Biosynthesis of pectin and its vital role in the bioavailability of phytochemicals associated with therapeutic properties

Pharmacological Research - Natural Products Pub Date : 2025-03-25 DOI:10.1016/j.prenap.2025.100214

Venkatesh Kumar R., Devika Srivastava, Abhishek Verma, Akash Mishra

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Abstract

Pectin is a complex and multifunctional heteropolysaccharide that plays a significant role in various industries, including food, pharmaceuticals, and cosmetics. This review comprehensively explores the biosynthesis of pectin, highlighting its formation in plants and subsequent digestion in the form of fermentation, primarily through fermentation by the gut microbiome. Furthermore, the role of pectin in enhancing the bioavailability of plant-derived nutraceuticals is discussed, emphasizing its potential as a delivery vehicle for bioactive compounds. The paper also examines the wide-ranging biological activities of pectin, including its anticancer, antidiabetic, cardioprotective, hepatoprotective, neuroprotective, anti-inflammatory, and antioxidant properties. By integrating current research, this review provides a holistic understanding of pectin's multifaceted roles in human health, positioning it as a promising functional food ingredient and therapeutic agent.

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果胶的生物合成及其在与治疗特性相关的植物化学物质的生物利用度中的重要作用

果胶是一种复杂的多功能杂多糖，在食品、医药、化妆品等行业中发挥着重要作用。这篇综述全面探讨了果胶的生物合成，重点介绍了它在植物中的形成和随后以发酵的形式消化，主要是通过肠道微生物群的发酵。此外，讨论了果胶在提高植物源性营养保健品的生物利用度方面的作用，强调了果胶作为生物活性化合物递送载体的潜力。本文还研究了果胶广泛的生物活性，包括其抗癌、降糖、心脏保护、肝脏保护、神经保护、抗炎和抗氧化特性。通过整合目前的研究，本文综述了果胶在人类健康中的多方面作用，并将其定位为一种有前途的功能性食品成分和治疗剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Pharmacological Research - Natural Products

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