Application of antibody coupling technique in targeted drug delivery (3/2025)

Abstract

Antibodies, a critical component of the human immune defense system, are produced in large quantities by the body when foreign antigens or newly generated self-antigens are present. Through the specific binding of variable regions to antigens, antibodies can directly neutralize pathogens or inhibit their ability to infect host cells. Further modification of antibodies, enabling them to carry highly toxic small molecules, cytotoxic cells, polymers, or oligonucleotides, allows antibodies to precisely target cancer cells. This enhances therapeutic efficacy and enhance the therapeutic efficacy, significantly improves overall treatment effectiveness against cancer. This picture consists of cancer cells, two people driving rockets, antibody-drug conjugates, and targets. Among them, the person who drives the rocket is used as a metaphor for antibody-drug conjugates, where the rocket refers to the antibody and the person refers to various conjugated drugs. The screws and masks on the cells represent the difficulty of tumor cell infiltration, and the screws on antibodies represent that the antibodies have been engineered and modified. Through engineered modified antibodies, highly active drugs can be loaded onto the antibodies to precisely target tumor cells, thereby more efficiently disintegrating the cancer cells and achieving therapeutic effects.