Interdisciplinary Medicine最新文献

{"title":"The role of dynamic interplay exists between sympathetic and parasympathetic nerve in gastric tumorigenesis","authors":"Diqun Chen,&nbsp;Xunjun Li,&nbsp;Yiyun Wang,&nbsp;Xinxin Li,&nbsp;Hongxia Zhang,&nbsp;Lina Zhang,&nbsp;Jia Yang,&nbsp;Haoyang Tan,&nbsp;Yingxin Xie,&nbsp;Yingyi Liuzhou,&nbsp;Jiayun Qiu,&nbsp;Miao Shi,&nbsp;Feiran Zhang,&nbsp;Wu Zhong,&nbsp;Kexing Xi,&nbsp;Chuanfa Fang,&nbsp;Alpha Ibrahima Balde,&nbsp;Jiang Yu,&nbsp;Tao Chen","doi":"10.1002/INMD.20230040","DOIUrl":"10.1002/INMD.20230040","url":null,"abstract":"<p>Recent research underscores the significance of the nervous system in tumor progression. Nonetheless, understanding the intricate roles of nerves in gastric tumorigenesis remains limited. Our study aims to elucidate nerve alterations, associated key genes, and signaling pathways during gastric tumorigenesis. We enroll 257 patients with gastric precancerous lesions (GPLs) from four national cohorts. Utilizing immunohistochemistry and digital analysis, we quantified the densities of sympathetic and parasympathetic nerves, as well as Schwann cells in patient slides. We collected three mRNA expression profiles of GPL samples from the gene expression omnibus database and assessed them for nerve expression signatures, differentially expressed genes, enriched pathways, and the immune microenvironment. Parasympathetic nerve and Schwann cell densities display a progressive increase, while sympathetic nerve exhibits an inverse trend along the precancerous spectrums. Notably, CD8+ T cells, natural killer cells, and antigen-presenting cells (APC) co-inhibition decrease, while epithelial-mesenchymal transition increases significantly from early to late premalignancy. Several key nerve-regulating genes (<i>NTRK3</i>, <i>MYBL2</i>, <i>NRP1</i>, <i>BCL2</i>, <i>CCND1</i>, <i>VEGFA</i>, <i>PLXNA2</i>, <i>ADRB2</i>), and pathways (mitogen-activated protein kinase [MAPK]/ERK, PI3K/AKT, Wnt) emerge as potential contributors to precancerous progression. Our study reveals a dynamic relationship between sympathetic and parasympathetic nerves, characterized by a gradual increase in parasympathetic nerve and Schwann cell density, contrasting with an inverse trend in sympathetic nerve across precancerous spectrums. Targeting the interaction between tumor cells and nerves, including sympathetic and parasympathetic nerves, has emerged as a promising strategy for the prevention and treatment of gastric cancer.</p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20230040","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140366358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanothermometry for cellular temperature monitoring and disease diagnostics","authors":"Meilin Liu,&nbsp;Yaru Sun,&nbsp;Daniel Boon Loong Teh,&nbsp;Yi Zhang,&nbsp;Donglin Cao,&nbsp;Qingsong Mei","doi":"10.1002/INMD.20230059","DOIUrl":"10.1002/INMD.20230059","url":null,"abstract":"<p>Body temperature variations, including the generation, transfer, and dissipation of heat, play an important role throughout life and participate in all biological events. Cellular temperature information is an indispensable link in the comprehensive understanding of life science processes, but traditional testing strategies cannot provide sufficient information due to their low precision and inefficient cellular-entrance. In recent years, with the help of luminescent nanomaterials, a variety of new thermometers have been developed to achieve real-time temperature measurement at the micro/nano scale. In this review, we summarized the latest advances in several nanoparticles for cellular temperature detection and their related applications in revealing cell metabolism and disease diagnosis. Furthermore, this review proposed a few challenges for the nano-thermometry, expecting to spark novel thought to push forward its preclinical and translational uses.</p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20230059","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140385078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inorganic nanoparticles-based strategies for the microbial detection in infectious diseases","authors":"Xinyu Ding,&nbsp;Juntao Ma,&nbsp;Tao Fan,&nbsp;Rahma Issa,&nbsp;Yaxin Li,&nbsp;Dan Weng,&nbsp;Dagan Zhang,&nbsp;Yuxin Chen","doi":"10.1002/INMD.20230045","DOIUrl":"10.1002/INMD.20230045","url":null,"abstract":"<p>Infectious diseases pose significant threats to public health and the global economy, necessitating rapid and accurate detection of the causative microorganisms to prevent their transmission. Nanomaterials, with their unique size-dependent physical and chemical attributes, present innovative solutions for the detection of infectious diseases, thereby playing a crucial role in the development of advanced detection technologies. This review describes the application of inorganic nanomaterials in the detection of infectious diseases, focusing on the potential uses of nanomaterials, including carbon nanoallotropes, quantum dots, gold and silver nanoparticles, magnetic nanoparticles and upconversion nanoparticles.</p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20230045","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140210511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PDE5 inhibitors against cancer via mediating immune cells in tumor microenvironment: AI-based approach for future drug repurposing exploration","authors":"Zhenzhan Zhang,&nbsp;Donghua Huang,&nbsp;Junjie Feng,&nbsp;Wangji Li,&nbsp;Zhe Wang,&nbsp;Mengting Lu,&nbsp;Yangyang Luo,&nbsp;Weihao Yang,&nbsp;Zhou Xu,&nbsp;Qingfeng Xie,&nbsp;Wenfu Ding,&nbsp;Xin Tan,&nbsp;Wenjun He,&nbsp;Guoxin Li,&nbsp;Hao Liu,&nbsp;Shangtong Lei","doi":"10.1002/INMD.20230062","DOIUrl":"10.1002/INMD.20230062","url":null,"abstract":"<p>Phosphodiesterase-5 (PDE5) inhibitors are used clinically for the treatment of erectile dysfunction, pulmonary arterial hypertension, and other urological diseases. Emerging evidences have suggested the therapeutic capacity of PDE5 inhibitors as the repurposed drugs in oncology. However, the essential immune function of PDE5 inhibitors against cancer in tumor microenvironment (TME) remains unclear. This review aimed to summarize the recent advances regarding the repurposing of PDE5 inhibitors as anti-cancer agents for cancer management to enhance the anti-tumor immune response by mediating various immune cells, which included the myeloid-derived suppressor cells, macrophages, T cells, fibroblasts, and natural killer cells in TME. Moreover, artificial intelligence (AI), as a new approach, is composed of traditional machine learning and deep learning methods and could be potentially used to identify the targets of immune cells in TME and predict the efficacy for repurposed drug toward malignancies. In summary, these endeavors provide novel insights into the comprehensive strategies for PDE5 inhibitors mediating immune cells against cancer and AI-based approach for future drug repurposing exploration.</p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"2 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20230062","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140236727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical practice guidelines for gene therapy to treat hereditary hearing loss","authors":"Jieyu Qi,&nbsp;Fangzhi Tan,&nbsp;Liyan Zhang,&nbsp;Ling Lu,&nbsp;Hongyang Wang,&nbsp;Wenyan Li,&nbsp;Wenwen Liu,&nbsp;Xiaolong Fu,&nbsp;Zuhong He,&nbsp;Xiaoqiong Ding,&nbsp;Shan Sun,&nbsp;Qiaojun Fang,&nbsp;Yaodong Dong,&nbsp;Xuewei Zhu,&nbsp;Busheng Tong,&nbsp;Xianbao Cao,&nbsp;Min Guo,&nbsp;Xinmiao Fan,&nbsp;Qin Wang,&nbsp;Lu Ma,&nbsp;Tianhong Zhang,&nbsp;Yafeng Yu,&nbsp;Yongxin Li,&nbsp;Jiangang Fan,&nbsp;Yong Cui,&nbsp;Peina Wu,&nbsp;Hongzheng Zhang,&nbsp;Jie Tang,&nbsp;Weiwei Guo,&nbsp;Dingjun Zha,&nbsp;Fanglei Ye,&nbsp;Shuangba He,&nbsp;Wei Cao,&nbsp;Jianming Yang,&nbsp;Xiaoyun Qian,&nbsp;Yu Zhao,&nbsp;Jingwu Sun,&nbsp;Xiaowei Chen,&nbsp;Yu Sun,&nbsp;Ming Xia,&nbsp;Qiuju Wang,&nbsp;Huijun Yuan,&nbsp;Yong Feng,&nbsp;Weijia Kong,&nbsp;Shiming Yang,&nbsp;Haibo Wang,&nbsp;Maoli Duan,&nbsp;Xia Gao,&nbsp;Huawei Li,&nbsp;Lei Xu,&nbsp;Renjie Chai","doi":"10.1002/INMD.20240008","DOIUrl":"10.1002/INMD.20240008","url":null,"abstract":"<p>Hereditary deafness is a common neurosensory disorder, and 148 non-syndromic deafness genes have been identified to date. Gene therapy has been used to treat a variety of genetic diseases, but no gene therapy drug for hereditary deafness has been approved for clinical use. At present, several clinical trials of gene therapy for hereditary deafness are underway. However, few normative documents have been issued to guide the standardization of gene therapy for hearing loss, and this document is the first global gene therapy guideline for hereditary hearing loss. The guidelines were jointly developed and drafted by experienced audiologists, virologists and biologists who are vigorously involved in inner ear gene therapy research in the Hearing, Speech and Communication Subsociety of Biophysical Society of China, Audiology Development Foundation Of China and Audiology Subsociety of Jiangsu Medical Association. These guidelines cover preclinical research and clinical practice of gene therapy for hereditary deafness, including indications, key points of pre-clinical research, patient selection criteria, pre-clinical preparation, drug efficacy, drug safety evaluation criteria, ethical review, etc. We hope that the guidelines will promote the standardization of clinical practice related to gene therapy for hereditary deafness in China and around the world.</p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20240008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140236446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The application of extracellular vesicles in orthopedic diseases","authors":"Yuexin Li,&nbsp;Haiyan Zhang,&nbsp;Yu Jiang,&nbsp;Jian Yang,&nbsp;Daozhang Cai,&nbsp;Xiaochun Bai","doi":"10.1002/INMD.20230055","DOIUrl":"10.1002/INMD.20230055","url":null,"abstract":"<p>Orthopedic diseases, such as osteoarthritis and fractures, place a significant burden on individuals and healthcare systems worldwide. Extracellular vesicles (EVs), which are membrane-derived particles, have emerged as a novel tool in the field of orthopedics. EVs play a crucial role in diagnosing, regenerating, and treating orthopedic diseases. In terms of diagnosis, EVs serve as potential biomarkers, carrying unique donor cell information and circulating effectively in bodily fluids. Specific biomolecules within EVs, including proteins, nucleic acids, and microRNAs, hold promise as biological markers for the early detection and monitoring of orthopedic diseases. EVs have shown significant potential in promoting bone and cartilage regeneration. They can enhance tissue regeneration by stimulating various stem cells to proliferate, migrate, and differentiate into mature chondrocytes and osteocytes. EVs can also target specific tissues, making them attractive candidates for drug delivery in orthopedic diseases. They can efficiently deliver therapeutic cargo, such as anti-inflammatory agents and growth factors, to the affected sites, enhancing treatment efficacy while minimizing toxicity and adverse effects. In conclusion, EVs have significant potential in diagnosing, regenerating, and treating orthopedic diseases.</p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"2 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20230055","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140248187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracellular DNA as potential contributors to pathological calcification","authors":"Longzhang Niu,&nbsp;Yina Zhu,&nbsp;Meichen Wan,&nbsp;Chenyu Wang,&nbsp;Xinyi Hao,&nbsp;Jinghan Song,&nbsp;Chen Lei,&nbsp;Zixuan Qin,&nbsp;Franklin Tay,&nbsp;Lina Niu","doi":"10.1002/INMD.20230061","DOIUrl":"10.1002/INMD.20230061","url":null,"abstract":"<p>Some biomolecules involved in pathological calcification have been identified. However, the exact mechanism in which this intricate process occurs remains unknown. Extracellular DNA (exDNA) has recently been recognized as a partaker in this ectopic phenomenon. Extracellular DNA acts as an intercellular messenger that transmits information and orchestrates complex inflammatory responses. Changes in the morphology or function of exDNA may trigger calcification under pathological conditions. In the present review, recent advances on how DNA is released into the extracellular milieu to become exDNA will be highlighted in conjunction with how exDNA directly and indirectly contributes to the progression of pathological calcification. Emphasis is placed on the “gluing” effect of neutrophil extracellular traps that act as a bridge between inflammation and pathological calcification. Manipulation of exDNA may open new vistas for the development of enterprising strategies that prevent or treat pathological calcification.</p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20230061","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140264008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Label-free surface-enhanced Raman spectroscopy coupled with machine learning algorithms in pathogenic microbial identification: Current trends, challenges, and perspectives","authors":"Jia-Wei Tang,&nbsp;Quan Yuan,&nbsp;Xin-Ru Wen,&nbsp;Muhammad Usman,&nbsp;Alfred Chin Yen Tay,&nbsp;Liang Wang","doi":"10.1002/INMD.20230060","DOIUrl":"10.1002/INMD.20230060","url":null,"abstract":"<p>Infectious diseases caused by microbial pathogens remain a primary contributor to global health burdens. Prompt control and effective prevention of these pathogens are critical for public health and medical diagnostics. Conventional microbial detection methods suffer from high complexity, low sensitivity, and poor selectivity. Therefore, developing rapid and reliable methods for microbial pathogen detection has become imperative. Surface-enhanced Raman Spectroscopy (SERS), as an innovative non-invasive diagnostic technique, holds significant promise in pathogenic microorganism detection due to its rapid, reliable, and cost-effective advantages. This review comprehensively outlines the fundamental theories of Raman Spectroscopy (RS) with a focus on label-free SERS strategy, reporting on the latest advancements of SERS technique in detecting bacteria, viruses, and fungi in clinical settings. Furthermore, we emphasize the application of machine learning algorithms in SERS spectral analysis. Finally, challenges faced by SERS application are probed, and the prospective development is discussed.</p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"2 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20230060","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140264134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When nanozymes meet deoxyribonucleic acid: Understanding their interactions and biomedical diagnosis applications","authors":"Hao Liang,&nbsp;Xinyu Chen,&nbsp;Zhijian Bu,&nbsp;Qinqin Bai,&nbsp;Jinjin Liu,&nbsp;Qingzhen Tian,&nbsp;Zheng Tang,&nbsp;Shu Li,&nbsp;Qiaoqiao Diao,&nbsp;Xiangheng Niu","doi":"10.1002/INMD.20230057","DOIUrl":"10.1002/INMD.20230057","url":null,"abstract":"<p>As emerging alternatives to natural enzymes, nanoscale materials featuring enzyme-like catalytic behaviors (nanozymes) exhibit some attractive merits including robust activity, low cost, and easy-to-regulate performance. These merits have enabled them to be intensively used in the biomedical field in recent years. To remedy the lack of catalytic selectivity in most nanozymes, deoxyribonucleic acid (DNA) chains with specific recognition functions are utilized to integrate with nanozymes to produce various nanozyme–DNA combinations via adsorption/desorption. In the formed combinations, the DNA component provides the molecular/ionic recognition role, and the nanozyme part offers response with catalytically amplified signals, enabling them to detect analytes and biomarkers selectively and sensitively. To highlight this interesting topic, here we made a critical review of the interactions between nanozymes and DNA and their applications in biosensing and disease diagnosis. First, strategies for the conjugation of DNA chains onto nanozyme surface were introduced briefly. Then, the interactions between DNA and nanozymes were summarized in detail, where flexible modulations of nanozyme activity by DNA adsorption/desorption as well as various factors were analyzed, and potential impacts caused by nanozymes on the recognition characteristics of DNA chains were pointed out. After that, typical applications of DNA-mediated nanozyme modulation in toxic ion sensing, health risk factor monitoring, and biomedical diagnosis were introduced. In the end, prospects of the combination of nanozymes and DNA chains were presented, and future challenges of the emerging field were also discussed, to attract more interest and effort to advance this promising area.</p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20230057","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140265946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Host-pathogen dialogues in different cell death modes during Mycobacterium tuberculosis infection","authors":"Hongxia Ruan,&nbsp;Mengyuan Lyu,&nbsp;Hongli Lai,&nbsp;Lu Niu,&nbsp;Zhenzhen Zhao,&nbsp;Tangyuheng Liu,&nbsp;Shuting Lei,&nbsp;Binwu Ying","doi":"10.1002/INMD.20230044","DOIUrl":"10.1002/INMD.20230044","url":null,"abstract":"<p>Tuberculosis (TB) is a fatal infectious disease that continues to pose a serious public health threat. The emergence of drug-resistant TB has further worsened the burden of the disease. The interaction between the host and the pathogen involves multiple modes of cell death, which play a role in determining immune outcomes. Several studies have established a strong correlation between cell death and TB progression. This review explores the molecular mechanisms of various cell death modes in <i>Mycobacterium tuberculosis</i> (Mtb) infection and how Mtb's virulence effectors regulate these pathways, including apoptosis, autophagy, pyroptosis, ferroptosis, and necrosis. Furthermore, therapeutic strategies targeting cell death pathways have shown promising results in TB treatment. Importantly, this review highlights the significant potential of mitochondria in mediating communication between different cell death modes and influencing the final outcomes. Overall, this work provides a comprehensive summary of the role of cell death in host immune responses and immune evasion by Mtb. It also offers valuable insights into the pathogenesis of TB and immune evasion strategies employed by Mtb and contributes to the development of more effective anti-TB therapies.</p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20230044","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139857023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}