{"title":"Intelligent Construction Strategies and Application Potential of 3D-Printed Cardiac Patches (3/2025)","authors":"Mingru Kong, Zhen Wu, Zeliang Zheng, Binrui Zhang, Yuting Zeng, Hao Deng, Dongyi Feng, Wenjun Zhang, Congru Li, Xiaodong Fu, Leyu Wang","doi":"10.1002/inmd.70037","DOIUrl":null,"url":null,"abstract":"<p>The cover image presents an innovative therapeutic strategy for the repair of myocardial infarction-induced cardiac damage, employing 3D printing technology. This approach integrates several cutting-edge 3D printing techniques aimed at advancing cardiac tissue regeneration and functional restoration, with a focus on multi-photon 3D printing, microfluidic 3D printing, multi-nozzle 3D printing, and photopolymerization 3D printing technologies. The integration of these highly specialized techniques not only enables the precise construction of biofunctionalized patches for tissue repair but also allows for customization according to the complex structure and physiological demands of the heart, significantly enhancing tissue compatibility and repair efficacy.</p><p>The heart model depicted in the image is equipped with these advanced 3D-printed structures, particularly the central patch, which is specifically designed for direct application to the infarcted area of the myocardium. This patch not only facilitates cellular interaction and tissue regeneration but also regulates the local microenvironment to promote self-repair and regeneration of cardiac tissue. Furthermore, the application of single-cell sequencing at the heart’s base, as shown in the image, provides an in-depth analysis of the molecular mechanisms underlying myocardial infarction treatment, revealing dynamic cellular changes and regeneration processes, offering a precise understanding of cellular behaviors and their interactions.</p><p>The flowing lines in the image symbolize the energy transformation or biological signal transmission involved in the treatment process, while the floating bio-microdevices highlight the precision, controllability, and futuristic nature of this therapeutic approach. This integrated treatment model not only demonstrates unprecedented potential in the repair of cardiac tissue damage but also provides novel perspectives and research avenues for the study of molecular mechanisms in cardiac regeneration, marking a significant advancement in the field of cardiovascular disease treatment.\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"3 3","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/inmd.70037","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Interdisciplinary Medicine","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/inmd.70037","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
The cover image presents an innovative therapeutic strategy for the repair of myocardial infarction-induced cardiac damage, employing 3D printing technology. This approach integrates several cutting-edge 3D printing techniques aimed at advancing cardiac tissue regeneration and functional restoration, with a focus on multi-photon 3D printing, microfluidic 3D printing, multi-nozzle 3D printing, and photopolymerization 3D printing technologies. The integration of these highly specialized techniques not only enables the precise construction of biofunctionalized patches for tissue repair but also allows for customization according to the complex structure and physiological demands of the heart, significantly enhancing tissue compatibility and repair efficacy.
The heart model depicted in the image is equipped with these advanced 3D-printed structures, particularly the central patch, which is specifically designed for direct application to the infarcted area of the myocardium. This patch not only facilitates cellular interaction and tissue regeneration but also regulates the local microenvironment to promote self-repair and regeneration of cardiac tissue. Furthermore, the application of single-cell sequencing at the heart’s base, as shown in the image, provides an in-depth analysis of the molecular mechanisms underlying myocardial infarction treatment, revealing dynamic cellular changes and regeneration processes, offering a precise understanding of cellular behaviors and their interactions.
The flowing lines in the image symbolize the energy transformation or biological signal transmission involved in the treatment process, while the floating bio-microdevices highlight the precision, controllability, and futuristic nature of this therapeutic approach. This integrated treatment model not only demonstrates unprecedented potential in the repair of cardiac tissue damage but also provides novel perspectives and research avenues for the study of molecular mechanisms in cardiac regeneration, marking a significant advancement in the field of cardiovascular disease treatment.
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