Interdisciplinary Medicine最新文献

{"title":"Biocompatible Polyethersulfone Membrane Modified by Hydrohalic Polymer Decorated Magnetic Nanoparticles Gilded by Facile External Magnetic Field (3/2024)","authors":"Mohammed Kamal Hadi,&nbsp;Huanzhong Zeng,&nbsp;Manasa Pantrangi,&nbsp;Sambasivam Sangaraju,&nbsp;Fen Ran","doi":"10.1002/inmd.12119","DOIUrl":"https://doi.org/10.1002/inmd.12119","url":null,"abstract":"<p>In this cover, we use elements of ancient Chinese style to showcase this work named Biocompatible polyethersulfone membrane modified byhydrophilic polymer decorated magnetic nanoparticlesgilded by facile external magnetic field. We describe a picture of the layout of mountains and lakes in thunderstorm weather. The calm and serene lake surface represents the surface of the polyethersulfone membrane prepared by the phase transition method, and the lotus roots hidden under the lake surface represent Fe₃O₄ nanoparticles. The stem segment to which it is attached is the RAFT-KH550 polymer chain segment, and this element of the lotus leaf shows the PVP molecule grafted onto the chain segment. The lotus leaves spread throughout the lake demonstrate that polyethersulfone membranes modified with modified Fe₃O₄ nanoparticles modulated by an external magnetic field have a more hydrophilic surface with dispersion in the membrane matrix. The protein liquid represented by the rain will be intercepted by the lotus leaves as it falls onto the lake surface and slowly proceeds to slide down, with no apparent adhesion of the raindrops representing the protein liquid. The whole picture demonstrates that the modified membrane prepared by external magnetic field modulation has excellent anti-protein adhesion ability, which can be applied in biomedical field.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"2 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/inmd.12119","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141968425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Red blood cell derived nanocarrier drug delivery system: a promising strategy for tumor therapy (3/2024)","authors":"Xin Wang,&nbsp;Kuirong Mao,&nbsp;Xiaonan Zhang,&nbsp;Yuning Zhang,&nbsp;Yong-Guang Yang,&nbsp;Tianmeng Sun","doi":"10.1002/inmd.12117","DOIUrl":"https://doi.org/10.1002/inmd.12117","url":null,"abstract":"<p>This illustration depicts two primary strategies for nano-drug delivery systems targeting tumor treatment, utilizing red blood cell (RBC) carriers: RBC-hitchhiking and bionic nanomaterials coated with erythrocyte membranes loaded with drugs. Red blood cells are abundantly present in circulation, and their membranes serve as natural carriers for nanomaterial delivery. In the diagram, two major blood vessels extend towards the tumor; the proximal vessels represent nanoparticles coated with RBC membranes, while the distal vessels illustrate the RBC-hitchhiking approach. This review briefly examines the effects of nanoparticles on RBC morphology and function and discusses the application of RBC membranes as nano-drug delivery systems in tumor therapy. This provides a foundation for understanding the mechanisms of nanoparticles and optimizing RBC-based nanocarriers <i>in vivo</i>.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"2 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/inmd.12117","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141968429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PDE5 Inhibitors Against Cancer Via Mediating Immune Cells in Tumor Microenvironment: AI-Based Approach for Future Drug Repurposing Exploration (3/2024)","authors":"Zhenzhan Zhang,&nbsp;Donghua Huang,&nbsp;Junjie Feng,&nbsp;Wangji Li,&nbsp;Zhe Wang,&nbsp;Mengting Lu,&nbsp;Yangyang Luo,&nbsp;Weihao Yang,&nbsp;Zhou Xu,&nbsp;Qingfeng Xie,&nbsp;Wenfu Ding,&nbsp;Xin Tan,&nbsp;Wenjun He,&nbsp;Guoxin Li,&nbsp;Hao Liu,&nbsp;Shangtong Lei","doi":"10.1002/inmd.12116","DOIUrl":"https://doi.org/10.1002/inmd.12116","url":null,"abstract":"<p>This review summarized the effects of PDE5 inhibitors on immune cells in the tumor microenvironment (TME). By combining new methods of artificial intelligence (AI), it proposes that AI can explore the drug targets of PDE5 inhibitors on immune cells in the TME and predict pharmacodynamic targets and responses, has significant scientific implications.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"2 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/inmd.12116","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141968428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Table of Content","authors":"","doi":"10.1002/inmd.12035","DOIUrl":"https://doi.org/10.1002/inmd.12035","url":null,"abstract":"<p>No abstract is available for this article.</p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"2 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/inmd.12035","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141968427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overcoming Challenges of Clinical Cell Therapies for Parkinson's Disease with Photobiomodulation (3/2024)","authors":"Hossein Chamkouri,&nbsp;Jianmin Si,&nbsp;Peng Chen,&nbsp;Haiyong Ni,&nbsp;Denis E. Bragin,&nbsp;Majid Ahmadlouydarab,&nbsp;Chaoshi Niu,&nbsp;Lei Chen","doi":"10.1002/inmd.12118","DOIUrl":"https://doi.org/10.1002/inmd.12118","url":null,"abstract":"<p>We are in a new era of developing interdisciplinary medicine by cross-sectionally employing advanced photonic technology, quantum techniques, transcranial magnetic stimulation, etc., which will widely affect human civilization. Photobiomodulation uses specific wavelengths of light to modulate cellular activity with non-invasive nature and agile ability to target cellular mechanisms directly, promisingly promoting neuronal survival and function without the adverse effects associated with traditional drugs. This makes it a viable alternative for conditions like Parkinson’s disease (PD) and Alzheimer’s disease (AD), where current treatments fail to address the underlying neuronal degeneration effectively.</p><p>The PBM method presented in this paper is particularly noteworthy for its interdisciplinary approach, integrating principles from neurology, photonics, and cellular biology. This approach not only broadens the scope of therapeutic strategies but also fosters collaboration across various scientific disciplines, driving innovation in medical treatment. By understanding the specific effects of different wavelengths on cellular processes in PD, researchers can tailor PBM therapies to optimize patient outcomes, potentially slowing disease progression and improving quality of life.</p><p>PBM’s application in PD therapy highlights its potential to overcome traditional challenges, such as managing chronic symptoms and mitigating the side effects of long-term medication use. By focusing on the therapeutic mechanisms at the cellular level, PBM offers a novel way to protect neurons and support their function, paving the way for more effective management of neurodegenerative disorders.</p><p>Moreover, the development of PBM represents a significant advancement in medical treatment, offering a non-invasive, side-effect-free alternative to traditional therapies for PD. Its interdisciplinary nature promotes collaboration and innovation, making it a promising avenue for future research and application in neurodegenerative disease management.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"2 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/inmd.12118","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141968424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photochemical regulatory strategies for nucleic acid function and their biomedical applications","authors":"Menglu Hu,&nbsp;Yihui Wang,&nbsp;Xiaoming Zhou","doi":"10.1002/INMD.20240006","DOIUrl":"10.1002/INMD.20240006","url":null,"abstract":"<p>Nucleic acids are not only essential biomolecules that drive critical life processes such as growth, development, reproduction, inheritance, and mutation, but also serve as significant markers for disease diagnosis, pathogen identification, and cancer screening. Nevertheless, several challenges have hindered the widespread use of nucleic acids in biomedicine, such as susceptibility to degradation, limited cellular uptake efficiency, potential toxicity, and uncontrollable activity. Photo-regulation offers an effective solution to address these challenges. It allows for the precise control of nucleic acid structure and function and enhances the stability and safety of their application in biomedicine. In this review, we systematically review the structural characteristics of the three primary photosensitive groups commonly used in the regulation of nucleic acid molecules (i.e., photocleavable molecules, photoisomerization molecules, and photo-crosslinking molecules) under light irradiation. Subsequently, recent research advances in the development and application of photo-modulation strategies based on these photosensitive molecules in antisense oligonucleotides, RNA interference, nucleic acid amplification, and CRISPR/Cas systems are outlined. Finally, we discuss the challenges faced in the widespread application of these photo-regulatory strategies and outline potential future directions for their development.</p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"2 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20240006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141798522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overcoming challenges of clinical cell therapies for Parkinson's disease with photobiomodulation","authors":"Hossein Chamkouri,&nbsp;Jianmin Si,&nbsp;Peng Chen,&nbsp;Haiyong Ni,&nbsp;Denis E. Bragin,&nbsp;Majid Ahmadlouydarab,&nbsp;Chaoshi Niu,&nbsp;Lei Chen","doi":"10.1002/INMD.20240013","DOIUrl":"10.1002/INMD.20240013","url":null,"abstract":"<p>Photobiomodulation (PBM) has emerged as a rapidly growing and innovative therapeutic method for various illnesses in recent years. Due to the irreversible nature of Parkinson's disease (PD), it has proven challenging to impede or postpone the progression of the disease. Despite research on pharmacological approaches to halt neuronal degeneration, the viability of these techniques has been called into doubt due to apprehensions over potential side effects and the ethical implications associated with the utilization of embryonic cell transplantation. Hence, developing an innovative therapeutic approach to halting neuronal degeneration and safeguarding neurons from this neurodegenerative disorder is imperative. This review examines the pathogenesis, challenges, and limitations of conventional PD therapies, allowing a closer examination of PBM's distinctive approach within this medical context. Delving into PBM's therapeutic mechanisms in the cells, the effects of different wavelengths on cell therapies in PD patients, and considerations for patient care administration to overcome traditional challenges, this study offers insights into its potential as a promising avenue for PD management.</p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"2 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20240013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141805833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress of serum albumin in the field of drug delivery","authors":"Hanxu Ji,&nbsp;Ziyang Zheng,&nbsp;Siqi Li,&nbsp;Xian Xiao,&nbsp;Wenxia Tang,&nbsp;Xuehao Zhang,&nbsp;Qimin Guo,&nbsp;Qi He,&nbsp;Shulong Cai,&nbsp;Pan Jiang,&nbsp;Hongxun Wang,&nbsp;Longjie Li,&nbsp;Xianjin Xiao,&nbsp;Limei Wang","doi":"10.1002/INMD.20240010","DOIUrl":"10.1002/INMD.20240010","url":null,"abstract":"<p>As a drug delivery system with wide application potential, serum albumin drug-carrying nanoparticles have attracted extensive attention in the field of drug delivery in recent years. This review aims to summarize the research progress of serum albumin drug-loaded nanoparticles in the field of drug delivery. Firstly, the excellent properties of serum albumin as a drug carrier were introduced, several methods of preparing serum albumin nanoparticles were discussed in depth, and their advantages and disadvantages were compared. Then, the design of the nanoparticle albumin drug carrier is discussed, including the control of the size of the nanoparticle, the surface properties and the amount of drug loading, so as to achieve better drug delivery effect. Finally, a series of therapeutic approaches using serum albumin nanoparticles as drug carriers, such as anti-cancer drug delivery and drug delivery across the blood-brain barrier, are systematically summarized. In summary, the research of serum albumin drug-carrying nanoparticles has brought new possibilities and opportunities to the field of drug delivery, and inspired more innovative research and practical applications.</p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"2 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20240010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141807334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Red blood cell derived nanocarrier drug delivery system: A promising strategy for tumor therapy","authors":"Xin Wang,&nbsp;Kuirong Mao,&nbsp;Xiaonan Zhang,&nbsp;Yuning Zhang,&nbsp;Yong-Guang Yang,&nbsp;Tianmeng Sun","doi":"10.1002/INMD.20240014","DOIUrl":"https://doi.org/10.1002/INMD.20240014","url":null,"abstract":"<p>Nano drug delivery systems have been widely used in tumor therapy. Researchers have been devoted to exploring novel nano-carriers to prolong circulation time biocompatibility and tumor targeting efficiency in vivo. Erythrocyte membranes as bionic nano-drug delivery systems have attracted more attention recently. There are abundant red blood cells (RBCs) in circulation, which are natural carriers for nanomaterial delivery. There are mainly two strategies to use RBCs as nanomaterial carriers: RBC-hitchhiking and bionic nanomaterial coated with erythrocyte membrane loading with drugs. Although nano-carrier based on RBCs have yielded some progress, the mechanism of mutual effect between nanoparticles and RBCs is still unclear. Here, we review the effects of nanoparticles on RBCs (morphology and function, <i>etc</i>) and application of RBCs membrane as nano-drug delivery carriers in tumor therapy.</p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"2 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20240014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141968033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration of artificial intelligence in clinical laboratory medicine: Advancements and challenges","authors":"Heying Xie,&nbsp;Yin Jia,&nbsp;Shanrong Liu","doi":"10.1002/INMD.20230056","DOIUrl":"10.1002/INMD.20230056","url":null,"abstract":"<p>Artificial intelligence (AI)-driven analysis of comprehensive clinical parameters is bringing about a significant transformation in traditional routine clinical laboratory testing. This transformation impacts the prediction, prevention, diagnosis, and prognosis of human diseases. AI possesses the capability to efficiently analyze and process vast and intricate datasets, thereby facilitating the development of diverse and efficient diagnostic or predictive models. This advancement is fueling significant improvements in laboratory quality, automation, and the accuracy of diagnoses. In this context, we conducted a thorough review and discussion on the progression of AI applications in clinical laboratory medicine, encompassing advancements, implementation, and challenges. Our conclusion underscores that integrating AI into clinical laboratory testing will notably propel personalized precision medicine forward and enhance diagnostic accuracy, especially benefiting patients for whom accurate diagnoses are elusive through traditional laboratory testing systems.</p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"2 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20230056","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141345115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}