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Analgesic Mechanism of Action of Structural Analogues of 4-Aminopiperidine Phenoxy-Derivatives 4-氨基哌啶苯氧基衍生物结构类似物的镇痛作用机制
Pharmacological Research - Natural Products Pub Date : 2026-06-01 Epub Date: 2026-06-30 DOI: 10.1016/j.prenap.2026.100672
Mouhamadou Thiam, Rokhyatou Seck, Ndèye Fatim Fall, Charlot Diatta, Oumar Sambou, Fatimata Seydy Ball, Mamadou Fodé Camara, El Hadji Dione, Faty Keita, Yancouba Cheikh Diedhiou, Abdoulaye Gassama, Guata Yoro Sy
{"title":"Analgesic Mechanism of Action of Structural Analogues of 4-Aminopiperidine Phenoxy-Derivatives","authors":"Mouhamadou Thiam, Rokhyatou Seck, Ndèye Fatim Fall, Charlot Diatta, Oumar Sambou, Fatimata Seydy Ball, Mamadou Fodé Camara, El Hadji Dione, Faty Keita, Yancouba Cheikh Diedhiou, Abdoulaye Gassama, Guata Yoro Sy","doi":"10.1016/j.prenap.2026.100672","DOIUrl":"10.1016/j.prenap.2026.100672","url":null,"abstract":"","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"11 ","pages":"Article 100672"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148565633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The anti-inflammatory and pro-resolving effects of the indigenous South African medicinal plant Warburgia salutaris (G. Bertol.) Chiov 南非本土药用植物白杨的抗炎和促溶作用（G. Bertol.）Chiov
Pharmacological Research - Natural Products Pub Date : 2026-06-01 Epub Date: 2026-06-30 DOI: 10.1016/j.prenap.2026.100623
Gugulethu Philadelphia Khumalo
{"title":"The anti-inflammatory and pro-resolving effects of the indigenous South African medicinal plant Warburgia salutaris (G. Bertol.) Chiov","authors":"Gugulethu Philadelphia Khumalo","doi":"10.1016/j.prenap.2026.100623","DOIUrl":"10.1016/j.prenap.2026.100623","url":null,"abstract":"","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"11 ","pages":"Article 100623"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148566108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the antihyperglycemic effect of Voacanga africana in experimental models of acute hyperglycemia and type 2 diabetes in rats. 非洲核桃对大鼠急性高血糖和2型糖尿病模型的降糖作用评价。
Pharmacological Research - Natural Products Pub Date : 2026-06-01 Epub Date: 2026-06-30 DOI: 10.1016/j.prenap.2026.100645
Salimata Diagne HOUNDJO, Alhadj Mahamat MOUSTAPHA, Madieye SENE
{"title":"Evaluation of the antihyperglycemic effect of Voacanga africana in experimental models of acute hyperglycemia and type 2 diabetes in rats.","authors":"Salimata Diagne HOUNDJO, Alhadj Mahamat MOUSTAPHA, Madieye SENE","doi":"10.1016/j.prenap.2026.100645","DOIUrl":"10.1016/j.prenap.2026.100645","url":null,"abstract":"","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"11 ","pages":"Article 100645"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148566135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antioxidant and anti-inflammatory activities of the hydroethanolic extract of the leaves of Launaea taraxacifolia (Willd) Amin ex C. Jeffrey and its role in the inhibition of atherosclerosis taraxacifolia (Willd) Amin ex C. Jeffrey叶水乙醇提取物的抗氧化、抗炎活性及其对动脉粥样硬化的抑制作用
Pharmacological Research - Natural Products Pub Date : 2026-06-01 Epub Date: 2026-06-30 DOI: 10.1016/j.prenap.2026.100644
KOUKOUI Omédine *, BETIRA Mansouratou, AMAGBEGNON Jean-Baptiste, VIANOU Bertin, SETON Santorin, AUBOUY Agnès
{"title":"Antioxidant and anti-inflammatory activities of the hydroethanolic extract of the leaves of Launaea taraxacifolia (Willd) Amin ex C. Jeffrey and its role in the inhibition of atherosclerosis","authors":"KOUKOUI Omédine *, BETIRA Mansouratou, AMAGBEGNON Jean-Baptiste, VIANOU Bertin, SETON Santorin, AUBOUY Agnès","doi":"10.1016/j.prenap.2026.100644","DOIUrl":"10.1016/j.prenap.2026.100644","url":null,"abstract":"","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"11 ","pages":"Article 100644"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148566134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antihyperglycemic activity and hypoglycemic risk of “Diabetes free”, a remedy from an Ivorian traditional practitioner with antidiabetic aims 抗高血糖活性和“无糖尿病”的低血糖风险，这是科特迪瓦传统医生以抗糖尿病为目的的一种治疗方法
Pharmacological Research - Natural Products Pub Date : 2026-06-01 Epub Date: 2026-06-30 DOI: 10.1016/j.prenap.2026.100625
Effo KE, Vodi M, Amichia M, Silué GA, Adehouni YA, Kouakou SL, Djadji ATL, Irié-N’Guessan AG, Kouakou-Siransy NG
{"title":"Antihyperglycemic activity and hypoglycemic risk of “Diabetes free”, a remedy from an Ivorian traditional practitioner with antidiabetic aims","authors":"Effo KE, Vodi M, Amichia M, Silué GA, Adehouni YA, Kouakou SL, Djadji ATL, Irié-N’Guessan AG, Kouakou-Siransy NG","doi":"10.1016/j.prenap.2026.100625","DOIUrl":"10.1016/j.prenap.2026.100625","url":null,"abstract":"","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"11 ","pages":"Article 100625"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148572198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antifungal Properties of Abnormal Cannabinoid Derivatives: Disruption of Biofilm Formation and Gene Expression in Candida Species 异常大麻素衍生物的抗真菌特性：假丝酵母物种生物膜形成和基因表达的破坏
Pharmacological Research - Natural Products Pub Date : 2026-06-01 Epub Date: 2026-06-30 DOI: 10.1016/j.prenap.2026.100701
Prince Ofori, Ronit Vogt Sionov, Doron Steinberg, Raphael Mechoulam, Natalya Kogan, Francesca Levi-Schaffer
{"title":"Antifungal Properties of Abnormal Cannabinoid Derivatives: Disruption of Biofilm Formation and Gene Expression in Candida Species","authors":"Prince Ofori, Ronit Vogt Sionov, Doron Steinberg, Raphael Mechoulam, Natalya Kogan, Francesca Levi-Schaffer","doi":"10.1016/j.prenap.2026.100701","DOIUrl":"10.1016/j.prenap.2026.100701","url":null,"abstract":"","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"11 ","pages":"Article 100701"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148573133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From Tradition to Therapy: Guinean Plants and Prostate Diseases 从传统到治疗：几内亚植物和前列腺疾病
Pharmacological Research - Natural Products Pub Date : 2026-06-01 Epub Date: 2026-06-30 DOI: 10.1016/j.prenap.2026.100631
Tanou Valdez Bah *, Véronique Mégalizzi, Séré Diané, Mohamed Kerfalla Camara, Elhadj Saidou Baldé
{"title":"From Tradition to Therapy: Guinean Plants and Prostate Diseases","authors":"Tanou Valdez Bah *, Véronique Mégalizzi, Séré Diané, Mohamed Kerfalla Camara, Elhadj Saidou Baldé","doi":"10.1016/j.prenap.2026.100631","DOIUrl":"10.1016/j.prenap.2026.100631","url":null,"abstract":"","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"11 ","pages":"Article 100631"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148573306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metformin ameliorates bleomycin-induced pulmonary fibrosis by inhibiting autophagy in fibroblast-myofibroblast differentiation via AMPK/FoxO3a pathway 二甲双胍通过AMPK/FoxO3a通路抑制成纤维细胞-肌成纤维细胞分化的自噬，改善博来霉素诱导的肺纤维化
Pharmacological Research - Natural Products Pub Date : 2026-06-01 Epub Date: 2026-06-30 DOI: 10.1016/j.prenap.2026.100654
Hongliang Dong, Minghan Cheng, Qingxu Ha, Jian Gao
{"title":"Metformin ameliorates bleomycin-induced pulmonary fibrosis by inhibiting autophagy in fibroblast-myofibroblast differentiation via AMPK/FoxO3a pathway","authors":"Hongliang Dong, Minghan Cheng, Qingxu Ha, Jian Gao","doi":"10.1016/j.prenap.2026.100654","DOIUrl":"10.1016/j.prenap.2026.100654","url":null,"abstract":"","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"11 ","pages":"Article 100654"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148573418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
LW-AFC protects against neurological and neuropsychiatric effects of SARS- CoV-2 spike protein in mice LW-AFC保护小鼠免受SARS- CoV-2刺突蛋白的神经和神经精神影响
Pharmacological Research - Natural Products Pub Date : 2026-06-01 Epub Date: 2026-06-30 DOI: 10.1016/j.prenap.2026.100628
Ning Jiang
{"title":"LW-AFC protects against neurological and neuropsychiatric effects of SARS- CoV-2 spike protein in mice","authors":"Ning Jiang","doi":"10.1016/j.prenap.2026.100628","DOIUrl":"10.1016/j.prenap.2026.100628","url":null,"abstract":"","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"11 ","pages":"Article 100628"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148582773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis, characterization and pharmacological evaluation of gossypetin encapsulated silk fibroin nanoparticles for colorectal cancer therapy 用于结直肠癌治疗的棉sypetin包封丝素纳米颗粒的合成、表征及药理评价
Pharmacological Research - Natural Products Pub Date : 2026-06-01 Epub Date: 2026-06-03 DOI: 10.1016/j.prenap.2026.100785
Muthulakshmi Muthumanickam , Rameshthangam Palanivel
{"title":"Synthesis, characterization and pharmacological evaluation of gossypetin encapsulated silk fibroin nanoparticles for colorectal cancer therapy","authors":"Muthulakshmi Muthumanickam ,&nbsp;Rameshthangam Palanivel","doi":"10.1016/j.prenap.2026.100785","DOIUrl":"10.1016/j.prenap.2026.100785","url":null,"abstract":"<div><div>Gossypetin is a well-known bioflavonoid that shows several therapeutic applications. However, due to its slow rate of dissolution, high intestinal metabolism, and limited solubility in water, it has a low bioavailability throughout treatment. Due of its large surface area and compact size, nanocarriers such as biopolymer nanoparticles have been the focus of studies aimed at increasing the therapeutic efficiency of gossypetin. The silkworm, <em>Bombyx mori,</em> produces silk fibroin, a biologically compatible, biodegradable material with amphiphilic chemistry and strong mechanical properties that makes it a viable option for a controlled-releasing drug delivery system. This study explored the potential of G-SNPs by the desolvation method and was characterized via DLS, FTIR as well as TGA. MTT assay has been employed to cytotoxicity, while Western blot analysis and fluorescence-based labeling verified apoptotic cell death. The investigation demonstrates that the 148 nm sized G-SNPs nanoparticles have good encapsulation efficiency. Spectrophotometric investigation indicated efficient drug release control and encapsulation. Findings of the cytotoxicity experiment demonstrated the promising anticancer potential of G-SNPs against colorectal cancer cells. Western blot analysis and fluorescence-based labeling were used to validate apoptosis, and they also showed alterations in the expression of the proteins Bax and Bcl-2. In summary, gossypetin-loaded silk fibroin nanoparticles serve as a biodegradable as well as biocompatible delivery technology that could potentially be utilized for the treatment of colorectal cancer cells.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"11 ","pages":"Article 100785"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148241174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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