Interdisciplinary Medicine最新文献_第8页

Extracellular vesicles in skin health, diseases, and aging 皮肤健康、疾病和衰老中的细胞外囊泡

Interdisciplinary Medicine Pub Date : 2024-05-29 DOI: 10.1002/INMD.20240011

Juan Wang, Siqi Yuan, Yidong Tu, Zhi Lv, Hua Cheng, Xiaolei Ding

引用次数: 0

Biocompatible polyethersulfone membrane modified by hydrophilic polymer decorated magnetic nanoparticles gilded by facile external magnetic field 亲水性聚合物修饰的聚醚砜膜通过简易外磁场镀金磁性纳米粒子实现生物兼容

Interdisciplinary Medicine Pub Date : 2024-05-11 DOI: 10.1002/INMD.20240004

Mohammed Kamal Hadi, Huanzhong Zeng, Manasa Pantrangi, Sambasivam Sangaraju, Fen Ran

{"title":"Biocompatible polyethersulfone membrane modified by hydrophilic polymer decorated magnetic nanoparticles gilded by facile external magnetic field","authors":"Mohammed Kamal Hadi, Huanzhong Zeng, Manasa Pantrangi, Sambasivam Sangaraju, Fen Ran","doi":"10.1002/INMD.20240004","DOIUrl":"10.1002/INMD.20240004","url":null,"abstract":"Polymer-based membranes such as polyethersulfone are widely used for hemodialysis and bio-related applications; however, this type of membrane still fails to satisfy optimum performance in terms of clearance, safety, and bio-adaptability. Herein, a polymer brush of polyvinylpyrrolidone is decorated on the surface of magnetic nanoparticles by using reversible addition-fragmentation chain transfer polymerization (RAFT), and under the guidance of an external magnetic field, the prepared magnetic nanoparticles with the polymer brush system are blended with a polyethersulfone membrane during a liquid-liquid phase inversion process. The prepared membranes with different loads of the pure magnetic nanoparticle and polyvinylpyrrolidone@magnetic nanoparticle polymer brushes are prepared, compared with the pristine membrane, the modified membrane shows a high flux value at 349 L m−2 h−1 and 99.9% bovine serum albumin protein rejection. This membrane also demonstrated improved hydrophilicity and pore structure compared with the pristine membrane. Concerning the blood biocompatibility analysis, the modified membranes acquire prolonged time for clotting factors such as prothrombin time, activated partial thromboplastin time, and thrombin time while exhibiting less fibrinogen concertation at 0.4 g L−1. Furthermore, for the first time, an innovative method for fouling detection based on magnetic field attenuation due to protein accumulation on the membrane surface is reported; the method in this work could be a positive booster for the safe use of polymeric membranes in hemodialysis and bio-based applications.","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"2 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20240004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140987639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical research on neurological and psychiatric diagnosis and monitoring using wearable devices: A literature review 使用可穿戴设备进行神经和精神诊断与监控的临床研究：文献综述

Interdisciplinary Medicine Pub Date : 2024-05-11 DOI: 10.1002/INMD.20230037

Jielin Huang, Huidi Wang, Qiheng Wu, Jia Yin, Hongwei Zhou, Yan He

{"title":"Clinical research on neurological and psychiatric diagnosis and monitoring using wearable devices: A literature review","authors":"Jielin Huang, Huidi Wang, Qiheng Wu, Jia Yin, Hongwei Zhou, Yan He","doi":"10.1002/INMD.20230037","DOIUrl":"10.1002/INMD.20230037","url":null,"abstract":"Wearable devices have opened up exciting possibilities for monitoring and managing home health, particularly in the realm of neurological and psychiatric diseases. These devices capture signals related to physiological and behavioral changes, including heart rate, sleep patterns, and motor functions. Their emergence has resulted in significant advancements in the management of such conditions. Traditional clinical diagnosis and assessment methods heavily rely on patient reports and evaluations conducted by healthcare professionals, often leading to a detachment of patients from their home environment and creating additional burdens for both patients and healthcare providers. The increasing popularity of wearable devices offers a potential solution to these challenges. This review focuses on the clinical utility of wearable devices in diagnosing and monitoring neurological and psychiatric diseases. Through research findings and practical examples, we highlight the potential role of wearable devices in diagnosing and monitoring conditions such as autism spectrum disorder, depression, epilepsy, stroke prognosis, Parkinson's disease, dementia, and other diseases. Additionally, the review discusses the benefits and limitations of wearable devices in clinical applications, while highlighting the challenges they face. Finally, it provides prospects for enhancing the value of wearable devices in the monitoring and diagnosis of neurological and psychiatric diseases.","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"2 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20230037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140988837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Host-Pathogen Dialogues in Different Cell Death Modes during Mycobacterium Tuberculosis Infection (2/2024) 结核分枝杆菌感染过程中不同细胞死亡模式下的宿主-病原体对话 (2/2024)

Interdisciplinary Medicine Pub Date : 2024-04-20 DOI: 10.1002/inmd.12097

Hongxia Ruan, Mengyuan Lyu, Hongli Lai, Lu Niu, Zhenzhen Zhao, Tangyuheng Liu, Shuting Lei, Binwu Ying

引用次数: 0

Biological particle separation techniques based on microfluidics 基于微流控技术的生物颗粒分离技术

Interdisciplinary Medicine Pub Date : 2024-04-20 DOI: 10.1002/INMD.20240003

Saijie Wang, Quanchen Xu, Yanwei Cai, Qian Wang, Ying Liu, Dou Wang

{"title":"Biological particle separation techniques based on microfluidics","authors":"Saijie Wang, Quanchen Xu, Yanwei Cai, Qian Wang, Ying Liu, Dou Wang","doi":"10.1002/INMD.20240003","DOIUrl":"https://doi.org/10.1002/INMD.20240003","url":null,"abstract":"Biological particle separation has wide applications in medical diagnosis, bioengineering, and various other domains. Traditional methods, such as filtration, density gradient centrifugation, and size exclusion chromatography, face many challenges, including low separation resolution, low purity, and the inability to be seamlessly integrated into continuous processes. The development of microfluidics has paved the way for efficient and precise biological particle separation. Microfluidic chip-based methods can generally be performed continuously and automatically, and microfluidic chips can integrate multilevel operations, including mixing, separation, detection, and so forth, thereby achieving continuous processing of particles at various levels. This review comprehensively investigates biological particle separation techniques based on microfluidic chips. According to the different sources of force effect on the particles during the separation process, they can be divided into active separation, passive separation, and affinity separation. We introduce the principles and device design of these methods respectively, and compare their advantages and disadvantages. For the introduction of each method, we used the most classic and latest research cases as much as possible. Additionally, we discussed the differences between experimental standard particles and biological particles. Finally, we summarized the current limitations and challenges of existing microfluidic separation techniques, while exploring future trends and prospects.","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20240003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140621334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of dynamic interplay exists between sympathetic and parasympathetic nerve in gastric tumorigenesis (2/2024) 交感神经和副交感神经在胃肿瘤发生中的动态相互作用 (2/2024)

Interdisciplinary Medicine Pub Date : 2024-04-20 DOI: 10.1002/inmd.12098

Diqun Chen, Xunjun Li, Yiyun Wang, Xinxin Li, Hongxia Zhang, Lina Zhang, Jia Yang, Haoyang Tan, Yingxin Xie, Yingyi Liuzhou, Jiayun Qiu, Miao Shi, Feiran Zhang, Wu Zhong, Kexing Xi, Chuanfa Fang, Alpha Ibrahima Balde, Jiang Yu, Tao Chen

{"title":"The role of dynamic interplay exists between sympathetic and parasympathetic nerve in gastric tumorigenesis (2/2024)","authors":"Diqun Chen, Xunjun Li, Yiyun Wang, Xinxin Li, Hongxia Zhang, Lina Zhang, Jia Yang, Haoyang Tan, Yingxin Xie, Yingyi Liuzhou, Jiayun Qiu, Miao Shi, Feiran Zhang, Wu Zhong, Kexing Xi, Chuanfa Fang, Alpha Ibrahima Balde, Jiang Yu, Tao Chen","doi":"10.1002/inmd.12098","DOIUrl":"https://doi.org/10.1002/inmd.12098","url":null,"abstract":"The illustration demonstrates the dynamic process of nerve remodeling during gastric precancerous progression. The density of parasympathetic nerve and Schwann cell exhibited a gradual increase, whereas the sympathetic nerve showed a reduced trend across the spectrum of precancerous lesions. There is a dynamic relationship between sympathetic and parasympathetic nerves resulting from crosstalk among inflammation, immune regulation, and neural regulation during gastric tumorigenesis. This specific pattern of nerve distribution is validated by gene-level nerve-related signatures. Several key nerve-regulating genes and pathways, such as MAPK/ERK, PI3K/AKT/mTOR signaling are also identified. These findings highlight the importance of comprehending the interaction between nerves and tumor cells, offering potential avenues for future clinical translation targeting the nervous system and disrupting nerves-cancer crosstalk. \u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture>\u0000 </div>\u0000 </figure>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/inmd.12098","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140621344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanothermometry for Cellular Temperature Monitoring and Disease Diagnostics (2/2024) 用于细胞温度监测和疾病诊断的纳米温度计 (2/2024)

Interdisciplinary Medicine Pub Date : 2024-04-20 DOI: 10.1002/inmd.12096

Meilin Liu, Yaru Sun, Daniel Boon Loong Teh, Yi Zhang, Donglin Cao, Qingsong Mei

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Table of Content 目录

Interdisciplinary Medicine Pub Date : 2024-04-20 DOI: 10.1002/inmd.12099

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Engineered oncolytic bacteria for malignant solid tumor treatment 用于恶性实体瘤治疗的工程溶瘤菌

Interdisciplinary Medicine Pub Date : 2024-04-12 DOI: 10.1002/INMD.20240005

Minjia Wang, Xuejiao Song, Xianglong Liu, Chuan Ma, Jing Ma, Leilei Shi

引用次数: 0