Pharmacological Research - Natural Products最新文献

{"title":"A leafy vegetable, Marsilea minuta L.: Review of ethnomedicine, phytochemistry, and pharmacological properties","authors":"Varsha Yadav ,&nbsp;Sinchan Das ,&nbsp;Souvik Mukherjee ,&nbsp;Altamash Khan ,&nbsp;Vivekananda Mandal ,&nbsp;Swaha Satpathy ,&nbsp;Manoj Goyal ,&nbsp;Arjun Patra","doi":"10.1016/j.prenap.2025.100263","DOIUrl":"10.1016/j.prenap.2025.100263","url":null,"abstract":"<div><h3>Introduction</h3><div>Medicinal plants have been a source of therapeutic agents for the treatment and management of various disease conditions in humans and animals. For research on natural products or medicinal plants, the most significant step is proper selection of a plant species. Furthermore, to carry out research in a specific direction, an extensive literature survey and finding the gap is unavoidable. A leafy vegetable, <em>Marsilea minuta</em> L. has been traditionally used for treating different diseases.</div></div><div><h3>Methodology</h3><div>Literature available in Scopus database was retrieved by using the keyword: <em>Marsilea minuta</em> and all documents were downloaded, screened and considered the traditional uses, phytochemistry and pharmacological activities. In this review, we have compiled the traditional uses, phytochemistry and pharmacological activities of <em>M. minuta</em>. We have also analyzed all the documents and presented some bibliometric research scenario on this plant species.</div></div><div><h3>Results</h3><div>Traditionally the plant is used in diseases of nervous, digestive, respiratory and cardiovascular system. It is also employed in diabetes, migraine, body pain, insomnia and cough. The major chemical compounds identified in the plant include flavonoids such as quercetin-3-O-glucoside, kaempferol-3-O-glucoside, quercetin-3-O-galactoside, chalcone-3-O-glucoside, quercetin-3-rutinoside, and naringenin-7-O-glucoside; and phenolic acids like gallic acid, caffeic acid, 4-hydroxy-3-methoxy benzoic acid, p-coumaric acid, m-coumaric acid, chromatoropic acid, vanillic acid, syringic acid, ferulic acid, and chlorogenic acid. The plant showed antidepressant, anxiolytic, hepatoprotective, antitussive, antioxidant, antimicrobial, anti-aggressive, antipyretic and analgesic activities. The leafy vegetable contains different bioactive compounds, which might be responsible for biological activities. The plant species could be developed as a nutraceutical.</div></div><div><h3>Conclusion</h3><div>This collection and collation of information confirms the potential of <em>M. minuta</em> as a drug candidate and would be helpful for researchers to further explore this plant species.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"7 ","pages":"Article 100263"},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144168287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the multifaceted wound healing potential of Grewia asiatica leaf extracts in incision, excision and cotton pellet models","authors":"Abhay Kumar Upadhyay,&nbsp;Shivangi Kumari,&nbsp;Tuhin Mukherjee,&nbsp;Nikita Nayak,&nbsp;Ravi Pratap Singh,&nbsp;Payel Mal,&nbsp;Satyajit Mohanty,&nbsp;Ashok Pattnaik","doi":"10.1016/j.prenap.2025.100258","DOIUrl":"10.1016/j.prenap.2025.100258","url":null,"abstract":"<div><h3>Background</h3><div>Wound healing therapy has advanced significantly as there is still no promising therapy to handle the intricacy of different wound types. This calls for the upbringing of agents with proper formulation for detailed wound healing.</div></div><div><h3>Objectives</h3><div>The aim of this study was to identify the appropriate solvent extract of <em>Grewia asiatica</em> (Linn) through a series of phytochemical analyses. Subsequently, the selected extract was incorporated into a suitable topical formulation (gel) and evaluated for its effectiveness as a wound-healing agent. The evaluation involved <em>in-vitro</em> and <em>in-vivo</em> modes using responsible enzymes and animal models (Swiss albino mice) to assess physical, biochemical, and histological parameters.</div></div><div><h3>Materials and methods</h3><div>In order to investigate the wound healing efficacy, various analyses were conducted including DPPH, ABTS, nitric oxide and hydrogen peroxide scavenging activity assays, estimation of total phenolic and flavonoid content, analgesic activity, and histopathology studies using excision, incision, and cotton pellet wound models. The Ethyl acetate extract was found to have the highest concentration of desirable phytochemicals and was therefore incorporated in <em>in-vivo</em> experiments. The percentage of wound contraction in mice and tensile strength were assessed in various wound models.</div></div><div><h3>Results</h3><div>The results of the study showed that the ethyl acetate fraction was found to be effective in suppressing DPPH, nitric oxide, and hydrogen peroxide when compared to ascorbic acid as standard. Additionally, when compared to the methanol and control groups, the group treated with ethyl acetate demonstrated the highest percentage of wound contraction and improved tensile strength. Morphological and histopathological examinations of the regenerated skin indicated a noticeable improvement in healing. These findings suggest that the formulated gel has significant wound-healing properties.</div></div><div><h3>Conclusion</h3><div>The plant was selected primarily based on its traditional use in folklore medicine. The traditional use was scientifically validated through a series of successful in vitro and in vivo experiments, which established the plant's potent anti-oxidant and skin regeneration capacity. These findings strongly suggest that the plant has significant wound-healing activity.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"7 ","pages":"Article 100258"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vivo antibacterial activities of aqueous stem bark extract of Ficus abutilifolia (Miq) in mice experimentally infected with Salmonella typhi","authors":"Usman Ahmad ,&nbsp;Nura Salisu ,&nbsp;Patricia Ishaku Kobo ,&nbsp;Hindatu Yusuf ,&nbsp;Ibrahim Sham’un Eshi ,&nbsp;Dahiru Sani","doi":"10.1016/j.prenap.2025.100262","DOIUrl":"10.1016/j.prenap.2025.100262","url":null,"abstract":"<div><div>Traditional medicine practitioners use <em>Ficus abutilifolia</em> to treat typhoid fever, chronic dysentery, and infertility. This study evaluated the antibacterial efficacy of aqueous stem bark extract of <em>Ficus abutilifolia</em> in Swiss albino mice experimentally infected with <em>Salmonella typhi</em>. Following plant identification, the stem bark extract was prepared using aqueous maceration and evaporation. Thirty mice were challenged with 1 ml containing 10³cfu/ml cells by gavage and randomly divided into six groups (n = 5). Mice in group I served as normal control, II as infected-untreated, III was treated with ciprofloxacin (14.3 mg/kg BW; positive control), IV, V, and VI were treated with oral gavage of stem bark extract at 100, 200 and 400 mg/kg, respectively, for seven consecutive days. Mean body weight and relative weight gain were calculated. Blood samples were collected for hematological examination and oxidative stress markers. The survival rate of the 400 mg/kg and ciprofloxacin-treated groups were 100 %. The 400 mg/kg-treated group exhibited the lowest bacterial load (p &lt; 0.05) at 5.33 ± 1.52 CFU/ml by day 7 in comparison to ciprofloxacin and other treatment groups. The highest weight gain (p &lt; 0.05) was recorded in 400 mg/kg (4.02 ± 0.01 g) in comparison to ciprofloxacin (2.67 ± 0.00 g). There was significant increase (p &lt; 0.05) in blood profiles, with the 400 mg/kg recording RBC of 8.57 ± 0.2510⁹/L, PCV of 51.00 ± 2.00 %, and Hb of 8.90 ± 0.85 g/dl. The ciprofloxacin-treated group had lower RBC (10.67 ± 0.15 ˣ10⁹/L) and WBC counts (5.07 ± 0.1510¹²/L) in comparison to the infected-untreated group. There was significant increased (p &lt; 0.05) glutathione peroxidase in 200 mg/kg (0.26 ± 0.01 U/L) and 400 mg/kg (0.26 ± 0.02 U/L) in comparison to ciprofloxacin (0.22 ± 0.01 U/L). The malondialdehyde level was significantly (p &lt; 0.05) elevated in the infected/untreated group (46.66 ± 1.47nMol/L) in comparison to ciprofloxacin (19.06 ± 1.86nMol/L) and 400 mg/kg (16.35 ± 1.08nMol/L). <em>Ficus abutilifolia</em> extract significantly reduced bacterial load, improved hematological indices, and enhanced antioxidant response, suggesting a potential immune-modulatory effect. Given ciprofloxacin resistance concerns, <em>Ficus abutilifolia</em> may serve as a promising alternative in typhoid management.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"7 ","pages":"Article 100262"},"PeriodicalIF":0.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144124127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuropharmacological, cytotoxic, and anthelmintic potentials of Lasia spinosa (L.) Thwaites rhizome: In vivo, in vitro, and computational approach","authors":"Mahathir Mohammad ,&nbsp;Md. Hossain Rasel ,&nbsp;Fahmida Tasnim Richi ,&nbsp;Md. Jahirul Islam Mamun ,&nbsp;Md. Ekramul Haque Ekram ,&nbsp;Sayed Al Hossain Rabbi ,&nbsp;Sakhaoyat Hossain ,&nbsp;Md. Amzad Hasan ,&nbsp;Md. Farhad Sarker ,&nbsp;Safaet Alam","doi":"10.1016/j.prenap.2025.100254","DOIUrl":"10.1016/j.prenap.2025.100254","url":null,"abstract":"<div><div><em>Lasia spinosa</em> (L.) Thwaites is a large herbaceous plant, belongs to the Araceae family with a creeping, spiky rhizome. The purpose of this study was to investigate <em>Lasia spinosa</em> rhizome methanolic extract (LSR-ME) for potential neuropharmacological, cytotoxic, and anthelmintic activities. On Swiss albino mice, the neuropharmacological activity was assessed using a range of bioactive assays. The cytotoxic effects were evaluated using the <em>in vitro</em> brine shrimp lethality assay. In addition, <em>Pheretima posthuma</em> was used for an <em>in vitro</em> anthelmintic test. Additionally, using a variety of online resources, molecular docking and admet SAR analysis were carried out to assess the potential of the mentioned phytochemicals. LSR-ME (400 mg/kg) substantially surpassed the control in the Elevated plus maze test, exhibiting anxiolytic activity (185.57 ± 1.79 s in open arms, p &lt; .001). In the hole board test, LSR-ME at 400 mg/kg dosage (40.33 ± 1.20) moderately increased head dipping behavior. At 400 mg/kg, LSR-ME induced significant transitions (9.33 ± 1.20) in the light-dark box test, suggesting anxiolytic behavior. Significant antidepressant efficacy is indicated by LSR-ME (400 mg/kg), which demonstrated reduced immobility time in the forced swimming and tail suspension tests (106.33 ± 6.23 s and 115 ± 4.58 s, respectively). Significant sedative activity was observed by LSR-ME (400 mg/kg) in the open field and hole cross tests, where there was a decrease in the number of movements (44.33 ± 1.20 and 7.33 ± 0.33, respectively). With an LC₅₀ value of 53.05 μg/mL, the extract demonstrated a substantial cytotoxic effect in the brine shrimp lethality assay. The extract exhibited anthelmintic activity as it killed <em>Pheretima posthuma</em> in 35.33 ± 2.31 minutes at 10 µg/mL, while standard albendazole took 24.67 ± 1.53 minutes at the same concentration. All of these findings are also verified by molecular docking experiments. In conclusion, as natural products like medicinal plants have been a source of new therapeutic applications, the extract may be a promising agent with neuropharmacological, cytotoxic, and anthelmintic activity and a possible target for drug discovery.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"7 ","pages":"Article 100254"},"PeriodicalIF":0.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144089275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytotoxic effects of herbal medicine: An overview of mechanistic pathways and clinical relevance","authors":"Deepika Bairagee ,&nbsp;Pankaj S. Patel ,&nbsp;Johee Pradhan ,&nbsp;Sunita Panchawat","doi":"10.1016/j.prenap.2025.100259","DOIUrl":"10.1016/j.prenap.2025.100259","url":null,"abstract":"<div><div>Herbal medicines have been used for centuries for their therapeutic benefits. However, the potential cytotoxic effects of certain herbal compounds pose significant safety concerns. This review explores the mechanistic pathways underlying the cytotoxicity of herbal medicines, the factors influencing these effects, and their clinical relevance. It also examines current research on identifying and mitigating these risks to improve the safety and efficacy of herbal therapeutics. The article highlights the need for comprehensive toxicological assessments and regulatory frameworks to balance the benefits and risks of traditional herbal products.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"7 ","pages":"Article 100259"},"PeriodicalIF":0.0,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lecaniodiscus cupanioides leaf extract attenuates Plasmodium berghei-induced malaria infection in albino mice via modulation of serum biochemical and hematological markers","authors":"Aderonke A. Aderinola ,&nbsp;Jane I. Ejiofor ,&nbsp;Luqman O. Ogunjimi ,&nbsp;Abdullahi A. Murtala ,&nbsp;Oyinloye E. Oladapo ,&nbsp;Farouk A. Oladoja","doi":"10.1016/j.prenap.2025.100257","DOIUrl":"10.1016/j.prenap.2025.100257","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Malaria has been among the predominant reasons for hospitalization and death in numerous tropical and/or subtropical African territories due to treatment failure resulting from the development of drug-resistant species of &lt;em&gt;Plasmodium falciparum&lt;/em&gt;, highlighting the need for alternative therapeutic approaches.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;The intent of this research was to explore the antiplasmodial efficacy of ethanol extract of the leaf of &lt;em&gt;Lecaniodiscus cupanioides&lt;/em&gt; in mice infected with &lt;em&gt;Plasmodium berghei&lt;/em&gt; having altered biochemical and/or hematological markers.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Method&lt;/h3&gt;&lt;div&gt;An acute toxicity study (LD50) of &lt;em&gt;Lecaniodiscus cupanioides&lt;/em&gt; leaf extracted with ethanol was conducted in 12 mice using Lorke’s methodology. Screening for phytochemicals and HPLC study of the leaf extract were also conducted. The leaf extract’s &lt;em&gt;in-vivo&lt;/em&gt; antimalarial activity against &lt;em&gt;Plasmodium berghei&lt;/em&gt; (NK65) strain was tested through a 4-day suppressive study, prophylactic test and curative test at 200, 400 and 800 mg/kg dosages.&lt;/div&gt;&lt;div&gt;Following a 7-day treatment period, five mice from the curative group were sacrificed under light ether, and their serum was utilized to evaluate liver enzymes, hematological markers, and inflammatory biomarkers associated with malaria severity.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;No deaths were observed at the maximum extract dose of 5000 mg/kg. Preliminary phytochemical screening and HPLC study of the leaf extract indicated the availability of biological constituents of pharmacological importance. The extract at all tested doses of 200, 400 and 800 mg/kg showed significant (&lt;em&gt;P ≤ 0.05&lt;/em&gt;) dose-dependent chemosuppressive effect, with percentage (%) chemosuppression of 73.79 % at 200 mg/kg, 81.55 % at 400 mg/kg and notable efficacy (84.65 %) at the 800 mg/kg dose in the Peters 4-day suppressive test. A significant (&lt;em&gt;P ≤ 0.05&lt;/em&gt;) dose-dependent reduction in the parasitaemia levels of the treated mice, with the 800 mg/kg dose displaying the highest antimalarial activity was produced in the curative study. The extract displayed dose-dependent prophylactic activity against the &lt;em&gt;P. berghei-&lt;/em&gt;induced parasitaemia in the mice, making 45.22 % and 61.34 % at 200 and 400 mg/kg, and the 800 mg/kg dose showing a highly significant effect (75.59 %). The group treated with chloroquine exhibited superior percentage (%) chemosuppression of 100 % in the suppressive, curative and prophylactic studies compared to the groups treated with &lt;em&gt;Lecaniodiscus cupanioides&lt;/em&gt; extract. For every administered dose, the extract successfully normalized aberrations in hematological markers, reduced elevated liver enzymes and mitigated inflammatory biomarkers induced by an infection &lt;em&gt;wi&lt;/em&gt;th &lt;em&gt;Plasmodium berghei&lt;/em&gt; in the mice.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;Results of this study validated the traditional usage of &lt;em&gt;Lecaniodis","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"7 ","pages":"Article 100257"},"PeriodicalIF":0.0,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the potential of herbal bioactives to treat acne: A perspective review","authors":"Pratibha Dhiwar ,&nbsp;Trilochan Satapathy ,&nbsp;Arun Kumar Sahu ,&nbsp;Nikita Patel","doi":"10.1016/j.prenap.2025.100260","DOIUrl":"10.1016/j.prenap.2025.100260","url":null,"abstract":"<div><div>Millions of individuals worldwide suffer from acne, a common skin ailment that is frequently caused by hormonal imbalance, bacterial infections, inflammation, and excessive sebum production. Despite their effectiveness, conventional therapies can result in antibiotic resistance and adverse consequences. The potential of herbal bioactive substances as an alternate therapeutic strategy for acne treatment is examined in this review. Numerous medicinal herbs those are high in antibacterial, anti-inflammatory, and antioxidant compounds have demonstrated potential in minimizing the symptoms of acne. Important bioactive from plants like tea tree, Aloe vera, and neem, containing flavonoids, alkaloids, and essential oils, have demonstrated strong anti-acne effects by regulating sebum production, preventing Propionibacterium acnes, and accelerating skin healing. In this review, the authors tried to explore the safety profile and therapeutic applications of potent herbal bioactives for the treatment of acne. The authors also expect that, the information containing in this review will pave the way and helpful for the researchers engaged in the field of acne and associated skin disorders.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"7 ","pages":"Article 100260"},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143942057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonanal inhibits growth and virulence factors in Candida albicans","authors":"Sayali A. Chougule ,&nbsp;Tanjila C. Gavandi ,&nbsp;Shivani B. Patil ,&nbsp;Sargun T. Basrani ,&nbsp;Deepak Sawant ,&nbsp;Shivanand R. Yankanchi ,&nbsp;Ashwini K. Jadhav ,&nbsp;Sankunny M. Karuppayil","doi":"10.1016/j.prenap.2025.100256","DOIUrl":"10.1016/j.prenap.2025.100256","url":null,"abstract":"<div><div>The recent surge in fungal infections, particularly caused by <em>Candida albicans</em>, is an important public health concern, especially among immunocompromised individuals. The current study aims to elucidate antifungal activity of nonanal against <em>C. albicans</em> (ATCC 90028) and clinical isolates. A range of quantitative methods was employed, including minimum inhibitory concentration (MIC) determination, cell cycle analysis, biofilm assays, microscopic observation of yeast to hyphal transitions, scanning electron microscopy of biofilms, and assessments of ergosterol inhibition and cell membrane damage. The results demonstrated that nonanal effectively inhibits the growth, morphogenesis, and biofilm formation at concentrations of 63 µg/ml, 125 µg/ml, and 16 µg/ml, respectively for <em>C. albicans</em> ATCC 90028, and at 125 µg/ml, 500 µg/ml, and 63 µg/ml, respectively for C1 and C2. Nonanal was able to induce cell cycle arrest and increase the reactive oxygen species (ROS) level in all strains of <em>C. albicans</em>. qRT-PCR analysis showed the downregulation of expression of key genes <em>RAS1, BCY1, ECE1, CEK1</em>, and <em>HWP1</em> in ATCC 90028 and C1 isolte, while the negative regulator <em>TUP1</em> was significantly upregulated ATCC 90028. Nonanal also affected the ergosterol synthesis and cell membrane in all the tested strains. Moreover, nonanal exhibited <em>in vivo</em> antifungal efficacy in silkworm animal model. These findings advance our understanding of nonanal as a novel potential antifungal agent, laying the groundwork for future antifungal strategies.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"7 ","pages":"Article 100256"},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144068549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antidiabetic properties of Cymbopogon spp.: Bridging preclinical findings with therapeutic applications in diabetes","authors":"Ailton Santos Sena-Júnior ,&nbsp;Francielly Lima da Fonseca ,&nbsp;Daiane Caroline Santos Teles ,&nbsp;Luiz André da Silva Santos ,&nbsp;Weslley Gabriel Dias Silva ,&nbsp;Ênio Pereira Telles ,&nbsp;Felipe J. Aidar ,&nbsp;Bárbara Melo Santos do Nascimento ,&nbsp;Lysandro Pinto Borges ,&nbsp;Divaldo Pereira de Lyra ,&nbsp;Lucindo José Quintans-Júnior ,&nbsp;Rogéria de Souza Nunes ,&nbsp;Paulo Ricardo Martins-Filho ,&nbsp;Ana Amélia Moreira Lira","doi":"10.1016/j.prenap.2025.100255","DOIUrl":"10.1016/j.prenap.2025.100255","url":null,"abstract":"<div><h3>Background</h3><div>Diabetes mellitus (DM) is a significant global health challenge with increasing prevalence. Conventional treatments often have side effects that impact patient compliance. This has stimulated interest in alternative therapies, including the use of medicinal plants such as <em>Cymbopogon spp</em>., known for their hypoglycemic properties.</div></div><div><h3>Objective</h3><div>This scoping review aims to assess the scientific evidence supporting the antidiabetic effects of <em>Cymbopogon spp</em>., focusing on its use in managing both Type 1 and Type 2 diabetes.</div></div><div><h3>Methods</h3><div>Following PRISMA guidelines, we conducted a comprehensive search across PubMed/Medline, Scopus, Web of Science, EMBASE, and LILACS from September 2023 to June 2024. Studies involving the use of <em>Cymbopogon</em> extracts and essential oils in mammals with DM were included. The selection criteria, structured around the PICO framework (Population, Intervention, Comparison, Outcome), guided our systematic evaluation of the studies, with data subsequently analyzed through descriptive methods.</div></div><div><h3>Results</h3><div>Our search yielded 172 articles, of which 11 met the inclusion criteria after screening and assessments. These studies, primarily preclinical, consistently demonstrated significant reductions in blood glucose levels and improvements in lipid profiles among diabetic models treated with <em>Cymbopogon spp</em>. Additionally, antioxidant and anti-inflammatory effects were noted, indicating broader therapeutic potential.</div></div><div><h3>Conclusions</h3><div>The findings suggest that <em>Cymbopogon spp</em>. may offer beneficial effects in diabetes management, improving glycemic control and metabolic outcomes. However, further clinical studies are required to validate these effects in human populations and to explore the mechanisms of action, optimal dosages, and long-term safety of <em>Cymbopogon spp</em>.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"7 ","pages":"Article 100255"},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143941954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flavonoids as bioenhancers: A critical review on their potential to improve drug delivery and therapeutic outcomes","authors":"Rakesh Mishra ,&nbsp;Jitendra Hiwarkar ,&nbsp;Abhishek Nikam ,&nbsp;Tanaji Nandgude ,&nbsp;Vivekanand Chatap ,&nbsp;Abhishek Jha","doi":"10.1016/j.prenap.2025.100251","DOIUrl":"10.1016/j.prenap.2025.100251","url":null,"abstract":"<div><h3>Purpose</h3><div>The purpose of this review is to explore how flavonoids can enhance the bioavailability and effectiveness of various medicinal substances as bioenhancers. The focus is on examining the interactions of flavonoids with medications, enzymes, and biological barriers to improve therapeutic outcomes. The main aim is to demonstrate the potential benefits of incorporating flavonoids as additives in pharmaceutical formulations to enhance drug delivery and improve health outcomes.</div></div><div><h3>Methods</h3><div>Comprehensive literature search was undertaken, covering research from early developments to current findings, using online search tools (PubMed, Google Scholar, Science Direct and Scopus).</div></div><div><h3>Results</h3><div>The review findings suggest that flavonoids have significant potential as bioenhancers, playing a crucial role in increasing the bioavailability and efficacy of different medicinal compounds. Through synergistic interactions with medications and biological systems, flavonoids contribute to improving treatment outcomes. Additionally, the review also pointed the pathways that underlie flavonoid-mediated bio-enhancement, and synergistic actions illuminating their potential use in pharmaceutical formulations for enhanced clinical efficacy and optimised drug delivery.</div></div><div><h3>Conclusion</h3><div>This review underscores the significant role of flavonoids as bioenhancers, highlighting their ability to synergistically improve the bioavailability and efficacy of pharmaceutical compounds. By elucidating the underlying mechanisms of flavonoid-drug interactions, this study provides valuable insights for leveraging flavonoids in drug delivery strategies mainly in the area of cancer and antibiotic therapy<em><strong>.</strong></em></div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"7 ","pages":"Article 100251"},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144068548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}