Interdisciplinary Medicine最新文献_第10页

Nanoparticles derived from herbal preparations May represent a novel nucleic acid therapy 从草药制剂中提取的纳米粒子可能代表一种新型核酸疗法

Interdisciplinary Medicine Pub Date : 2024-02-02 DOI: 10.1002/INMD.20230029

Tingle Feng, Waqas Ahmed, Talha Ahmed, Lukui Chen

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Interdisciplinary Medicine Pub Date : 2024-01-31 DOI: 10.1002/inmd.12082

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Nucleic acid drug and delivery techniques for disease therapy: present situation and future prospect (1/2024) 用于疾病治疗的核酸药物和递送技术：现状与前景 (1/2024)

Interdisciplinary Medicine Pub Date : 2024-01-31 DOI: 10.1002/inmd.12078

Tianjiao Wang, Youhong Tang, Yuandong Tao, Huixia Zhou, Dan Ding

{"title":"Nucleic acid drug and delivery techniques for disease therapy: present situation and future prospect (1/2024)","authors":"Tianjiao Wang, Youhong Tang, Yuandong Tao, Huixia Zhou, Dan Ding","doi":"10.1002/inmd.12078","DOIUrl":"https://doi.org/10.1002/inmd.12078","url":null,"abstract":"<p>RNA molecules hold many properties that facilitate their application as therapeutic drugs. RNAs could fold to form complex conformations to bind to proteins, small molecules, or other nucleic acids, and some even form catalytic centers. Protein-encoding RNAs are the carriers of genetic information from DNA to ribosomes, and various types of non-coding RNAs cooperate in the transcription and translation of genetic information through various mechanisms. To date, three mainstream RNA therapies have drawn widespread attention: 1) messenger RNA (mRNA) that encodes therapeutic proteins or vaccine antigens; 2) small interfering RNA (siRNA), microRNA (miRNA), antisense nucleonic acid (ASO) that inhibit the activity of pathogenic RNAs; 3) Aptamers that regulate protein activity. Here, we summarized the current research and perspectives of RNA therapies, which may provide innovative highlights for cancer therapy. The lipid nanoparticles (LNP) are commonly composed of four components including ionizable lipids, neutral helper phospholipids, cholesterol, and PEGylated lipids. In relative acidic environment, the ionizable cationic phospholipids carries a positive charge and realize electrostatic complexation with negatively charged mRNA molecules to form complex and improve mRNA stability. Upon attachment, the cationic phospholipids fuse with negatively charged cell membranes, trigger membrane destabilization, and promote mRNA molecule delivery. After internalization into cells, the more acidic environment and hydrolases in lysosomes protonate and destroy the bilayer structure of LNP and release mRNA. LNPs can also be expelled from the cell via opposite exocytosis, which is also a concern for mRNA administration via LNPs.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/inmd.12078","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139676831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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High-Throughput Single-Cell Microarray Platform for CAR-T In Vitro Systemic Immunotherapy Function Evaluation (1/2024) 用于 CAR-T 体外系统免疫疗法功能评估的高通量单细胞芯片平台 (1/2024)

Interdisciplinary Medicine Pub Date : 2024-01-31 DOI: 10.1002/inmd.12077

Chao Wang, Chunhua Wang, Huimin Liu, Songbo Zhao, Jiaoyan Qiu, Ping Li, Zhongqian Liu, Mingyuan Sun, Xiaowei Shao, Yihe Wang, Xiaohong Liang, Lifen Gao, Chunhong Ma, Wei Song, Yu Zhang, Lin Han

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DNA nanotechnology in tumor liquid biopsy: enrichment and determination of circulating biomarkers (1/2024) 肿瘤液体活检中的DNA纳米技术：循环生物标记物的富集和测定 (1/2024)

Interdisciplinary Medicine Pub Date : 2024-01-31 DOI: 10.1002/inmd.12080

Yitong Zhu, Wenbin Li, Fei Lan, Siting Chen, Xiaofei Chen, Xiaohe Zhang, Xiaohui Yan, Ye Zhang

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Intelligent Point of Care Testing for Medicine Diagnosis (1/2024) 用于医学诊断的智能医疗点检测 (1/2024)

Interdisciplinary Medicine Pub Date : 2024-01-31 DOI: 10.1002/inmd.12079

Qiya Gao, Shuang Li

{"title":"Intelligent Point of Care Testing for Medicine Diagnosis (1/2024)","authors":"Qiya Gao, Shuang Li","doi":"10.1002/inmd.12079","DOIUrl":"https://doi.org/10.1002/inmd.12079","url":null,"abstract":"<p>Intelligent Point-of-Care Testing (iPOCT) is an inevitable consequence of the development of point-of-care testing technology towards precision, automation, and cloud-based integration. As a crucial component of the in vitro diagnostic product industry, iPOCT possesses innovative characteristics rooted in the Internet mindset and has emerged as a vital avenue for achieving precision medicine. Patients can leverage wearable devices or small-sized in vitro diagnostic products to rapidly detect and monitor common physiological and biochemical indicators in real-time. These data are wirelessly transmitted to smart display devices and uploaded to cloud platforms for analysis by medical institutions, enabling healthcare professionals to diagnose diseases with greater precision, enhance the accuracy and efficiency of clinical diagnosis, and reduce human errors. By collecting and analyzing a large volume of medical data, iPOCT technology allows medical institutions to gain a better understanding of patients' conditions and medical\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/inmd.12079","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139676752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Recent advances in photobiomodulation therapy for brain diseases 光生物调制疗法治疗脑部疾病的最新进展

Interdisciplinary Medicine Pub Date : 2024-01-23 DOI: 10.1002/INMD.20230027

Sihan Dong, Hang Ren, Rui Zhang, Xunbin Wei

{"title":"Recent advances in photobiomodulation therapy for brain diseases","authors":"Sihan Dong, Hang Ren, Rui Zhang, Xunbin Wei","doi":"10.1002/INMD.20230027","DOIUrl":"10.1002/INMD.20230027","url":null,"abstract":"<p>Light therapy techniques, such as photobiomodulation therapy (PBMT), photodynamic therapy (PDT), and laser photoablation, have gained widespread attention and become indispensable physiotherapy methods in clinical practice. PBMT involves the application of low-level laser/LED to modulate the function of nerve cells, relieve neuroinflammation, promote neurogenesis and vascular growth. Recent studies have shown that PBMT holds promise as a complementary or alternative treatment of Alzheimer's disease (AD), traumatic brain injury (TBI), major depressive disorder (MDD), etc. However, the therapeutic effect of PBMT is influenced by various factors, such as the patients' condition, brain structure and function, illumination parameters, etc. Therefore, the optimized parameters, personalized therapeutic schedules, and precise evaluation of the therapeutic effect are crucial to the treatment success. In this review, we identified the recent experimental and clinical successes, existing obstacles, and future opportunities for PBMT in the treatment of the brain diseases. As a non-invasive, side-effect-free, and highly accessible technique, PBMT brings a glimmer of light for the treatment of neuropsychiatric disorders and the neuro-rejuvenation of human brains.</p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20230027","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139605125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Bottom-up DNA nanostructure-based paper as point-of-care diagnostic: From method to device 自下而上的 DNA 纳米结构纸作为护理点诊断：从方法到设备

Interdisciplinary Medicine Pub Date : 2024-01-08 DOI: 10.1002/INMD.20230033

Xueping Gao, Liu Feng, Ruijia Deng, Binpan Wang, Yuan He, Ligai Zhang, Dan Luo, Ming Chen, Kai Chang

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Programmable droplet microfluidics for complex multistep bioassays 用于复杂多步骤生物测定的可编程液滴微流控技术

Interdisciplinary Medicine Pub Date : 2024-01-08 DOI: 10.1002/INMD.20230026

Enqi Huang, Yu Wang, Dongyang Cai, Dayu Liu

{"title":"Programmable droplet microfluidics for complex multistep bioassays","authors":"Enqi Huang, Yu Wang, Dongyang Cai, Dayu Liu","doi":"10.1002/INMD.20230026","DOIUrl":"10.1002/INMD.20230026","url":null,"abstract":"<p>Programmable droplet microfluidics (PDM) refers to a microfluidic device that integrates the functionality of a series of droplets with distinct spatial locations in a designated temporal order. PDM streamlines the intricate workflow of complex bioassays by enabling programmable and macroscopic droplet displacements, in which the droplets serve as reservoirs for reagents, microvalves for liquid insulation, and in some cases micropumps for mass transportation. As these droplets are intangible structures, the need for expensive microfabrication procedures is eliminated. Furthermore, the parallelization of the droplet series provides flexibility in controlling the throughput of the microfluidic analysis system. This paper provides a comprehensive review of PDMs enabled by various microfluidic mechanisms, including magnetism actuation, relative liquid displacement, capillary suction and sequential microdisplacement. Additionally, important applications of PDM systems for nucleic acid detection, immunoassay, drug testing, and sample recovery are also introduced. In conclusion, PDM demonstrates its potential as a highly advantageous tool for executing intricate multistep bioassays on a microfluidic platform. These technologies have exhibited superiority over their traditional counterparts in terms of size reduction, automation, and low sample/reagent consumption.</p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20230026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139445964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Advances in DNA walking nanomachine-based biosensors 基于 DNA 步行纳米机械的生物传感器的研究进展

Interdisciplinary Medicine Pub Date : 2024-01-05 DOI: 10.1002/INMD.20230046

Bo Shen, Li Li, Minghui Guo, Xinyu Li, Yunpeng Fan, Xinmin Li, Rui Chen, Shijia Ding, Wei Cheng

{"title":"Advances in DNA walking nanomachine-based biosensors","authors":"Bo Shen, Li Li, Minghui Guo, Xinyu Li, Yunpeng Fan, Xinmin Li, Rui Chen, Shijia Ding, Wei Cheng","doi":"10.1002/INMD.20230046","DOIUrl":"10.1002/INMD.20230046","url":null,"abstract":"<p>The field of DNA nanotechnology has evolved beyond the realm of controllable movements and randomly shaped nanostructures, now encompassing a diverse array of nanomachines, each with unique nanostructures and biofunctional attributes. These DNA nanostructures boast exceptional characteristics such as programmability, integrability, biocompatibility, and universality. Among this variety, DNA walking nanomachines have emerged as one of the most prominent nanomotors, distinguished by their ingenious design and comprehensive functionality. In recent times, these DNA walkers have witnessed remarkable advancements in areas ranging from nanostructural designs to biological applications, including the creation of sophisticated biosensors capable of efficiently detecting tumor-related biomarkers and bioactive substances. This review delves into the operational mechanisms of DNA walking nanomachines, which are driven by processes such as protease and DNAzyme action as well as strand displacement and photoactivated reactions. It further provides a comprehensive overview of DNA walking nanomachines with different dimensional (1D, 2D, and 3D) walking tracks. A subsequent section introduces the biosensing applications of DNA walking nanomachines including electrochemical, optical, and other biosensors. The review concludes with a forward-looking perspective on the novel advancements and challenges in developing DNA walking nanomachine-based biosensors.</p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20230046","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139381671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0