and web sites were also included. A total of 51 relevant literature sources were included which met the inclusion criteria. This review aims to provide a botanical description, phytochemistry, pharmacology, and reported mechanisms of action. Plant includes 129 natural chemicals that have a range of biological effects, including hepatoprotective, antitumor, antioxidant, antidiabetic, and antitumor properties. The mechanisms of the unstudied phytochemicals should be further investigated since they may serve as a starting point for the development of new herbal medicines.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"5 ","pages":"Article 100102"},"PeriodicalIF":0.0,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142422652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HPLC analysis and antibacterial activity of methanolic extract of Centella asiatica (L.) urban","authors":"Vinod K. Bisht ,&nbsp;Arvind K. Bhandari ,&nbsp;Rakesh S. Bisht ,&nbsp;L.S. Kandari ,&nbsp;Subhash Chandra ,&nbsp;T. Negi ,&nbsp;Santwana Palai ,&nbsp;Janini Filgueira Rosas ,&nbsp;Jonas Ildefonso Junior ,&nbsp;Davi Antas e Silva ,&nbsp;Henrique Douglas Melo Coutinho","doi":"10.1016/j.prenap.2024.100106","DOIUrl":"10.1016/j.prenap.2024.100106","url":null,"abstract":"<div><h3>Objectives</h3><div>Increasingly resistant antibiotics and new bacteria have fueled the demand for herbal remedies. Our current study aimed to find out whether the methanolic extract from Centella asiatica aerial parts contained asiatic acid and madecassoside, as well as their antibacterial properties.</div></div><div><h3>Methods</h3><div>A high-performance liquid chromatography (HPLC) technique was used to measure asiatic acid and madecassoside. We assessed the antibacterial activity of both compounds and crude aerial methanolic extract using the agar-well diffusion method.</div></div><div><h3>Results</h3><div>As identified through HPLC analysis, madecassoside was found to be 1.89 % and asiatic acid to be 0.35 %. C. asiatica had strong inhibitory activity against E. coli (MIC of 6.25 mg ml-1 and ZOI of 9 mm) and S. aureus (MIC of 3.12 mg ml-1 and ZOI of 8 mm). The ZOI for S. typhimurium, P. vulgaris, and B. subtilis was 7, 6, and 10 mm, respectively, and the MIC was 12.5 mg ml-1. Comparing asiatic acid to madecassoside, it has a potent antibacterial effect.</div></div><div><h3>Conclusions</h3><div>The methanolic crude extract and measured compounds of C. asiatica exhibit strong antibacterial activity, especially against S. typhimurium and E. coli. The asiatic acid and madecassoside identified by HPLC analysis could potentially be associated with this activity. These compounds exhibit antimicrobial activity can be found and employed as low-resistance, multi-target antibacterial drugs to treat a range of bacterial and fungal infections that have become resistant to existing antibiotics.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"5 ","pages":"Article 100106"},"PeriodicalIF":0.0,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142422698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticancer activity of Nigella sativa and its bioactive compounds: An update","authors":"Mst.Asma Aktar ,&nbsp;Md.Shimul Bhuia ,&nbsp;Raihan Chowdhury ,&nbsp;Shrabonti Biswas ,&nbsp;Mst.Rifah Sanzida ,&nbsp;Fatema Akter Sonia ,&nbsp;Jannatul Ferdous ,&nbsp;Razina Rouf ,&nbsp;Mohammad S. Mubarak ,&nbsp;Lucia Raquel de Lima ,&nbsp;Henrique Douglas Melo Coutinho ,&nbsp;Edinardo F.F. Matias ,&nbsp;João Paulo Martins Lima ,&nbsp;Janini Filgueira Rosas ,&nbsp;Muhammad Torequl Islam","doi":"10.1016/j.prenap.2024.100100","DOIUrl":"10.1016/j.prenap.2024.100100","url":null,"abstract":"<div><div><em>Nigella sativa (black cumin)</em> is a widely recognized medicinal plant in traditional medicine, and its seeds and seed oil are used in the treatment of various diseases. This plant and its bioactive compounds exhibit numerous biological activities such as anti-diabetic, anticancer, antimicrobial, and anti-inflammatory, among others. <em>N. sativa</em> contains many bioactive compounds, including important antineoplastic agents such as thymoquinone, α-hederin, carvacrol, and thymol. This review focuses on and discusses the medicinal and health-promoting effects of <em>N. sativa and</em> covers the recent developments that deal with the anticancer activity of this medicinal plant and its bioactive compounds, with an emphasis on the mechanism of action. The findings demonstrated that the preventive effect of <em>N. sativa</em>and its bioactive phytochemicals are associated with its ability to decrease inflammation and exert immune-enhancing actions. The plant and its phytochemicals also enhance natural killer (NK) cell cytotoxicity, apoptotic effects on carcinoma cells, and control signal transduction pathways including caspases, p53, ROS, AMPK/mTOR, NF-κB, JAK2/STAT3, and PI3K/Akt in suppressing cancer and tumorigenesis. However, this suggests the use of the plant as a chemotherapeutic agent and further clinical assessment of the bioactive phytochemicals to establish a reliable anticancer drug.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"5 ","pages":"Article 100100"},"PeriodicalIF":0.0,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142422697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical screening and evaluation of antibacterial, antipyretic, hypoglycemic, and anxiolytic effects of Adiantum philippense leaf extracts","authors":"Farhana Sharmin Zumu ,&nbsp;Md. Showkoth Akbor ,&nbsp;Ahmed Al Amin ,&nbsp;Mst. Farjanamul Haque ,&nbsp;Irin Sultana ,&nbsp;Abdullah Al Faruq ,&nbsp;Carolina Bandeira Domiciano ,&nbsp;Henrique Douglas Melo Coutinho ,&nbsp;Muhammad Torequl Islam","doi":"10.1016/j.prenap.2024.100108","DOIUrl":"10.1016/j.prenap.2024.100108","url":null,"abstract":"<div><div><em>Adiantum philippense</em> (AP) is a source of various important phytochemicals and has been traditionally used to cure many diseases, including dysentery, ulcers, fevers, cooling, and elephantiasis<em><strong>.</strong></em> This study aimed to evaluate the anti-bacterial, anti-pyretic, analgesic, and anxiolytic effects of AP using a number of <em>in vitro</em> and <em>in vivo</em> test protocols. For this, dried leaves were extracted by the Soxhlet extractor using ethanol. The crude ethanol extract was then fractionated by treating with chloroform and n-hexane. A preliminary phytochemical screening was done for its crude extracts. The antibacterial activity of ethanol, chloroform, and n-hexane extracts of AP was tested against 10 pathogenic bacteria at concentrations of 500 µg/disc. The ethanol extract showed significant activity against Gram (+ve) and Gram (-ve) bacteria. In mice, the chloroform extracts showed significant (p &lt;0.05) antipyretic and hypoglycemic effects, while the ethanol extract exerted significant anxiolytic effects on mice. The results obtained from this study indicate that AP leaf extracts contain important phytochemical groups and exert antibacterial, antipyretic, hypoglycemic, and anxiolytic effects. Further studies are required to isolate the bioactive compounds responsible for these claimed biological activities.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"5 ","pages":"Article 100108"},"PeriodicalIF":0.0,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142422207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comprehensive review on exploring Thymoquinone as novel therapeutic molecule for clinical management of Glioblastoma Multiforme","authors":"Sagar Trivedi ,&nbsp;Ujban Hussain ,&nbsp;Rishabh Agade ,&nbsp;Veena Belgamwar","doi":"10.1016/j.prenap.2024.100107","DOIUrl":"10.1016/j.prenap.2024.100107","url":null,"abstract":"<div><div>Glioblastoma Multiforme (GBM) is a deadly and aggressive brain cancer with rapid progression and resistance to conventional treatments. Patients suffering from GBM have a median survival of just over a year after diagnosis, and low potential of current treatments urges to discover novel molecules and therapies for its management. Thymoquinone (TH), a bioactive compound from <em>Nigella sativa</em> seeds, has shown potent antitumour effects in preclinical studies. TH's antioxidant properties are crucial in treating GBM, by oxidative stress-based treatment. Nanoparticles or nanocarriers entrapping TH's has substantially improved the efficacy of TH, and nanotechnology advancements can enhance targeted drug delivery. Combination therapy strategies with TH, targeting multiple vulnerabilities and disrupting pro-tumourigenic signalling cascades, may improve outcomes. TH has potential anti-GBM activity by modulating key signalling pathways, including NF-κB, PI3K/Akt, MAPK, and STAT3. It is an adjunctive in standard treatments for GBM, targeting residual tumour cells to inhibit postoperative growth and improve radiation therapy efficiency. Understanding TH-mediated immunosuppression in GBM and its effects on metabolic pathways and epigenetic regulation could lead to new therapeutic targets. This review gives a detail idea about the latest advancement made till date in the field of GBM treatment using TH as novel and potent molecule coupled with various immunology, nanotechnology, conventional therapies and other molecules.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"5 ","pages":"Article 100107"},"PeriodicalIF":0.0,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142422699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Piper attenuatum leaves extract reduced renal crystallization formation in urolithiasis might be due to probable interaction with uromodulin protein: An evidence based in vivo and in silico studies","authors":"Shikha Sharma ,&nbsp;Gaurav Kumar ,&nbsp;Monika Meghani ,&nbsp;Nitin Kumar ,&nbsp;Neeraj Kumar Sethiya ,&nbsp;Dheeraj Bisht","doi":"10.1016/j.prenap.2024.100101","DOIUrl":"10.1016/j.prenap.2024.100101","url":null,"abstract":"<div><div>Urolithiasis can cause excruciating pain and hardly managed by allopathic medicine without surgery. Recently, many of research on validation of traditional medicinal plants provided a hope for management of urolithiasis. In this context, we have found a gap between traditional claims and scientific validation on use of <em>Piper attenuatum</em> (<em>P. attenuatum</em>) towards mangement of renal caliculi. Therefore, present study was planned to determine anti-urolithiatic efficacy of ethanol extract of <em>P. attenuatum</em> (EEPA) leaves on ethylene glycol induced urolithiasis on male Wistar rats. Further, study pertaining to phytochemical analysis followed by molecular docking of selected bioactive phytochemicals of <em>P. attenuatum</em> against human uromodulin <strong>(</strong>a key potential biomarkers relevant for renal function and chronic kidney disease including urolithiasis) protein. As a result, EEPA (400 mg/kg/bw) was found to significantly improves various urinary (volume: 7.19 ± 0.11 ml/24 hr; calcium: 6.15 ± 0.51 mg/dl; phosphate: 7.83 ± 0.56 mg/dl and oxalate: 1.78 ± 0.03 mg/dl) and serum parameters (creatinine: 1.85 ± 0.04 mg/dl; uric acid: 1.65 ± 0.08 mg/dl and blood urea nitrogen or BUN: 32.20 ± 1.41 mg/dl), when compared with negative control group followed by reverse in changes as an evidence of histological studies. Additionally, molecular docking studies revealed higher binding affinity to some selected phytoconstituents against human uromodulin enzyme. It was further concluded that EEPA leaves exhibits significant antiurolithiatic activity due to presence of aristolactam A II, cepharadione A and B, piperolactam A, norcepharadione B and pipoxide chlorohydrin via strong binding efficiency with uromodulin protein.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"5 ","pages":"Article 100101"},"PeriodicalIF":0.0,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142422694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chitosan nanoparticle-mediated drug delivery for linoleic acid isolated from Melastomastrum capitatum Fern. leaf extract against MCF-7 and OV7 cancer cells","authors":"C.A. Ukwubile ,&nbsp;A. Ahmed ,&nbsp;U.A. Katsayal ,&nbsp;J. Ya’u ,&nbsp;H. Nettey","doi":"10.1016/j.prenap.2024.100105","DOIUrl":"10.1016/j.prenap.2024.100105","url":null,"abstract":"<div><div>The number of cancer cases worldwide is rising, resulting in approximately 40 million deaths each year due to the inability to effectively deliver drugs that specifically target cancer cells. The study's aim was to utilize chitosan nanoparticles containing linoleic acid extracted from <em>Melastomastrum capitatum</em> leaves to specifically target MCF-7 and OV7 cancer cells. The study conducted toxicity tests on Wistar rats to evaluate the potential harmful effects of the extract at different doses. It also examined the extract's impact on vital organs through histopathological analysis. Chitosan nanoparticles containing the extract were developed using the spray drying method. In addition, the study analyzed various characteristics of the chitosan-loaded extract, such as % yield, drug entrapment efficiency, morphology, particle size, thermal properties, drug release, and swelling index. <em>In vitro</em> studies were conducted on MCF-7 and OV7 cell lines to assess the extract's anticancer properties. <em>In vivo</em> studies were performed on tumor-induced Wistar rats, with five rats in each of the five groups, using hemocytometer trypan blue cell counting. The study found that the crude leaf extract of M. capitatum (MCE) was well tolerated at a dose of 5000 mg/kg in rats, with only partial congestion observed in the lungs and testis. The extract exhibited higher cytotoxicity against the ovarian cancer cell line OV7 compared to the breast cancer cell line MCF-7, with an IC₅₀ value of 10.13±2.20. In vitro studies showed that a chitosan nanoparticle-loaded version of the extract (CSLA3) induced apoptosis and increased caspase-3 activity in OV7 cells. In vivo studies showed that treatment with the chitosan-loaded extract significantly increased mean survival time and percentage increase in life span in tumor-induced rats. Tumor cell volume and viable cell counts decreased, while non-viable cell count increased in the treated group. The study concluded that CSLA3 effectively inhibited the growth of ovarian cancer cells and demonstrated the potential of chitosan nanoparticles to deliver anticancer plant extracts. This also supports the traditional use of <em>M. capitatum</em> leaf extract as a treatment for ovarian cancer.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"5 ","pages":"Article 100105"},"PeriodicalIF":0.0,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142422692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural products as a source of cholinesterase inhibitors","authors":"Pamella Christina Ortega de Oliveira ,&nbsp;Gabriel Matias da Silva ,&nbsp;Quezia Bezerra Cass ,&nbsp;Marcela Cristina de Moraes ,&nbsp;Carmen Lúcia Cardoso","doi":"10.1016/j.prenap.2024.100099","DOIUrl":"10.1016/j.prenap.2024.100099","url":null,"abstract":"<div><div>As the global population ages, the incidence of neurodegenerative diseases such as Parkinson’s disease and dementia including Alzheimer's disease (AD) rises. The characteristic cognitive, behavioral, and motor impairments of these conditions are often linked to dysregulated cholinergic system. Various neurodegenerative diseases have been associated with altered levels of the neurotransmitter acetylcholine (ACh) and changes in the expression and function of receptors in specific areas of the nervous system. For instance, while AD development is not fully understood, the AD cholinergic hypothesis considers that AD patients exhibit low ACh concentrations, and that many dementia symptoms could potentially stem from this deficiency. Moreover, it has been speculated that acetylcholine dysfunction might not be the primary pathological cause but rather a consequence of AD. Hence, one approach to developing new drugs to treat AD involves identifying compounds that can inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), the two enzymes underlying ACh hydrolysis. Natural products offer wide structural diversity, which makes them an important source of bioactive compounds. This article reviews the literature on how natural compounds have contributed to the discovery and design of new cholinesterase inhibitors over the past two decades. The review encompasses a brief historical overview of inhibitors that are used to treat AD in clinical settings, a discussion of the different classes of natural products that act to inhibit AChE and BChE, and a concise presentation of the screening assays that are employed to identify AChE and BChE ligands.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"5 ","pages":"Article 100099"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142422695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zootherapeuticals of the three geo-political regions of Southern Nigeria","authors":"Olayide Muideen Oladepo ,&nbsp;Waheed Adeola Adedeji ,&nbsp;Musa Oladejo ,&nbsp;Mohammed Wulgo Ali ,&nbsp;Oyindamola Olajumoke Abiodun ,&nbsp;Oluwakanyinsola Salawu","doi":"10.1016/j.prenap.2024.100095","DOIUrl":"10.1016/j.prenap.2024.100095","url":null,"abstract":"<div><h3>Ethnopharmacological relevance</h3><div>Drug bioprospecting from natural products is arguably a gold mine. Ethnopharmacological studies have primarily focused on the use of plant materials for drug discovery, though other natural products including animal species are commonly used for managing diseases in Nigeria. Review and documentation of zootherapy studies in Southern Nigeria are scattered, and inventory and cross-indexing of zootherapeutics in the region are scarce.</div></div><div><h3>Aim of the study</h3><div>We reviewed and inventoried studies on the practice of zootherapy in managing diseases in the three geopolitical regions of Southern Nigeria.</div></div><div><h3>Materials and methods</h3><div>Inclusion criterion for the papers used was limiting utilization of animal species to medicinal purposes only. Publications between 1988 and 2021 were examined using databases like Google Scholar, Scopus, Web of Science, PubMed and Medline. Popularity ratio (P.R) and impart factor (IF) were assigned to an animal family to denote number of places in the Southern Nigeria where it is used and number of diseases it is used to manage respectively.</div></div><div><h3>Results</h3><div>Data were gathered from 81 published papers or books out of which 26 were on the practices of zootherapy in different states of Southern Nigeria, 45 were on the practices of zootherapy in other parts of the world for correlations and cross indexing, 8 were referenced for natural medicines generally while the remaining two were relevant literatures. Ninety-eight (98) species of medicinal animals and products were used in the South-Western, seventy-nine (79) in the South-Southern and twenty (20) in the South-Eastern regions of Nigeria. Oyo State was reported for the highest therapeutic usage while Abia State has the lowest value. The animal product with the most medicinal usage in Southern Nigeria are Bovidae with an impart factor (IF) of 100 while Anatidae, Osteridae and Colubrida each has an impart factor of 4.76. The animal parts (bone, tail, head, skin, fur, milk, hoof, horn, egg and honey; skull and teeth) are the most commonly used in the South-East, whole animal in the South-West and flesh in the South-South.</div></div><div><h3>Conclusions</h3><div>This review of the zootherapy practices in Nigeria may further enhance the study and development of new drugs by researchers interested in ethnopharmacology.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"5 ","pages":"Article 100095"},"PeriodicalIF":0.0,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142422693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}