{"title":"Inflammatory bowel disease and metabolic reprogramming: From pathological mechanisms to targeted interventions (1/2026)","authors":"Zemin Tian, Yinde Huang, Ying Wang, Chenyu Zhao, Zhaokai Zhou, Hua Yang, Yuan Qiu","doi":"10.1002/inmd.70107","DOIUrl":"https://doi.org/10.1002/inmd.70107","url":null,"abstract":"<p>This cover visualizes immunometabolic dysregulation in inflammatory bowel disease (IBD) through a split intestinal mucosa. The blue side depicts homeostatic epithelium with intact brush border, preserved barrier architecture, and healthy mitochondrial function, reflecting balanced oxidative metabolism that supports epithelial integrity. The red side represents active inflammation, featuring oxidative stress and immune-cell accumulation, symbolizing metabolic reprogramming that weakens the epithelial barrier and amplifies inflammatory circuits. Above, a stream of microbiota-derived metabolites (e.g., SCFAs, bile acids, and tryptophan derivatives) flows from the lumen into the mucosa, highlighting how microbial metabolism shapes host immunity and barrier repair via key signaling axes.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"4 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/inmd.70107","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146154884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mimicking DOUGONG brackets orchestrate regulating inflammation and mechanical stimuli for osteochondral regeneration using 3D printing (1/2026)","authors":"Bo Li, Yaqi Zhang, Xuerui Zhou, Weiguo Wang, Fan Yang, Qiushi Wei, Leilei Chen, Ziqi Li, Mincong He, Xiaoming He, Shengting Chai, Xiuhong Cao, Rui Wang, Tongmeng Jiang, Chen Wang, Wei He","doi":"10.1002/inmd.70101","DOIUrl":"10.1002/inmd.70101","url":null,"abstract":"<p>Inspired by the Chinese myth of “Nüwa Mending the Sky” (女娲 补天), this cover art transforms ancient symbolism into a vision of regenerative healing. Here, the goddess Nüwa embodies the physicians and engineers who crafted 3D-printed scaffolds to repair osteochondral defects—damaged joints ravaged by osteoarthritis—represented by the “broken sky.” The “molten stones” Nüwa used to rebuild the heavens become a 3D-printed DOUGONG (斗拱) bracket structure made from an akermanite/SrSiO<sub>3</sub> composite. The DOUGONG structure—a defining feature of traditional Chinese architectural systems—exhibits remarkable load transfer efficiency for both vertical and horizontal forces, owing to its intricate 3D interlocking network architecture. This unique mechanical property, rooted in millennia of structural wisdom, may facilitate cell-extracellular matrix (ECM) interactions, thereby supporting robust tissue integration. These architecturally inspired scaffolds work in concert: they precisely modulate inflammation and mechanical stimuli to orchestrate the regeneration of healthy osteochondral tissue, turning a mythological act of cosmic repair into a tangible promise of restored joint function. Designed by Jialin Guo, Guangzhou Academy of Fine Arts.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"4 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/inmd.70101","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146136570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Inflammatory bowel disease and metabolic reprogramming: From pathological mechanisms to targeted interventions (1/2026)","authors":"Zemin Tian, Yinde Huang, Ying Wang, Chenyu Zhao, Zhaokai Zhou, Hua Yang, Yuan Qiu","doi":"10.1002/inmd.70107","DOIUrl":"10.1002/inmd.70107","url":null,"abstract":"<p>This cover visualizes immunometabolic dysregulation in inflammatory bowel disease (IBD) through a split intestinal mucosa. The blue side depicts homeostatic epithelium with intact brush border, preserved barrier architecture, and healthy mitochondrial function, reflecting balanced oxidative metabolism that supports epithelial integrity. The red side represents active inflammation, featuring oxidative stress and immune-cell accumulation, symbolizing metabolic reprogramming that weakens the epithelial barrier and amplifies inflammatory circuits. Above, a stream of microbiota-derived metabolites (e.g., SCFAs, bile acids, and tryptophan derivatives) flows from the lumen into the mucosa, highlighting how microbial metabolism shapes host immunity and barrier repair via key signaling axes.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"4 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/inmd.70107","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146154881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Progress in the Detection of Gut Microbiota Based on Microfluidic Technolog (1/2026)","authors":"Yuan Tan, Jiayue Huang, Yi Liu, Xiaofei Lai","doi":"10.1002/inmd.70100","DOIUrl":"10.1002/inmd.70100","url":null,"abstract":"<p>This cover image highlights microfluidic technology for gut microbiota detection. At its center, a transparent microfluidic chip with interlaced branched microchannels shows fluid transport and reaction of intestinal microbial samples, which reflects the core principle of precise microbiota processing via microscale fluid manipulation and embodies the technique’s advantages of low reagent consumption and high efficiency.</p><p>Behind the chip, a fluorescent intestinal structure hosts microbial particles of diverse morphologies and colors. This recreates the intestine as a microbial niche, symbolizes gut microbiota diversity, and aligns with the goal of detecting its composition, structure, and functions.</p><p>A deep blue-purple background with tech light trails merges microscale biology and engineering—the key interdisciplinary integration of this review. This integration bridges life sciences and engineering, enabling innovative analytical approaches while underscoring the review’s microscale exploration of gut microbiota. It further distills the logic of technical application: using the chip to analyze microbiota-host interactions, thereby advancing intestinal disease diagnosis and treatment through such interdisciplinary innovation.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"4 1","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/inmd.70100","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146136571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}