Pharmacological Research - Natural Products最新文献

{"title":"Chemical composition, antibacterial activity, and antibiotic-potentiating effect mediated by the essential oil of the leaves of Croton urticifolius Lam. (Euphorbiaceae)","authors":"Antonio Junior Costa Barbosa ,&nbsp;José Jailson Lima Bezerra ,&nbsp;Havana Lorena Silva de Araujo ,&nbsp;Mateus Araújo da Luz ,&nbsp;Joseilton Franco França ,&nbsp;Maisa Fernanda dos Santos Barbosa ,&nbsp;Márcia Vanusa da Silva ,&nbsp;Maria da Conceição de Menezes Torres","doi":"10.1016/j.prenap.2025.100369","DOIUrl":"10.1016/j.prenap.2025.100369","url":null,"abstract":"<div><div>The <em>Croton</em> genus belongs to the Euphorbiaceae family and groups aromatic species that produce essential oils characterized by presenting a broad pharmacological spectrum, such as anti-inflammatory, antioxidant, antimicrobial, and anticancer activities. In this context, the present study aimed to investigate the chemical composition and evaluate the antibacterial and antibiotic-potentiating activity of the essential oil from <em>Croton urticifolius</em> leaves (EOCU). The EOCU was analyzed by gas chromatography coupled with mass spectrometry (GC-MS) to identify its chemical constituents. The analysis conducted by GC-MS allowed the identification of 18 compounds (95.0 %) and the main constituents were <em>α</em>-pinene (21.70 %), bicyclogermacrene (21.46 %), and (<em>E</em>)-caryophyllene (17.34 %). Regarding antibacterial activity, EOCU exhibited a minimum inhibitory concentration (MIC) value of 512 μg/mL against <em>Escherichia coli</em>. In combination with ciprofloxacin, EOCU potentiated the effect of this antibiotic against multidrug-resistant <em>Staphylococcus aureus</em>. In summary, these results suggest that the synergistic effects observed in the combination of EOCU and ciprofloxacin may represent a promising therapeutic alternative to overcome the resistance of pathogenic bacteria. This study is the first to report the potentiating effect of <em>C. urticifolius</em> essential oil combined with commercial antibiotics.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100369"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145059824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dose-dependent evaluation of chronic oleocanthal on metabolic phenotypes and organ toxicity in 5xFAD mice","authors":"Euitaek Yang ,&nbsp;Nour F. Al-Ghraiybah ,&nbsp;Amer E. Alkhalifa ,&nbsp;Lauren N. Woodie ,&nbsp;Samuel P. Swinford ,&nbsp;Judy King ,&nbsp;Michael W. Greene ,&nbsp;Amal Kaddoumi","doi":"10.1016/j.prenap.2025.100357","DOIUrl":"10.1016/j.prenap.2025.100357","url":null,"abstract":"<div><div>In Alzheimer's disease (AD), alterations in the basal metabolic rate (BMR) and energy expenditure, known as metabolic phenotyping, are present early in the disease, which progresses as the disease advances. The Mediterranean diet, including extra-virgin olive oil (EVOO), has been known to reduce AD risk. Oleocanthal (OC) is a major phenolic compound in EVOO. Previous research showed that OC reduced brain amyloid-β, tau hyperphosphorylation, neuroinflammation, and improved blood-brain barrier and memory functions in AD mouse models. In this work, we aimed to investigate the dose-dependent impact of chronic oral OC treatment on modulating metabolic phenotypes affected by AD and its toxicity in 5xFAD mice, an AD mouse model. 5xFAD mice were treated with OC for 3 months, starting at the ages of one (prevention mode, before the pathology hallmarks appear) and 6 months (treatment mode, after the pathology hallmarks appear). Findings demonstrated OC altered metabolic phenotypes in the 5–20 mg/kg dose range in both groups. Furthermore, OC proved not toxic except at 20 mg/kg, where hepatic toxicity is observed. In conclusion, these findings highlight the OC effect in rectifying metabolic phenotypes in AD. However, it limits the dose range in mice to 5 and 10 mg/kg despite exhibiting a favorable response in metabolic parameters due to observed hepatotoxicity with the 20 mg/kg.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100357"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144931612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the therapeutic potential of Grewia asiatica L.: A correlative analysis through in-vitro and in-vivo approaches","authors":"Sayema Khanum ,&nbsp;Md. Farhad Sarker ,&nbsp;Mohammad Kamrul Islam Joy ,&nbsp;Md. Mahbubur Rahman Bhuiyan ,&nbsp;Mohammad Saydur Rahman ,&nbsp;Md. Hemayet Hossain","doi":"10.1016/j.prenap.2025.100362","DOIUrl":"10.1016/j.prenap.2025.100362","url":null,"abstract":"<div><h3>Objective</h3><div>This study was designed to appraise the phytochemical composition and pharmacological potential of different fractions from <em>Grewia asiatica</em> (Family: Tiliaceae) leaves by <em>in-vitro</em> and <em>in-vivo</em> assessments.</div></div><div><h3>Methods</h3><div>Various fractions of <em>Grewia asiatica</em> L. leaves were subjected to qualitative and quantitative phytochemical analyses to identify and quantify phenolics, flavonoids, and proanthocyanidins. Antioxidant activities were assessed using DPPH radical scavenging, iron reducing potential, and total antioxidant activity assays. Anti-nociceptive potency was evaluated through acetic acid-induced writhing, Eddy's hot plate, formalin-induced paw licking, and tail immersion methods at a dose of 200 mg/kg body weight in Swiss albino mice. The polyphenolic profile was determined by HPLC-DAD analysis. The anti-inflammatory potential was investigated using carrageenan-induced paw edema and formalin-induced paw edema models. A heatmap correlation analysis was conducted to identify relationships between phytochemical content and pharmacological activities.</div></div><div><h3>Results</h3><div>The ethyl acetate fraction (EAFGA) demonstrated the highest content of phenolics (375.15 mg GAE/g dried extract), flavonoids (235.13 mg QE/g dried extract), and proanthocyanidins (367.36 mg CAT Eq/g dried extract). In the DPPH assay, chloroform and ethyl acetate fraction showed IC₅₀ values of 19.66 and 19.72 μg/mL, respectively, as compared to the standard BHT. Among the extractives, ethyl acetate fraction demonstrated the highest iron reducing capacity and total antioxidant activity. Analgesic assays revealed significant reductions (P &lt; 0.001) in writhes and licking time, with EAFGA demonstrating 50.39 % inhibition in the formalin test, while the anti-inflammatory assay showed a significant (P &lt; 0.001) inhibition of paw edema in the carrageenan model. Heatmap analysis showed strong correlations between phenolic and flavonoid contents with analgesic and anti-inflammatory activities, highlighting their key roles in the observed effects.</div></div><div><h3>Conclusion</h3><div>The study suggests that phenolic, flavonoid, and proanthocyanidin compounds contribute to the antioxidant, analgesic, and anti-inflammatory activities, validating the traditional use of <em>G. asiatica</em> in treating various ailments like removing pain and inflammation. Ethyl acetate extractive showed potential for drug development, shedding light on the need for further research to isolate bioactive compounds and clarify their mechanisms.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100362"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polyphenolic diversity in different ethanolic extract of Malaysian Heterotrigona itama propolis: Correlation with antioxidant and cytotoxic properties","authors":"Hamidah Mohd Zain ,&nbsp;Muhammad Ariffuddin Abd Hamid ,&nbsp;Noorfatimah Yahaya ,&nbsp;Nik Nur Syazni Nik Mohamed Kamal","doi":"10.1016/j.prenap.2025.100371","DOIUrl":"10.1016/j.prenap.2025.100371","url":null,"abstract":"<div><div>Propolis, a resinous substance produced by bees, is often regarded as a waste by-product in the beekeeping and honey production industry. However, its promising medicinal and therapeutic properties elevate it into a highly valued resource for numerous applications. Nevertheless, a key challenge lies in the varying phytochemical content, which may contribute to the inconsistency in its bioactivity and therapeutic effects. Therefore, this study aimed to produce a standardized propolis extract based on specific chemical markers and to evaluate its antioxidant and cytotoxic activities. Bioactive compounds from three different ethanolic extracts were analyzed using chromatographic and spectrophotometric techniques. Among these extracts, the 70 % ethanolic extract of propolis (EEP) showed the most abundant phytochemical profiles with benzenecarboxylic acid (benzoic acid) identified as the key compound. The 70 % EEP exhibited high total phenolic content (TPC) and total flavonoid content (TFC), which strongly correlated with its potent antioxidant activity and selective cytotoxicity. Moreover, this extract demonstrated considerable growth inhibitory effect with IC₅₀ value of 50.35 µg/mL, 55.47 µg/mL, 71.67 µg/mL against MCF-7, A549 and THP-1 macrophages, respectively. These findings highlight the importance of phenolic content in determining propolis bioactivity and support the development of standardized, bioactive natural products for therapeutic use.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100371"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145059847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tea catechin extracts reduced sub-acute and sub-chronic toxicity of the cisplatin drug in BALB/c mice","authors":"Joseph Ndacyayisenga ,&nbsp;Esther N. Maina ,&nbsp;Festus M. Tolo ,&nbsp;Fred Wamunyokoli","doi":"10.1016/j.prenap.2025.100367","DOIUrl":"10.1016/j.prenap.2025.100367","url":null,"abstract":"<div><div>Cisplatin is an effective chemotherapeutic drug but causes kidney, liver, gastrointestinal, and heart toxicity. Tea catechins, with antioxidant and anti-inflammatory properties, may synergistically reduce these adverse effects. This study aimed to evaluate the protective effects of tea catechin extracts against cisplatin-induced toxicity in female BALB/c mice. An in vivo experimental study was conducted using 48 female BALB/c mice, aged 7–8 weeks and weighing 25–30 g, divided equally into sub-acute (28 days) and sub-chronic (90 days) toxicity models. Mice were allocated into four groups: control, catechin-only, cisplatin-only, and catechin plus cisplatin. Tea catechins were extracted from BB35 and Purple (TRFK306) tea clones and quantified using High-Performance Liquid Chromatography (HPLC). Mice received catechin extract at 100 mg/kg/day orally and cisplatin at 7 mg/kg intraperitoneally. Haematological (Complete Blood Count (CBC)) and biochemical parameters (Alkaline phosphatase (ALP), Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Creatine kinase (CK), Lactate dehydrogenase (LDH), Creatinine, and Blood urea nitrogen (BUN)), interleukins (Interleukin-1β (IL-1β) and Interleukin-6 (IL-6)), and gene expression analyses using Quantitative Real-Time PCR (qPCR) were performed. Catechin extracts increased White Blood Cells (WBC), Red Blood Cells (RBC), Platelets (PLT), Haemoglobin (HB), and Haematocrit (HCT) in cisplatin-induced toxicity mice. They reduced biochemical markers of toxicity: ALP (209.55 ± 17.18 U/L), ALT (111.6 ± 13.15 U/L), AST (114.35 ± 4.38 U/L), CK (586 ± 48.08 µg/mL), LDH (586 ± 48.08 U/L), BUN (7.68 ± 0.25 mmol/L), and Creatinine (50.5 ± 3.53 µmol/L). They also downregulated gene expression: <em>IL-1β</em> (1.87 ± 0.74/1.09 ± 0.74), <em>IL-6</em> (1.34 ± 0.81/1.43 ± 0.24), <em>Mip-1a</em> (1.12 ± 0.60/1.94 ± 1.05), and <em>Nfkb1</em> (1.24 ± 0.58/1.98 ± 0.29). In conclusion, catechin extracts reduced sub-acute and sub-chronic cisplatin-induced toxicity in female BALB/c mice.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100367"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145048570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anemonin is one of two anti-mitotic activities present in extracts from the Canadian Prairie Crocus, Pulsatilla nuttalliana","authors":"Shannon M. Healy Knibb ,&nbsp;Tanner C. Lockwood ,&nbsp;Benjamin Yeremy ,&nbsp;Layla Molina ,&nbsp;Chad R. Beck ,&nbsp;Araba Sagoe-Wagner ,&nbsp;David E. Williams ,&nbsp;Raymond J. Andersen ,&nbsp;Roy M. Golsteyn","doi":"10.1016/j.prenap.2025.100361","DOIUrl":"10.1016/j.prenap.2025.100361","url":null,"abstract":"<div><div>We are investigating plants from the prairie ecological zone of Canada to identify natural products that inhibit mitosis in cancer cells. Extracts prepared from the Canadian prairie plant species <em>Pulsatilla nuttalliana</em> (Ranunculaceae) exhibited anti-mitotic activity on human cancer cell lines. <em>P. nuttalliana</em>-treated cells acquired a rounded morphology and were positive for phospho-histone H3, a mitotic protein. Further investigation revealed that some arrested cells displayed mitotic spindles, whereas others lacked detectable spindles. Fractionation of the extract prepared from plant stems revealed two distinct anti-mitotic activities, each of which exhibited different effects on spindle organization. Using biology-guided fractionation, we isolated one of the anti-mitotic compounds as the natural product anemonin and are the first to report its anti-mitotic activity. In addition, this is the first report of two distinct anti-mitotic activities in one botanical species and contributes to a growing body of evidence that select Canadian prairie plants have a range of anti-mitotic activities.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100361"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145010212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular docking study and antibacterial evaluation of Leucas lavandulifolia Sm. against bacterial DNA gyrase","authors":"Pallabi Mohapatra ,&nbsp;Manoja Das ,&nbsp;Manish Kumar","doi":"10.1016/j.prenap.2025.100363","DOIUrl":"10.1016/j.prenap.2025.100363","url":null,"abstract":"<div><div>In order to facilitate the development of new drugs and validate established medical applications, plant compounds are studied for their antibacterial potentials in an effort to find safe, natural, and efficient agents that fight microorganisms, including drug-resistant strains. <em>L. lavandulifolia</em> Sm<em>.</em>, is traditionally utilized for its medicinal properties and holds potential as an antibacterial agent due to its rich phytochemical composition. This study aims to assess the antibacterial activity of <em>L. lavandulifolia</em> against bacterial DNA gyrase, a crucial enzyme in DNA replication and repair. Using antibacterial assays and molecular docking studies, the effectiveness of <em>L. lavandulifolia</em> extracts against a gram-negative bacterium, <em>E. coli</em> was evaluated. <em>In vitro</em> examining the antibacterial properties of different parts of <em>Leucas lavandulifolia</em> against <em>E. coli</em> revealed that the leaf extract exhibited the highest zone of inhibition<em>.</em> The secondary metabolite of the studied plant baicalin showed as a most potential antibacterial candidate with a hight docking score of −8.7 kCal/mol as compared to other phytocompounds present in the plant. This study concludes the therapeutic potential of <em>L. lavandulifolia</em> and adds to the ongoing efforts to treat antimicrobial resistance pathogens by bridging traditional knowledge with contemporary scientific study.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100363"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145048572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Syringic acid interference ameliorates HFD-induced oculo-inflammatory disorder via downregulation of NF-κB-TNFα-iNOS signaling pathway in male Wistar rats","authors":"Olubisi E. Adeyi ,&nbsp;Oluwatobi T. Somade ,&nbsp;Emmanuel I. Ugwor ,&nbsp;Olukunle S. Ajayi ,&nbsp;Akindele O. Adeyi ,&nbsp;Selimot O. Adams ,&nbsp;Marvelous O. Ayanwale ,&nbsp;Oluwabunmi O. Adediran ,&nbsp;Gbemisola Ambali ,&nbsp;Yetunde P. Phillip ,&nbsp;David Omotayo Abass ,&nbsp;Yusuf O. Adebisi ,&nbsp;Kelvin A. Okwori ,&nbsp;Damilola Moses","doi":"10.1016/j.prenap.2025.100360","DOIUrl":"10.1016/j.prenap.2025.100360","url":null,"abstract":"<div><h3>Background</h3><div>High fat diets (HFD) have been associated with many pathological disorders including retinopathy which is an aftermath of retinal inflammation. These have led to vision impairment in victims. Syringic acid (SyA) is a naturally existing phenolic compound that exhibits clinical benefits attributed to its various therapeutic effects. These effects include anti-inflammatory, antioxidant, anti-diabetic, anticancer, and anti-cardiovascular properties. In the quest for tackling this occurrence, this study therefore investigated the effect of SyA treatments on HFD-induced oculo-inflammatory response in male Wistar rats.</div></div><div><h3>Methods</h3><div>Twenty-five male rats were divided into five groups of five animals each. Animals in groups I (control) and II (50 mg/kg SyA) were served normal rat chow. On the other hand, groups III, IV, and V were served HFD, but only animals in groups IV and V were treated with 25 and 50 mg/kg SyA, respectively.</div></div><div><h3>Results</h3><div>Data obtained revealed a significant increase in the levels of nuclear factor kappa-B (NF-κB), tumor necrosis factor-alpha (TNF-α), inducible nitric oxide synthase (iNOS), interleukin-6 (IL-6), and cyclooxygenase-2 (COX-2) in rats served HFD. SyA intervention (50 mg/kg) reversed these outcomes.</div></div><div><h3>Conclusion</h3><div>Gathered results showed the anti-inflammatory effect of SyA in a dose-dependent manner via the downregulation of NF-κB-TNFα-iNOS signaling pathway in the eyes of rats.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100360"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145010211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Herbal ingredients in anti-aging cream formulations: A comprehensive review of their bioactive components, molecular mechanisms, and dermatological benefits","authors":"Aybeniz Yıldırım ,&nbsp;Rümeysa Yücer ,&nbsp;Ali Şen ,&nbsp;Leyla Bitiş","doi":"10.1016/j.prenap.2025.100365","DOIUrl":"10.1016/j.prenap.2025.100365","url":null,"abstract":"<div><div>The growing interest in anti-aging skincare products has led to increased scrutiny of synthetic ingredients, resulting in a shift toward plant-based alternatives. This review provides a comprehensive analysis of the bioactive compounds present in herbal ingredients commonly used in anti-aging cream formulations and their dermatological benefits. For this purpose, anti-aging creams listed under the cosmetics section of RxMediaPharma® 2025 were examined, and their botanical components were identified. A detailed literature search was conducted using PubMed, Scopus, Google Scholar, Embase, and Web of Science to determine the bioactive constituents and their effects. The study identified a total of 215 plant species frequently used in anti-aging formulations. Among them, <em>Aloe vera, Simmondsia chinensis</em> (jojoba), and <em>Vitis vinifera</em> (grape seed) were the most commonly utilized. The presence of flavonoids, polyphenols, tannins, vitamins (A, C, E), and essential minerals such as selenium and zinc was highlighted as key contributors to their anti-aging properties. These bioactive compounds exhibit antioxidant, anti-inflammatory, moisturizing, and collagen-boosting effects, making them valuable ingredients in cosmetic formulations. In conclusion, the widespread use of plant-based ingredients in anti-aging skincare underscores their dermatological potential. However, further preclinical and clinical studies are needed to validate their efficacy and safety, ensuring their standardized use in cosmetic applications.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100365"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive compounds with antidepressant potential in rodents: A narrative review","authors":"Deepak Lamba ,&nbsp;Monu Yadav ,&nbsp;Shilpi Chauhan ,&nbsp;Diksha Nagpal ,&nbsp;Shrestha Sharma ,&nbsp;Durgesh Kumar Dwivedi","doi":"10.1016/j.prenap.2025.100354","DOIUrl":"10.1016/j.prenap.2025.100354","url":null,"abstract":"<div><div>Plant bioactive compounds are a potential source to alleviate depression symptoms and management of this disorder. Depression is a multifactorial mental health disorder that significantly impairs an individual's social functioning and is commonly associated with persistent stress, maladaptive coping mechanisms, and an unhealthy lifestyle. Several hypotheses, such as neurotransmitter modulation, oxidative damage, neuroinflammation, hyperactivity of the Hypothalamic-pituitary-adrenal (HPA) axis, etc., have been suggested to elucidate the pathophysiology of depression. On these hypotheses, many synthetic antidepressants have been discovered to cure depression. These agents are therapeutically effective in reducing symptoms of depression but are associated with various side effects. Therefore, medicinal plant-based therapy has achieved considerable attention as these agents have negligible side effects. The present review consolidates findings on 90 phytoconstituents, identified through a comprehensive literature survey spanning the past 33 years, utilizing search terms related to bioactive compounds with demonstrated antidepressant activity. Based on the analysis, ConBr emerged as the most potent compound, exhibiting efficacy at doses of 0.1–50 μg/site i.c.v. In addition, Ursolic acid, Forskolin, Dehydrozingerone, Hesperidin, Montamine, and Ascorbic acid were also identified as bioactive phytomolecules with notable antidepressant potential. Moreover, possible mechanisms of action of the antidepressant effects have also been mentioned in this review. The findings of this review suggest that most bioactive compounds alleviate depression by influencing the synaptic regulation of crucial neurotransmitters like serotonin, noradrenaline, and dopamine, inhibiting the activity of monoamine oxidase-A (MAO-A), modulating the hypothalamic-pituitary-adrenal axis, reinforcing the anti-oxidant defense system, and reducing inflammatory mediators. The multi-faceted pathways through which these bioactive compounds alleviate depression highlight their potential as a novel source for developing antidepressants. However, further research might be needed to understand the detailed mechanisms of action for many of these herbal bioactive compounds before clinical studies.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100354"},"PeriodicalIF":0.0,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144913659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}