Red blood cell derived nanocarrier drug delivery system: a promising strategy for tumor therapy (3/2024)

Interdisciplinary Medicine Pub Date : 2024-07-31 DOI:10.1002/inmd.12117

Xin Wang, Kuirong Mao, Xiaonan Zhang, Yuning Zhang, Yong-Guang Yang, Tianmeng Sun

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Abstract

This illustration depicts two primary strategies for nano-drug delivery systems targeting tumor treatment, utilizing red blood cell (RBC) carriers: RBC-hitchhiking and bionic nanomaterials coated with erythrocyte membranes loaded with drugs. Red blood cells are abundantly present in circulation, and their membranes serve as natural carriers for nanomaterial delivery. In the diagram, two major blood vessels extend towards the tumor; the proximal vessels represent nanoparticles coated with RBC membranes, while the distal vessels illustrate the RBC-hitchhiking approach. This review briefly examines the effects of nanoparticles on RBC morphology and function and discusses the application of RBC membranes as nano-drug delivery systems in tumor therapy. This provides a foundation for understanding the mechanisms of nanoparticles and optimizing RBC-based nanocarriers in vivo.

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源自红细胞的纳米载体给药系统：一种前景广阔的肿瘤治疗策略 (3/2024)

这幅插图描述了利用红细胞（RBC）载体进行肿瘤治疗的纳米药物输送系统的两种主要策略：红细胞搭载和红细胞膜包覆药物的仿生纳米材料。红细胞大量存在于血液循环中，其膜是纳米材料输送的天然载体。在图中，两条主要血管向肿瘤延伸；近端血管代表涂有红细胞膜的纳米粒子，而远端血管则说明了红细胞搭便车的方法。本综述简要探讨了纳米颗粒对 RBC 形态和功能的影响，并讨论了 RBC 膜作为纳米药物输送系统在肿瘤治疗中的应用。这为了解纳米粒子的机制和优化体内基于 RBC 的纳米载体奠定了基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Interdisciplinary Medicine

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