Anqi Liu, Gang Yang, Yijie Zhao, Jiajia Deng, Jialiang Liu, Kairun Zhang, Li Mei, Yan Liu, Tingjiao Liu
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Bone-Targeted Hybrid Extracellar Vesicles for Alveolar Bone Regeneration(3/2025)
Prolonged tooth loss causes a blade-like narrowing of the alveolar bone, severely impairing chewing function and aesthetics and complicating subsequent orthodontic or restorative treatments. Bone morphogenetic protein-2 (BMP-2) can induce bone formation, but may cause many side effects in vivo due to insufficient cell targeting. In this study, we modified BMP-2 with DNA nanostructures to construct BMP-2-loaded hybrid extracellular vesicles, which were combined with a hydrogel sustained-release system. This combination effectively repaired alveolar bone defects and demonstrated the potential to promote bone tissue repair and regeneration.
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