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ISOLATION AND CHARACTERIZATION OF THE HEPATOPROTECTIVE PHYTOCONSTITUENTS FROM THE LEAF FRACTIONS OF Lophira Lanceolata (Ochnaceae) 杉木叶中保肝成分的分离与鉴定
Pharmacological Research - Natural Products Pub Date : 2026-06-01 Epub Date: 2026-06-30 DOI: 10.1016/j.prenap.2026.100621
Omale F. O, Akah P. A, Nworu C. S, Igoli J. O
{"title":"ISOLATION AND CHARACTERIZATION OF THE HEPATOPROTECTIVE PHYTOCONSTITUENTS FROM THE LEAF FRACTIONS OF Lophira Lanceolata (Ochnaceae)","authors":"Omale F. O, Akah P. A, Nworu C. S, Igoli J. O","doi":"10.1016/j.prenap.2026.100621","DOIUrl":"10.1016/j.prenap.2026.100621","url":null,"abstract":"","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"11 ","pages":"Article 100621"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148573305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phytochemical study and evaluation of acute and subacute toxicities induced by a decoction of the vine bark of Landolphia owariensis P. Beauv. (Apocynaceae), a plant from the Ivorian flora used for the treatment of hemorrhoidal attacks in rats from Wistar springs. 山竹藤皮煎剂急性和亚急性毒性的植物化学研究及评价。（夹竹桃科），一种科特迪瓦植物，用于治疗来自Wistar泉的大鼠痔疮发作。
Pharmacological Research - Natural Products Pub Date : 2026-06-01 Epub Date: 2026-06-30 DOI: 10.1016/j.prenap.2026.100659
Yaya Fofana
{"title":"Phytochemical study and evaluation of acute and subacute toxicities induced by a decoction of the vine bark of Landolphia owariensis P. Beauv. (Apocynaceae), a plant from the Ivorian flora used for the treatment of hemorrhoidal attacks in rats from Wistar springs.","authors":"Yaya Fofana","doi":"10.1016/j.prenap.2026.100659","DOIUrl":"10.1016/j.prenap.2026.100659","url":null,"abstract":"","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"11 ","pages":"Article 100659"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148573399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The pharmacological study of antiarrhythmic traditional/multicomponent medicine opens a new horizon for ameliorating the proarrhythmic effects of antiarrhythmic drugs 传统/多组分抗心律失常药物的药理研究为改善抗心律失常药物的促心律失常作用开辟了新的视野
Pharmacological Research - Natural Products Pub Date : 2026-06-01 Epub Date: 2026-06-30 DOI: 10.1016/j.prenap.2026.100635
Yuling Ma
{"title":"The pharmacological study of antiarrhythmic traditional/multicomponent medicine opens a new horizon for ameliorating the proarrhythmic effects of antiarrhythmic drugs","authors":"Yuling Ma","doi":"10.1016/j.prenap.2026.100635","DOIUrl":"10.1016/j.prenap.2026.100635","url":null,"abstract":"","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"11 ","pages":"Article 100635"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148582839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Wound healing effect of the combination of Alchornea cordifolia (Schum. & Thonn. Müll.) leaves and Ricinus communis (Linn.) seeds on excision wounds in Rattus norvegicus rats 合用堇青花的创面愈合效果。& Thonn。褐家鼠（Rattus norvegicus）大鼠切除伤口上的麻<s:1> (ll.)叶和蓖麻种子
Pharmacological Research - Natural Products Pub Date : 2026-06-01 Epub Date: 2026-06-30 DOI: 10.1016/j.prenap.2026.100624
Ayoman Thierry Lenoir Djadji , Nounaferitien Awa Silue
{"title":"Wound healing effect of the combination of Alchornea cordifolia (Schum. & Thonn. Müll.) leaves and Ricinus communis (Linn.) seeds on excision wounds in Rattus norvegicus rats","authors":"Ayoman Thierry Lenoir Djadji ,&nbsp;Nounaferitien Awa Silue","doi":"10.1016/j.prenap.2026.100624","DOIUrl":"10.1016/j.prenap.2026.100624","url":null,"abstract":"","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"11 ","pages":"Article 100624"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148357661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multi-target therapeutic mechanisms of Azadirachta indica (Neem) in Alzheimer’s disease: Insights from network pharmacology and molecular docking approaches 印楝多靶点治疗阿尔茨海默病的机制：来自网络药理学和分子对接方法的见解
Pharmacological Research - Natural Products Pub Date : 2026-06-01 Epub Date: 2026-05-23 DOI: 10.1016/j.prenap.2026.100774
Md. Mainuddin Hossain , Juthi Adhikari , Abu Zaffar Shibly
{"title":"Multi-target therapeutic mechanisms of Azadirachta indica (Neem) in Alzheimer’s disease: Insights from network pharmacology and molecular docking approaches","authors":"Md. Mainuddin Hossain ,&nbsp;Juthi Adhikari ,&nbsp;Abu Zaffar Shibly","doi":"10.1016/j.prenap.2026.100774","DOIUrl":"10.1016/j.prenap.2026.100774","url":null,"abstract":"<div><div><em>Azadirachta indica</em> (<em>A. indica</em>) has shown potential in treating Alzheimer's disease (AD) due to its bioactive compounds. However, the precise molecular mechanisms underlying their therapeutic effects remain insufficiently understood. Therefore, this study aims to elucidate the mechanisms of action of <em>A. indica</em> in the treatment of AD through an integrated approach involving network pharmacology and molecular docking analyses. Bioactive compounds of <em>A. indica</em> were obtained from IMPATT and PubChem, and potential targets were identified using SwissTargetPrediction. AD-related targets were retrieved from GeneCards, CTD and DisGeNET databases. Protein–protein interaction (PPI) networks were constructed using STRING and visualized in Cytoscape to identify hub genes via the CytoHubba plugin. Common targets were analyzed through Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment using DAVID. Finally, molecular docking was performed to assess binding interactions between active compounds and target proteins. Our analysis identified 3 active compounds (Nimbolide, Meliantriol, and Vilasinin), 36 therapeutic targets, and 11 hub genes, with 5 key hub genes including APP, EGFR, mTOR, PPARG, and GSK3B, were associated with the PI3K-Akt, ErbB, Neurotrophin, and HIF-1 signaling pathways, and were involved in functions including protein binding, ATP binding, and kinase activity of AD. molecular docking revealed that 3 compounds exhibited favorable binding affinities with the top 5 hub genes. The study revealed that the <em>A. indica</em>-mediated treatment of AD is a multifaceted process involving multiple bioactive compounds, molecular targets, and signaling pathways. These findings provide valuable insights into the potential molecular mechanisms through which <em>A. indica</em> exert their therapeutic effects on AD.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"11 ","pages":"Article 100774"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148184128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prescription Of Multi-Therapies Based On Artemisinin Within The Urban Primary Health Training Of Gesco From January 2020 To September 2023 2020年1月- 2023年9月Gesco城市初级卫生培训中基于青蒿素的综合疗法处方
Pharmacological Research - Natural Products Pub Date : 2026-06-01 Epub Date: 2026-06-30 DOI: 10.1016/j.prenap.2026.100692
Kakou Augustine, Nénin Lou Irié Larissa, N’Zoué Kanga Sita, Daubrey-Potey Thérèse, Kamagaté Mamadou
{"title":"Prescription Of Multi-Therapies Based On Artemisinin Within The Urban Primary Health Training Of Gesco From January 2020 To September 2023","authors":"Kakou Augustine,&nbsp;Nénin Lou Irié Larissa,&nbsp;N’Zoué Kanga Sita,&nbsp;Daubrey-Potey Thérèse,&nbsp;Kamagaté Mamadou","doi":"10.1016/j.prenap.2026.100692","DOIUrl":"10.1016/j.prenap.2026.100692","url":null,"abstract":"","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"11 ","pages":"Article 100692"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148565326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-urolithiatic Activities of Momordica charantia Leaf Extract via Antioxidant, Anti-inflammatory, and Crystallization Inhibitory Mechanisms 苦瓜叶提取物抗氧化、抗炎和结晶抑制机制的抗尿石活性
Pharmacological Research - Natural Products Pub Date : 2026-06-01 Epub Date: 2026-06-30 DOI: 10.1016/j.prenap.2026.100667
Mikhail Olugbemiro Nafiu, Maryam Abisola Afolabi
{"title":"Anti-urolithiatic Activities of Momordica charantia Leaf Extract via Antioxidant, Anti-inflammatory, and Crystallization Inhibitory Mechanisms","authors":"Mikhail Olugbemiro Nafiu,&nbsp;Maryam Abisola Afolabi","doi":"10.1016/j.prenap.2026.100667","DOIUrl":"10.1016/j.prenap.2026.100667","url":null,"abstract":"","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"11 ","pages":"Article 100667"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148565635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of Dry Dosage Forms from Aqueous Extracts of a Traditional Mixture of Adansonia digitata, Grewia bicolor and Hibiscus sabdariffa 牡丹、双色葛兰和芙蓉传统混合物水提物的干剂型研制
Pharmacological Research - Natural Products Pub Date : 2026-06-01 Epub Date: 2026-06-30 DOI: 10.1016/j.prenap.2026.100643
Moussa Diop, Djiby Faye, Mor Fall, Abdou Sar, Abssatou Deme, Khouma Saliou, Mohamed Sidy Dieng, Abssatou Diaw, Dior Fall
{"title":"Development of Dry Dosage Forms from Aqueous Extracts of a Traditional Mixture of Adansonia digitata, Grewia bicolor and Hibiscus sabdariffa","authors":"Moussa Diop,&nbsp;Djiby Faye,&nbsp;Mor Fall,&nbsp;Abdou Sar,&nbsp;Abssatou Deme,&nbsp;Khouma Saliou,&nbsp;Mohamed Sidy Dieng,&nbsp;Abssatou Diaw,&nbsp;Dior Fall","doi":"10.1016/j.prenap.2026.100643","DOIUrl":"10.1016/j.prenap.2026.100643","url":null,"abstract":"","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"11 ","pages":"Article 100643"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148566111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting of Inflammatory Signalling Pathways by Natural Products from African Plants 来自非洲植物的天然产物靶向炎症信号通路
Pharmacological Research - Natural Products Pub Date : 2026-06-01 Epub Date: 2026-06-30 DOI: 10.1016/j.prenap.2026.100639
Olumayokun Olajide
{"title":"Targeting of Inflammatory Signalling Pathways by Natural Products from African Plants","authors":"Olumayokun Olajide","doi":"10.1016/j.prenap.2026.100639","DOIUrl":"10.1016/j.prenap.2026.100639","url":null,"abstract":"","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"11 ","pages":"Article 100639"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148566136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vitro antiplasmodial activity of polysaccharides from Argemone mexicana L. (Papaveraceae) 木瓜科银莲花多糖体外抗疟原虫活性研究
Pharmacological Research - Natural Products Pub Date : 2026-06-01 Epub Date: 2026-06-30 DOI: 10.1016/j.prenap.2026.100658
Adama Dénou, Abubakar Ahmed, Dalen G. Dafam, Adiaratou Togola, Sékou Bah, Rokia Sanogo, Berit S. Paulsen
{"title":"In vitro antiplasmodial activity of polysaccharides from Argemone mexicana L. (Papaveraceae)","authors":"Adama Dénou,&nbsp;Abubakar Ahmed,&nbsp;Dalen G. Dafam,&nbsp;Adiaratou Togola,&nbsp;Sékou Bah,&nbsp;Rokia Sanogo,&nbsp;Berit S. Paulsen","doi":"10.1016/j.prenap.2026.100658","DOIUrl":"10.1016/j.prenap.2026.100658","url":null,"abstract":"","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"11 ","pages":"Article 100658"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148572180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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