Pharmacological Research - Natural Products最新文献

{"title":"Anti-inflammatory and antioxidant potentials of ethanol extract of Hymenodictyon pachyantha leaves: An in vitro and in silico study","authors":"Emmanuel Chiagozie Aham ,&nbsp;Stephen Chukwubuikem Nnemolisa ,&nbsp;Olamide Esther Asaluwala ,&nbsp;Ogechukwu Colet Okeke ,&nbsp;Michael Chinedu Chukwu ,&nbsp;Ernest Chinemerem Nkagbu ,&nbsp;Casmir Chima Uzoefuna ,&nbsp;Innocent Uzochukwu Okagu","doi":"10.1016/j.prenap.2025.100353","DOIUrl":"10.1016/j.prenap.2025.100353","url":null,"abstract":"<div><h3>Background</h3><div>The side effects of existing anti-inflammatory drugs have spurred the quest for safer and more effective anti-inflammatory agents. Medicinal plants used in folk medicine for inflammation-related conditions, such as <em>Hymenodictyon pachyantha</em> K.Krause, are increasingly recognized as potential sources of anti-inflammatory candidates.</div></div><div><h3>Aim</h3><div>To investigate the anti-inflammatory and radical-scavenging activities of the <em>H. pachyantha</em> leaves ethanol extract (EEHP) using <em>in vitro</em> and <em>in silico</em> techniques.</div></div><div><h3>Methodology</h3><div>Gas chromatography-flame ionization detector was used to characterize the bioactive components of EEHP, while 2,2′-azinobis(3-ethylbenz-thiazoline-6-sulfonic acid (ABTS) and hydrogen peroxide (H₂O₂) scavenging assays were used to evaluate the antioxidant potential. The inhibition of the anti-inflammatory activities was evaluated via cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) activities. <em>In silico</em> techniques were used to understand the mechanism of action against COX-2, 5-LOX, and phospholipase A2 (PLA2) and the drug-like properties of EEHP’s phytoconstituents.</div></div><div><h3>Results</h3><div>EEHP scavenged 74.40 % and 70.72 % of ABTS and H₂O₂-radicals, respectively, compared with 86.28 % and 72.31 %, respectively, by reference antioxidant (ascorbic acid). EEHP inhibited COX-2 (IC₅₀ = 0.65 mg/ml) and 5-LOX (IC₅₀ = 0.38 mg/ml) activities. Lunamarine, kaempferol, anthocyanin, and flavan-3-ol identified in EEHP were shown to inhibit COX-2 by interacting with Phe518, Arg120, Ala527, Leu352, Tyr385, Trp387, Leu384, Phe381, and Leu384), 5-LOX by interacting with Arg246 and Val243, and PLA2 by interacting with Asp49, Gly30, Gly32, Gly53, and Leu130 amino acids crucial for activities.</div></div><div><h3>Conclusion</h3><div>Our data suggest that <em>H. pachyantha</em> is a reservoir of phytochemicals with anti-inflammatory and antioxidant properties and a potential resource in developing new candidates for inflammation-related conditions.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100353"},"PeriodicalIF":0.0,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144903385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zea mays L.: Nature’s Pharmacy hidden in a cereal crop","authors":"Rajeshwari S. ,&nbsp;Suresh Joghee ,&nbsp;Erica Alves ,&nbsp;Gurupadayya Bannimath ,&nbsp;Aishwarya Susil ,&nbsp;Haritha Harindaranath ,&nbsp;Archana Pilli ,&nbsp;BR Prashantha Kumar ,&nbsp;Abu Safana Biswas ,&nbsp;Pooja G. Achar","doi":"10.1016/j.prenap.2025.100351","DOIUrl":"10.1016/j.prenap.2025.100351","url":null,"abstract":"<div><div><em>Zea mays L</em>. (maize) is not only one of the world’s most extensively cultivated cereal crops but also a reservoir of pharmacologically active compounds with significant therapeutic potential. This review consolidates current knowledge on the diverse phytochemical constituents of maize—including polyphenols, phenolic acids (notably ferulic and p-coumaric acid), flavonoids, carotenoids, sterols, and tannins—distributed across its anatomical parts. Ferulic acid, a key secondary metabolite, biosynthesized via the phenylpropanoid pathway, exhibits broad-spectrum bioactivity including antioxidant, anti-inflammatory, antidiabetic, and anticancer effects. In addition, underexplored maize components such as corn silk, roots, bracts, and cobs demonstrate promising pharmacological actions including hepatoprotective, diuretic, neuroprotective, and cardioprotective effects. Recent advances in extraction technologies and molecular modeling techniques (e.g., docking, network pharmacology) have enhanced understanding of the mechanisms underlying these activities. By systematically evaluating maize phytochemicals and their functional implications, this review provides a strategic framework for the future development of maize-derived nutraceuticals, phytopharmaceuticals, and functional food products, potentially transforming this staple crop into a globally relevant therapeutic agent.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100351"},"PeriodicalIF":0.0,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144903386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro analysis of antioxidant capacity of Bauhinia variegata (L.) Benth leaf extract","authors":"Sonu Ambwani,&nbsp;Priya Chand,&nbsp;Sampat Kumar Kumawat,&nbsp;Himani Singh,&nbsp;Deepak Koranga","doi":"10.1016/j.prenap.2025.100350","DOIUrl":"10.1016/j.prenap.2025.100350","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Bauhinia variegata</em> (L.) Benth, belonging to the Fabaceae family and renowned for its medicinal value, is recognized for its anti-tumor, anti-inflammatory, anti-diabetic and antioxidant properties. Additionally, it is used in indegenous delicacies and as livestock fodder. This research focused on evaluating the <em>in vitro</em> antioxidant capacity of <em>Bauhinia variegata</em> leaf extract using chicken splenocyte culture system.</div></div><div><h3>Methods</h3><div>The fifty percent hydromethanolic leaves extract of <em>Bauhinia variegata</em> (BVE) was prepared and Fourier Transform Infrared spectroscopy (FTIR) was conducted to find out presence of various functional groups. BVE was subjected to GC-MS and LC-MS analyses along with various qualitative, quantitative and antioxidant biochemical assays to detect the presence of phytochemicals and to assess its antioxidative potential. The maximum non-cytotoxic dose of BVE was utilized for <em>in vitro</em> exposure of chicken splenocytes to evaluate its effect on cellular antioxidant status through assays measuring lipid peroxidation (LPO), reduced glutathione (GSH), superoxide dismutase (SOD) and nitric oxide (NO).</div></div><div><h3>Results</h3><div>FTIR analysis detected presence of hydroxyl (O-H), alkane (C-H), carbonyl (C<img>O), aromatic (C<img>C stretching) functional groups in BVE. GC-MS revealed presence of 38 compounds whereas LC-MS displayed 25 and 26 compounds in positive and negative mode ionization analysis, respectively. Significant antioxidant potential was observed through all the <em>in vitro</em> antioxidant assays conducted on BVE, <em>viz</em>., total antioxidative capacity assay, reducing power capacity assay, nitric oxide scavenging assay, DPPH assay, metal ion chelating activity, ferrous reducing antioxidant power activity and hydroxyl radical scavenging activity. It’s <em>in vitro</em> exposure to chicken splenocytes reveled improved antioxidant status of the cells as compared to control cells.</div></div><div><h3>Conclusions</h3><div>This study displayed significant antioxidant potential of BVE that could be responsible for its medicinal properties. However, scientific validation using suitable <em>in vitro</em>/ <em>in vivo</em> analyses are required before utilizing this plant bioresource for specific purpose.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100350"},"PeriodicalIF":0.0,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144893227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoration of silver nanoparticles over Galphimia gracilis leaves extract and assessment of their antioxidant properties","authors":"Narasimha Raghavendra ,&nbsp;Soukhyarani Gopal Nayak ,&nbsp;Kirti T. Bandiwaddar ,&nbsp;Divya Kulkarni","doi":"10.1016/j.prenap.2025.100348","DOIUrl":"10.1016/j.prenap.2025.100348","url":null,"abstract":"<div><div>This study used a green method to create stable and biocompatible <em>Galphimia gracilis</em> leaves extract-silver nanoparticles (GGLE-AgNPs) by using nontoxic plant extract molecules. The presence of several different components, including as polyphenols, flavonoids, saponins, and tannins was confirmed by the qualitative phytochemical analysis of GGLE. These substances are essential for reducing and capping AgNPs. Uv-visible, FT-IR, optical profilometer, particle size and zeta potential analysis have all been used to describe the shape, size and stability of the produced GGLE-AgNPs. Computational studies by DFT and MC simulation was used to study the interaction between the silver cations and plant extract species. The synthesis of GGLE-AgNPs involved the use of several functional groups of the organic compounds found in GGLE as reducing, capping, and stabilizing agents, according to FT-IR studies. The average particle diameter of the generated GGLE-AgNPs is 328 nm and the zeta potential verified the stability of the GGLE-AgNPs. Spherical, polydispersed AgNPs with a high roughness value was detected by optical profilometer imaging. Antioxidant properties were screened by the DPPH (2,2-diphenyl-1-picrylhydrazyl) and hydrogen peroxide (H₂O₂) method. The antioxidant property's EC50 value was also determined in this investigation. As determined by the DPPH and H₂O₂ method, the samples' antioxidant potential was evaluated. The GGLE showed EC50 values of roughly 90.78 ± 0.09 µg/ml and 116.75 ± 0.15 µg/ml, respectively. In contrast, the GGLE-AgNPs showed higher activity, with EC50 values of 78.37 ± 0.11 µg/ml and 85.42 ± 0.13 µg/ml, respectively.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100348"},"PeriodicalIF":0.0,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144887115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extraction of chitosan from cuttlebone waste of Sepia kobiensis (Hoyle 1885), conversion and anticoagulant property of its sulfated derivative","authors":"Karthik Rajkumar ,&nbsp;Yagniyasree Manogaran ,&nbsp;Pasiyappazham Ramasamy","doi":"10.1016/j.prenap.2025.100349","DOIUrl":"10.1016/j.prenap.2025.100349","url":null,"abstract":"<div><div>Sulfated polysaccharides from marine creatures have received a lot of interest for their many biological activities, especially their anticoagulant characteristics. This study aims to extract sulfated polysaccharides from <em>Sepia kobiensis</em> cuttlebone waste and assess their ability to suppress blood clot formation. Polysaccharides were successfully extracted and purified from <em>Sepia kobiensis</em> cuttlebone waste using a well-established and standardized technique that ensured consistency and dependability in yield and composition. Chemical sulfation was used to increase the anticoagulant activity of the isolated polysaccharides. Advanced analytical approaches were used for structural characterisation, such as Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), and Scanning Electron Microscopy (SEM). In vitro tests, such as activated partial thromboplastin time (APTT), prothrombin time (PT) and thromboplastin time (TT), showed that sulfated polysaccharides dramatically delayed clotting durations when compared to Heparin. The extracted sulfated polysaccharides, in particular, demonstrated dose-dependent anticoagulant action, with APTT, PT, and TT values equivalent to or slightly lower than heparin. These findings demonstrate the intrinsic anticoagulant effects of sulfated polysaccharides produced from cuttlebone waste. This work indicates the feasibility of using <em>Sepia kobiensis</em> cuttlebone waste as a source of physiologically active sulfated polysaccharides, encouraging both sustainable waste management and the discovery of novel anticoagulants.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100349"},"PeriodicalIF":0.0,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144878921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plant-derived nanoparticles as anti-diabetic agents: Exploring mechanisms and therapeutic applications","authors":"Prachi Tiwari ,&nbsp;Suhana Malik ,&nbsp;Anuradha Singhaniya ,&nbsp;Chandrababu Rejeeth","doi":"10.1016/j.prenap.2025.100346","DOIUrl":"10.1016/j.prenap.2025.100346","url":null,"abstract":"<div><div>Diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose levels, primarily due to insufficient insulin secretion or the body’s inability to respond effectively to insulin produced by pancreatic cells. Diabetes is a major global health concern, with its associated complications contributing significantly to mortality worldwide. Nanotechnology is rapidly advancing in pharmaceutical sciences, offering enhanced drug efficacy through targeted delivery mechanisms. Plant-derived nanoparticles, synthesized using bioactive phytochemicals such as flavonoids, alkaloids, saponins, tannins, and terpenoids, exhibit promising regulatory potential with minimal side effects. This review highlights the reported anti-diabetic efficacy of metallic and biopolymeric nanoparticles including silver, gold, zinc oxide, copper, selenium, iron oxide, and chitosan biosynthesized via green nanotechnological approaches. These nano-bioactive agents modulate therapeutic targets such as pancreatic α-amylase, intestinal α-glucosidase, insulin signaling, and glucose uptake across various <em>in vitro</em> and <em>in vivo</em> models. The integration of nanotechnology with phytomedicine opens avenues for identifying novel therapeutic candidates and improving diabetes management strategies.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100346"},"PeriodicalIF":0.0,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144887114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mimosine: A multifaceted non-protein amino acid with potent anticancer potential across diverse malignancies","authors":"Khalid Imtiyaz ,&nbsp;Mohsin Shafi ,&nbsp;Beenish Mirza ,&nbsp;M. Moshahid Alam Rizvi","doi":"10.1016/j.prenap.2025.100347","DOIUrl":"10.1016/j.prenap.2025.100347","url":null,"abstract":"<div><div>Mimosine, a non-protein amino acid found in <em>Mimosa pudica</em> and <em>Leucaena</em> species, exhibits potent anticancer properties across various malignancies, including glioma, breast, melanoma, cervical, hepatocellular, prostate, pancreatic, osteosarcoma, leukemia, lymphoma, and lung cancers. Structurally similar to tyrosine, mimosine inhibits tyrosinase and acts as an iron chelator, disrupting critical cellular processes such as DNA synthesis and cell cycle progression. Its primary mechanism involves inducing apoptosis via the intrinsic mitochondrial pathway, driven by reactive oxygen species (ROS) generation, which activates caspase-9 and caspase-3, leading to programmed cell death. Mimosine also induces G0/G1 phase cell cycle arrest by upregulating cyclin-dependent kinase inhibitors (p21, p27) and downregulating cyclins (D1, A, E) and CDKs, mediated through HIF-1α stabilization and Myc suppression. Its iron-chelating activity inhibits ribonucleotide reductase, stalling DNA replication and causing double-strand breaks. Additionally, mimosine modulates signaling pathways, including MAPK (p38, JNK) and NF-κB, and regulates tumor suppressor genes like NDRG1 and Btg2, enhancing its anti-proliferative and anti-metastatic effects. In specific cancers, such as breast (MCF-7) and cervical (HeLa), mimosine exhibits context-dependent effects, including estrogenic activity or selective translation regulation. Despite challenges in cell permeability, advances in peptide synthesis and click chemistry offer promise for enhancing mimosine’s therapeutic potential. Its multifaceted mechanisms, including ROS-mediated apoptosis, cell cycle arrest, and enzyme inhibition, position mimosine as a promising candidate for developing novel anticancer therapies.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100347"},"PeriodicalIF":0.0,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144890087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical composition and pharmacological benefits of Majuphal","authors":"Anil Kumar Vadaga,&nbsp;Sai Shashank Gudla,&nbsp;Suchitra Poritigadda,&nbsp;Dipayan Debnath,&nbsp;Sri Latha Hanumanthu,&nbsp;Venkata Harini Gudala,&nbsp;Jyothi Doddipatla","doi":"10.1016/j.prenap.2025.100342","DOIUrl":"10.1016/j.prenap.2025.100342","url":null,"abstract":"<div><div><em>Quercus infectoria</em> galls, traditionally known as Manjakani, have been extensively used in Ayurveda and Unani medicine for centuries due to their potent therapeutic properties. Rich in bioactive compounds particularly tannins (up to 70 %), flavonoids, gallic acid, and ellagic acid these galls exhibit a broad spectrum of pharmacological activities. They are widely recognized for their anti-inflammatory, antimicrobial, antioxidant, and astringent effects. Traditionally employed in the treatment of gastrointestinal disorders, wound healing, and women’s reproductive health (especially postpartum care), <em>Q. infectoria</em> galls have recently gained scientific validation for additional therapeutic benefits.</div><div>Modern pharmacological studies highlight their efficacy in managing diabetes, arthritis, and fungal infections. Their anti-diabetic action is primarily attributed to the inhibition of key enzymes such as α-amylase and α-glucosidase, aiding in the regulation of glucose and lipid metabolism. Furthermore, the galls demonstrate neuroprotective, cardioprotective, hepatoprotective, and anticancer properties exerting effects through mechanisms such as apoptosis induction and inhibition of tumor-associated pathways. This review explores the phytochemical profile and diverse pharmacological actions of <em>Quercus infectoria</em> galls, emphasizing their potential as a natural therapeutic agent in both traditional and modern medicine.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100342"},"PeriodicalIF":0.0,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144878920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic approaches using natural substances on the thioacetamide-induced animal model of acute liver failure: UHPLC analysis, biochemical and histopathological studies","authors":"Hanane El Fatimi ,&nbsp;Bilal El-Mansoury ,&nbsp;Naima Fdil ,&nbsp;Maroua Ait Tastift ,&nbsp;Soukaina Ouhaddou ,&nbsp;Karima Lafhal ,&nbsp;Lahcen Tamegart ,&nbsp;Sabir Es-said ,&nbsp;Aicha Ezoubeiri ,&nbsp;Halima Gamrani ,&nbsp;Abdelaati El Khiat","doi":"10.1016/j.prenap.2025.100345","DOIUrl":"10.1016/j.prenap.2025.100345","url":null,"abstract":"<div><div>The present study aimed to evaluate the possible preventive and therapeutic effects of Ononis natrix L. against thioacetamide (TAA, 200 mg/kg BW)-induced acute liver failure in rats. The therapeutic effect on liver failure was assessed by intragastric administration of Ononis natrix extract in a model of thioacetamide (TAA)-induced liver failure for 11 days of treatment. Subsequently, liver function was evaluated through biochemical analysis, complemented by morphometric assessments and histopathological examination of hepatic tissue. Our results showed that TAA administration in rats led to exacerbated and impaired liver function, accompanied by alterations in the liver weight ratio. However, pretreatment with the crude extract of Ononis natrix significantly restored the biochemical parameters, normalized the liver weight ratio, and ameliorated the histopathological damage induced by TAA.Therefore, Ononis natrix extract, particularly at a dose of 500 mg/kg body weight, can be considered a potent hepatoprotective agent that dose-dependently protects the liver against acute hepatotoxicity induced by TAA. To sum up, the oral administration of the hydro-ethanolic extract of Ononis natrix effectively prevents the biochemical and physiological alterations induced by TAA and restores the hepatic architecture in rats.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100345"},"PeriodicalIF":0.0,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144852247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review on cow ghee formulations anti-epileptic activity in in-vivo models","authors":"Nidhin M M ,&nbsp;Bharat Rathi","doi":"10.1016/j.prenap.2025.100343","DOIUrl":"10.1016/j.prenap.2025.100343","url":null,"abstract":"<div><h3>Introduction</h3><div>Consciousness disruptions and recurring seizures are hallmarks of epilepsy, a chronic neurological disorder. It shares similarities with the Ayurvedic notion of <em>Apasmara</em>, which is marked by intermittent unconsciousness, uncomfortable symptoms such frothy vomiting, and unusual body postures.</div><div>According to <em>Ayurveda</em>, <em>Ghrita</em> (Ghee), especially <em>Go Ghrita</em> (Cow Ghee), which is made from cow's milk, is a nutritious diet and medication with therapeutic benefits.<em>Go Ghrita</em> is extremely valuable, because of its ability to maintain the <em>Pitta</em> and <em>Vata Doshas</em> in balance and because of its lipophilic qualities, which allow it to pass through the blood-brain barrier for more targeted administration and absorption. The ‘<em>Rasayana’</em> characteristic of <em>Go Ghrita</em> implies that regular use may help lower the likelihood of epilepsy recurrence. <em>Ghrita</em> improves the medicinal qualities of pharmaceuticals when it is processed, which could make formulations using <em>Go Ghrita</em> more beneficial and effective for treating epilepsy.</div></div><div><h3>Aim</h3><div>To do A Systematic Review on Cow Ghee Formulations <em>(Go Ghrita kalpana</em>) Anti-Epileptic Activity in In-Vivo Models</div></div><div><h3>Methodology</h3><div>The systematic review exclusively included in-vivo animal research on the antiepileptic efficacy of Cow Ghee Formulations <em>(Go Ghrita kalpana)</em>. The study papers and journal studies were sourced from resources like PubMed, Science Direct, and Google Scholar. These databases serve as the foundation for the rapid review process's selection of research articles and journals.</div></div><div><h3>Result &amp; conclusion</h3><div>Thirty studies were discovered after 11 studies were chosen using the selection strategy. All of the studies that were chosen for the systematic review did so due to the noteworthy antiepileptic effects of different <em>Ghrita Kalpana</em>.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100343"},"PeriodicalIF":0.0,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144841360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}