Interdisciplinary Medicine最新文献

{"title":"Table of Content","authors":"","doi":"10.1002/inmd.70040","DOIUrl":"https://doi.org/10.1002/inmd.70040","url":null,"abstract":"<p>No abstract is available for this article.</p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/inmd.70040","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144220034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intelligent Construction Strategies and Application Potential of 3D-Printed Cardiac Patches (3/2025)","authors":"Mingru Kong,&nbsp;Zhen Wu,&nbsp;Zeliang Zheng,&nbsp;Binrui Zhang,&nbsp;Yuting Zeng,&nbsp;Hao Deng,&nbsp;Dongyi Feng,&nbsp;Wenjun Zhang,&nbsp;Congru Li,&nbsp;Xiaodong Fu,&nbsp;Leyu Wang","doi":"10.1002/inmd.70037","DOIUrl":"https://doi.org/10.1002/inmd.70037","url":null,"abstract":"<p>The cover image presents an innovative therapeutic strategy for the repair of myocardial infarction-induced cardiac damage, employing 3D printing technology. This approach integrates several cutting-edge 3D printing techniques aimed at advancing cardiac tissue regeneration and functional restoration, with a focus on multi-photon 3D printing, microfluidic 3D printing, multi-nozzle 3D printing, and photopolymerization 3D printing technologies. The integration of these highly specialized techniques not only enables the precise construction of biofunctionalized patches for tissue repair but also allows for customization according to the complex structure and physiological demands of the heart, significantly enhancing tissue compatibility and repair efficacy.</p><p>The heart model depicted in the image is equipped with these advanced 3D-printed structures, particularly the central patch, which is specifically designed for direct application to the infarcted area of the myocardium. This patch not only facilitates cellular interaction and tissue regeneration but also regulates the local microenvironment to promote self-repair and regeneration of cardiac tissue. Furthermore, the application of single-cell sequencing at the heart’s base, as shown in the image, provides an in-depth analysis of the molecular mechanisms underlying myocardial infarction treatment, revealing dynamic cellular changes and regeneration processes, offering a precise understanding of cellular behaviors and their interactions.</p><p>The flowing lines in the image symbolize the energy transformation or biological signal transmission involved in the treatment process, while the floating bio-microdevices highlight the precision, controllability, and futuristic nature of this therapeutic approach. This integrated treatment model not only demonstrates unprecedented potential in the repair of cardiac tissue damage but also provides novel perspectives and research avenues for the study of molecular mechanisms in cardiac regeneration, marking a significant advancement in the field of cardiovascular disease treatment.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/inmd.70037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144220019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone-Targeted Hybrid Extracellar Vesicles for Alveolar Bone Regeneration(3/2025)","authors":"Anqi Liu,&nbsp;Gang Yang,&nbsp;Yijie Zhao,&nbsp;Jiajia Deng,&nbsp;Jialiang Liu,&nbsp;Kairun Zhang,&nbsp;Li Mei,&nbsp;Yan Liu,&nbsp;Tingjiao Liu","doi":"10.1002/inmd.70039","DOIUrl":"https://doi.org/10.1002/inmd.70039","url":null,"abstract":"<p>Prolonged tooth loss causes a blade-like narrowing of the alveolar bone, severely impairing chewing function and aesthetics and complicating subsequent orthodontic or restorative treatments. Bone morphogenetic protein-2 (BMP-2) can induce bone formation, but may cause many side effects in vivo due to insufficient cell targeting. In this study, we modified BMP-2 with DNA nanostructures to construct BMP-2-loaded hybrid extracellular vesicles, which were combined with a hydrogel sustained-release system. This combination effectively repaired alveolar bone defects and demonstrated the potential to promote bone tissue repair and regeneration.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/inmd.70039","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144220369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of antibody coupling technique in targeted drug delivery (3/2025)","authors":"Meng Li,&nbsp;Tiantian Wang,&nbsp;Dan Tan,&nbsp;Mengqi Wang,&nbsp;Changhai Lei,&nbsp;Yuqing Wang,&nbsp;Shi Hu","doi":"10.1002/inmd.70038","DOIUrl":"https://doi.org/10.1002/inmd.70038","url":null,"abstract":"<p>Antibodies, a critical component of the human immune defense system, are produced in large quantities by the body when foreign antigens or newly generated self-antigens are present. Through the specific binding of variable regions to antigens, antibodies can directly neutralize pathogens or inhibit their ability to infect host cells. Further modification of antibodies, enabling them to carry highly toxic small molecules, cytotoxic cells, polymers, or oligonucleotides, allows antibodies to precisely target cancer cells. This enhances therapeutic efficacy and enhance the therapeutic efficacy, significantly improves overall treatment effectiveness against cancer. This picture consists of cancer cells, two people driving rockets, antibody-drug conjugates, and targets. Among them, the person who drives the rocket is used as a metaphor for antibody-drug conjugates, where the rocket refers to the antibody and the person refers to various conjugated drugs. The screws and masks on the cells represent the difficulty of tumor cell infiltration, and the screws on antibodies represent that the antibodies have been engineered and modified. Through engineered modified antibodies, highly active drugs can be loaded onto the antibodies to precisely target tumor cells, thereby more efficiently disintegrating the cancer cells and achieving therapeutic effects.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/inmd.70038","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144220095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction strategies for 3D printed cardiac tissue repair materials and their application potential","authors":"Mingru Kong,&nbsp;Zhen Wu,&nbsp;Zeliang Zheng,&nbsp;Binrui Zhang,&nbsp;Yuting Zeng,&nbsp;Hao Deng,&nbsp;Dongyi Feng,&nbsp;Wenjun Zhang,&nbsp;Congru Li,&nbsp;Xiaodong Fu,&nbsp;Leyu Wang","doi":"10.1002/INMD.20240085","DOIUrl":"https://doi.org/10.1002/INMD.20240085","url":null,"abstract":"<p>As a major cause of death worldwide, heart disease has significant limitations in traditional treatments. However, 3D printing technology, with its personalized, precise, and multifunctional features, provides a new idea for developing cardiac tissue repair materials. This review analyzes the three core advantages of 3D printing technology in cardiac repair materials: the realization of personalized medicine, the intelligent construction of complex tissue structures, and the optimization of the functions of multi-material combinations. Combined with specific research cases, this review reveals the progress of 3D printing in heart valve replacement, heart patches, vascular stent manufacturing, and composite material development, especially the potential of carbon-based conductive materials, biomass-based materials, and bio-based materials in cardiac tissue repair. In addition, this review discusses the innovative applications of advanced 3D printing technologies in the design of prosthetic materials, including coaxial printing, microfluidic extrusion printing, stereospecific rapid prototyping, and two-photon printing. Finally, this review summarizes the significant advantages of 3D printing technology in cardiac tissue repair and proposes future research directions. It emphasizes the importance of combining 3D printing technology with the study of cardiac tissue engineering to further improve the performance and repair effectiveness of cardiac repair materials. Meanwhile, the potentials of single-cell technology, spatial genomics, and protein prediction technology in optimizing the biocompatibility and functionality of repair cardiac repair materials are envisioned to provide scientific support for more efficient cardiac tissue repair through precise regulation of cell behavior, remodeling of the tissue microenvironment, and the development of personalized materials.</p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20240085","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144220358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress of antibody coupling technique in targeted drug delivery","authors":"Meng Li,&nbsp;Tiantian Wang,&nbsp;Dan Tan,&nbsp;Mengqi Wang,&nbsp;Changhai Lei,&nbsp;Yuqing Wang,&nbsp;Shi Hu","doi":"10.1002/INMD.20240108","DOIUrl":"https://doi.org/10.1002/INMD.20240108","url":null,"abstract":"<p>Antibody-drug conjugates are a cutting-edge biotechnology recently attracting wide attention in the medical field. Binding antibodies to drug molecules could deliver drugs precisely to the site of the lesion, which shows great potential in the treatment of tumors and immune diseases. In this paper, we outlined the current popular antibody-coupling techniques and summarized various common antibody-coupling techniques, including antibody-coupled small toxic molecules, antibody-coupled oligenucleotides, antibody-coupled cells, and antibody-coupled polymers. It provided a new therapeutic strategy and means for targeted drug delivery technology. Finally, we discussed the challenges and future development of the antibody-drug conjugates.</p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20240108","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144220046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting SHMT2-mediated membrane phospholipid remodeling for enhanced anti-GCSCs treatment","authors":"Liping Yang,&nbsp;Fangli Liao,&nbsp;Yanran Tong,&nbsp;Tong Huang,&nbsp;Yan-e Du,&nbsp;Siyang Wen,&nbsp;Linshan Jiang,&nbsp;Lanlang Peng,&nbsp;Hua Sun,&nbsp;Gaoli Zhang,&nbsp;Weixian Chen","doi":"10.1002/INMD.20240106","DOIUrl":"https://doi.org/10.1002/INMD.20240106","url":null,"abstract":"<p>Cancer stem cells exhibit flexible metabolic profiles. However, the underlying mechanisms for differential metabolic pathways affecting stemness maintenance in gastric cancer are poorly understood. Here, we reveal the role of serine hydroxymethyltransferase-2 (SHMT2)/serine-mediated crosstalk between one-carbon metabolism and lipid metabolism in the stemness maintenance of gastric cancer. Clinically, SHMT2 was significantly highly expressed in Gastric cancer cells (GCs) and gastric cancer stem cells, and was associated with clinical malignant features and poor prognosis in gastric cancer patients. Mechanistically, inhibition of SHMT2 expression resulted in diminished serine levels in one-carbon metabolism, which subsequently modified the composition and fluidity of membrane phospholipids, leading to a reduction in lipid rafts within cellular membranes. The remodeling of membrane phospholipids hindered the localization of γ-secretase to lipid rafts, thereby inhibiting the cleavage of CD44 and the subsequent production of CD44-ICD. Consequently, the transcriptional regulation of c-Myc and KLF4 by CD44-ICD was reduced, ultimately disrupting the maintenance of stemness in gastric cancer cells. Together, these results provide compelling evidence for the metabolic adaptability of cancer stem cells, and the SHMT2/serine/lipid rafts signaling axis holds promise as a potential biomarker for the diagnosis and prognosis of gastric cancer. Furthermore, we synthesized HA-Exo-si SHMT2 to investigate targeted therapy for GC, offering a novel approach for the clinical treatment of gastric cancer.</p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20240106","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144220299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone-targeted hybrid extracellular vesicles for alveolar bone regeneration","authors":"Anqi Liu,&nbsp;Gang Yang,&nbsp;Yijie Zhao,&nbsp;Jiajia Deng,&nbsp;Jialiang Liu,&nbsp;Kairun Zhang,&nbsp;Li Mei,&nbsp;Yan Liu,&nbsp;Tingjiao Liu","doi":"10.1002/INMD.20240126","DOIUrl":"https://doi.org/10.1002/INMD.20240126","url":null,"abstract":"<p>Prolonged tooth loss causes a blade-like narrowing of the alveolar bone, severely impairing chewing function and aesthetics and complicating subsequent orthodontic or restorative treatments. Bone morphogenetic protein-2 (BMP-2) is widely used to induce osteogenesis; however, its lack of cellular targeting in complex microenvironments often results in significant side effects. Developing a safe, stable, and osteoblast-targeted drug delivery system is crucial for precise bone regeneration. Nanoparticles, as ideal drug delivery vehicles, offer highly controllable cellular targeting. This study introduces an innovative approach using DNA nanostructure-modified BMP-2-loaded hybrid extracellular vesicles (EVs) formed by fusing liposomes and EVs. Screening identified 180 nm as the optimal particle size for EVs fusion efficiency. The system achieved osteoblast-specific targeting by attaching the DNA aptamer 19S to the hybrid EVs membrane. The hybrid EVs were further combined with a hydrogel sustained-release system, creating a drug delivery platform that effectively repaired alveolar bone defects. This approach demonstrated significant potential for advancing bone tissue repair and regeneration.</p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20240126","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144220180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ruthenium Nanozyme@Magnesium silicate nanosheets encapsuled in microneedle patches promote repair of radiation-induced skin defects by remodeling pathological environment","authors":"Zhongyi Sun,&nbsp;Haibo Liu,&nbsp;Mengting Yin,&nbsp;Ningning Cheng,&nbsp;Wencheng Liu,&nbsp;Kangkang Zhao,&nbsp;Hua Zeng,&nbsp;Xuming Chen,&nbsp;Zijie Wang,&nbsp;Xuhui Zhou,&nbsp;Xinyu Zhao,&nbsp;Feng Chen","doi":"10.1002/INMD.20240124","DOIUrl":"https://doi.org/10.1002/INMD.20240124","url":null,"abstract":"<p>Radiotherapy induced skin defect (RISD) is a severe radiotherapy complication with persistent oxidative stress and recurrent excessive reactive oxygen species (ROS), impeding normal tissue repair processes. Nevertheless, the lack of a standardized animal model severely hinders the progress of related research work. We develop a novel strategy for repairing the RISD microenvironment, which combines initial ROS clearance, subsequent inhibition of ROS production and the repair of proliferation related cell pathways/functions. As a proof of concept, a composite microneedle (MN) patch comprising γ-polyglutamic acid as the base and ruthenium (Ru) clusters modified magnesium silicate nanosheets (MSR NSs) as the enzyme-like component is prepared. The Ru clusters have excellent ROS scavenging ability and help activate the peroxisome proliferators activated receptor signaling pathway confirmed by the sequencing analysis while the magnesium silicate is degraded under physiological conditions to release magnesium ions and silicate ions, enhancing cell proliferation, migration, and angiogenesis ability. The radiation induced skin defect animal model is established to evaluate the RISD repair efficacy of our MSR@MN patch in comparison with γPGA-MSR ointment and commercial product Orgotein. The results show that our MSR@MN patch effectively improves the pathological microenvironment of abnormal ROS accumulation, reduces inflammatory response and promotes mature angiogenesis and tissue remodeling.</p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20240124","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144220445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting the crosstalk between glutamine metabolism and tumor immune microenvironment for lung cancer immunotherapy (2/2025)","authors":"Jingyang Li,&nbsp;Li Xiang,&nbsp;Shaohui Wang,&nbsp;Yingrui Zhang,&nbsp;Shiyi Zhao,&nbsp;Di Zhang,&nbsp;Xianli Meng,&nbsp;Yi Zhang,&nbsp;Jin-Ming Lin","doi":"10.1002/inmd.70020","DOIUrl":"https://doi.org/10.1002/inmd.70020","url":null,"abstract":"<p>This image represents the key concepts of our paper on glutamine metabolic reprogramming in the immune microenvironment of lung tumors. The central figure symbolizes a lung with tumor. Red cells on the right denote lung cancer cells, while the other cells represent normal lung cells and immune cells. The candy-shaped objects symbolize glucose, and the spherical shapes represent glutamine. This visual representation highlights the metabolic processes of glucose and glutamine within the lung tumor immune microenvironment. The whole picture demonstrates that lung cancer cells exhibit a higher affinity for glutamine uptake compared to immune cells, which offers novel insights for developing lung cancer immunotherapy strategies.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/inmd.70020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}