Interdisciplinary Medicine最新文献_第6页

Stimuli-responsive hydrogels: An intelligent tool for wound management 刺激反应水凝胶：伤口管理的智能工具

IF 13.6

Interdisciplinary Medicine Pub Date : 2026-03-30 Epub Date: 2026-03-10 DOI: 10.1002/inmd.70104

Debin Zheng, Meiqi Zhu, Xi Liu, Cuiping Zhang, Di Wu, Tianyu Xie, Chen Li, Pei Zhao, Wenting Chen, Xiaobing Fu, Xiaoxue Li

{"title":"Stimuli-responsive hydrogels: An intelligent tool for wound management","authors":"Debin Zheng, Meiqi Zhu, Xi Liu, Cuiping Zhang, Di Wu, Tianyu Xie, Chen Li, Pei Zhao, Wenting Chen, Xiaobing Fu, Xiaoxue Li","doi":"10.1002/inmd.70104","DOIUrl":"10.1002/inmd.70104","url":null,"abstract":"Wound healing represents a well-coordinated and sophisticated biological process characterized by the need for precise regulation and spatiotemporal synergy of multiple cells, regulatory cytokines, and signaling pathways, ultimately achieving repair and functional reconstruction of damaged tissues. In complex situations such as war, disasters and diseases, how to carry out wound management in a truly effective manner still stands as a notable challenge. The microenvironment of wound is multi-dimensional, dynamic and complex, the wound healing process is collectively regulated by endogenous biochemical signals and exogenous physical, chemical, biological factors, which makes traditional dressings often fall short of expectations in the wound healing. Stimuli-responsive hydrogels, by sensing endogenous factors (like pH, reactive oxygen species, and glucose, along with specific enzymes) or exogenous factors (light, temperature, electric fields, etc.), exhibit various intelligent characteristics, such as interacting with wounds, monitoring wound conditions or microenvironment changes, achieving precise drug release control or dynamic assessment of the wound healing process, thereby effectively promoting wound healing. Stimuli-responsive hydrogel tissue engineering strategies (scaffolds, nanofibers, microneedles, microspheres, etc.) also provide more options for wound repair. Serving as a critical overview of stimuli-responsive hydrogels, this review delves into the recent application scenarios of these hydrogels in wound management, systematically summarizes the attendant challenges, and seeks to offer a useful reference for studies in this research field.","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"4 2","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/inmd.70104","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147668268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sequential ultrasound-driven dynamic control of macrophage polarization combined with hydrogel for mechano-chemical synergistic tissue repair 顺序超声驱动巨噬细胞极化动态控制与水凝胶联合进行机械化学协同组织修复

IF 13.6

Interdisciplinary Medicine Pub Date : 2026-03-30 Epub Date: 2026-01-06 DOI: 10.1002/inmd.70076

Fulong Man, Kun Wang, Zichen Yang, Lulu An, Caoyi You, Rongjie Li, Yanni Cai, Yang Li, Li Chen, Yiqiong Liu, Yan Li, Haiqing Dong, Yongyong Li

{"title":"Sequential ultrasound-driven dynamic control of macrophage polarization combined with hydrogel for mechano-chemical synergistic tissue repair","authors":"Fulong Man, Kun Wang, Zichen Yang, Lulu An, Caoyi You, Rongjie Li, Yanni Cai, Yang Li, Li Chen, Yiqiong Liu, Yan Li, Haiqing Dong, Yongyong Li","doi":"10.1002/inmd.70076","DOIUrl":"10.1002/inmd.70076","url":null,"abstract":"Precise regulation of macrophage fate is crucial for effective management of inflammation. However, conventional biochemical strategies often suffer from limitations in safety and efficiency, necessitating the development of more effective and controllable alternatives. In this study, we develop an ultrasound-engineered cell culture device capable of delivering finely tuned ultrasonic mechanical stimulation and demonstrate for the first time that ultrasound can remotely and dynamically modulate macrophage phenotypic fate. Our results demonstrate that ultrasound stimulation not only induces flexible transitions between macrophage subtypes but also exhibits superior immunomodulatory performance in induction efficiency, dynamic responsiveness, and spatio-temporal controllability compared to classical biochemical methods. Transcriptome sequencing reveals that ultrasound directionally polarizes M2a macrophages via activation of the integrin αXβ2/TGF-β/c-Fos/IL-10 pathway. Based on the programmable dynamic control of macrophage phenotype, we propose “sequential ultrasound therapy” and combine it with metformin hydrogel with controlled-release function to construct a physicochemically coordinated “inflammatory switch and angiogenesis promotion” therapeutic platform, exhibiting superior inflammatory repair effects than single treatment for in vivo diabetic wounds and myocardial infarction models. Overall, this study not only advances the mechanistic understanding of ultrasound in tissue repair but also proposes a remote, non-invasive ultrasound immunotherapy paradigm with clinical translation potential.","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"4 2","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/inmd.70076","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147668165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intratumoral bacteria engineered for tumor therapy 用于肿瘤治疗的肿瘤内细菌

IF 13.6

Interdisciplinary Medicine Pub Date : 2026-03-30 Epub Date: 2026-03-10 DOI: 10.1002/inmd.70106

Huajie Zhang, Zelin Chen, Zeyu Yao, Sishi Luo, Cheng Luo, Rui Yang, Hao Fu, Songyin Huang

{"title":"Intratumoral bacteria engineered for tumor therapy","authors":"Huajie Zhang, Zelin Chen, Zeyu Yao, Sishi Luo, Cheng Luo, Rui Yang, Hao Fu, Songyin Huang","doi":"10.1002/inmd.70106","DOIUrl":"10.1002/inmd.70106","url":null,"abstract":"Intratumoral bacteria play vital roles in regulating tumor progression by stimulating pro-inflammatory signals or modulating the tumor microenvironment. Due to distinct characteristics, such as intrinsic targeting of tumors or inherent immunogenicity, intratumoral bacteria are capable of inducing specific tumor cell apoptosis and necrosis, or even reprogramming the tumor immune microenvironment by interacting with the immune system. Such efficacy can be further enhanced by the modifications and engineering processes, which may efficiently inhibit tumor growth with minimal side effects, thus demonstrating promising clinical translation potential. Therefore, in this review, the development and characteristics of intratumoral bacteria and their impact on tumor progression are described in detail. Moreover, the strategies and applications of these intratumoral bacteria, which are explicitly engineered to induce tumor regression through direct killing or immune modulation, are also included. Additionally, the mechanisms by which these engineered intratumoral bacteria regulate tumor progression are elucidated and discussed. More importantly, the translational significance, current challenges in clinical adaptation, and possible solutions to these challenges of engineered intratumoral bacteria are also highlighted. Overall, this comprehensive review may provide perspectives regarding the intratumoral bacteria and may offer new insights for developing novel bacteria-based therapeutic platforms against tumors.","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"4 2","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/inmd.70106","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147668270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Achieving superior therapeutic effects on methicillin-resistant Staphylococcus aureus infection via simple sulfonation process for preparing zwitterionic photosensitizer 采用简单磺化法制备两性离子光敏剂，对耐甲氧西林金黄色葡萄球菌感染的治疗效果较好

IF 13.6

Interdisciplinary Medicine Pub Date : 2026-03-30 Epub Date: 2026-01-21 DOI: 10.1002/inmd.70095

Changxu Zhu, Yin Li, Qiyun Deng, Ruixin Guo, Yu Huang, Wenyan Guo, Xi Chen, Ben Zhong Tang, Zhiming Wang, Lidan Chen, Zhaohui Sun

{"title":"Achieving superior therapeutic effects on methicillin-resistant Staphylococcus aureus infection via simple sulfonation process for preparing zwitterionic photosensitizer","authors":"Changxu Zhu, Yin Li, Qiyun Deng, Ruixin Guo, Yu Huang, Wenyan Guo, Xi Chen, Ben Zhong Tang, Zhiming Wang, Lidan Chen, Zhaohui Sun","doi":"10.1002/inmd.70095","DOIUrl":"10.1002/inmd.70095","url":null,"abstract":"Drug-resistant bacterial biofilm-associated infections pose a significant threat to human health, as the physical barrier and protective matrix of biofilms enable bacterial evasion of antibiotic effects, leading to refractory infections. To address this challenge, we develop a novel photosensitizer PY and its sulfonated zwitterionic derivative PYSO3. Both photosensitizers exhibit aggregation-induced emission (AIE) properties coupled with exceptional photodynamic and photothermal performance in aggregates. Sulfonated zwitterionic modification significantly enhance the biological activity of PYSO3, demonstrating potent bactericidal efficacy against methicillin-resistant Staphylococcus aureus (MRSA) and mature biofilms under laser irradiation. Mechanistically, PYSO3-mediated combinational photodynamic therapy and photothermal therapy disrupt critical bacterial survival pathways, including quorum sensing systems, glycolysis/gluconeogenesis pathways, and oxidative stress homeostasis, thereby inhibiting normal bacterial metabolism and biofilm formation. In vivo experiments reveal remarkable antibacterial performance with accelerated wound healing rates and favorable biosafety profiles. This AIE-active zwitterionic photosensitizer not only holds great promise for combating MRSA infections but also provides new design strategies for developing multifunctional antimicrobial agents targeting drug-resistant pathogens.","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"4 2","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/inmd.70095","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147668578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammatory bowel disease and metabolic reprogramming: From pathological mechanisms to targeted interventions 炎症性肠病和代谢重编程：从病理机制到针对性干预

IF 13.6

Interdisciplinary Medicine Pub Date : 2026-03-30 DOI: 10.1002/inmd.70124

引用次数: 0

Non-invasive and efficient diabetic retinal mitochondrial repair nanoplatform based on engineered endothelial mitochondrial-derived vesicles with dynamic integrated stress response modulation 基于工程内皮线粒体源性囊泡和动态综合应激反应调节的无创高效糖尿病视网膜线粒体修复纳米平台

IF 13.6

Interdisciplinary Medicine Pub Date : 2026-03-30 Epub Date: 2026-01-19 DOI: 10.1002/inmd.70085

Siyu Gui, Jie Gao, Tianchang Tao, Peng Wang, Zhihao Huang, Yuyang She, Jiajie Li, Jingwan Su, Zhe Lu, Jianchao Qiao, Song Wang, Xiaodong Sun, Mohan Li

{"title":"Non-invasive and efficient diabetic retinal mitochondrial repair nanoplatform based on engineered endothelial mitochondrial-derived vesicles with dynamic integrated stress response modulation","authors":"Siyu Gui, Jie Gao, Tianchang Tao, Peng Wang, Zhihao Huang, Yuyang She, Jiajie Li, Jingwan Su, Zhe Lu, Jianchao Qiao, Song Wang, Xiaodong Sun, Mohan Li","doi":"10.1002/inmd.70085","DOIUrl":"10.1002/inmd.70085","url":null,"abstract":"Diabetic retinopathy (DR) is driven by chronic oxidative stress and mitochondrial dysfunction, yet effective, non-invasive strategies for mitochondrial quality control (MQC) that can traverse the blood–retinal barrier (BRB) remain limited. Here, we systematically develop and investigate a bioengineered nanoplatform—endothelial mitochondria-derived vesicles (EMDVs) from retinal microvascular cells. Through optimized functional extraction and membrane potential-preserving bioengineering, EMDVs retain critical mitochondrial membrane potential and adenosine triphosphate synthesis capabilities. Upon Coenzyme Q10 (CoQ10) modification, EMDVs exhibit potent antioxidant activity. Kinetic and phenotypic recovery assays demonstrate that EMDVs non-invasively penetrate the retina and efficiently deliver CoQ10 across the BRB to all retinal layers, restoring mitochondrial homeostasis and remodeling antioxidant defenses. Transcriptomic and mechanistic analyses further reveal that topical administration of EMDVs and CoQ10-engineered vesicles dynamically modulates the disease-dependent eIF2α-ATF4-CHOP-integrated stress response axis, facilitating repair and remodeling of the retinal barrier, particularly the microvasculature, in both early- and late-stage DR. Long-term in vivo safety evaluation confirms no systemic toxicity or local inflammation. This study introduces a mitochondria-derived vesicle nanoplatform with high BRB permeability and efficient MQC function, highlighting its translational potential as a dynamic, targeted therapeutic strategy for mitochondrial dysfunction-related degenerative diseases and versatile drug delivery across biological barriers.","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"4 2","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/inmd.70085","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147668805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adipose-derived small extracellular vesicles exacerbate microvascular dysfunction in heart failure with preserved ejection fraction via mmu-miR-582-3p-mediated Rap1b suppression 脂肪来源的小细胞外囊泡通过免疫球蛋白- mir -582-3p介导的Rap1b抑制，加剧了保留射血分数的心力衰竭微血管功能障碍

IF 13.6

Interdisciplinary Medicine Pub Date : 2026-03-30 Epub Date: 2026-01-19 DOI: 10.1002/inmd.70090

Lu Chen, Qiuhan Wang, Mengjia Shen, Mingjue Li, Yingqi Zhu, Cankun Zheng, Siyuan Ma, Hairuo Lin, Xiaokang Fu, Rui Zhang, Jianping Bin, Yulin Liao, Qiancheng Wang

{"title":"Adipose-derived small extracellular vesicles exacerbate microvascular dysfunction in heart failure with preserved ejection fraction via mmu-miR-582-3p-mediated Rap1b suppression","authors":"Lu Chen, Qiuhan Wang, Mengjia Shen, Mingjue Li, Yingqi Zhu, Cankun Zheng, Siyuan Ma, Hairuo Lin, Xiaokang Fu, Rui Zhang, Jianping Bin, Yulin Liao, Qiancheng Wang","doi":"10.1002/inmd.70090","DOIUrl":"10.1002/inmd.70090","url":null,"abstract":"Heart failure with preserved ejection fraction (HFpEF) is characterized by diastolic dysfunction despite a preserved left ventricular ejection fraction, and visceral adipose tissue is implicated in its pathogenesis. We hypothesize that VAT-derived small extracellular vesicles (sEVs) impair coronary microcirculation in HFpEF, and that the SGLT2 inhibitor canagliflozin can mitigate this effect. Using a mouse model of HFpEF established by a high-fat diet and L-NAME, we found that these mice exhibited significant coronary microcirculation dysfunction. Isolated VAT-sEVs from HFpEF mice were shown to exacerbate cardiac microvascular endothelial cell (CMEC) apoptosis and impair coronary flow reserve. Mechanistically, miRNA sequencing identified mmu-miR-582-3p as a key mediator enriched in these sEVs, which promotes CMEC apoptosis and mitochondrial dysfunction by directly targeting and downregulating Rap1b. Treatment with canagliflozin improved cardiac function, reduced CMEC apoptosis, and was associated with the downregulation of mmu-miR-582-3p in VAT-sEVs and the subsequent upregulation of Rap1b in CMECs. Our findings demonstrate that VAT-sEVs contribute to coronary microcirculation dysfunction in HFpEF via the mmu-miR-582-3p/Rap1b signaling pathway. Furthermore, the therapeutic benefit of SGLT2 inhibition is associated with modulation of this pathway; however, this association may be secondary to overall disease improvement, and a direct causal link requires future validation.","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"4 2","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/inmd.70090","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147668806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular crosstalk via exosomes in lung cancer progression 肺癌进展中外泌体的分子串扰

IF 13.6

Interdisciplinary Medicine Pub Date : 2026-03-30 Epub Date: 2026-01-23 DOI: 10.1002/inmd.70088

Rajib Dhar, Vinoth Kumarasamy, Brian G. Oliver, Vetriselvan Subramaniyan

引用次数: 0

Inflammatory bowel disease and metabolic reprogramming: From pathological mechanisms to targeted interventions 炎症性肠病和代谢重编程：从病理机制到针对性干预

IF 13.6

Interdisciplinary Medicine Pub Date : 2026-03-30 DOI: 10.1002/inmd.70123

{"title":"Inflammatory bowel disease and metabolic reprogramming: From pathological mechanisms to targeted interventions","authors":"","doi":"10.1002/inmd.70123","DOIUrl":"10.1002/inmd.70123","url":null,"abstract":"This cover image is intended to demonstrate that lymphatic system serves not only as an important transport pathway in the body, but also as a highly promising medium for liquid biopsy. In the foreground, the lymphatic vessels contain a range of biomarkers, including cell-free DNA(cfDNA), cell-free RNA(cfRNA), extracellular vesicles(EVs), and other disease-related components. Their movement along the lymphatic network toward the lymph nodes visually illustrates the transport, enrichment, and exchange of these signals within the lymphatic system, while also suggesting that the lymphatic system holds abundant diagnostic information that remains far from fully explored. The enlarged glowing lymph node serves as the visual focal point, symbolizing a key site of immune activity and biological signal convergence. The surrounding analytical devices represent major biomarker detection technologies, including microfluidic chips and next-generation sequencing. Together, these biological and technological elements highlight the central theme of this review: integrating lymph-derived biomarkers with advanced analytical methods to support disease diagnosis, monitoring, and precision medicine.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture>\u0000 </div>\u0000 </figure>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"4 2","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/inmd.70123","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147668919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 13.6

Interdisciplinary Medicine Pub Date : 2026-03-24

引用次数: 0