Pharmacological Research - Natural Products最新文献

{"title":"Metabolic effects of a low-dose propolis extract from Apis mellifera on the glycemic and lipid profile, insulin resistance, and markers of oxidative stress in a randomized double-blind clinical trial","authors":"Joseane Colzani ,&nbsp;José Celso de Borba Júnior ,&nbsp;Júlia Beatriz Berkenbrock Masote ,&nbsp;Scarlet Schiquet ,&nbsp;Sheila Wayszceyk ,&nbsp;Sabrina Hochheim ,&nbsp;Sérgio Luis Althoff ,&nbsp;Débora Delwing Dal Magro ,&nbsp;Alessandro Guedes ,&nbsp;Martinho Rau ,&nbsp;Caio Mauricio Mendes de Cordova","doi":"10.1016/j.prenap.2025.100329","DOIUrl":"10.1016/j.prenap.2025.100329","url":null,"abstract":"<div><div>Propolis extracts have been evaluated regarding their effect on carbohydrates, lipid metabolism, and oxidative stress in considerably high doses (400–1500 mg/day). We aimed to evaluate the metabolic effects of a low-dose <em>Apis mellifera</em> propolis extract (100 mg/day) on the glycemic and lipid profile, insulin resistance, and oxidative stress markers. The propolis extract was chemically characterized by gas chromatography coupled to mass spectrometry (GC-MS). The research was conducted with 79 participants between 20 and 64 years old with or without a diagnosis of previous metabolic disease, over a duration of 90 days. We observed an increase in fasting insulin levels, Homeostatic Model Assessment 2 for Insulin Resistance (HOMA2-IR), Homeostatic Model Assessment 2 for beta-cells function (HOMA2-β), and total sulfhydryl content with propolis extract use. While a higher propolis dose may be necessary to affect lipid metabolism, a low dose (100 mg/day) may be sufficient to improve pancreatic beta-cell function and oxidative stress. Lupeol acetate, dotriacontane, eicosane, and heneicosane were the compounds that most contributed to the results.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100329"},"PeriodicalIF":0.0,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144750282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethnomedicinal potential and phytochemical profile of Rhynchospora Vahl (Cyperaceae): A scientifically underexplored genus","authors":"José Jailson Lima Bezerra,&nbsp;Antônio Fernando Morais de Oliveira","doi":"10.1016/j.prenap.2025.100328","DOIUrl":"10.1016/j.prenap.2025.100328","url":null,"abstract":"<div><div><em>Rhynchospora</em> is one of the most diverse genera of Cyperaceae with a widespread occurrence across various regions of the world. Although some species are used in medical systems of many traditional communities, few studies have investigated the chemical and pharmacological potential of this genus. In this context, the present study aimed to review the ethnomedicinal uses, biological activities, and phytochemical evidence of <em>Rhynchospora</em> species to direct future experimental research. The literature was retrieved from the Google Scholar, PubMed®, SciELO, ScienceDirect®, and Scopus® databases. According to the scientific documents analyzed, it was observed that a total of seven species of <em>Rhynchospora</em> are used medicinally in countries on the African, Asian, North and South American continents. These plants are primarily employed for the treatment of infectious diseases (22 %), fever (19 %), flu, cold and cough (19 %), and inflammation (13 %). The whole plant (46 %) of <em>Rhynchospora</em> spp. is widely used in traditional preparations. <em>Rhynchospora corymbosa</em> and <em>R. nervosa</em> stood out for their reports of ethnomedicinal uses, evaluation of biological activities, and phytochemical analysis. Meanwhile, the traditional uses of <em>R. rubra, R. barbata, R. cephalotes,</em> and <em>R. pubera</em> have not been investigated in experimental research to date. The flavonoid tricin has been identified in several species of <em>Rhynchospora</em>. This review represents the first effort to bring together literature publications concerning the ethnomedicinal uses and biological activities of <em>Rhynchospora</em>. Considering the promising results related to the pharmacological potential of <em>R. nervosa</em> and <em>R. corymbosa</em>, it is important to conduct new studies focusing on the development of possible phytoproducts from extracts of these plants.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100328"},"PeriodicalIF":0.0,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144750283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical screening and assessment of the in-vitro wound healing activity of Bidens pilosa leaves","authors":"B. Kaihra Pfoze ,&nbsp;Rajkumar Romeshkumar Singh ,&nbsp;B. Koshoni Pekosii ,&nbsp;Thokchom Prasanta Singh ,&nbsp;Okram Mukherjee Singh","doi":"10.1016/j.prenap.2025.100331","DOIUrl":"10.1016/j.prenap.2025.100331","url":null,"abstract":"<div><div><em>Bidens pilosa</em> is an annual herb that is widely used for the treatment of various diseases around the world. This study presents the qualitative phytochemical analysis, cytotoxicity, and <em>in-vitro</em> wound healing activity of different extracts from <em>B. pilosa</em> leaves on HaCaT cell lines. The phytochemical screening revealed the presence of alkaloids, carbohydrates, phenolics, flavonoids, volatile oils, phytosterols, and terpenoids in the extracts of petroleum ether, ethyl acetate, and methanol. The extracts demonstrated cytotoxic activity at various concentrations, with the ethyl acetate extract showing a higher toxicity (IC₅₀ = 27.9 ± 0.18 μg/ml) compared to petroleum ether extract (IC₅₀ = 48.4 ± 0.19 μg/ml) analyzed using GraphPad Prism 6<em>.</em> In the wound scratch assay conducted on HaCaT cell lines, treated cells exhibited significant wound closure on compared to control cells. Specifically, the scratch area decreased by 52.72 ± 5.67 % with petroleum ether extract and 53.58 ± 6.19 % with ethyl acetate extract within 24 h. This indicates that the extracts promote cell migration, which is a crucial aspect of wound healing. This experimental evidence is promising to continue with further research, for the development of new agents to treat various wounds.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100331"},"PeriodicalIF":0.0,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144757820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the in vitro anticoagulant and free radical scavenging ability of heparin like polysaccharide from gladius of Doryteuthis sibogae (Adam, 1954)","authors":"Dhivyashri Senthilkumar ,&nbsp;Aayisha Aathila Saleem ,&nbsp;Suresh Sasikala ,&nbsp;Namasivayam Subhapradha ,&nbsp;Pasiyappazham Ramasamy","doi":"10.1016/j.prenap.2025.100327","DOIUrl":"10.1016/j.prenap.2025.100327","url":null,"abstract":"<div><div>This study focused on extracting heparin-like polysaccharide (HLP) from the gladius of <em>Doryteuthis sibogae</em> and evaluating its anticoagulant and antioxidant potential. The structural characterization of extract was studied using FTIR, FESEM and XRD and the presence of HLP was confirmed. The anticoagulant properties of HLP were studied using the APTT and PT kits. In addition, antioxidant evaluation was performed using DPHH, Hydroxyl radical scavenging assay, and the chelating ability of ferrous ions. The HLP showed anticoagulant efficacy of 6.72 IU/mg and 1.69 IU/mg for APTT and PT assay respectively. HLP extracted from <em>D. sibogae</em> demonstrated antioxidant properties comparable to those of the control substances used in various tests. The increase in the concentration of the polysaccharide extract was directly proportional to the antioxidant properties elicited by the HLP of <em>D. sibogae</em>. Finally, HLP extracted from <em>D. sibogae</em> showed significant anticoagulant and free radical-scavenging activities.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100327"},"PeriodicalIF":0.0,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144739744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pfaffia glomerata tetraploid extract induces penile erection and modulates Leydig cell hormonal production","authors":"Fernanda C.R. Dias ,&nbsp;Sérgio Luis P. Matta ,&nbsp;Wagner C. Otoni ,&nbsp;Marcos L.M. Gomes","doi":"10.1016/j.prenap.2025.100326","DOIUrl":"10.1016/j.prenap.2025.100326","url":null,"abstract":"<div><div>Infertility and erectile dysfunction are significant global public health issues, and herbal remedies provide an alternative to the high costs of treatments. <em>Pfaffia glomerata</em> is commonly used as an aphrodisiac, and its biological effects have been proven. Due to commercial interest, a tetraploid P. glomerata plant was recently produced to achieve higher yields of secondary metabolites of interest. The present study aimed to observe whether the polyploid <em>P. glomerata</em> accession (BGEt) would negatively impact penile tissue and testicular parenchyma, thereby impairing the reproductive parameters of male Swiss mice. Thirty-six male Swiss mice were randomly divided into control (water) and control sildenafil citrate (7 mg/kg), with BGEt at 100, 200, and 400 mg/kg, and BGEDt 200 mg/kg (treated with BGE every three days). The data underwent normality testing and analysis of variance, with values of p &lt; 0.05 considered significant. The testes and penises were fixed and frozen for Leydig cell and penile analyses. Damage to Leydig cells was observed, which did not interfere with hormone production. Testosterone and 17β-estradiol production were higher in the BGEt animals. Nitric oxide levels and the cavernous body increased following BGEt intake. Therefore, BGEDt enhances erection by elevating penile nitric oxide, collagen, and corpora cavernosa body size, without significantly altering hormone production by Leydig cells.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100326"},"PeriodicalIF":0.0,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144720802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular identification of Gracilaria tenuistipitata isolated from the Bay of Bengal and appraisal of its comprehensive phytochemical profiling, and antioxidant potential","authors":"Hafiza Akter Laboni ,&nbsp;Sayem Sarkar ,&nbsp;Md. Ariful Islam ,&nbsp;M. Ariful Islam ,&nbsp;Minhajul Islam ,&nbsp;Chadni Lyzu ,&nbsp;Mohammad Mahfuzur Rahman ,&nbsp;Md. Morshedul Alam ,&nbsp;Abdullah Mohammad Shohael ,&nbsp;M. Rezaul Karim","doi":"10.1016/j.prenap.2025.100324","DOIUrl":"10.1016/j.prenap.2025.100324","url":null,"abstract":"<div><div>In the present study, we focused on the molecular identification of <em>Gracilaria tenuistipitata</em> (a red sea algae), screening of its effective bioactive compounds and appraisal of their therapeutic potency. To confirm its identity, we conducted the first molecular analysis, utilizing the plastid-encoded <em>rbc</em>L gene and mitochondrial Cytochrome c Oxidase Subunit I 5′ region (COI-5P) to accurately determine the species. This study aimed to profile and evaluate the biological potential of <em>G. tenuistipitata</em> by comparing its ethanolic and isopropanolic extracts using HPLC, GC-MS, and FTIR. Phytochemical screening revealed a diverse biochemical composition, including alkaloids, phenolic compounds, and flavonoids. The ethanolic extract exhibited higher total phenolic (18.94 mg GAE/g) and flavonoid (42.375 mg QE/g) content compared to the isopropanolic extract. This corresponded with its greater antioxidant potential, as shown by a lower DPPH IC50 value (770.88 µg/mL vs. 821 µg/mL for isopropanolic) and higher total antioxidant capacity. HPLC analysis quantified 11 polyphenols, with gallic acid being most abundant in the ethanolic extract (653.06 µg/g), while GC-MS identified 9 key volatile compounds, with hexadecanoic acid, methyl ester predominating in the isopropanolic extract (67.357 µg/mL). FTIR analysis confirmed the presence of hydroxyl, carboxyl, and carbonyl functional groups and supported the seaweed's safety by indicating the absence of toxic cyanide groups. Collectively, this study provides a foundational, comparative chemical profile of <em>G. tenuistipitata</em>, highlighting how solvent choice impacts bioactive yield and underscoring its potential as a source of natural antioxidants.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100324"},"PeriodicalIF":0.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144702294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radical scavenging, anti-inflammatory and glucose metabolising enzymes activity of Secamone afzelii K. leaf and vine: In vitro and in silico studies","authors":"Franklyn Nonso Iheagwam ,&nbsp;Gloria Aniedi Itina ,&nbsp;Oyinkansola Ayobolanle Faluyi ,&nbsp;Olawumi Toyin Iheagwam","doi":"10.1016/j.prenap.2025.100325","DOIUrl":"10.1016/j.prenap.2025.100325","url":null,"abstract":"<div><div><em>Secamone afzelii</em> is commonly used in folk medicine as a galactagogue infusion for pain relief and diabetes management. This study investigated the hydroethanol extracts of <em>S. afzelii</em> leaf (SALE) and vine (SAVE) for their phytochemical content, radical scavenging abilities, anti-inflammatory properties, and inhibitory effects against α-amylase and α-glucosidase. Furthermore, the phytocompounds responsible for the enzyme inhibitory activity and their mechanisms were assessed using molecular docking to validate in vitro findings. Tannins, alkaloids, flavonoids, and phenols were detected, while terpenoids and glycosides were not present in both <em>S. afzelii</em> extracts. The total content of β-carotene, lycopene, phenolics, flavonoids, and flavanols in SALE was greater than in SAVE. Similarly, SALE exhibited superior radical scavenging activities, antioxidant capacities, albumin denaturation protection, and red blood cell haemolysis protection properties. A dose-dependent inhibition of α-glucosidase and α-amylase activity was observed in the extracts, with the α-amylase inhibitory activity of SALE significantly higher than that of SAVE. However, no difference was found in the α-glucosidase inhibitory properties among SALE, SAVE, and acarbose. <em>S. afzelii</em> demonstrated a respective noncompetitive and uncompetitive mode of inhibition on α-amylase and α-glucosidase activities, validated by molecular docking. The compounds 5α-androstan-16-one, cyclic ethylene mercaptole, oxalic acid, mono-{5-[(2-bromophenyl)(2,2-dimethylpropionyloxy)methyl]-7,8-dihydro-5H-[1,3]dioxolo[4,5-<em>g</em>]isoquinolin-6-yl} ester, guanosine, and glucosamine, N-acetyl-N-benzoyl- were identified as responsible for the α-glucosidase and α-amylase inhibitory activity of SALE and SAVE based on their binding energy. Therefore, <em>S. afzelii</em> could be explored as a natural alternative source for managing diabetes mellitus-induced postprandial hyperglycaemia and its downstream inflammatory and oxidative stress complications.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100325"},"PeriodicalIF":0.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144695171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antidiabetic, antimicrobial, and wound healing activities of Dioscorea bulbifera L. methanol extract and its fractions in alloxan-induced diabetic Wistar rats’ model","authors":"Mercy Nkechi Ofonegbu ,&nbsp;Uju Marie-Esther Dibua ,&nbsp;Ifunaya Rejoice Akaniro ,&nbsp;Collins Chimezie Udechukwu ,&nbsp;Kelvin Olutimilehin Jolayemi","doi":"10.1016/j.prenap.2025.100321","DOIUrl":"10.1016/j.prenap.2025.100321","url":null,"abstract":"<div><div><em>Dioscorea bulbifera L.</em> has diverse applications in folkloric medicine. This study assessed its anti-diabetic, cytotoxic, and antimicrobial activities on diabetic wound pathogens using Wistar rats. Extraction was performed via maceration in 70 % methanol, yielding ethyl acetate (EAF) and ethanol (EF) fractions. Phytochemical screening identified bioactive compounds, and acute toxicity studies ensured safety. The antimicrobial efficacy of the crude methanol extract (CME) and fractions was tested against <em>Staphylococcus aureus</em>, <em>Escherichia coli</em>, and <em>Pseudomonas aeruginosa</em> using disc diffusion and colony count methods. Anti-diabetic potential was evaluated in alloxan-induced diabetic rats by measuring blood glucose levels. Rats were grouped (Normal, diabetic [untreated], positive [Glibenclamide 5 mg/kg], 200 mg/kg CME, EAF, EF), with extracts administered orally. A circular excision wound (0.2 cm) was induced, and wound contraction monitored. At the end of the experiment, skin, liver, and kidney were harvested for histopathological examination. Phytochemical analysis revealed saponins, tannins, flavonoids, alkaloids, phenols, and cardiac glycosides, with EAF particularly rich in these compounds. The LD50 was &gt; 5000 mg/kg with no mortality. EAF exhibited the highest antimicrobial activity (p &lt; 0.05) and colony count reduction (p &lt; 0.01). It also significantly lowered blood glucose levels (p &lt; 0.01) and enhanced wound healing, with greater re-epithelialization, granulation, and collagen deposition (p &lt; 0.05). Histopathology showed normal organ architecture. <em>Dioscorea bulbifera L</em>. extract, particularly EAF demonstrated strong antimicrobial, anti-diabetic, and wound-healing properties with no toxicity. Its efficacy in reducing blood glucose, inhibiting pathogens, and promoting tissue regeneration highlights its therapeutic potential for diabetic wound management. Further studies should isolate active compounds and explore their mechanisms of action.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100321"},"PeriodicalIF":0.0,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144680789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ameliorative effects of aqueous extract of stem bark of Ficus platyphylla Del. Holl on some biological parameters in the high-fat diet and streptozotocin-induced type 2 diabetes model","authors":"Aboubakary ,&nbsp;David Miaffo ,&nbsp;Zacharie Tchoubou ,&nbsp;Jean Paul Bayang ,&nbsp;Benoît Bargui Koubala","doi":"10.1016/j.prenap.2025.100323","DOIUrl":"10.1016/j.prenap.2025.100323","url":null,"abstract":"<div><div><em>Ficus platyphylla</em> is a plant of the Moraceae family, widely used in traditional Cameroonian pharmacopoeia for several pathologies including diabetes mellitus. This work aimed to evaluate the antidiabetic activity of aqueous extract of <em>Ficus platyphylla</em> stem bark (AEFP) in Wistar rats. In fact, a high-fat diet combined with an intraperitoneal injection of streptozotocin (35 mg/kg) was used to induce diabetes in male rats. Animals declared diabetic were selected, divided into groups, and treated for 28 days with insulin (175 µg/kg), metformin (40 mg/kg), and AEFP (93, 186, and 372 mg/kg). Parameters such as body weight and water and food consumption, glucose, insulin, glycosylated hemoglobin and hepatic glycogen levels, activities of some hepatic enzymes of carbohydrate metabolism, markers of hepatorenal function, pro-inflammatory cytokines, oxidative and lipid profiles, and histological examination of the pancreas were evaluated. AEFP increased body weight, glycogen levels, reduced glutathione, total protein, HDL-c, and hemoglobin, as well as glucokinase, glucose-6-phosphate dehydrogenase, catalase, and superoxide dismutase activities. In contrast, AEFP reduced food and water intake and glucose, insulin, malondialdehyde, total cholesterol, triglycerides, LDL-c, glycosylated hemoglobin, nitric oxide, urea, uric acid, and creatinine levels. AEFP also decreased transaminase, glucose-6-phosphatase, and fructose-1,6-bisphosphate activities, as well as interleukin-1β, interleukin-6, and tumor necrosis factor-alpha levels. These results confirm the hypoglycemic, antioxidant, hypolipidemic and anti-inflammatory effects of AEFP.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100323"},"PeriodicalIF":0.0,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Curcumin mitigates dichlorvos-induced organ toxicity, restoring hematological and metabolic functions","authors":"Saka Waidi Adeoye ,&nbsp;Igbayilola Yusuff Dimeji ,&nbsp;Hamidu Lawan Jabba ,&nbsp;Ngabea Murtala ,&nbsp;Zakari Muhammed Baba ,&nbsp;Adekola Saheed Ayodeji ,&nbsp;Farayade Naomi Oluwaseyifunmi ,&nbsp;Echatah Antoinette Ebodiame ,&nbsp;Oluwole Praise Alaba ,&nbsp;Solanke Aishat Abisoye","doi":"10.1016/j.prenap.2025.100322","DOIUrl":"10.1016/j.prenap.2025.100322","url":null,"abstract":"<div><div>Curcumin, a bioactive compound found in turmeric and ginger, is renowned for its anti-inflammatory and antioxidant properties. Dichlorvos (DDVP), a commonly used organophosphate pesticide for pest control in homes and farms, is associated with significant toxicity. This study investigated the protective effects of curcumin on health parameters in male Wistar rats exposed to DDVP. The rats were divided into four groups: Group A (control), Group B (DDVP only), Group C (DDVP + curcumin), and Group D (curcumin only). Exposure to DDVP resulted in altered hematological parameters, with decreased hemoglobin (HGB), mean corpuscular volume (MCV), and mean corpuscular hemoglobin concentration (MCHC), alongside increased red blood cells (RBCs) and platelets (PLT). Immune function was compromised, indicated by elevated neutrophils and eosinophils and reduced lymphocytes. Lipid profile disturbances were observed, including increased total cholesterol and LDL levels and decreased HDL levels. Liver dysfunction was marked by elevated aspartate aminotransferase (AST), alkaline phosphatase (ALP), and alanine aminotransferase (ALT) levels. Thyroid disruption was evident through decreased T₃ and T₄ levels and altered TSH levels. Curcumin treatment significantly mitigated these adverse effects. It normalized RBC and PLT counts, balanced neutrophil, eosinophil, and lymphocyte levels, and corrected lipid profile imbalances by reducing cholesterol and LDL while increasing HDL levels. Liver toxicity was alleviated, and thyroid function showed partial restoration with normalized TSH levels. This study concludes that curcumin demonstrates significant protective effects against dichlorvos-induced toxicity, highlighting its potential as a therapeutic agent to mitigate pesticide-related health impacts.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100322"},"PeriodicalIF":0.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144702295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}