Pharmacological Research - Natural Products最新文献

{"title":"From roots to remedies: Exploration of medicinal potential of Fumaria parviflora Lam. in drug discovery","authors":"Archana Sharma ,&nbsp;Deepa ,&nbsp;Priya Yadav ,&nbsp;Radha Jangra ,&nbsp;Shailja Singh ,&nbsp;Vijay Kumar ,&nbsp;Parul Badhwar ,&nbsp;Natarajan Gopalan ,&nbsp;Sarvajeet Singh Gill ,&nbsp;Ritu Gill","doi":"10.1016/j.prenap.2025.100319","DOIUrl":"10.1016/j.prenap.2025.100319","url":null,"abstract":"<div><div><em>Fumaria parviflora</em> Lam., (synonym <em>Fumaria indica</em>) an important medicinal herb widely known in Ayurvedic and Unani system of medicine for its diuretic, laxative, antihelmintic, antimicrobial, stomachic and blood purifier properties. It has been used as antimicrobial, antiviral, hepatoprotective, antidiabetic, anti-inflammatory, antioxidant, wound healing properties and in reproductive health etc. The present review aims to focus on the traditional uses, pharmacology, and phytochemistry of <em>F. parviflora</em>. Findings based on the scientific evidence suggested that <em>F. parviflora</em> has been widely studied for both <em>in-vitro</em> as well as on animal models. Additionally, <em>F. parviflora</em> has also been tested clinically for skin diseases such as eczema, uremic pruritus among hemodialysis patients and hot flashes in breast cancer survivors. The biological activities are majorly associated with the presence of alkaloids and other secondary metabolites. Furthermore, <em>in-silico</em> studies revealed the role of extracted compounds from <em>F. parviflora</em> against the proteins involved in various diseases.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100319"},"PeriodicalIF":0.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The in vitro and in vivo whitening activity of ergothioneine by autophagy induction through organic cation transporter 1 into melanocytes and keratinocytes","authors":"You-Cheng Hseu ,&nbsp;Yan-Zhen Zhang ,&nbsp;Sudhir Pandey ,&nbsp;Siang-Jyun Chen ,&nbsp;Da-Gong Huang ,&nbsp;Yen-Chun Chen ,&nbsp;Hung-Rong Yen ,&nbsp;Jhih-Hsuan Hseu ,&nbsp;Hsin-Ling Yang","doi":"10.1016/j.prenap.2025.100320","DOIUrl":"10.1016/j.prenap.2025.100320","url":null,"abstract":"<div><div>Ergothioneine (EGT) has been utilized as a cosmetic ingredient, but its whitening potency has to be examined. We probed skin whitening mechanism of low concentration of EGT (0–500 nM) through autophagy induction in melanoma B16F10 and keratinocyte HaCaT cells, and suppression of ROS-intervened UVA-irradiated-α-MSH or UVB-irradiated ET-1 expression via Nrf2 pathway in HaCaT cells. EGT-incited autophagy in B16F10 and HaCaT cells was evidenced by increased LC3-II/p62 accretion, ATG4B inhibition, ATG5/ATG7 expression, Beclin-1/Bcl-2 ratio, AMPK/mTOR/ULK1 pathway, autophagosome GFP-LC3 puncta, and autolysosome AVO formation. Furthermore, EGT decreased melanosome gp100 expression and melanin accumulation by instigating autophagy in B16F10 and HaCaT cells. TEM microscopy revealed that EGT amplified melanosome-engulfing autophagosomes and autolysosomes. Further, autophagy inhibitor 3-MA/CQ or LC3 silencing attenuated EGT-mediated anti-melanogenesis in B16F10 cells and melanin degradation in melanin-feeding HaCaT cells. Interestingly, mTOR silencing triggered antimelanogenesis in B16F10 cells or enhanced melanin degradation in melanin-feeding HaCaT cells through autophagy. Notably, EGT provoked its transporter OCTN-1 expression, whereas OCTN-1 silencing prevented EGT-induced autophagy in HaCaT and B16F10 cells. <em>In vivo</em> zebrafish model confirmed that EGT triggered antimelanogenesis and melanin degradation by autophagy induction through OCTN-1. Additionally, EGT provoked autophagic p62-mediated Keap-1 degradation and then facilitated antioxidant Nrf2 activation in HaCaT cells. EGT triggered antimelanogenesis by inhibiting ROS-mediated UVA (3 J/cm²)-irradiated α-MSH expression and UVB (80 mJ/cm²)-irradiated ET-1 expression by upregulating Nrf2-transcribed antioxidant proteins HO-1, NQO-1, and γ-GCLC expression in HaCaT cells, whereas OCTN-1 or Nrf2 silencing reversed these effects. EGT could be utilized as a skin-whitening ingredient in the preparation of topical cosmeceutics.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100320"},"PeriodicalIF":0.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144680787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticancer activity of Abelmoschus esculentus (L.) Moench against lung cancer cell: A literature review","authors":"Md Abu Sayeed ,&nbsp;Emon Mia ,&nbsp;Ali Mohamod Wasaf Hasan ,&nbsp;Md. Sakib Al Hasan ,&nbsp;Md. Arif Hossain ,&nbsp;Imam Hossen Rakib ,&nbsp;Moushumi Afroza Mou ,&nbsp;Mst. Sumaia Akter ,&nbsp;Sujoy Das ,&nbsp;Muhammad Torequl Islam","doi":"10.1016/j.prenap.2025.100317","DOIUrl":"10.1016/j.prenap.2025.100317","url":null,"abstract":"<div><div><em>Abelmoschus esculentus</em> L. Moench (okra), a member of the Malvaceae family, is gaining recognition for its potential as a natural anticancer agent due to its diverse bioactive constituents, including flavonoids, polysaccharides, and polyphenols. This review investigates its therapeutic potential in lung cancer prevention and treatment. A systematic literature search was conducted using databases such as Google Scholar, PubMed and Web of Science to identify studies published between 2000 and 2025. The inclusion criteria focused on research examining the effects of <em>A. esculentus</em> extracts on lung cancer cell lines, particularly A549, emphasizing on apoptosis and antiproliferative activities. Results demonstrate strong cytotoxic effects, with IC₅₀ values as low as 1.74 µg/mL for flower extract, while bioactive compounds such as quercetin derivatives effectively inhibit proliferation and induce apoptosis. Despite these promising preclinical outcomes, the exploration of <em>A. esculentus</em> in cancer therapy is still in its early stages, with limited clinical data. These findings suggest its potential as an adjunct therapy, providing enhanced outcomes with minimal toxicity. However, further clinical trials are needed to confirm its therapeutic efficacy and safety in humans.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100317"},"PeriodicalIF":0.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144662828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peptide extract from Hexaplex trunculus: A promising antimicrobial agent with inhibitory effects on quorum sensing and biofilm formation","authors":"Kofi Junior Osei ,&nbsp;De-youngster Wereko Brobbey ,&nbsp;Jennifer Tetteh ,&nbsp;Michael Konney Laryea ,&nbsp;Godfred Darko ,&nbsp;Lawrence Sheringham Borquaye","doi":"10.1016/j.prenap.2025.100315","DOIUrl":"10.1016/j.prenap.2025.100315","url":null,"abstract":"<div><h3>Purpose</h3><div>Infectious diseases are a global concern and antimicrobial resistance is a major cause of their prevalence. Antimicrobial peptides (AMPs), which are key components of the innate immune system of marine invertebrates, provide a rapid and immediate response against invading microbes. They possess remarkable antimicrobial activities and slower rates of resistance acquisition, making them an attractive target for new antimicrobial therapeutics. This work seeks to extract peptides from the marine mollusc, <em>Hexaplex trunculus</em>, and explore their antimicrobial activity.</div></div><div><h3>Methods</h3><div>Peptides were precipitated from the body tissue of <em>H. trunculus,</em> and the peptides were characterized using spectroscopic methods such as FTIR and UV. The broth dilution technique was used to determine the peptides' minimum inhibitory concentrations (MICs). The peptide extract was tested against <em>Escherichia coli, Enterococcus faecalis, Staphylococcus aureus, Candida albicans,</em> and <em>Pseudomonas aeruginosa.</em> The study also evaluated the effect of the peptide extracts on quorum sensing-mediated processes in <em>Pseudomonas aeruginosa</em>.</div></div><div><h3>Results</h3><div>The MIC values obtained against the various microorganisms ranged between 0.50 mg/mL and 0.25 mg/mL<em>.</em> Minimum bactericidal concentration (MBC) determination showed that the peptide extract at 0.50 mg/mL and 0.25 mg/mL had bacteriostatic effects. The results showed that the crude peptide extract inhibited biofilm formation in <em>Pseudomonas aeruginosa</em>. The expression of pyocyanin and pyoverdine, which are mediated by cell-to-cell communication, was inhibited by 88% and 66%, respectively, at 1/2 MIC of the peptide extract.</div></div><div><h3>Conclusion</h3><div>These findings suggest that crude peptide extract from <em>Hexaplex trunculus</em> may serve as a potential source of new antimicrobial agents to combat infectious diseases.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100315"},"PeriodicalIF":0.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144680788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abelmoschus esculentus: A multifaceted approach to hyperglycemia and associated disorders","authors":"Loushambam Samananda Singh ,&nbsp;Waikhom Somraj Singh ,&nbsp;Lautambam Sanathoiba Singha","doi":"10.1016/j.prenap.2025.100316","DOIUrl":"10.1016/j.prenap.2025.100316","url":null,"abstract":"<div><div><em>Abelmoschus esculentus</em> (AE), commonly designated as okra or ladies' finger, possesses a well-documented historical background as a natural therapeutic agent for numerous health ailments. Empirical research has elucidated that the extracts derived from this botanical species exhibit antidiabetic characteristics and influence related pathological conditions, which may be attributable to the presence of bioactive constituents that underlie their pharmacological efficacy. Moreover, its substantial dietary fiber content facilitates a decrease in the absorption of glucose within the intestine. In light of its nutritional and medicinal properties, AE emerges as a promising and cost-effective functional food, replete with bioactive compounds and antioxidants, which not only furnish essential nutrients but also significantly contribute to the management of diabetes and associated disorders while promoting overall health. The objective of this review is to elucidate the chemical composition and the extensive therapeutic potential of AE.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100316"},"PeriodicalIF":0.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144662939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytotoxic and antiviral properties of Canarium patentinervium Miq. Against H1N1 influenza virus; insilico and invitro insights","authors":"Najwan Jubair ,&nbsp;Mogana R ,&nbsp;Yasir K. Mahdi ,&nbsp;Ayesha Fatima ,&nbsp;Iana L. Esaulkova ,&nbsp;Yulia N. Pavlyukova ,&nbsp;Anna A. Muryleva ,&nbsp;Alexandrina S. Volobueva ,&nbsp;Vladimir V. Zarubaev ,&nbsp;Norhayati Binti Abdullah","doi":"10.1016/j.prenap.2025.100318","DOIUrl":"10.1016/j.prenap.2025.100318","url":null,"abstract":"<div><div>The seasonal flu virus can cause serious illness or death. Medical therapies and vaccinations have reduced influenza infections, yet they remain a public health hazard. Folk medicine uses <em>Canarium patentinervium</em> Miq, to cure respiratory problems and inflammation. Nevertheless, little is known about this plant's antiviral properties. This study aims to test the antiviral activity of several extracts and isolated compounds from <em>Canarium patentinervium</em> Miq. against the H1N1 virus in insilico and invitro models. The leaf and bark ethanol extracts exhibited the highest activity, with CC₅₀ &gt; 300 µg/mL, IC₅₀= 30.2 µg/mL, and SI = 10. Catechin was isolated from the plant leaf and bark along with scopoletin, scoparone, hyperin, and cynaroside. All the isolated compounds were tested against H1N1 drug targets neuraminidase, hemagglutinin, and matrix protein 2 in insilico study. Catechin had the highest affinity (∆G= −10.4 Kcal/mol) and binding free energy (∆Gbind= −92.6 ± 0.3 KJ/mol) for matrix protein 2. The in vitro investigation demonstrated that catechin had minimal toxicity and some effect on the H1N1 virus (CC₅₀&gt;300 µg/mL, IC₅₀= 41.5 µg/mL, and SI = 7). Catechin and oseltamivir synergy was tested using virus yield reduction assays. Influenza decreased significantly by oseltamivir-catechin at 1 and 100 µg/mL dosages with strong synergy indicated through viral titer. For the first time, the antiviral activity of the <em>Canarium patentinervium</em> miq plant was reported in this study, and it suggests that using plant phytochemicals in combination with oseltamivir may improve flu outcomes, especially for patients who are very sick or immunocompromised.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100318"},"PeriodicalIF":0.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144662938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acetic acid-induced ulcerative colitis alleviation by Xylopia aethiopica (Dunal) A. Rich in Sprague Dawley rats","authors":"Newman Osafo ,&nbsp;Kofi Oduro Yeboah ,&nbsp;Michael Hagan ,&nbsp;Ellis Jeff Aidoo ,&nbsp;Mavis Sersah Nyarko ,&nbsp;Aaron Opoku Antwi","doi":"10.1016/j.prenap.2025.100314","DOIUrl":"10.1016/j.prenap.2025.100314","url":null,"abstract":"<div><div>Ulcerative colitis is a chronic idiopathic inflammatory disorder characterized by immune system dysregulation, with oxidative stress and humoral immunity significantly involved. While many advances in therapy exist, ongoing challenges highlight the need for new therapies. Medicinal plants, like <em>Xylopia aethiopica</em>, show promise due to their ability to modulate inflammation, reduce oxidative stress, and enhance tissue healing, all with fewer side effects and lower costs. This study sought to investigate the chemo-profile of the aqueous ethanol extract of the dried fruit of <em>X. aethiopica</em> and its alleviating potential of ulcerative colitis induced with acetic acid in rats. After extraction of the dried fruit of <em>X. aethiopica</em>, HPLC finger print was generated using established method. Sprague Dawley rats were treated with <em>Xylopia aethiopica</em> extract at doses of 30, 100 and 300 mg/kg for 8 days with colitis being induced on the 4th day of treatment, using normal saline and 500 mg/kg sulphasalazine as naïve and positive controls, respectively. The different compounds identified in the dried fruit extract of <em>X. aethiopica</em> were seven bands. Findings from this study also showed that treatment with <em>X. aethiopica</em> extract suppresses macroscopic and histologic damage, improves mucosal regeneration by reducing silver-stained nucleolar organizer regions, and significantly increases antioxidant enzymes; ascorbate peroxidase, catalase and superoxide dismutase. Thus, the hydroethanolic dried fruit extract of <em>Xylopia aethiopica</em> is effective in acetic acid-induced ulcerative colitis and may serve as alternate therapy or source of drug leads in the treatment of ulcerative colitis and this may be attributed to a myriad of compounds in the extract.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100314"},"PeriodicalIF":0.0,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro activity of Citrus IntegroPectin against lung cancer cells","authors":"Caterina Di Sano ,&nbsp;Claudia D’Anna ,&nbsp;Giovanna Li Petri ,&nbsp;Giuseppe Angellotti ,&nbsp;Francesco Meneguzzo ,&nbsp;Rosaria Ciriminna ,&nbsp;Mario Pagliaro","doi":"10.1016/j.prenap.2025.100313","DOIUrl":"10.1016/j.prenap.2025.100313","url":null,"abstract":"<div><div><em>Citrus</em> IntegroPectin bioconjugates obtained through acoustic cavitation in water of different <em>Citrus</em> fruit (lemon, red orange, and sweet orange) processing waste show substantial anticancer activity <em>in vitro</em> against human non-small cell lung cancer cells. Dissolved in aqueous phase at different concentrations, all bioconjugates tested affected long-term proliferation and cell migration of adenocarcinoma cells of line A549. Compared to the bioconjugate sourced from sweet orange, IntegroPectin phytocomplexes from lemon and red orange were more effective in reducing colony formation activity. Pointing to significant reduction in cancer cell progression, these first results concerning lung cancer cells support further investigation of these new low methoxyl pectins rich in citrus flavonoids and RG-I regions for the treatment of cancer.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100313"},"PeriodicalIF":0.0,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144695170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antinociceptive effects of ursolic acid in rats with diabetic peripheral neuropathy: Behavioral, biochemical, and molecular docking evidence","authors":"Varsha Motilal Shende,&nbsp;Deepti Dinesh Bandawane","doi":"10.1016/j.prenap.2025.100305","DOIUrl":"10.1016/j.prenap.2025.100305","url":null,"abstract":"<div><h3>Introduction</h3><div>Diabetic peripheral neuropathy (DPN) is a common and disabling complication of diabetes, driven by oxidative stress, inflammation, nerve degeneration, and pain sensitization. In DPN, PPAR-γ regulates inflammation and lipid metabolism, while TRPV1 mediates pain and neuroinflammation. Ursolic acid (UA), a natural triterpenoid, may mitigate these pathological processes via PPAR-γ activation and TRPV1 inhibition.</div></div><div><h3>Objective</h3><div>To evaluate the efficacy of UA alone and in combination with amitriptyline (AMT) and methylcobalamin (MeCbl) in preventing neuropathic pain and biochemical imbalance in diabetic rats, and to investigate UA’s molecular mechanism through docking analysis.</div></div><div><h3>Methods</h3><div>Type 2 diabetes was induced in Sprague-Dawley rats using a high-fat diet followed by streptozotocin injection. Diabetic rats (n = 8/group) were treated with UA (40 mg/kg), AMT (30 mg/kg), MeCbl (0.5 mg/kg), or their subeffective combinations for 6 weeks. Evaluations included pain behaviors, glycometabolic indices, lipid profile, oxidative stress and inflammatory biomarkers, and histopathological alterations in pancreas and sciatic nerve. UA’s interaction with PPAR-γ and TRPV1 was assessed via molecular docking.</div></div><div><h3>Results</h3><div>UA treatment reduced hyperalgesia by 64.0 % (P &lt; 0.05, <em>d</em> = 2.02) and cold allodynia by 47.2 % (P &lt; 0.05, <em>d</em> = 2.29), compared to diabetic control, while combination therapy improved both pain indices by over 82 % (P &lt; 0.001, <em>d</em> &gt; 2.5). UA significantly enhanced grip strength (+38.4 %) and walking ability (−16.6 % time; P &lt; 0.05), and improved glucose tolerance by reducing OGTT AUC by 39 % compared to diabetic control. UA lowered IL-6 (−18.9 %, P &lt; 0.05, <em>d</em> = 2.84) and TNF-α (−25.3 %, P &lt; 0.05, <em>d</em> = 1.76), normalized lipid profile (↓cholesterol by 26.7 %, ↓triglycerides by 24.4 %, ↑HDL by 56.9 %), and restored oxidative balance (↓MDA by 24.7 %, ↑GSH by 60.4 %, ↑catalase by 50.3 %; all P &lt; 0.01). Histopathological scores showed preserved islet architecture and nerve integrity with UA and combination treatments. Docking results confirmed moderate affinity of UA for PPAR-γ (−6.554 kcal/mol) and strong binding to TRPV1 (−8.214 kcal/mol).</div></div><div><h3>Conclusion</h3><div>Early intervention with UA, particularly in combination with AMT and MeCbl, attenuated DPN progression by modulating oxidative stress, inflammation, and neuropathic pain. These preclinical findings suggest UA’s potential as a complementary agent in DPN management, warranting further validation.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100305"},"PeriodicalIF":0.0,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Herbal pharmacopeias: Bridging ancient traditions, nanotechnological innovation, and global regulatory cohesion for equitable healthcare","authors":"Kushagra Sharma","doi":"10.1016/j.prenap.2025.100301","DOIUrl":"10.1016/j.prenap.2025.100301","url":null,"abstract":"<div><div>This review examines the role of herbal pharmacopeias in integrating ancient healing traditions, nanotechnology-driven innovations, and global regulatory frameworks to advance equitable healthcare. It addresses critical challenges such as low bioavailability, inconsistent quality control, and fragmented regulations hindering the integration of herbal medicines into mainstream healthcare systems. By synthesizing ethnobotanical knowledge, nanotechnology applications, and regulatory science, this review evaluates advancements such as nanocarriers (e.g., liposomes, phytosomes) and Traditional Chinese Medicine (TCM) supermolecules (e.g., berberine-rhein complexes). Regional case studies from China, Brazil, and Africa are analyzed to highlight contributions like genomic databases, biodiversity-driven innovations, and standardized monographs. Key findings demonstrate nanotechnology’s potential to enhance solubility, targeted delivery, and therapeutic efficacy of herbal compounds. Regional initiatives, such as China’s genomic resources and Africa’s pharmacopeial monographs, underscore diverse contributions. Persistent challenges include herb-drug interactions, variable raw material quality, and inadequate pharmacovigilance systems. Harmonized regulations (e.g., European Pharmacopeia, World Health Organization (WHO) initiatives) and AI-driven safety monitoring are identified as pivotal solutions. The integration of ethnobotanical wisdom, nanotechnology, and global regulatory cohesion is essential to unlock the full potential of herbal medicines. Interdisciplinary collaboration, ethical benefit-sharing frameworks (e.g., Nagoya Protocol), and robust pharmacovigilance are critical for achieving scalable, equitable healthcare solutions. Herbal pharmacopeias must evolve as interconnected systems, balancing tradition with innovation to address 21st-century health disparities.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"8 ","pages":"Article 100301"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144572021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}