Pharmacological Research - Natural Products最新文献

{"title":"In vivo hepatoprotective evaluation of Selaginella bryopteris ethanolic extract against CCl4 mediated free radical induced liver damage","authors":"Deena Prakash ,&nbsp;Divya Bisht ,&nbsp;Brijesh Shivhare ,&nbsp;Maneesha Pandey ,&nbsp;Ramesh Kumar ,&nbsp;Arvind Kumar Shakya","doi":"10.1016/j.prenap.2025.100141","DOIUrl":"10.1016/j.prenap.2025.100141","url":null,"abstract":"<div><h3>Background</h3><div><em>Selaginella bryopteris</em> (L.) also known as Sanjeevani, is a traditional medicinal herb used in treating liver diseases at its native place. It is scientifically unexplored herb for the treatment of various diseases including liver diseases.</div></div><div><h3>Purpose</h3><div>The present study aimed to investigate the hepatoprotective potential of ethanolic extract of <em>Selaginella bryopteris</em> (SBEE) against carbon tetrachloride (CCl₄) induced liver damage in rat model.</div></div><div><h3>Materials and methods</h3><div>Hepatoprotective activity of SBEE was evaluated at three doses i.e., 250 mg/kg, 500 mg/kg and 750 mg/kg <em>p.o.</em> against CCl₄ (1.5 ml/kg <em>i.p.</em>) exposure once only in male Wistar rats. After 24 hours of the last treatment, all the experimental animals were euthanized to collect blood and liver tissue for the analysis of blood and tissue biochemistry parameters along with histopathological analysis.</div></div><div><h3>Results</h3><div>Carbon tetrachloride (CCl₄) intoxication in animals significantly elevated hepatospecific markers such as AST, ALT, LDH, and bilirubin in the bloodstream. Administration <em>of Selaginella bryopteris</em> ethanolic extract (SBEE) at doses of 250 mg/kg, 500 mg/kg, and 750 mg/kg restored these markers in a dose-dependent manner. The increased tissue lipid peroxidation (LPO) and depleted reduced glutathione (GSH) levels in CCl₄ treated rats were also significantly restored by SBEE therapy (p ≤ 0.05). Histological analysis supported these biochemical findings, showing dose-dependent recovery of liver cellular architecture in SBEE-treated groups compared to the CCl₄-intoxicated group. The dose dependent hepatoprotective effects of SBEE were comparable to those observed with the positive control group treated with Silymarin. The 750 mg/kg dose of SBEE showed the most pronounced recovery in serological liver markers, tissue biochemical parameters, and histological integrity, as confirmed by statistical analysis.</div></div><div><h3>Conclusions</h3><div>These results suggest that ethanolic extract of <em>Selaginella bryopteris</em> exhibits liver protection by ameliorating the blood and tissue biochemical markers with improved the cellular morphology against CCl₄ induced damage. This protective effects of SBEE are likely due to the synergistic effect of its phytochemical constituents which contribute to its antioxidant and hepatoprotective effect.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"6 ","pages":"Article 100141"},"PeriodicalIF":0.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of chemical composition, antimicrobial activity and in silico investigation of the essential oil extracted from peels of Citrus medica (Jora Tenga) & Citrus jambhiri (Gol Nemu) grown in north eastern region of India","authors":"Rashmita Gogoi ,&nbsp;Siddhartha Sankar Das ,&nbsp;Simi Deka ,&nbsp;Abhijita Talukder ,&nbsp;Bhargab Jyoti Sahariah ,&nbsp;Tarun Kumar Dua ,&nbsp;Koushik Nandan Dutta","doi":"10.1016/j.prenap.2024.100139","DOIUrl":"10.1016/j.prenap.2024.100139","url":null,"abstract":"<div><div><em>Citrus medica</em> and <em>Citrus jambhiri</em> locally known as ''Jora tenga,' and ‘Gul nemu' in Assam, which has been traditionally used in the region for its medicinal properties and is highly regarded for their therapeutic benefits in local remedies. Our aim in this study to explore the chemical composition of the essential oil isolated from <em>C. medica</em> and <em>C. jambhiri</em> peel and determine their in vitro and <em>in silico</em> antimicrobial activity. GCMS study of the oils extracted from <em>C. medica</em> and <em>C. jambhiri</em> fruits yielded a total of 177 and 227 compounds, respectively. The common chemicals are found from both the lemon peel oil are D-Limonene, α -Pinene, Geraniol, β -Bisabolene, α -Bisabolol, Linalool, and Caryophyllene. <em>In silico</em> study showed that these compounds should be responsible for antibacterial activity, which are most abundant in oil. <em>C. medica</em> and <em>C. jambhiri</em> peel oil also showed promising antibacterial activity against gram positive bacteria <em>Enterococcus faecalis a</em>nd gram negative bacteria <em>Escherichia coli.</em></div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"6 ","pages":"Article 100139"},"PeriodicalIF":0.0,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calendula officinalis - A comprehensive review","authors":"Ilias Zournatzis,&nbsp;Vasileios Liakos,&nbsp;Savvas Papadopoulos,&nbsp;Eleni Wogiatzi","doi":"10.1016/j.prenap.2024.100140","DOIUrl":"10.1016/j.prenap.2024.100140","url":null,"abstract":"<div><div><em>Calendula officinalis</em>, also known as pot marigold, is a member of the composite family (Asteraceae) and is important for the treatment of various diseases. It has a long history as a traditional remedy for inflammation, ulcers, skin and digestive problems, nervousness, insomnia and many other ailments. Calendula contains a wide range of constituents, including lipids, terpenoids, carotenoids, coumarins and quinones. Several studies have scientifically confirmed the plant's medicinal properties, including anti-inflammatory, healing, regenerative, antimicrobial, anticancer, antigenotoxic and genotoxic, hepatoprotective, neuroprotective, cardioprotective, gastroprotective, antioxidant, spasmogenic and spasmolytic, antiprotozoal, anthelmintic, acaricidal, antiviral, anti-ageing, photoprotective, and immunostimulant effects. Its therapeutic potential has been tested in clinical trials, where it was found to be effective in ulcers, radiodermatitis, burn wounds, oropharyngeal mucositis, plague, and gingivitis, with no toxicity. As a result, it is included in many medicines, but it is also used in the food industry because its flowers are edible and can be used fresh in salads or dried as a dye. The aim of this study is to provide detailed information on the distribution of marigold, its botanical characteristics, cultivation practises, traditional uses, phytochemistry and pharmacological activities.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"6 ","pages":"Article 100140"},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemoprofiling and Antimalarial potentials of methanol extract of Solanum dasyphyllum against Plasmodium berghei infected mice","authors":"Elijah Oladapo Oyinloye ,&nbsp;Abdullahi Akanji Murtala ,&nbsp;Farouk Adedeji Oladoja ,&nbsp;Olufemi Lionel Okunye ,&nbsp;Akinyinka Oyedolapo Alabi ,&nbsp;Kehinde Joshua Ogundeyi","doi":"10.1016/j.prenap.2024.100138","DOIUrl":"10.1016/j.prenap.2024.100138","url":null,"abstract":"<div><div><em>Solanum dasyphyllum</em> has traditionally been used as antivenom, painkiller, antipyretic and anticonvulsant ethnomedically, claim that the plant's large amount of bioactive compounds, such as flavonoids, saponins, and alkaloids, is what provides it with its antimalarial activity. This study investigates the Chemo-Profiling of the methanol extract of <em>Solanum dasyphyllum</em> (MESD) leaves by High performance liquid chromatography (HPLC) and Fourier-transform infrared spectroscopy (FT-IR) analysis and its antimalarial activity in <em>Plasmodium berghei</em> infected mice. <em>Solanum dasyphyllum</em> leaves were extracted with 80 % methanol, HPLC and FT-IR finger print were conducted on the extract using established methods. Seventy five Swiss mice, infected with <em>Plasmodium beghei</em> (NK65) were divided into five groups (n = 5), in 4-day suppressive test (4-DST), prophylaxis test (PT), and curative test (CT). The mice were treated orally with 1 % Tween80 (control), methanol extract of <em>Solanum dasyphyllum</em> (MESd) 250, 500 and 1000 mg/kg and chloroquine (10 mg/kg). The different compounds identified in the leaves of methanol extract of <em>Solanum dasyphyllum</em> by HPLC and FT-IR were nine and five bands respectively. The MESd 250, 500 and 1000 mg/kg, (24.0, 49.0 and 66.0 % and 14.0 %, 55.0 % and 71.0 %) demonstrated significant percentage chemosuppresion compared to control in 4-DST and PT respectively. In CT, mean survival time of MESd 250, 500 and 1000 mg/kg, (16.0 ± 1.0, 23.3 ± 0.9 and 25.3 ± 1.2 days) significantly increased relative to control (10.3 ± 0.5 days) respectively. The conclusion of the present study suggested the antimalarial potential of methanol extract of <em>Solanum dasyphyllum</em> leaves might be due to different important constituents revealed by chemo profiling.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"6 ","pages":"Article 100138"},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The antibacterial, antioxidant and sun protection potential of a benzophenone from Dolichopentas decora (S. Moore)","authors":"Peter Sekandi ,&nbsp;Jane Namukobe ,&nbsp;Robert Byamukama ,&nbsp;Christine Betty Nagawa ,&nbsp;Markus Bacher ,&nbsp;Thomas Rosenau ,&nbsp;Linda Langat ,&nbsp;Eduard Mas-Claret ,&nbsp;Dulcie Mulholland","doi":"10.1016/j.prenap.2024.100135","DOIUrl":"10.1016/j.prenap.2024.100135","url":null,"abstract":"<div><div><em>Dolichopentas decora</em> (S.Moore) (Rubiaceae) is used locally in Western Uganda in the treatment of microbial skin infections and could therefore be a potential source of antimicrobial agents. This study aimed at the isolation and identification of compounds from <em>D. decora</em> leaf extracts and an investigation of their bioactivities. The compounds were sequentially extracted from the powdered aerial plant parts using <em>n-</em>hexane, EtOAc, MeOH, and distilled water, and compounds were isolated using a combination of chromatographic techniques. Structure elucidation was performed using NMR spectroscopy and mass spectrometric techniques. This resulted in the identification of seven known compounds: squalene (<strong>1</strong>), β-sitosterol (<strong>2</strong>), stigmasterol (<strong>3</strong>), ursolic acid (<strong>4</strong>), rutin (<strong>5</strong>), mitraphenone A (<strong>6</strong>), and protocatechuic acid (<strong>7</strong>). An investigation of the antibacterial activity of the extracts and isolated compounds was carried out using an agar well diffusion test against <em>Pseudomonas aeruginosa</em>, <em>Staphylococcus aureus, Escherichia coli,</em> and <em>Klebsiella pneumoniae.</em> In addition, the extracts and isolated compounds were screened for antioxidant activity using the 2,2-diphenyl-1-picryl-hydrazyl (DPPH) radical scavenging assay. Compound (<strong>6</strong>) was screened for sun protection potential between 290 and 320 nm. The binding interactions of compound <strong>6</strong> against the penicillin-binding protein 1b (PBP 1b) of <em>E. coli</em> were studied using Molecular Operating Environment (MOE) 2015.10 software. Compound <strong>6</strong> was found to be active against <em>K. pneumoniae</em> (zone of inhibition, 10.0 ± 0.1 mm), it showed a good sun protection factor (SPF = 24.61) and a low radical scavenging activity (28.8 %). Compound <strong>6</strong> binds better to lysine through the hydroxyl group of C-6’’ with a binding affinity value (ΔG = − 3.7 kcal/mol). This study is the first report of compounds <strong>1</strong>–<strong>7</strong> from <em>D. decora</em>.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"6 ","pages":"Article 100135"},"PeriodicalIF":0.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prophylactic administration of naringin prevents anticancer drug 5-fluorouracil-induced hepatorenal toxicity via suppressing lipid peroxidation and oxidative stress in rats","authors":"Ademola C. Famurewa ,&nbsp;Patrick M. Aja ,&nbsp;Morufu E. Balogun ,&nbsp;John O. Medewase ,&nbsp;Innocent Abi ,&nbsp;Adewale I. Adeolu ,&nbsp;Tawakalitu B. Aliu ,&nbsp;Opeyemi J. Olatunji","doi":"10.1016/j.prenap.2024.100137","DOIUrl":"10.1016/j.prenap.2024.100137","url":null,"abstract":"<div><h3>Background</h3><div>5-fluorouracil (5-FU)-based anticancer chemotherapy is widely used in many solid tumours; however, hepatorenal toxicity is a serious side effect associated with its clinical use. Therefore, the current study investigated the potential of a natural flavonoid, naringin (NRG), for possible prevention of 5-FU hepatorenal toxicity in rats.</div></div><div><h3>Method</h3><div>Rats were divided into four groups (n = 6): Control, NRG, 5-FU, and NRG + 5-FU. Accordingly, rats were orally administered NRG (100 mg/kg bodyweight/day) for 10 days, while 5-FU (150 mg/kg bw/day) was intraperitoneally injected on day 8 only. On the 11th day, rats were sacrificed for collection of blood samples, liver and kidney organs for biochemical and histological analyses.</div></div><div><h3>Results</h3><div>5-FU injection induced significant (p &lt; 0.05) increases in activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and levels of uric acid, creatinine, urea, and malondialdehyde. It was observed that 5-FU considerably (p &lt; 0.05) reduced the antioxidant activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), and reduced glutathione (GSH) level. The histopathological abrasions revealed tissue damage consistent with oxidative stress-mediated injury. Interestingly, the prophylactic administration of NRG significantly (p &lt; 0.05) prevented the 5-FU-induced alterations in the hepatorenal markers and maintained the antioxidant status comparable to the control. The NRG dose also ameliorated the oxidative tissue damage in this study.</div></div><div><h3>Conclusion</h3><div>It is evident from the findings that NRG may prevent 5-FU-induced oxidative hepatorenal injury in rats.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"6 ","pages":"Article 100137"},"PeriodicalIF":0.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticancer potential of different phytoconstituents against breast cancer: Is the hope for the new drug discovery","authors":"Akash Vikal ,&nbsp;Rashmi Maurya ,&nbsp;Satyam Khare ,&nbsp;Saurabh Bhargava ,&nbsp;Preeti Patel ,&nbsp;Ghanshyam Das Gupta ,&nbsp;Balak Das Kurmi","doi":"10.1016/j.prenap.2024.100133","DOIUrl":"10.1016/j.prenap.2024.100133","url":null,"abstract":"<div><div>This review explores the potential of phytoconstituents derived from plants as a novel and effective strategy for treating breast cancer, a prevalent and life-threatening condition affecting women worldwide. The study conducted a systematic review of the literature, analyzing data from diverse studies, including <em>in vitro</em> and <em>in vivo</em> experiments as well as clinical trials. The search focused on natural compounds' impact on breast cancer cells, emphasizing mechanisms such as apoptosis induction, hormonal signaling regulation, and overcoming drug resistance while minimizing adverse effects. The findings reveal a myriad of natural compounds demonstrating anticancer potential in breast cancer cells. These compounds, sourced from plants, exhibit the ability to target multiple pathways, offering a multi-faceted approach to breast cancer treatment. Notably, many of these compounds show minimal adverse effects, indicating their potential for clinical application. The study underscores the promise of phytoconstituents in enhancing survival rates and improving the quality of life for individuals with breast cancer. This review not only consolidates existing knowledge but also paves the way for future investigations into these biological agents, offering hope for a new era in breast cancer treatment and inspiring optimism among patients and clinicians alike.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"6 ","pages":"Article 100133"},"PeriodicalIF":0.0,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effects of sclareol against paracetamol-induced liver damage in rats, possibly through an oxidative stress-reducing pathway","authors":"Muhammad Torequl Islam ,&nbsp;Maisha Maliha Medha ,&nbsp;Md. Amirul Islam ,&nbsp;Milon Mondal ,&nbsp;Sushmita Saha ,&nbsp;Chandan Sarkar ,&nbsp;Henrique Douglas Melo Coutinho","doi":"10.1016/j.prenap.2024.100132","DOIUrl":"10.1016/j.prenap.2024.100132","url":null,"abstract":"<div><div>This study evaluates the liver-protective properties of sclareol (SCL), a diterpene derived from plant clary sage. Because of its antioxidant properties, sterol is often used in food and cosmetics. In addition, SCL has neuropharmacological, immune-modulating, anti-inflammatory, anti-hypertensive, and anti-cancer properties. The investigation sought to determine the efficacy of SCL in reducing paracetamol (PCM)-induced liver toxicity in rats. The animals were allocated into five separate groups and given the following care: the vehicle group received normal saline; the PCM dosage for the negative control (NC) group was 640 mg/kg; in addition to 640 mg/kg PCM, the treatment groups received SCL at dosages of 5 or 10 mg/kg, while the positive control (PC) group was given 50 mg/kg of silymarin. Blood and tissue samples were obtained from rats treated with an oral dose of paracetamol at 640 mg/kg for 14 consecutive days. Serum and hepatic tissue samples were subjected to histological and biochemical assessment. The data showed that PCM therapy resulted in considerable necrosis and inflammatory cell infiltration, while the liver structure remained intact in SCL and PC groups. SCL significantly reduced hepatotoxic indicators and corrected PCM-tempted alterations in hepatic enzymes, plasma proteins, serum bilirubin, antioxidant enzymes, lipid peroxidation, and cholesterol levels, particularly at 10 mg/kg dosage. In summary, SCL demonstrated substantial hepatoprotective benefits against paracetamol-induced hepatic toxicity in laboratory animals.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"6 ","pages":"Article 100132"},"PeriodicalIF":0.0,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143156207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical study and biological activity of Morettia philaeana (Delile) DC","authors":"Amel H.I. Elfaky ,&nbsp;Gihan O.M. El hassan ,&nbsp;Saad M. Howladar ,&nbsp;Sakina Yagi","doi":"10.1016/j.prenap.2024.100127","DOIUrl":"10.1016/j.prenap.2024.100127","url":null,"abstract":"<div><div><em>Morettia phillaeana</em> (Delile) DC. (family Brassicaceae) is used in Sudan traditionally to treat some skin and digestive tract diseases. The aim of this study was to investigate the chemical profile of the root, stem, leaf, flower and fruit of <em>M. phillaeana</em> and to evaluate their cytotoxicity, antibacterial, antigiardial, antimalarial and antioxidant activities. Extracts were prepared by sequential maceration of powder of each organ in acetone and methanol. Cytotoxicity was tested against normal Vero cell line. Antibacterial activity was determined by the disc diffusion method. Antimalarial and antigiardial activities were determined by microplate assay against the K1 parasite strain of <em>Plasmodium falciparum</em> and <em>Giardia duodenalis</em> respectively. The DPPH and ABTS assays were adopted to evaluate the antioxidant activity. Phytochemical analysis revealed the presence of alkaloids, flavonoids, tannins, steroids, terpenes and saponins as metabolites. The stem, fruit and leaf accumulated the highest total phenolic (3903.85 GAE mg/g), flavonoids (1078.37 mg QE/g) and tannins (1009.05 TAE mg/g) contents respectively. Results of biological activity revealed that the plant possessed mainly significant antigiardial and antibacterial activities. The highest antigiardial effect was recorded from the acetone and ethanol extracts of the leaf (IC₅₀ 4.40 and 4.49 and µg/mL, <em>p</em> ≥ 0.05) and the highest antibacterial activity was obtained against <em>Escherichia coli</em> from the ethanolic extracts of leaf (inhibition zone = 23.2 mm). The acetone extract of the fruit displayed moderate ABTS radical scavenging activity (66.7 %). All organs’ extracts exerted weak antimalaria activity (IC₅₀ 172.2–238.5 µg/mL). All extracts, except the acetone extract of the stem (IC₅₀ 43.48 µg/mL), were not toxic (IC₅₀ ≥ 222.09 µg/mL). In conclusion, it is worth mentioning that the present study demonstrates for the first time the cytotoxicity, antigiardial and antimalarial properties of <em>M. phillaeana</em> and the results obtained partly supported its traditional uses. The plant could be a promising source of bioactive molecules for different pharmaceutical applications.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"5 ","pages":"Article 100127"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142756803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Saussurea costus (falc.) lipsch: A promising ally against cancer","authors":"Rakesh Kumar ,&nbsp;Shailesh Kumar Patel ,&nbsp;Abhishek Verma ,&nbsp;Gaurav Santoshrao Joshi ,&nbsp;Harsh Krishnakumar Bisen ,&nbsp;Rajesh Kumar Asrani ,&nbsp;Jigyasa Rana ,&nbsp;Ankush Kiran Niranjan ,&nbsp;Nikhil K. C ,&nbsp;Megha Katare Pandey","doi":"10.1016/j.prenap.2024.100123","DOIUrl":"10.1016/j.prenap.2024.100123","url":null,"abstract":"<div><div><em>Saussurea costus (S. costus)</em> is a traditional medicinal plant found in the Himalayan region. It has notable ethnopharmacological properties and has been used in scientific studies to treat various ailments such as respiratory problems, body aches, headaches, epilepsy, gastritis, bacterial, fungal, parasitic, and viral infections. Various <em>in vivo</em> and <em>in vitro</em> studies, and scientific literature strongly support the anti-carcinogenic potential of the chemical constituents present in <em>S. costus</em>. Previous studies showed that <em>S. costus</em> has minimal or no side effects and might be used as a therapeutic and preventive drug against cancer. Despite the vast variety of constituents present in <em>S. costus</em> dehydrocostus lactone and costunolide are the most important sesquiterpenes phytochemicals to execute the anti-neoplastic action. To summarize the various medical benefits of <em>S. costus</em> and provide detailed information on its chemical constituents and anticancerous properties the data has been collected from previously published studies associated with <em>S. costus.</em> This study incorporates information sourced from diverse outlets including traditional knowledge, research papers, reviews, books, magazines, international databases, Red data books, abstracts and scientific reports. To extract the current information, web search engines such as Web of Science and Google Scholar were used. Moreover, databases like Wiley Online Library, Science Direct, PubMed, and Taylor and Francis were also utilized in the study.</div><div>To date, minimal scientific information on the <em>in vivo</em> or therapeutic potential of <em>S. costus</em> against cancers is available. The over-exploitation of <em>S. costus</em> has highlighted an alarming threat towards the extinction of this wonderful medicinal plant. In this article only a few <em>in vivo</em> and <em>in vitro</em> studies referenced that are accessible to substantiate the anti-carcinogenic properties of <em>S. costus</em>. The potential anti-carcinogenic effects signify the need for the conservation of this plant and its use at the clinical level against several deadly ailments like cancers.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"5 ","pages":"Article 100123"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143178276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}