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Interdisciplinary Medicine Pub Date : 2025-03-26 DOI: 10.1002/inmd.70018

引用次数: 0

mRNA Therapy：A New frontier in Regenerative Medicine (2/2025) mRNA治疗：再生医学的新前沿（2/2025）

Interdisciplinary Medicine Pub Date : 2025-03-26 DOI: 10.1002/inmd.70019

Ding-Ding Xue, Yue Zhang, An-Ran Shen, Tao-Tao Tang, Bi-Cheng Liu, Lin-Li Lv

{"title":"mRNA Therapy：A New frontier in Regenerative Medicine (2/2025)","authors":"Ding-Ding Xue, Yue Zhang, An-Ran Shen, Tao-Tao Tang, Bi-Cheng Liu, Lin-Li Lv","doi":"10.1002/inmd.70019","DOIUrl":"https://doi.org/10.1002/inmd.70019","url":null,"abstract":"This image illustrates the therapeutic potential of mRNA in repairing damaged tissues. At the bottom of the image, cells are displayed as losing vitality due to various damaging factors, creating a desolate and lifeless landscape. In the center, a root system symbolizes the therapeutic mRNA, with its intricate network representing the regenerative power of this innovative therapy. Surrounding the roots are cells that have been repaired and regenerated. The spherical structures between the mRNA roots and the cells represent engineered mRNA delivery vehicles, highlighting the critical role of advanced delivery systems in this process. The green sprouts growing from the land symbolize new life and hope.The overarching concept of the design is a barren land scattered with dying cells, where an \"mRNA seed\" takes root and begins to grow. As the roots extend, damaged tissues experience healing and regeneration, offering hope for the cure of diseases. This visual metaphor captures the essence of mRNA therapy as a groundbreaking approach to tissue repair and regeneration.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture>\u0000 </div>\u0000 </figure>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/inmd.70019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanomaterials for acute myeloid leukemia therapy: Current progress and future perspectives 纳米材料治疗急性髓细胞白血病：目前进展和未来展望

Interdisciplinary Medicine Pub Date : 2025-03-21 DOI: 10.1002/INMD.20240131

Jiarui Zhao, Jiaqi Cui, Lixuan Wang, Xinyi Shi, Jiayan Ding, Muhammad Farhan Sohail, Irshad Hussain, Qihui Liu, Fangfang Chen

{"title":"Nanomaterials for acute myeloid leukemia therapy: Current progress and future perspectives","authors":"Jiarui Zhao, Jiaqi Cui, Lixuan Wang, Xinyi Shi, Jiayan Ding, Muhammad Farhan Sohail, Irshad Hussain, Qihui Liu, Fangfang Chen","doi":"10.1002/INMD.20240131","DOIUrl":"https://doi.org/10.1002/INMD.20240131","url":null,"abstract":"Acute myeloid leukemia (AML) is a highly aggressive hematologic malignancy characterized by poor prognosis, high relapse rates, and resistance to conventional chemotherapy. The limitations of standard treatments, including systemic toxicity and non-specific drug distribution, highlight the need for novel therapeutic strategies. Nanoparticles (NPs) represent a promising approach for enhancing AML treatment by improving drug solubility, bioavailability, and targeted delivery while simultaneously minimizing adverse effects. Various NPs, including liposomes, polymeric micelles, dendrimers, carbon-based, and metal NPs, have been explored for their ability to selectively target leukemic cells through passive and active targeting mechanisms. Functionalized NPs can exploit the enhanced permeability and retention effect for passive accumulation in leukemia-affected tissues, while ligand-modified NPs enable active targeting of AML-specific biomarkers such as CD33, CD123, and folate receptors. Furthermore, NPs facilitate combination therapies, controlled drug release, and intracellular drug delivery, overcoming multidrug resistance and enhancing therapeutic efficacy. This review discusses the latest advancements in NP-based AML therapies, their targeting strategies, and prospects for clinical translation, emphasizing the potential of nanotechnology in revolutionizing AML treatment.","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20240131","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144220443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plant extracellular vesicles: A promising bionic medicine platform for disease treatment and drug delivery 植物细胞外囊泡：一个有前景的疾病治疗和药物输送仿生医学平台

Interdisciplinary Medicine Pub Date : 2025-03-20 DOI: 10.1002/INMD.20240101

Jichun Yang, Yuhan Wang, Yunqian Fu, Sitong Wang, Yao Luo, Xin Cui, Chenyu Sun, Jianing Ji, Jiaxi Mo, Yang Wang, Yilin Liu, Xinghong Hu, Xiaohui Chen, Yimin Jia, Yang Luo

{"title":"Plant extracellular vesicles: A promising bionic medicine platform for disease treatment and drug delivery","authors":"Jichun Yang, Yuhan Wang, Yunqian Fu, Sitong Wang, Yao Luo, Xin Cui, Chenyu Sun, Jianing Ji, Jiaxi Mo, Yang Wang, Yilin Liu, Xinghong Hu, Xiaohui Chen, Yimin Jia, Yang Luo","doi":"10.1002/INMD.20240101","DOIUrl":"https://doi.org/10.1002/INMD.20240101","url":null,"abstract":"Plant extracellular vesicles (PEVs) are nanoscale vesicles secreted by plant cells with intact membrane architecture, which encapsulate a diverse array of biomolecules, including lipids, proteins and RNA. They are integral to both intra-cellular communication within plants and inter-species signaling. Recently, some PEVs have been regarded as competitive candidates for disease therapy due to their beneficial components and distinctive hollow biomembrane structure. However, the broader applications of PEVs are currently impeded by several challenges of complicated extraction processes, compositional heterogeneity, the lack of reliable biomarkers and unclear therapy mechanisms. A detailed comprehension of their preparation techniques and biological functions is essential for leveraging their potential in clinical medicine. This article first presented a synthesis of the current methodologies for PEV isolation, purification and characterization. Then, it revealed the therapeutic implications of PEVs as medicines in some common diseases based on their bioactive molecules inside, such as cancer, inflammation, and metabolic disorders. We especially explored the emerging role of PEVs with low immunogenicity and the power for biological barriers crossing as drug delivery systems, underscoring their potential for further industry and clinical applications. At last, the bottleneck problems and a vision of PEVs for disease therapy were also presented to evoke more insightful deliberation. This review aims to provide directions for the development of PEV-derived innovative drugs.","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20240101","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144220361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of reactive oxygen species and antioxidant strategies on wound healing in diabetes 活性氧和抗氧化策略对糖尿病创面愈合的影响

Interdisciplinary Medicine Pub Date : 2025-03-18 DOI: 10.1002/INMD.20240062

Qiuyi Yu, Zijun Zheng, Huihui Zhang, Erlian Xie, Lianglong Chen, Ziwei Jiang, Yanbin Gao, Jun Ma, Lei Yang

{"title":"Effects of reactive oxygen species and antioxidant strategies on wound healing in diabetes","authors":"Qiuyi Yu, Zijun Zheng, Huihui Zhang, Erlian Xie, Lianglong Chen, Ziwei Jiang, Yanbin Gao, Jun Ma, Lei Yang","doi":"10.1002/INMD.20240062","DOIUrl":"https://doi.org/10.1002/INMD.20240062","url":null,"abstract":"With the rising global prevalence of diabetes, the rate of chronic wounds associated with this disease is also escalating. Although the mechanisms underlying this trend are not fully understood, accumulating evidence suggests a critical role for reactive oxygen species (ROS). Increased blood glucose levels, bacterial infections, and impaired energy utilization lead to an imbalance between oxidative and antioxidant responses, resulting in ROS accumulation. The cellular antioxidant system can manage a small amount of ROS; however, excessive exogenous ROS acts upon the cell membrane or even penetrates the cell, consequently affecting its activity. Excessive ROS cause enhanced expression of inflammatory factors, impaired cellular proliferation, vascular vessel damage, and extracellular matrix remodeling disturbance, ultimately hindering diabetic wound healing. The regulation of ROS during wound healing is intricate and involves diverse mechanisms throughout the entire wound-healing process. This review provides a systematic overview of the relationship between ROS and inflammatory signaling pathways in diabetic wounds along with the most recent antioxidant strategies targeting these pathways. The aim of this review was to outline effective strategies for mitigating oxidative stress in chronic wounds and to provide novel insights into future research.","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20240062","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular subtyping and precision therapy for esophageal cancer 食管癌分子分型及精准治疗

Interdisciplinary Medicine Pub Date : 2025-03-14 DOI: 10.1002/INMD.20240105

Guangkun Pei, Zhuoran Liang, Bianli Gu, Linlin Shi, Ze-Xian Liu, Shegan Gao

{"title":"Molecular subtyping and precision therapy for esophageal cancer","authors":"Guangkun Pei, Zhuoran Liang, Bianli Gu, Linlin Shi, Ze-Xian Liu, Shegan Gao","doi":"10.1002/INMD.20240105","DOIUrl":"https://doi.org/10.1002/INMD.20240105","url":null,"abstract":"Esophageal cancer (EC) is a prevalent malignancy of the digestive tract with high rates of morbidity and mortality. Two main types of EC, Esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC), differ significantly in their molecular characteristics and response to treatment. Current clinical management primarily involves surgery and chemoradiotherapy; however, the limited efficacy and severe side effects of traditional treatments have led to unsatisfactory outcomes. Recent advancements in molecular classification and precision therapy offer new strategies for improving EC treatment. This article reviews the progress in the molecular classification of EC and its application in precision therapy, providing a theoretical basis and practical guidance for clinical management. We emphasize how multiple omics, such as genomics, transcriptomics and proteomics, enhance our understanding of the molecular characteristics of EC. Additionally, we analyze current clinical research and the effectiveness of targeted therapies and immunotherapies. We found that significant progress has been made in the molecular classification of EC, and studies have revealed the impact of multiple key gene mutations and signaling pathways (e.g., TP53, PIK3CA, EGFR) across different subtypes. Although targeted therapy and immunotherapy have shown good clinical efficacy, challenges such as high heterogeneity and drug resistance persist in current precision therapy. Future research should focus on overcoming drug resistance, finding new biomarkers, and optimizing treatment strategies.","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20240105","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144220103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic diseases and interferon immune responses 代谢性疾病和干扰素免疫反应

Interdisciplinary Medicine Pub Date : 2025-03-13 DOI: 10.1002/INMD.20240075

Haiyan Zhou, Chunyan Liu, Yuerong Zhang, Hui Zheng

{"title":"Metabolic diseases and interferon immune responses","authors":"Haiyan Zhou, Chunyan Liu, Yuerong Zhang, Hui Zheng","doi":"10.1002/INMD.20240075","DOIUrl":"https://doi.org/10.1002/INMD.20240075","url":null,"abstract":"Metabolic diseases, including obesity, diabetes, and metabolic-associated fatty liver disease (MAFLD), are increasingly common worldwide, posing a significant public health challenge. Recent research has revealed a complex interplay between these metabolic disorders and interferon (IFN) immune responses. As key immune regulators, interferons coordinate the host's defense against viral infections and are essential for maintaining immune homeostasis. However, metabolic dysregulation can significantly disrupt IFN signaling pathways, affecting the intensity and efficiency of immune responses. Conversely, alterations in IFN signaling can influence the onset and progression of metabolic diseases. This review explores the mechanisms by which metabolic diseases modulate IFN responses, focusing on how obesity, diabetes, and MAFLD alter IFN signaling. Additionally, we examine the implications of the changes in IFN immune responses for the progression of metabolic diseases. By synthesizing current research, this review aims to elucidate the interplay between IFN immune responses and common metabolic diseases, offering insights for future research and clinical applications in the field of IFN-related metabolic diseases.","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20240075","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineered strategies for the allergic disease therapy 变态反应性疾病治疗的工程策略

Interdisciplinary Medicine Pub Date : 2025-03-09 DOI: 10.1002/INMD.20240115

Yun Tian, Xin Wu, Xiaoqi Sun, Lei Rong, Kai Han

{"title":"Engineered strategies for the allergic disease therapy","authors":"Yun Tian, Xin Wu, Xiaoqi Sun, Lei Rong, Kai Han","doi":"10.1002/INMD.20240115","DOIUrl":"https://doi.org/10.1002/INMD.20240115","url":null,"abstract":"Allergic diseases with high recurrence rates have severely threatened human health around the world. Several strategies have been developed including the administration of allergens or neutralizing antibodies, while allergen-specific immunotherapy (AIT) has been considered as a cure for allergic diseases. However, AIT has some drawbacks including the anaphylactic side effects of the native allergen protein during therapy, poor biodistribution of allergen in targeted organs/cells, and unsatisfactory desensitization and long-term unresponsiveness after the treatment. Biomaterials including hydrogels, nanoparticles, polymers and nanoemulsions could improve the pharmacokinetics of allergens and avoid the leakage of free allergens, thereby improving therapeutic efficacy with reduced side effects. This review summarizes the recent advances of engineered biomaterials to alleviate allergic diseases, especially in the combination with AIT. Due to the prevalence of various allergic diseases and the very limited therapeutics for allergic patients, this review will provide new insights into the development of novel biomaterials for the prevention or treatment of allergic diseases with sustained unresponsiveness.","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20240115","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144220311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Establishing a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for both 18-hydroxycorticosterone and its interference: Revisiting the specificity characteristic of LC-MS/MS in the steroid measurement 建立液相色谱-串联质谱（LC-MS/MS）测定18-羟基皮质酮及其干扰物的方法：重新探讨LC-MS/MS在类固醇检测中的特异性

Interdisciplinary Medicine Pub Date : 2025-03-06 DOI: 10.1002/INMD.20240077

Songlin Yu, Jian Zhong, Xiaoli Ma, Ling Qiu

{"title":"Establishing a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for both 18-hydroxycorticosterone and its interference: Revisiting the specificity characteristic of LC-MS/MS in the steroid measurement","authors":"Songlin Yu, Jian Zhong, Xiaoli Ma, Ling Qiu","doi":"10.1002/INMD.20240077","DOIUrl":"https://doi.org/10.1002/INMD.20240077","url":null,"abstract":"Isomeric interference is essential in mass spectrometry (MS) analysis of steroid hormones. This study aims to investigate the specificity of liquid chromatography-tandem MS (LC-MS/MS) for measuring 18-hydroxycorticosterone (18-OHB) and to develop a validated LC-MS/MS method. To identify the interfering substance on 18-OHB quantification in plasma, high-performance liquid chromatography-tandem time-of-flight mass spectrometry was used for the retention time comparison and the fragment characteristics matching. 18-OHB, cortisone, and cortisol could be chromatographically separated using water containing 0.025 mM ammonium fluoride and acetonitrile on the UPLC BEH C8 column. The interference of 18-OHB with similar ion transitions was finally identified as 20β-dihydrocortisone (20α-DHE), instead of cortisone, cortisol, or 20β-dihydrocortisone. By using optimized chromatographic conditions, 18-OHB, and 20α-DHE were separated well and the linearities were ≥0.999. The recovery rates ranged from 94.59% to 105.27% for 18-OHB and 85.21%–101.23% for 20α-DHE. The total coefficient of variations in the precision evaluation was ≤4.6% for 18-OHB and ≤4.3% for 20α-DHE. The medians of 18-OHB and 20α-DHE levels in patients with primary aldosteronism were 0.48 ng/mL and 0.14 ng/mL, respectively. This study explored the potential risks associated with isomeric interference in LC-MS/MS for 18-OHB quantification and established a robust LC-MS/MS method for detecting plasma 18-OHB and 20α-DHE. Comprehensively assessing the effect of the underlying isomers when using LC-MS/MS for hormone measurements is recommended.","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20240077","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating emotion dynamics in mental health: A trimodal framework combining ecological momentary assessment, physiological measurements, and speech emotion recognition 在心理健康中整合情绪动态：一个结合生态瞬间评估、生理测量和言语情绪识别的三模态框架

Interdisciplinary Medicine Pub Date : 2025-03-05 DOI: 10.1002/INMD.20240095

Peng Wang, Ao Liu, Xu Sun

{"title":"Integrating emotion dynamics in mental health: A trimodal framework combining ecological momentary assessment, physiological measurements, and speech emotion recognition","authors":"Peng Wang, Ao Liu, Xu Sun","doi":"10.1002/INMD.20240095","DOIUrl":"https://doi.org/10.1002/INMD.20240095","url":null,"abstract":"The complex relationship between emotions and mental health demands a more comprehensive theoretical framework that can capture its dynamic and multifaceted nature. This perspective article proposes a novel trimodal approach that conceptually integrates three complementary methodologies: Ecological Momentary Assessment, physiological measurements, and Speech Emotion Recognition. By adopting a dynamical system perspective, we argue that the convergence of these methodologies could provide unprecedented insights into emotional dynamics in mental health research and practice. We discuss how this framework could transform our understanding by simultaneously capturing subjective experiences, physiological responses, and linguistic patterns in naturalistic settings. The proposed integration offers a conceptual foundation for developing more sophisticated approaches to mental health monitoring and intervention. We explore the theoretical implications, methodological considerations, and potential future directions of this integrated perspective, highlighting its promise for advancing both research and clinical practice in mental health.","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20240095","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144220207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0