Pharmacological Research - Natural Products最新文献

{"title":"Medicinal Plants and Chronic Diseases","authors":"Guata Yoro SY","doi":"10.1016/j.prenap.2026.100714","DOIUrl":"10.1016/j.prenap.2026.100714","url":null,"abstract":"","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"11 ","pages":"Article 100714"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148566139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clerodendrum glabrum biosynthesised silver nanoparticles as potential drugs for the treatment of diabetes and cancer","authors":"Mhlongo JK, Matsabisa M.G","doi":"10.1016/j.prenap.2026.100696","DOIUrl":"10.1016/j.prenap.2026.100696","url":null,"abstract":"","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"11 ","pages":"Article 100696"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148572822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical profile and multi-therapeutic potential of Justicia adhatoda: A focus on antidiabetic and antifungal bioactives","authors":"Gunjan Adwani,&nbsp;Sharda Bharti,&nbsp;Awanish Kumar","doi":"10.1016/j.prenap.2026.100772","DOIUrl":"10.1016/j.prenap.2026.100772","url":null,"abstract":"<div><div><em>Justicia adhatoda</em>, commonly known as Vasaka or Malabar nut or <em>Adhatoda vasica</em>, is a traditional medicinal plant extensively used for treating respiratory ailments. Recent studies on this plant have highlighted its potential as a source of bioactive compounds with significant antidiabetic and antifungal activities. This review critically explores the <em>J. adhatoda</em> phytochemical constituents, focusing on their particular compounds like quinazoline alkaloid moieties, vasicine, vasicinone, vasicoline, vasicol, and anisotine, flavonoids, terpenoids, phenols, sterols, and some of its glycosides and polysaccharides, which possess antidiabetic and antifungal properties. They have other distinct pharmacological actions and a wide range of biological functions, including antibacterial, analgesic, antimicrobial, anti-inflammatory, and antitubercular properties. In this review, emphasis is given to its mechanistic action through computational and preclinical studies, and its translational potential is highlighted to address its future potential. The necessity for this review for integrating <em>J. adhatoda's</em> medicinal potential is highlighted by the relative paucity of systematic literature pertaining to its antidiabetic and antifungal effects. The review emphasizes the necessity of highlighting <em>J. adhatoda's</em> dual significance as a medical resource, acting as both an antidiabetic and an antifungal agent. This makes it advantageous for diabetic patients with fungal comorbidities, of which candidiasis is the most prevalent.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"11 ","pages":"Article 100772"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148184184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive compounds and therapeutic potential of Cordyceps sinensis: Current insights and future directions","authors":"Rashmi Ghosh ,&nbsp;Shuvadip Bhowmik","doi":"10.1016/j.prenap.2026.100780","DOIUrl":"10.1016/j.prenap.2026.100780","url":null,"abstract":"<div><div>Caterpillar fungus, a parasitic fungus endemic to the Tibetan Plateau and Nepalese Himalayas, has been used in traditional medicine for several centuries. Their unique life cycle involves infecting moth larvae, consuming their internal organs, and producing fruiting bodies that emerge from the host. The fungus requires specific environmental conditions to grow and has seen a decline in natural abundance owing to overharvesting. To meet this demand, artificial cultivation methods are being explored. The fungus contains a diverse array of bioactive compounds including <em>Cordyceps sinensis</em>, polysaccharides, sterols, nucleosides, and fatty acids. These compounds have been found to possess immunomodulatory, anti-inflammatory, and anti-cancer properties. In particular, cordycepin has shown promise as an anticancer agent that induces apoptosis and inhibits cell proliferation in various cancer cell lines. Preclinical studies have demonstrated the efficacy of Cordyceps extracts in animal models of cancer. Cordycepin and other fungal compounds have been shown to inhibit tumor growth, induce apoptosis, and modulate immune responses. However, further research is needed to fully elucidate the mechanisms of action and their potential for clinical application. The safety and side effects of cordyceps have not been extensively studied in humans. Although generally considered safe, potential drug interactions and contraindications should be considered. Future studies should focus on identifying the most effective compounds, optimizing cultivation methods, and conducting well-designed clinical trials to assess the therapeutic potential of this fascinating fungus.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"11 ","pages":"Article 100780"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148184186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medicinal plants and breast cancer in Mitzic (Gabon): An ethnopharmacological study and review of the mechanisms of action of their bioactive compounds","authors":"Joseph-Arnold Obiang-Nze ,&nbsp;Juliette Ornely Orango Bourdette ,&nbsp;Cédric Sima Obiang ,&nbsp;Jean De La Croix Ndong ,&nbsp;Rick-Léonid Ngoua-Meye-Misso ,&nbsp;Joefred Mbogho Abogo ,&nbsp;Noé Essono Kollo ,&nbsp;Christine Phydélia Zang Ememaga ,&nbsp;Erwin Julda Mombo Mombo ,&nbsp;Herman Begouabe ,&nbsp;Guy-Roger Ndong Atome ,&nbsp;Joseph Privat Ondo ,&nbsp;Sophie Aboughe Angone ,&nbsp;Louis-Clément Obame Engonga","doi":"10.1016/j.prenap.2026.100787","DOIUrl":"10.1016/j.prenap.2026.100787","url":null,"abstract":"<div><h3>Background</h3><div>Breast cancer remains a major public health challenge in sub-Saharan Africa, where access to modern therapies is limited. Traditional medicinal knowledge may offer complementary options for prevention and treatment. This study documented medicinal plants traditionally used against breast cancer in Mitzic (Woleu-Ntem, Gabon) and assessed their therapeutic potential using ethnopharmacological indices and literature evidence.</div></div><div><h3>Methods</h3><div>An ethnopharmacological survey was conducted with 54 traditional healers across three areas of Mitzic. Ethnobotanical data were analyzed using quantitative indicators (RCF and UV). Multivariate analyses (PCA and MCA) were applied to identify species with high therapeutic relevance. A literature review was performed to evaluate the anticancer properties and mechanisms of bioactive compounds reported in the recorded species.</div></div><div><h3>Results</h3><div>47 species belonging to 25 families were documented, predominantly Fabaceae, Annonaceae, and Asteraceae. Leaves and bark were the most frequently used parts (37.0%), mainly prepared as decoctions (69.4%) and administered orally (67.6%). Ten species, including <em>Carica papaya</em>, <em>Annona muricata</em>, <em>Ricinodendron africanum</em>, <em>Croton oligandrus</em>, and <em>Bidens pilosa</em>, showed the highest ethnopharmacological relevance. Literature data support anticancer activities such as cytotoxicity, antiproliferative effects, immunomodulation, and antiangiogenesis.</div></div><div><h3>Conclusion</h3><div>The findings highlight the ethnomedical relevance and potential for further pharmacological validation of Gabonese medicinal plants as a complementary resource in breast cancer management. Further pharmacological and clinical investigations are required to validate efficacy and safety before integration into public health strategies.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"11 ","pages":"Article 100787"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148241053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Humulus lupulus L. and its potential application in dermocosmetics","authors":"Briolanja dos Santos ,&nbsp;Juliana Garcia ,&nbsp;Irene Gouvinhas ,&nbsp;Maria José Alves ,&nbsp;Olívia R. Pereira ,&nbsp;Maria Carmen Seijo ,&nbsp;Maria João Sousa","doi":"10.1016/j.prenap.2026.100779","DOIUrl":"10.1016/j.prenap.2026.100779","url":null,"abstract":"<div><div><em>Humulus lupulus</em> L<em>.</em> is traditionally exploited for brewing, however, its vegetative tissues and industrial residues remain largely underexplored. This study provides the first comprehensive and integrated comparison of cones, leaves, stems, seeds, bracts, and brewery by-products from three commercial cultivars (Nugget, Cascade, Chinook) and spontaneous wild hops collected in northeast Portugal, targeting their suitability as multifunctional dermocosmetic ingredients. Hydromethanolic extracts were characterised by UV–Vis and HPLC-DAD, revealing abundant flavonols/flavones, with isoquercetin reaching 6.14 g kg⁻¹ dry weight in Chinook cones. The amino acid profile of asparagine dominated the profile of all cone extracts, reaching 366 mg kg⁻¹ of dry weight in Cascade. Photoprotective evaluation demonstrated SPF values up to 19.83. Enzyme inhibition assays revealed marked anti-ageing potential, with elastase inhibition reaching 100%. The cone showed remarkable antibacterial activity against Cutibacterium acnes (MIC ≤ 250 µg mL⁻¹). Extracts also reduced nitric oxide production in LPS/IFN-γ-stimulated RAW 264.7 macrophages (IC₅₀ down to 9.66 µg mL⁻¹), indicating modulation of a key pro-inflammatory mediator. HaCaT keratinocyte and HFF-1 fibroblasts maintained ≥ 90% viability at concentrations up to 1 mg mL⁻¹ . Collectively, these results demonstrate that not only hop cones but also vegetative parts and industrial by-products represent sustainable and safe sources of bioactive compounds with antimicrobial, photoprotective, enzyme-inhibitory, nitric oxide-modulating activities and cytotoxicity. The valorisation of such materials aligns with circular-economy principles and offers a feasible pathway for the development of plant-based actives in next generation skincare formulations.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"11 ","pages":"Article 100779"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148241188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulation of inflammatory pathways by cannabigerol in the collagen induced arthritis model in rats","authors":"Ondřej Slanař,&nbsp;Monika Šteigerová,&nbsp;Michaela Sklenárová,&nbsp;Petr Jelinek,&nbsp;Miroslav Šoóš,&nbsp;Martin Šíma","doi":"10.1016/j.prenap.2026.100705","DOIUrl":"10.1016/j.prenap.2026.100705","url":null,"abstract":"","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"11 ","pages":"Article 100705"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148565215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nature-inspired innovations: Novel chemical entities and platforms for biological target exploration and therapeutics development against cancers and mechanistically related conditions","authors":"Amos Fatokun","doi":"10.1016/j.prenap.2026.100712","DOIUrl":"10.1016/j.prenap.2026.100712","url":null,"abstract":"","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"11 ","pages":"Article 100712"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148565295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant characterisation of bean to bar dark chocolates: Potential relationship with their endothelium-dependent vasorelaxation.","authors":"Pincemail J,&nbsp;Tabart J,&nbsp;Muzamel H,&nbsp;Cavalier Etienne,&nbsp;Matute A,&nbsp;Meziane S,&nbsp;Schini-Kerth V","doi":"10.1016/j.prenap.2026.100697","DOIUrl":"10.1016/j.prenap.2026.100697","url":null,"abstract":"","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"11 ","pages":"Article 100697"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148565325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eudragit-PEG Nanoparticles: Physicochemical Characterization and Interfacial Tension Measurements","authors":"Papa Mady Sy *,&nbsp;Nicolas Anton,&nbsp;Sidy Mouhamed Dieng,&nbsp;Alphonse Rodrigue Djiboune,&nbsp;Abdou Faye,&nbsp;Louis Augustin Diaga Diouf,&nbsp;Boucar Ndong,&nbsp;Gora Mbaye,&nbsp;Thierry Vandamme,&nbsp;Mounibé Diarra","doi":"10.1016/j.prenap.2026.100690","DOIUrl":"10.1016/j.prenap.2026.100690","url":null,"abstract":"","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"11 ","pages":"Article 100690"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148565448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}