Pharmacological Research - Natural Products最新文献

{"title":"Thymoquinone inhibits adipocyte development in 3T3-L1 cells system by modulating the AKT and AMPK signaling pathways","authors":"Shamima Ahmed ,&nbsp;Yuki Nishigaki ,&nbsp;Mohammad Shaokat Ali ,&nbsp;Isao Matsui-Yuasa ,&nbsp;Akiko Kojima-Yuasa","doi":"10.1016/j.prenap.2025.100149","DOIUrl":"10.1016/j.prenap.2025.100149","url":null,"abstract":"<div><h3>Aims</h3><div>Obesity, a major global health concern, leads to various metabolic disorders. Adipogenesis, the process of preadipocytes differentiating into mature adipocytes, is key to excessive lipid accumulation. This study examined the anti-obesity effects of thymoquinone (TQ), a compound from <em>Nigella sativa</em> seeds, using 3T3-L1 pre-adipocytes <em>in vitro.</em></div></div><div><h3>Main methods</h3><div>Cell viability was assessed with the neutral red assay. Lipid accumulation and GPDH activity were evaluated using oil red O staining and the Wise and Green method, respectively. Reactive oxygen species levels were quantified with the DCFH-DA method, while immunofluorescence staining was employed to examine the nuclear localization of C/EBPβ. The qRT-PCR and western blot assays were used to analyze the adipogenic and lipogenic markers.</div></div><div><h3>Key findings</h3><div>TQ inhibited lipid accumulation at concentrations of 6–30 µM without affecting cell viability. It also suppressed adipogenic transcription factors (PPARγ, C/EBPα, C/EBPβ, and SREBP-1c) and lipogenic genes (<em>AdipoQ, FABP4, FAS, and ACC1</em>). Additionally, TQ inhibited the AKT pathway and enhanced AMPK phosphorylation.</div></div><div><h3>Significance</h3><div>The results suggest that thymoquinone has anti-obesity properties by inhibiting adipogenic transcription factors and lipogenic genes through the regulation of AKT and AMPK pathways. Consequently, it could serve as a potential therapeutic agent for obesity.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"6 ","pages":"Article 100149"},"PeriodicalIF":0.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melatonin’s role in redox homeostasis: A preclinical and clinical perspective","authors":"Flaviene Felix Torres ,&nbsp;Victoria Simões Bernardo ,&nbsp;Ana Clara Albertin Zucão ,&nbsp;Lucas Gazarini ,&nbsp;Russel Joseph Reiter ,&nbsp;Danilo Grünig Humberto da Silva","doi":"10.1016/j.prenap.2025.100147","DOIUrl":"10.1016/j.prenap.2025.100147","url":null,"abstract":"<div><div>Melatonin is a phylogenetically ancient molecule with diverse biological activities, including anti-inflammatory and redox properties. Although its role as an antioxidant is well-established, the broader impact of melatonin on redox signaling pathways still needs to be explored. This review addresses this gap by providing an overview of melatonin's known mechanisms of action in major redox signaling pathways, such as Nrf2, NF-kB, and FoxO, as well as its involvement in epigenetic processes and the ubiquitin-proteasome system. The review also explores melatonin’s potential as a therapeutic agent in various pathological conditions, including cancer, Alzheimer’s disease, diabetes, and cardiomyopathy. Finally, we discuss recent clinical trials that underscore melatonin’s role in modulating hormesis-related redox signaling, suggesting its utility as a therapeutic adjuvant in diseases characterized by oxidative or inflammatory damage.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"6 ","pages":"Article 100147"},"PeriodicalIF":0.0,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143155959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HPLC profile, biochemical and histoarchitectural changes in loperamide-induced constipated Wistar rats after oral administration of aqueous extract of Cnestis ferruginea (Vahl ex DC) roots","authors":"Musa Toyin Yakubu ,&nbsp;Moses Dele Adams","doi":"10.1016/j.prenap.2025.100144","DOIUrl":"10.1016/j.prenap.2025.100144","url":null,"abstract":"<div><h3>Introduction</h3><div>Aqueous extract of <em>Cnestis ferruginea</em> roots (AECFR) have been documented to exhibit laxative activity with no information on biochemical and histoarchitectural changes that accompany such treatments. Hence, this study was aimed at determining the biochemical and histoarchitectural alterations in constipated rats after treatment with AECFR.</div></div><div><h3>Methodology</h3><div>Sixty, healthy, Wistar rats (150.30 ± 3.52 g) were completely randomized into six groups (A-F; n = 10/group). Animals in group A (sham control, SC) received distilled water (DW) whilst constipated (induced with 3 daily doses of loperamide (LPD, 3 mg/kg body weight, BW) rats in groups B (negative control, NC), C (positive control, PC), D, E and F were orally gavaged at same point time with DW, bisacodyl (BCL, referenced cathartics, 25 mg/kg BW), AECFR at 25, 50 and 100 mg/kg BW, respectively, once daily for 7 days. Biochemical and histoarchitectural analyses/examinations and High Performance Liquid Chromatography (HPLC) profiling of AECFR were done using standard methods.</div></div><div><h3>Results</h3><div>The LPD-treatment related significant (<em>p</em> &lt; 0.05) increases in liver ACP, liver and serum GGT, stomach and small intestine (SI) ALP, kidney AST, serum albumin (SALB), uric acid, urea, creatinine, TC, TAG, LDL-C and Cl^- were further sustained by AECFR and BCL. In contrast, the LPD-treatment related decreases in stomach ACP, serum globulin (SGB), total bilirubin (TB) and conjugated bilirubin (CB) were also reduced (<em>p</em> &lt; 0.05) by the AECFR and BCL. Furthermore, the increases in the activities/levels of liver, kidney and serum ALP, liver and serum ALT, SI and serum ACP and HDL-C were reduced (<em>p</em> &lt; 0.05) by the AECFR and BCL whereas the LPD-treatment related decreases in the activity/levels of kidney ALT, Na⁺, K⁺ and AI were increased after treatment with AECFR and BCL. In all, the alterations did not compare (<em>p</em> &gt; 0.05) favourably with the SC. Also, there were no treatment-related histoarchitectural changes in all the tissues. Ten chemical compounds were detected in AECFR with cephatonine (30.96 µg/100 g) and stepharanine (0.13 µg/100 g) being the most and the least abundant respectively.</div></div><div><h3>Conclusion</h3><div>The LPD, AECFR and BCL caused similar trend of damage and/or cellular dysfunction to the liver, kidney, stomach and small intestine of rats with no evidence of histoarchitectural distortion in all the tissues.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"6 ","pages":"Article 100144"},"PeriodicalIF":0.0,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143155960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ficus exasperata N-hexane-ethyl acetate extract inhibits lipoxygenase and protects against CCl4 – Induced TNF-α upregulation in Female Wistar Rats","authors":"Dorcas Ibukun Akinloye ,&nbsp;Adio Jamiu Akamo ,&nbsp;Ceaser Antiya Moses ,&nbsp;Abiodun Sunday Oyelakin ,&nbsp;Theophilus Aghogho Jarikre ,&nbsp;Toluwalase Ayobami Adeosun ,&nbsp;Adewale Segun James ,&nbsp;Ofem Effiom Eteng ,&nbsp;Olayinka Adebola Eruola ,&nbsp;Olatunbosun Samuel Sojinu","doi":"10.1016/j.prenap.2025.100148","DOIUrl":"10.1016/j.prenap.2025.100148","url":null,"abstract":"<div><h3>Background</h3><div>The excessive production of tumour necrosis factor-alpha (TNF-α) and lipoxygenase activity can lead to various adverse health effects. Traditional Chinese Medicine (TCM) has long been used to promote optimal well-being due to its bioactive constituents. Thus, one of the plant ingredients in TCM must be tested.</div></div><div><h3>Objectives</h3><div>The research seeks to examine the <em>in vitro</em> lipoxygenase inhibitory effects of <em>Ficus exasperata</em> N-hexane-ethyl acetate extract (NHEAE) and its <em>in vivo</em> protective role against CCl₄-induced TNF-α overexpression in female Wistar rats, utilising tissue damage biomarkers, the expression levels of TNF-α, interleukin 10 (IL-10), and nuclear factor kappa B (NF-kB), along with histopathological evaluations of the liver and kidneys and <em>in vitro</em> lipoxygenase inhibition as metrics.</div></div><div><h3>Methods</h3><div>Thirty-six female Wistar rats were assigned into groups A, B, C, D, E, and F (n = 6). Groups A and B were administered olive oil for fourteen days as a pretreatment. Groups C, D, E, and F received pretreatment with vitamin E at a dosage of 100 mg per kilogram body weight (kg bwt), NHEAE at a dosage of 100 mg/kg bwt, NHEAE at a dosage of 200 mg/kg bwt, and NHEAE at a dosage of 200 mg/kg bwt respectively for fourteen days. Subsequently, groups B, C, D, and E received single-dose injections of CCl₄ on day fourteen, precisely one hour after their last respective pretreatments.</div></div><div><h3>Results</h3><div>The <em>in vitro</em> lipoxygenase inhibition by NHEAE increases as the concentration of NHEAE increases compared to standard. The NHEAE pretreatment exhibited protective effects against CCl₄-induced impairments by preventing pathological lesions, linkages of tissue damage biomarker enzymes, and overexpression of NF-kB and TNF-α.</div></div><div><h3>Conclusion</h3><div>NHEAE demonstrated <em>in vitro</em> lipoxygenase inhibition and <em>in vivo</em> protection against CCl₄-induced TNF-α upregulation in female Wistar rats.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"6 ","pages":"Article 100148"},"PeriodicalIF":0.0,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of hypoglycaemic, hypolipidemic and glucose tolerant effect of Henna leaves on fructose-induced metabolic syndromes in Wistar rats","authors":"Youssef S'hih ,&nbsp;Ibrahim Hinad ,&nbsp;Abdechahid Loukili ,&nbsp;Abdelhalem Mesfioui ,&nbsp;Moulay Laarbi Ouahidi","doi":"10.1016/j.prenap.2025.100150","DOIUrl":"10.1016/j.prenap.2025.100150","url":null,"abstract":"<div><h3>Introduction</h3><div>The presence of fructose in the diet can cause metabolic syndromes (MS), which can lead to serious complications such as type 2 diabetes. Lawsonia inermis (LI) leaves are commonly used as a treatment, but the studies on their hypoglycaemic and hypolipidemic effects on fructose-induced Wistar rats are very limited. The aim of this study was to evaluate the hypoglycaemic and hypolipidemic effect of aqueous extract of Lawsonia inermis leaves (AELIL) in hyperglycaemic and hyperlipidaemic (HH) male Wistar rats induced by a high fructose diet (HFD).</div></div><div><h3>Methods</h3><div>To induce MS in Wistar rats by HFD, 6 groups (n = 6) were used, 1st and 2nd consisted of normal control (NC) rats, 3th,4th, 5th and 6th where the rats received HFD (20 % then 25 % w/v) (NF) for 12 weeks, followed by measurement of body weight (BW), fasting blood glucose (FBG), oral glucose tolerance test (OGTT), glucose, cholesterol (Chol) and triglyceride (TG) plasma levels. To assess the hypoglycaemic and hypolipidemic effect of AELIL, a dose of 500 mg.kg⁻¹_bw was tested by repeated oral administration for 28 days, for which 4 groups of rats were formed, the 1st was used as normal control (NC), the 2nd was HH control (HHC), the 3rd (HTM) and the 4th (HTEL) were HH groups to which the drug and the extract were administered. During treatment, changes in FBG and BW were recorded, oral glucose tolerance test (OGTT), total glucose, Chol and TG plasma levels were measured for all groups at the end of the experiments.</div></div><div><h3>Results</h3><div>During SM induction, HFD caused a highly significant increase (0.001) in mean of BW (387.25 ± 9.21 vs 283.33 ± 7.00 g), FBG (129.19 ± 3.46 vs 89.33 ± 2.73 mg. dl⁻¹) and serum concentration of Chol (80.67 ± 2.72 vs 53.05 ± 3.84) and TG (151.48 ± 3.46 vs 73.51 ± 2.78) compared with the control, while AELIL showed anti-hyperglycaemic, anti-hyperlipidaemic and tolerance glucose activities with a highly significant (0.001) decrease in serum concentration of glucose (98.78 ± 3.36 mg/dl vs 129.09 ± 2.48 mg/dl), cholesterol (97.55 ± 2.29 mg/dl vs. 104.09 ± 3.43 mg/dl) and TG (94.17 ± 3.94 mg/dl vs. 151.35 ± 3.56 mg/dl) compared with the control, these activities were approximately similar to those of the drug and were accompanied by a significant (p ⩽ 0.05) decrease in the BW of rats' (440.66 ± 8.25 vs. 465.33 ± 3.94687 g) compared with the control at the end of the 4th week of treatment.</div></div><div><h3>Conclusion</h3><div>HFD for 12 weeks caused significant hyperglycaemia and hyperlipidaemia but did not affect liver, pancreatic, and renal tissues of Wistar rats, whereas repeated treatment for 4 weeks with AELIL showed significant hypoglycaemic, hypolipidemic, and glucose tolerance effects, with different possible mechanisms of action. However, further studies are needed to verify and clarify its effects.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"6 ","pages":"Article 100150"},"PeriodicalIF":0.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HPLC-HRMS-SPE-NMR analysis of bioactive fractions from Thunbergia laurifolia and Senegalia rugata leaves extracts and the effects on Nrf2, HMOX-1, NQO1, and CYP1A1 expressions","authors":"Natchagorn Lumlerdkij ,&nbsp;Yong Zhao ,&nbsp;Rita de Cássia Lemos Lima ,&nbsp;Pravit Akarasereenont ,&nbsp;Dan Staerk ,&nbsp;Michael Heinrich","doi":"10.1016/j.prenap.2025.100146","DOIUrl":"10.1016/j.prenap.2025.100146","url":null,"abstract":"<div><div><em>Thunbergia laurifolia</em> and <em>Senegalia rugata</em> leaves have been used as cancer prevention in Thai traditional medicine and showed promising chemopreventive effects <em>in vitro</em> in previous studies. However, the relevant mechanism and the active metabolites were still unknown. The objectives of this study are to investigate chemopreventive mechanisms, identify active fractions, and to provide information on their phytochemistry. The effects of the extracts on gene expressions of HepG2 cells were investigated using real-time PCR. High-resolution radical scavenging assay to identify active fractions was performed using ABTS^•+ reduction assay. Chemical characterization of the active fractions was then performed by HPLC-HRMS-SPE-NMR analysis. <em>T.laurifolia</em> leaves extract did not act via induction of NQO1, Nrf2, and HMOX-1 gene expressions. Rosmarinic acid could be the active metabolite. Mechanisms of <em>S.rugata</em> leaves extract might be due to the induction of Nrf2 expression. Three apigenin glucosides, including 3,6-di-C-glucosyl apigenin, isoschaftoside, and schaftoside, were reported in <em>S.rugata</em> for the first time and might contribute to the activity. In addition, the effect on CYP1A1 expression suggested that there was a low risk of DNA damage from both leave extracts.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"6 ","pages":"Article 100146"},"PeriodicalIF":0.0,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143155958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green synthesis of silver nanoparticles using Boerhavia diffusa plant and the potential of its antioxidant and anticancer efficacy","authors":"Jasmin Maria James ,&nbsp;Alex Yagoo ,&nbsp;Jelin Vilvest ,&nbsp;A. Arokia Ahino Jessie","doi":"10.1016/j.prenap.2025.100142","DOIUrl":"10.1016/j.prenap.2025.100142","url":null,"abstract":"<div><div>Nanotechnology, which involves manipulating materials at the nanoscale (1–100 nanometers), offers unique properties with broad applications. This study focuses on the green synthesis of silver nanoparticles (AgNPs) using <em>Boerhavia diffusa</em> extract (BD extract), a method that is both cost-effective and environmentally friendly. The synthesized AgNPs were characterized using UV–visible spectroscopy, X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), and energy dispersive X-ray analysis (EDAX). The UV–visible spectroscopy results confirmed the formation of AgNPs with a characteristic peak at 427 nm. XRD analysis revealed a crystalline structure with an average crystallite size of 34 nm. FESEM images showed spherical nanoparticles ranging from 30 to 40 nm, while EDAX confirmed the presence of pure silver. The DPPH radical scavenging assay demonstrated strong antioxidant activity, with the AgNPs achieving 78.57 % scavenging efficiency in a concentration-dependent manner. Cytotoxicity studies on HeLa cells indicated significant anticancer potential, with a 64.12 % inhibition of cell growth at 100 μg/mL and an IC50 value of 45.47 μg/mL. Morphological observations of treated cells revealed apoptosis, marked by cell shrinkage, membrane blebbing, and the formation of apoptotic bodies. These results highlight the potential of BD- mediated AgNPs in both antioxidant and anticancer applications, while also suggesting their use as eco-friendly nanoparticle-based insecticides. The study provides a sustainable approach to nanoparticle synthesis with promising implications for biomedical and agricultural fields.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"6 ","pages":"Article 100142"},"PeriodicalIF":0.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vivo hepatoprotective evaluation of Selaginella bryopteris ethanolic extract against CCl4 mediated free radical induced liver damage","authors":"Deena Prakash ,&nbsp;Divya Bisht ,&nbsp;Brijesh Shivhare ,&nbsp;Maneesha Pandey ,&nbsp;Ramesh Kumar ,&nbsp;Arvind Kumar Shakya","doi":"10.1016/j.prenap.2025.100141","DOIUrl":"10.1016/j.prenap.2025.100141","url":null,"abstract":"<div><h3>Background</h3><div><em>Selaginella bryopteris</em> (L.) also known as Sanjeevani, is a traditional medicinal herb used in treating liver diseases at its native place. It is scientifically unexplored herb for the treatment of various diseases including liver diseases.</div></div><div><h3>Purpose</h3><div>The present study aimed to investigate the hepatoprotective potential of ethanolic extract of <em>Selaginella bryopteris</em> (SBEE) against carbon tetrachloride (CCl₄) induced liver damage in rat model.</div></div><div><h3>Materials and methods</h3><div>Hepatoprotective activity of SBEE was evaluated at three doses i.e., 250 mg/kg, 500 mg/kg and 750 mg/kg <em>p.o.</em> against CCl₄ (1.5 ml/kg <em>i.p.</em>) exposure once only in male Wistar rats. After 24 hours of the last treatment, all the experimental animals were euthanized to collect blood and liver tissue for the analysis of blood and tissue biochemistry parameters along with histopathological analysis.</div></div><div><h3>Results</h3><div>Carbon tetrachloride (CCl₄) intoxication in animals significantly elevated hepatospecific markers such as AST, ALT, LDH, and bilirubin in the bloodstream. Administration <em>of Selaginella bryopteris</em> ethanolic extract (SBEE) at doses of 250 mg/kg, 500 mg/kg, and 750 mg/kg restored these markers in a dose-dependent manner. The increased tissue lipid peroxidation (LPO) and depleted reduced glutathione (GSH) levels in CCl₄ treated rats were also significantly restored by SBEE therapy (p ≤ 0.05). Histological analysis supported these biochemical findings, showing dose-dependent recovery of liver cellular architecture in SBEE-treated groups compared to the CCl₄-intoxicated group. The dose dependent hepatoprotective effects of SBEE were comparable to those observed with the positive control group treated with Silymarin. The 750 mg/kg dose of SBEE showed the most pronounced recovery in serological liver markers, tissue biochemical parameters, and histological integrity, as confirmed by statistical analysis.</div></div><div><h3>Conclusions</h3><div>These results suggest that ethanolic extract of <em>Selaginella bryopteris</em> exhibits liver protection by ameliorating the blood and tissue biochemical markers with improved the cellular morphology against CCl₄ induced damage. This protective effects of SBEE are likely due to the synergistic effect of its phytochemical constituents which contribute to its antioxidant and hepatoprotective effect.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"6 ","pages":"Article 100141"},"PeriodicalIF":0.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of chemical composition, antimicrobial activity and in silico investigation of the essential oil extracted from peels of Citrus medica (Jora Tenga) & Citrus jambhiri (Gol Nemu) grown in north eastern region of India","authors":"Rashmita Gogoi ,&nbsp;Siddhartha Sankar Das ,&nbsp;Simi Deka ,&nbsp;Abhijita Talukder ,&nbsp;Bhargab Jyoti Sahariah ,&nbsp;Tarun Kumar Dua ,&nbsp;Koushik Nandan Dutta","doi":"10.1016/j.prenap.2024.100139","DOIUrl":"10.1016/j.prenap.2024.100139","url":null,"abstract":"<div><div><em>Citrus medica</em> and <em>Citrus jambhiri</em> locally known as ''Jora tenga,' and ‘Gul nemu' in Assam, which has been traditionally used in the region for its medicinal properties and is highly regarded for their therapeutic benefits in local remedies. Our aim in this study to explore the chemical composition of the essential oil isolated from <em>C. medica</em> and <em>C. jambhiri</em> peel and determine their in vitro and <em>in silico</em> antimicrobial activity. GCMS study of the oils extracted from <em>C. medica</em> and <em>C. jambhiri</em> fruits yielded a total of 177 and 227 compounds, respectively. The common chemicals are found from both the lemon peel oil are D-Limonene, α -Pinene, Geraniol, β -Bisabolene, α -Bisabolol, Linalool, and Caryophyllene. <em>In silico</em> study showed that these compounds should be responsible for antibacterial activity, which are most abundant in oil. <em>C. medica</em> and <em>C. jambhiri</em> peel oil also showed promising antibacterial activity against gram positive bacteria <em>Enterococcus faecalis a</em>nd gram negative bacteria <em>Escherichia coli.</em></div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"6 ","pages":"Article 100139"},"PeriodicalIF":0.0,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calendula officinalis - A comprehensive review","authors":"Ilias Zournatzis,&nbsp;Vasileios Liakos,&nbsp;Savvas Papadopoulos,&nbsp;Eleni Wogiatzi","doi":"10.1016/j.prenap.2024.100140","DOIUrl":"10.1016/j.prenap.2024.100140","url":null,"abstract":"<div><div><em>Calendula officinalis</em>, also known as pot marigold, is a member of the composite family (Asteraceae) and is important for the treatment of various diseases. It has a long history as a traditional remedy for inflammation, ulcers, skin and digestive problems, nervousness, insomnia and many other ailments. Calendula contains a wide range of constituents, including lipids, terpenoids, carotenoids, coumarins and quinones. Several studies have scientifically confirmed the plant's medicinal properties, including anti-inflammatory, healing, regenerative, antimicrobial, anticancer, antigenotoxic and genotoxic, hepatoprotective, neuroprotective, cardioprotective, gastroprotective, antioxidant, spasmogenic and spasmolytic, antiprotozoal, anthelmintic, acaricidal, antiviral, anti-ageing, photoprotective, and immunostimulant effects. Its therapeutic potential has been tested in clinical trials, where it was found to be effective in ulcers, radiodermatitis, burn wounds, oropharyngeal mucositis, plague, and gingivitis, with no toxicity. As a result, it is included in many medicines, but it is also used in the food industry because its flowers are edible and can be used fresh in salads or dried as a dye. The aim of this study is to provide detailed information on the distribution of marigold, its botanical characteristics, cultivation practises, traditional uses, phytochemistry and pharmacological activities.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"6 ","pages":"Article 100140"},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}