Pharmacological Research - Natural Products最新文献

{"title":"Neuropharmacological activities of 7,11-dimethyl-3-methylidenedodeca-1,6,10-triene, isolated from Elephantopus scaber Linn.","authors":"Preeti Avasthi ,&nbsp;Sujata Kumari ,&nbsp;Sunil Dutt ,&nbsp;Devinder Kumar ,&nbsp;Pankaj Kalia ,&nbsp;Pooja Thakur ,&nbsp;Shardendu Kumar Mishra ,&nbsp;Anupam Singh ,&nbsp;Lal Bahadur Prasad ,&nbsp;Rajesh Kumar","doi":"10.1016/j.prenap.2026.100783","DOIUrl":"10.1016/j.prenap.2026.100783","url":null,"abstract":"<div><h3>Background</h3><div>7,11-Dimethyl-3-methylidenedodeca-1,6,10-triene (<strong>F1</strong>), a bioactive sesquiterpene isolated from <em>Elephantopus scaber Linn.</em>, exhibits diverse pharmacological activities. Studies report its potent anti-inflammatory and analgesic effects through inhibition of pro-inflammatory mediators and modulation of cytokine release.</div></div><div><h3>Purpose</h3><div>This study evaluated the neuropharmacological profile of <strong>F1</strong> (0.1–10 mg/kg, p. o.), including anxiolytic-like, anticonvulsant activities, and explored its mechanisms using calcium channel-ligand, Human GABA_A receptor alpha1-beta2-gamma2 subtype in complex with GABA plus flumazenil, Serotonin-bound Serotonin 1 A (5-HT_1A) receptor-Gi protein complex, and Human GABA_A receptor alpha1-beta2-gamma2 subtype in complex with GABA plus Zolpidem receptors.</div></div><div><h3>Method</h3><div>Behavioral assessments were conducted using the Maximal electroshock seizures (MES), Pentylenetetrazole (PTZ) induced convulsions, elevated plus maze, and open field test.</div></div><div><h3>Results</h3><div>Results demonstrated that <strong>F1</strong> induced anxiolytic-like effects only at the highest dose (10 mg/kg) in the elevated plus-maze, alongside anticonvulsant activity in pentylenetetrazole-induced seizure models suggesting GABAergic involvement.</div></div><div><h3>Conclusion</h3><div>The present study revealed that <strong>F1</strong> exerts significant anxiolytic-like activity at higher doses and displays notable anticonvulsant efficacy, particularly in pentylenetetrazole-induced seizure models.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"11 ","pages":"Article 100783"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148184054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health benefits of Salacia crassifolia (Bacupari do Cerrado) as a potential herbal medicine: A comprehensive review","authors":"Katherine Costa Mello Simões ,&nbsp;Jane Sélia dos Reis Coimbra ,&nbsp;Sérgio Henrique Sousa Santos","doi":"10.1016/j.prenap.2026.100781","DOIUrl":"10.1016/j.prenap.2026.100781","url":null,"abstract":"<div><div><em>Salacia crassifolia</em> (Mart. ex Schult.) G. Don is a native plant of the Brazilian Cerrado widely used in traditional medicine, particularly for metabolic disorders such as diabetes. This review aims to critically evaluate and integrate current knowledge on its ethnobotanical relevance, phytochemical composition, pharmacological activities, and underlying molecular mechanisms, while identifying limitations and research gaps. The species contains bioactive compounds including gallic acid, ascorbic acid, triterpenes, flavonoids, and polyphenols, which exhibit antioxidant, hypoglycaemic, anti-inflammatory, antiviral, and antitumour effects. <em>In vitro</em> and <em>in vivo</em> studies show that its extracts inhibit digestive enzymes such as α-glucosidase and α-amylase, aiding glycaemic control. They also suppress pro-inflammatory cytokines, including interleukin-1 beta (IL-1β) and tumor necrosis factor alpha (TNF-α), and enhance endogenous antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), thereby protecting against oxidative stress. These mechanisms support the traditional use of the plant and highlight its potential as a source for new phytotherapeutics. However, despite promising results in experimental models, further preclinical and clinical studies are necessary to confirm its efficacy and safety in humans. Moreover, given the ecological importance of the Cerrado and the risk of overexploitation, urgent strategies are required for the conservation and sustainable cultivation of <em>S. crassifolia</em> to ensure its future availability and responsible use in pharmaceutical and nutraceutical industries.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"11 ","pages":"Article 100781"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148184185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"UPLC-QToF-MS/MS analysis of root alkaloid fraction from Sida keralensis and its anti-inflammatory effects on LPS-induced RAW 264.7 cells","authors":"G. Ashwathy ,&nbsp;K. Krishnakumar","doi":"10.1016/j.prenap.2026.100782","DOIUrl":"10.1016/j.prenap.2026.100782","url":null,"abstract":"<div><h3>Background</h3><div>Chronic inflammation contributes to diseases like arthritis, cardiovascular disorders, and neurodegeneration. Plant-derived compounds offer a safer alternative to synthetic anti-inflammatory drugs. The present study investigated the anti-inflammatory potential of the root alkaloid fraction of <em>Sida keralensis</em> (RAFSK).</div></div><div><h3>Objective</h3><div>To evaluate the anti-inflammatory potential of the root alkaloid fraction from <em>S. keralensis</em> (RAFSK), enzymatic assays, gene expression study, and cytotoxicity testing in LPS-stimulated RAW 264.7 cells.</div></div><div><h3>Methods</h3><div>RAFSK was subjected to UPLC-QToF-MS/MS analysis for identification of alkaloids. Anti-inflammatory activity was assessed via protein denaturation, proteinase inhibition, inhibition of COX, LOX, MPO, iNOS, and evaluation cellular nitrite. Cytotoxicity was evaluated using the MTT assay. mRNA expression levels of TNF-α, IL-1β, IL-10, and SOCS3 were quantified to assess transcriptional modulation.</div></div><div><h3>Results</h3><div>Fourteen alkaloids were tentatively identified, including known compounds (like ephedrine, vasicinone, cryptolepine, among others) and seven new reports. In LPS-stimulated RAW 264.7 cells, RAFSK significantly inhibited protein denaturation, proteinase, and key inflammatory enzymes (COX, LOX, MPO, and iNOS) with inhibition percentages and IC₅₀ values comparable to those of the standard anti-inflammatory drug diclofenac sodium (p &lt; 0.05). Gene expression analysis showed a downregulation of TNF-α, IL-1β, and an upregulation of IL-10 and SOCS3 expression. Cell viability was observed to be above 80% for all tested concentrations, confirming its non-toxicity.</div></div><div><h3>Conclusion</h3><div>RAFSK exhibited significant anti-inflammatory activity by suppressing pro-inflammatory mediators and enhancing anti-inflammatory mediators, with minimal cytotoxicity. The presence of diverse alkaloids positions <em>S. keralensis</em> as a novel candidate for plant-based anti-inflammatory therapeutics.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"11 ","pages":"Article 100782"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148184129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tackling Non-Communicable Disease in Africa: Epidemiology, Prevention, and AI Solutions","authors":"Bamba Gaye,&nbsp;Pasquale Maffia","doi":"10.1016/j.prenap.2026.100707","DOIUrl":"10.1016/j.prenap.2026.100707","url":null,"abstract":"","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"11 ","pages":"Article 100707"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148565213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology And Antimycobacterial Potentials Of Selected Medicinal Plants In The Littoral Region Cameroon","authors":"Kouemo motse Dorgelesse Francine Antoinette","doi":"10.1016/j.prenap.2026.100704","DOIUrl":"10.1016/j.prenap.2026.100704","url":null,"abstract":"","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"11 ","pages":"Article 100704"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148565214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing phytomedicine development in Africa: insights from the Guinean experience","authors":"Elhadj Saidou BALDE","doi":"10.1016/j.prenap.2026.100710","DOIUrl":"10.1016/j.prenap.2026.100710","url":null,"abstract":"","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"11 ","pages":"Article 100710"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148565297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Combretum Micranthum G. Don as a supplement in the treatment of type 2 diabetes on the glycemic balance of patients","authors":"Maïmouna Touré,&nbsp;Alioune D. Fall,&nbsp;Safiétou Thiam,&nbsp;Abdoulaye Ba,&nbsp;Modou Oumy Kane,&nbsp;Abdoulaye Samb,&nbsp;Sidy M. Seck","doi":"10.1016/j.prenap.2026.100648","DOIUrl":"10.1016/j.prenap.2026.100648","url":null,"abstract":"","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"11 ","pages":"Article 100648"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148565869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aqueous extract of Fagara macropylla induced NO mediated endothelium- dependent relaxation and prevented angiotensin II-induced endothelial dysfunction in porcine coronary artery rings","authors":"N'guessan Alain Roland YAO,&nbsp;Hira Muzammel,&nbsp;Aka Bilé Miezan,&nbsp;Said Amissi,&nbsp;Yeboué Koffi François Kouakou,&nbsp;Mamadou Kamagaté,&nbsp;Valérie Schini-Kerth","doi":"10.1016/j.prenap.2026.100650","DOIUrl":"10.1016/j.prenap.2026.100650","url":null,"abstract":"","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"11 ","pages":"Article 100650"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148566007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diuretic activity of Piper umbellatum leaves aqueous extract involves muscarinic and cholinergic pathway on normal wistar rat","authors":"Akoua Jeanne Kanga,&nbsp;Kouao Augustin Amonkan,&nbsp;N’guessan Alain Yao *,&nbsp;Kacou Jules Marius Djetouan,&nbsp;Koffi Bruno Koko,&nbsp;Brou André Konan,&nbsp;Séraphin Kati-Coulibaly","doi":"10.1016/j.prenap.2026.100651","DOIUrl":"10.1016/j.prenap.2026.100651","url":null,"abstract":"","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"11 ","pages":"Article 100651"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148566008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethnobotanical study of agricultural weeds in the Kaolack region","authors":"Sega Waly Diop,&nbsp;Doudou Diop,&nbsp;Abou Sarr,&nbsp;Kandioura Noba","doi":"10.1016/j.prenap.2026.100700","DOIUrl":"10.1016/j.prenap.2026.100700","url":null,"abstract":"","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"11 ","pages":"Article 100700"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148573132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}