Interdisciplinary Medicine最新文献_第5页

IF 13.6

Interdisciplinary Medicine Pub Date : 2026-05-12

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IF 13.6

Interdisciplinary Medicine Pub Date : 2026-04-27

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IF 13.6

Interdisciplinary Medicine Pub Date : 2026-04-09

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Chinese pan-cancer patient genomic characteristics: A comprehensive analysis based on the National Cancer Center–Clinical Diagnostics Knowledgebase real-world clinical sequencing cohort 中国泛癌症患者基因组特征：基于国家癌症中心-临床诊断知识库真实世界临床测序队列的综合分析

IF 13.6

Interdisciplinary Medicine Pub Date : 2026-03-30 Epub Date: 2026-01-15 DOI: 10.1002/inmd.70087

Hongrui Li, Shun Wang, Guowei Zhao, Jiangtao Li, Xin Li, Bingning Wang, Yi Zhang, Mengfei Yao, Lei Guo, Jianming Ying, Wenbin Li

{"title":"Chinese pan-cancer patient genomic characteristics: A comprehensive analysis based on the National Cancer Center–Clinical Diagnostics Knowledgebase real-world clinical sequencing cohort","authors":"Hongrui Li, Shun Wang, Guowei Zhao, Jiangtao Li, Xin Li, Bingning Wang, Yi Zhang, Mengfei Yao, Lei Guo, Jianming Ying, Wenbin Li","doi":"10.1002/inmd.70087","DOIUrl":"10.1002/inmd.70087","url":null,"abstract":"Precision oncology strategies guided by tumor molecular profiling often target key genomic aberrations in patients. Herein, we assembled National Cancer Center–Clinical Diagnostics Knowledgebase, compiling clinical targeted sequencing data from 6935 tumor tissues and matched normal samples, along with available pathological and clinical information. Comprehensive genomic profiling was conducted to characterize tumor type-specific somatic alterations, and comparative analyses were performed across distinct cohorts. Key genomic characteristics included high-frequency alterations in TP53 (57.8%), APC (22.6%), KRAS (21.3%), and EGFR (17.5%), among which EGFR mutations were significantly enriched in lung adenocarcinoma patients. In this cohort, 70.2% of the samples harbored at least one clinically actionable genomic aberration. 14.9% of patients showed high tumor mutational burden (TMB > 10 mutations/Mb), and the TMB level was significantly higher in patients with microsatellite instability-high than in those with microsatellite stability. We also correlated next-generation sequencing (NGS) results with conventional molecular pathology assays. We found high consistency between ERBB2 focal amplification cases determined by NGS and clinically targetable ERBB2 amplification/HER2 overexpression cases. In conclusion, this study constructed a large-scale real-world genomic dataset representative of Chinese cancer patients, spanning multiple tumor types. Moreover, our findings underscore the clinical value of NGS in identifying patients with ERBB2 amplification who may potentially benefit from targeted treatments, particularly in non-small-cell lung cancer cases where NGS panel testing is prioritized.","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"4 2","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/inmd.70087","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147668593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Placenta-derived extracellular vesicles: Signal messengers shuttling across the maternal-fetal barrier 胎盘来源的细胞外囊泡：穿越母胎屏障的信号信使

IF 13.6

Interdisciplinary Medicine Pub Date : 2026-03-30 Epub Date: 2026-03-23 DOI: 10.1002/inmd.70111

Jiale Du, Maliang Tao, Yanxuan Xiao, Zhijian Wang, Bo Situ, Lei Zheng

{"title":"Placenta-derived extracellular vesicles: Signal messengers shuttling across the maternal-fetal barrier","authors":"Jiale Du, Maliang Tao, Yanxuan Xiao, Zhijian Wang, Bo Situ, Lei Zheng","doi":"10.1002/inmd.70111","DOIUrl":"10.1002/inmd.70111","url":null,"abstract":"Intercellular communication across the maternal-fetal barrier is essential for maintaining physiological balance during pregnancy. As the structural foundation of the maternal-fetal barrier, the placenta is the core site for material exchange and signaling between the mother and the fetus. Placenta-derived extracellular vesicles (PEVs), owing to their nanoscale size and lipid bilayer membrane structure, can pass through the maternal-fetal barrier via mechanisms such as endocytosis and transcytosis across the syncytiotrophoblast. Enriched in proteins, miRNAs, and lipids, PEVs contribute to immune homeostasis at the maternal-fetal interface and support fetal growth and development. They are increasingly recognized as key mediators of information exchange between the mother and the fetus. Numerous studies have indicated that in significant pregnancy complications like preeclampsia, both the concentration and cargo of PEVs undergo remarkable changes, which are closely associated with the pathological processes of pregnancy. This suggests the potential utility of PEVs as biomarkers and therapeutic targets for pregnancy-related disorders. Based on the latest research advancements, this review systematically collates the biological properties of PEVs as signal messengers and analyzes their physiological and pathological functions during pregnancy, aiming to provide new insights for research and clinical management.","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"4 2","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/inmd.70111","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147668707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Gut microbiome-derived metabolites show promise in cancer research and therapy 肠道微生物衍生代谢物在癌症研究和治疗中显示出前景

IF 13.6

Interdisciplinary Medicine Pub Date : 2026-03-30 Epub Date: 2026-02-13 DOI: 10.1002/inmd.70096

Kangjie Yang, Yifan Wang, Daolin Tang, Peilong Li, Lutao Du

{"title":"Gut microbiome-derived metabolites show promise in cancer research and therapy","authors":"Kangjie Yang, Yifan Wang, Daolin Tang, Peilong Li, Lutao Du","doi":"10.1002/inmd.70096","DOIUrl":"10.1002/inmd.70096","url":null,"abstract":"The gut microbiome plays a critical role in regulating the host health and disease. Metagenomics has enhanced the understanding of microbial metabolic potential through direct analysis of microbial genomes in complex environmental specimens. Microbiome-derived metabolites are key biochemical mediators in host–microbe crosstalk and have emerged as a focal point in host physiology research. They are vital for maintaining intestinal homeostasis and physiological functions and are closely associated with disease pathogenesis, particularly tumorigenesis. These metabolites, as comprehensive indicators of microbial functional status, have been utilized in oncological clinical practice for diagnosis, prognosis evaluation, and therapeutic monitoring. Here, we summarize the composition and influencing factors of gut microbiome-derived metabolites, their roles in physiological and pathological processes—with a particular focus on their association with tumorigenesis—and discuss their potential applications as biomarkers for cancer diagnosis and monitoring, as well as their therapeutic implications. This study aims to elucidate the role of gut microbiome-derived metabolites in oncogenesis and to highlight key challenges and unresolved issues within this field.","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"4 2","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/inmd.70096","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147668660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammatory bowel disease and metabolic reprogramming: From pathological mechanisms to targeted interventions 炎症性肠病和代谢重编程：从病理机制到针对性干预

IF 13.6

Interdisciplinary Medicine Pub Date : 2026-03-30 DOI: 10.1002/inmd.70125

{"title":"Inflammatory bowel disease and metabolic reprogramming: From pathological mechanisms to targeted interventions","authors":"","doi":"10.1002/inmd.70125","DOIUrl":"10.1002/inmd.70125","url":null,"abstract":"The gut microbiome can generate bioactive metabolites through its metabolic activities. In the schematic diagram, the bright light around the gut microbiome is used to visually represent these bioactive metabolites, which have extensive physiological and pathological regulatory potential. These metabolites play significant roles in multiple stages of tumor occurrence, development, and metastasis, and exhibit notable bidirectional regulatory characteristics. To visually distinguish this bidirectional nature, the diagram employs a “heaven and hell” color scheme, with cool tones representing tumor-suppressive effects and warm tones indicating tumor-promoting actions. Further, the beam structure presented in the center of the diagram symbolizes the dynamic bidirectional communication network between the gut microbiome and the distal tumor microenvironment, with metabolites serving as information carriers. The magnifying glass symbols placed on both sides of the diagram represent the rapidly developing advanced detection technologies and analytical methods, which are conducive to the precise identification, quantitative analysis, and spatiotemporal dynamic monitoring of key microbiome-derived metabolites, deepening the understanding of their mechanisms of action in the tumor process. Additionally, the diagram also emphasizes the significant value of metabolites in the field of translational medicine: on one hand, they are expected to become novel liquid biopsy markers, providing new evidence for the early screening, prognosis assessment, and treatment response monitoring of tumors; on the other hand, intervention strategies targeting specific metabolites or their related pathways are gradually becoming emerging targets for tumor prevention and treatment, demonstrating potential clinical application prospects.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture>\u0000 </div>\u0000 </figure>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"4 2","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/inmd.70125","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147668922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Organoids and organ-on-a-chip models for investigating the pathophysiology of the human reproductive system 用于研究人类生殖系统病理生理学的类器官和器官芯片模型

IF 13.6

Interdisciplinary Medicine Pub Date : 2026-03-30 Epub Date: 2026-01-15 DOI: 10.1002/inmd.70094

Hongqi Zhang, Shiwen Deng, Fangfang Jin, Jiayao Qu, Xiang Fan, Peng Chen, Xinrong Fan

{"title":"Organoids and organ-on-a-chip models for investigating the pathophysiology of the human reproductive system","authors":"Hongqi Zhang, Shiwen Deng, Fangfang Jin, Jiayao Qu, Xiang Fan, Peng Chen, Xinrong Fan","doi":"10.1002/inmd.70094","DOIUrl":"10.1002/inmd.70094","url":null,"abstract":"Organoids and organ-on-a-chips (OoCs), as innovative tools that overcome the limitations of traditional cell and animal models, provide highly biomimetic platforms for studying the pathophysiological mechanisms of the reproductive system. This review emphasizes mechanistic discoveries, disease models, and translational prospects. In contrast to previous reviews that either addressed organoids and OoCs separately or concentrated on a single organ type, this article is unique in that it (i) integrates OoC and organoid platforms for both male and female reproductive systems; (ii) identifies four cross-cutting scientific challenges (vascularization/perfusion, dynamic endocrine modeling, immune-microenvironment reconstruction, and model standardization); and (iii) highlights translational pathways, such as artificial intelligence—enabled optimization and organoid-derived extracellular vesicles. We summarize representative organoid and OoC models of key male (testis, prostate, and epididymis) and female (ovary, endometrium, and placenta) reproductive organs, and discuss prospects for multi-organ integration, personalized drug testing, and regulatory standardization. Finally, we propose prioritized technological milestones and a roadmap to expedite the clinical translation of these technologies in reproductive system research.","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"4 2","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/inmd.70094","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147668297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Lymph-based liquid biopsy: Current progress and future potential 淋巴液体活检：目前的进展和未来的潜力

IF 13.6

Interdisciplinary Medicine Pub Date : 2026-03-30 Epub Date: 2026-01-26 DOI: 10.1002/inmd.70092

Dongdong Liu, Leheng Cheng, Xiaolin Hu, Sergio Bernardini, Hong Zhang, Ling Zhu, Yang Luo

{"title":"Lymph-based liquid biopsy: Current progress and future potential","authors":"Dongdong Liu, Leheng Cheng, Xiaolin Hu, Sergio Bernardini, Hong Zhang, Ling Zhu, Yang Luo","doi":"10.1002/inmd.70092","DOIUrl":"10.1002/inmd.70092","url":null,"abstract":"The lymphatic system plays a pivotal role in both physiological and pathological processes. Lymphatic fluid, owing to its anatomical proximity to disease sites and rich composition of biomarkers, represents a promising source for liquid biopsy. Furthermore, emerging evidence under the revised Starling principle indicates that lymph-based liquid biopsies may offer superior diagnostic performance over blood-based counterparts in certain clinical scenarios, such as early-stage solid tumor detection. In this comprehensive review, we systematically: compare the biochemical and cellular characteristics of lymph with those of other biofluids used in liquid biopsies, evaluate the clinical potential and current limitations of lymph-based liquid biopsy, including available sampling techniques, and assess the diagnostic utility of lymph-derived biomarkers across various disease contexts. Our analysis underscores that the primary challenge hindering broader clinical adoption is the lack of minimally invasive and clinically feasible lymphatic sampling methods. To advance translational applications, key developments are urgently needed in three areas: innovative sampling techniques, stringent quality control standards, and highly sensitive and accurate detection methodologies. This review aims to emphasize the value of lymphatic biomarkers in liquid biopsy and to stimulate further research and development in this emerging field.","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"4 2","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/inmd.70092","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147668905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Deep learning-driven methods for fluorescence imaging denoising 基于深度学习的荧光成像去噪方法

IF 13.6

Interdisciplinary Medicine Pub Date : 2026-03-30 Epub Date: 2026-03-19 DOI: 10.1002/inmd.70105

Xinyu Lu, Zixu Zhan, Bin Tan, Ruiwen Wang, Shuyue Wang, Diming Zhang, Bobo Cai, Zhijing Zhu

{"title":"Deep learning-driven methods for fluorescence imaging denoising","authors":"Xinyu Lu, Zixu Zhan, Bin Tan, Ruiwen Wang, Shuyue Wang, Diming Zhang, Bobo Cai, Zhijing Zhu","doi":"10.1002/inmd.70105","DOIUrl":"10.1002/inmd.70105","url":null,"abstract":"Fluorescence imaging, serving as the primary imaging modality in modern life science research, faces a fundamental challenge in achieving high-sensitivity imaging: optimizing the signal-to-noise ratio (SNR) under dynamic and complex experimental conditions. Due to autofluorescence, shot noise, and tissue scattering, this SNR deficiency disrupts subcellular morphometry, restricts recording reliability, and ultimately propagates artifacts in subsequent analysis. This review evaluates data-driven deep learning denoising methods that overcome conventional limitations through effective feature extraction and nonlinear modeling. Focusing on fluorescence imaging acquisition under photon-limited conditions, we delineate cutting-edge architectures, including supervised learning, unsupervised learning, zero-shot learning, and hybrid approaches. By producing higher-fidelity image data, these denoising methods enhance the reliability of live-cell imaging and the accuracy of neural mechanism analysis. This advancement provides a stronger foundation for elucidating dynamic biological processes and accelerating precision medicine.","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"4 2","pages":""},"PeriodicalIF":13.6,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/inmd.70105","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147668756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0