Interdisciplinary Medicine最新文献_第5页

Recent advances in low-background luminescent nanomaterials-enhanced lateral flow assays for clinical diagnosis 低背景发光纳米材料增强侧流检测在临床诊断中的最新进展

Interdisciplinary Medicine Pub Date : 2025-01-05 DOI: 10.1002/INMD.20240078

Liangwen Hao, Jing Chen, Quanshuang Li, Dongyu Zhang, Qingli Huang, Hao Zhang, Shibao Li

{"title":"Recent advances in low-background luminescent nanomaterials-enhanced lateral flow assays for clinical diagnosis","authors":"Liangwen Hao, Jing Chen, Quanshuang Li, Dongyu Zhang, Qingli Huang, Hao Zhang, Shibao Li","doi":"10.1002/INMD.20240078","DOIUrl":"https://doi.org/10.1002/INMD.20240078","url":null,"abstract":"<p>Lateral flow assays (LFAs) are widely applicable in clinical point-of-care testing (POCT) due to their unique advantages such as simplicity, rapidity, and cost-effectiveness. However, their sensitivity is often constrained by the background autofluorescence of the biological sample, the self-matrix, or the readout technique, thereby leading to overlooking trace amounts of biomarkers present in early disease. In recent years, various nanomaterials-based methods have been developed to address this issue, including the time-gated technique, wavelength-differentiated strategy and external modulated strategy for separation of background autofluorescence to minimize interference from biological samples. This review provides a comprehensive overview of various low-background luminescent nanoparticles (LBLNPs)-enhanced LFA systems, focusing on analyzing the underlying mechanism of these nanomaterials in improving the sensitivity and accuracy of the LFAs platform in clinical diagnosis. Representative examples are selected to demonstrate the clinical potential of these nanomaterials in detecting disease-associated biomarkers in various samples including blood, urine, saliva et al. Finally, unresolved challenges and future development prospects are briefly discussed.</p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20240078","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of psychobiotics in clinical treatment of mental disorders: Neurodevelopmental disorders, neurodegenerative diseases, depression and anxiety 精神生物制剂在精神障碍临床治疗中的应用：神经发育障碍、神经退行性疾病、抑郁和焦虑

Interdisciplinary Medicine Pub Date : 2025-01-05 DOI: 10.1002/INMD.20240041

Jingwei Cui, Wenxin Wang, Yue Tang, Siyuan Feng, Hong Liu, Zikai Hao

{"title":"Application of psychobiotics in clinical treatment of mental disorders: Neurodevelopmental disorders, neurodegenerative diseases, depression and anxiety","authors":"Jingwei Cui, Wenxin Wang, Yue Tang, Siyuan Feng, Hong Liu, Zikai Hao","doi":"10.1002/INMD.20240041","DOIUrl":"https://doi.org/10.1002/INMD.20240041","url":null,"abstract":"<p>Psychobiotics are a distinct category of probiotics known for their beneficial effects on human health, particularly in influencing mental well-being. Typical psychobiotics include genera such as <i>Lactobacillus</i>, <i>Streptococcus</i>, and <i>Bifidobacterium</i>. The gut microbiota influences bidirectional communication between the brain and the gastrointestinal (GI) system. Neurons in the enteric nervous system directly interact with neurotransmitters, short-chain fatty acids (SCFAs), gut hormones, and anti-inflammatory cytokines produced by the gut microbiota, thereby affecting signal transmission in the central nervous system. Unlike traditional probiotics, psychobiotics have the capacity to generate or stimulate the host to produce neurotransmitters, SCFAs, gut hormones, and anti-inflammatory cytokines. It is precisely this potential that has led to the widespread use of psychobiotics over the past decade to improve and treat mental disorders. This article briefly reviews the clinical applications of psychobiotics in improving and treating conditions such as neurodevelopmental disorders, neurodegenerative diseases, depression and anxiety. It is proposed that the novel therapeutic approach of using <i>Bacillus licheniformis</i> as an adjuvant treatment for patients with depression shows a certain degree of feasibility. Finally, this review suggests that the current evidence regarding the improvement and treatment of mental and neurological disorders with psychobiotics is still limited. Further in-depth research is needed to clarify their effectiveness and mechanisms of action in the clinical management of various mental disorders.</p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20240041","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143112187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of quantitative histomorphometric features in computational pathology 定量组织形态学特征在计算病理学中的应用

Interdisciplinary Medicine Pub Date : 2024-11-16 DOI: 10.1002/INMD.20240037

Yujie Shi, Bo Hu, Mingyan Xu, Yunhan Yao, Shuaiqiang Gao, Xiang Xia, Xikai Deng, Jianfeng Liu, Jia Gu, Shifu Chen

{"title":"Application of quantitative histomorphometric features in computational pathology","authors":"Yujie Shi, Bo Hu, Mingyan Xu, Yunhan Yao, Shuaiqiang Gao, Xiang Xia, Xikai Deng, Jianfeng Liu, Jia Gu, Shifu Chen","doi":"10.1002/INMD.20240037","DOIUrl":"https://doi.org/10.1002/INMD.20240037","url":null,"abstract":"<p>Computer vision has facilitated the execution of various computer-aided diagnostic tasks. From a methodological perspective, these tasks are primarily implemented using two dominant strategies: end-to-end Deep learning (DL)-based methods and traditional feature engineering-based methods. DL methods are capable of automatically extracting, analyzing, and filtering features, leading to final decision-making from whole slide images. However, these methods are often criticized for the “black box” issue, a significant limitation of DL. In contrast, traditional feature engineering-based methods involve well-defined quantitative input features. But it was considered as less potent than DL methods. Advances in segmentation technology and the development of quantitative histomorphometric (QH) feature representation have propelled the evolution of feature engineering-based methods. This review contrasts the performance differences between the two methods and traces the development of QH feature representation. The conclusion is that, with the ongoing progress in QH feature representation and segmentation technology, methods based on QH features will leverage their advantages—such as explainability, reduced reliance on large training datasets, and lower computational resource requirements—to play a more significant role in some clinical tasks. They may even replace DL methods somewhat or be used in conjunction with them to achieve accurate and understandable results.</p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20240037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143115461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stretchable and body conformable electronics for emerging wearable therapies 用于新兴可穿戴疗法的可拉伸和适合身体的电子产品

Interdisciplinary Medicine Pub Date : 2024-11-13 DOI: 10.1002/INMD.20240064

Benzhao Huang, Qian Wang, Wei Li, Desheng Kong

{"title":"Stretchable and body conformable electronics for emerging wearable therapies","authors":"Benzhao Huang, Qian Wang, Wei Li, Desheng Kong","doi":"10.1002/INMD.20240064","DOIUrl":"https://doi.org/10.1002/INMD.20240064","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <p>Wearable therapy represents a research frontier where material science, electrical engineering, and medical disciplines intersect, offering significant potential for remote and portable healthcare. Unlike conventional approaches that rely on rigid materials, the ability to stretch is crucial for therapeutic devices to achieve enhanced mechanical adaptability. Moreover, the conformable integration of these devices into the body is pivotal in establishing reliable interfaces for long-term treatment. These emerging devices provide an attractive platform for developing new therapeutic protocols that do not disrupt daily activities. This review comprehensively overviews recent progress in stretchable and body-conformable electronics for wearable therapeutic applications. The discussion begins with the design and fabrication of these devices through structural designs and material innovation. The therapeutic mechanisms adopted by these devices are then systematically explored. Furthermore, the article delineates the crucial characteristics of wearable therapeutic devices, such as biocompatibility, secure skin attachment, and effective moisture management. This review article is poised to inspire innovative device designs and treatment protocols for future medical technology.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20240064","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143114791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NIR-II emissive biohybrid nanovesicles as mild-temperature photothermal antibiofilm agents against acute bacterial skin and skin-structure infections NIR-II发射生物杂化纳米囊泡作为抗急性细菌性皮肤和皮肤结构感染的温和光热抗菌剂

Interdisciplinary Medicine Pub Date : 2024-11-09 DOI: 10.1002/INMD.20240053

Ji Wang, Zhihao Wu, Xiaoxi Ma, Zhihui Huang, Haorong Dong, Jinxin Zhang, Xiaoming Liu, Pengfei Zhang, Shuhuai Yao

{"title":"NIR-II emissive biohybrid nanovesicles as mild-temperature photothermal antibiofilm agents against acute bacterial skin and skin-structure infections","authors":"Ji Wang, Zhihao Wu, Xiaoxi Ma, Zhihui Huang, Haorong Dong, Jinxin Zhang, Xiaoming Liu, Pengfei Zhang, Shuhuai Yao","doi":"10.1002/INMD.20240053","DOIUrl":"https://doi.org/10.1002/INMD.20240053","url":null,"abstract":"<p>The emergence of antibiotic-resistant bacteria poses a significant challenge to the prompt and appropriate treatment of pathogenic bacteria infections, such as acute bacterial skin and skin-structure infections (ABSSSI), especially in the presence of biofilms. Bacterial biofilms are naturally resistant to antibiotics and the human immune system, making biofilm-based infections extremely difficult to treat. Therefore, developing new antibacterial therapies targeting biofilms is crucial. Aggregation-induced emission luminogens with fluorescence in the second near-infrared window (NIR-II AIEgens), which can be activated by a near-infrared laser to generate heat, offer an effective and precise photothermal therapy (PTT) approach for treating deep-tissue bacterial infections. However, the presence of biofilms impedes the entry of photosensitizers into the infected area, requiring higher drug doses and increasing the risk of PTT. Herein, we developed a biocompatible AIEgen-based biohybrid nano formulation that incorporates the BPBBT (NIR-II AIEgen) and antibiofilm <i>α</i>-amylase into a red blood cell (RBC) membrane-derived nanovesicle carrier for a PTT/biofilm degradation combination therapy. The synergistic effect of this new formulation enhances both the photothermal capability of BPBBT and the biofilm degradation compared to traditional individual treatments. The new combination therapy demonstrated significant improvement in treating severe <i>Staphylococcus aureus</i> infections caused by biofilms in vitro and in vivo, presenting a promising alternative to traditional antibiotic therapy.</p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20240053","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143113380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Field Effect Transistor Biosensors for Healthcare Monitoring (4/2024) 用于医疗监测的场效应晶体管生物传感器（4/2024）

Interdisciplinary Medicine Pub Date : 2024-10-30 DOI: 10.1002/inmd.12139

Zhicheng Zhang, Jing-Jing Hu, Shijun Lin, Jiajun Wu, Fan Xia, Xiaoding Lou

{"title":"Field Effect Transistor Biosensors for Healthcare Monitoring (4/2024)","authors":"Zhicheng Zhang, Jing-Jing Hu, Shijun Lin, Jiajun Wu, Fan Xia, Xiaoding Lou","doi":"10.1002/inmd.12139","DOIUrl":"https://doi.org/10.1002/inmd.12139","url":null,"abstract":"<p>As the demand for healthcare monitoring continues to grow, field-effect transistor (FET) biosensors are gaining increasing attention as an efficient detection technology. By integrating with microelectromechanical systems (MEMS) technology, FET biosensors can achieve miniaturized, multifunctional, and intelligent clinical diagnostic devices, offering transformative solutions and opportunities in the healthcare sector. These advancements hold significant potential for improving patient outcomes through more accurate, timely, and personalized diagnostics. In article number e20240032b, Zhicheng Zhang, Jing-Jing Hu, Xiaoding Lou, and colleagues summarize the key advancements in the development of FET biosensors for healthcare monitoring. The article also outlines the challenges and prospects for advancing their clinical applications, highlighting the profound impact these technologies could have on clinical practice and patient care.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"2 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/inmd.12139","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142561653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

scRNA-seq reveals NAMPT-mediated macrophage polarization shapes smooth muscle cell plasticity in pulmonary arterial hypertension (4/2024) scRNA-seq揭示NAMPT介导的巨噬细胞极化塑造了肺动脉高压中平滑肌细胞的可塑性 (4/2024)

Interdisciplinary Medicine Pub Date : 2024-10-30 DOI: 10.1002/inmd.12136

Zuoshi Wen, Liujun Jiang, Fangcong Yu, Xiaodong Xu, Mengjia Chen, Chenxi Li, Zhangquan Ying, Jianing Xue, Pengwei Zhu, Mairedan Muhetarijiang, Qingbo Xu, Zhoubin Li, Ting Chen

{"title":"scRNA-seq reveals NAMPT-mediated macrophage polarization shapes smooth muscle cell plasticity in pulmonary arterial hypertension (4/2024)","authors":"Zuoshi Wen, Liujun Jiang, Fangcong Yu, Xiaodong Xu, Mengjia Chen, Chenxi Li, Zhangquan Ying, Jianing Xue, Pengwei Zhu, Mairedan Muhetarijiang, Qingbo Xu, Zhoubin Li, Ting Chen","doi":"10.1002/inmd.12136","DOIUrl":"https://doi.org/10.1002/inmd.12136","url":null,"abstract":"<p>This image illustrates our paper on how NAMPT gene expression in a pulmonary hypertension environment regulates macrophage shaping of smooth muscle cell phenotypes. The red-highlighted area on the left represents the pathological environment of pulmonary hypertension. Arrows point to the right, explaining the mechanism. On the floor symbolizing the \"Pulmonary Artery Hypertension\" environment, a puppet representing macrophages sculpts a small sphere representing smooth muscle cells. This indicates how macrophages regulate smooth muscle cell phenotypes by altering the immune microenvironment, controlled by a hand symbolizing NAMPT expression. This personification visualizes the core concept of our paper.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"2 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/inmd.12136","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142561651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Capture of live circulating tumor cells via unique surface charges from cancer patients by a novel nanotechnology (4/2024) 利用新型纳米技术通过癌症患者独特的表面电荷捕获活的循环肿瘤细胞 (4/2024)

Interdisciplinary Medicine Pub Date : 2024-10-30 DOI: 10.1002/inmd.12138

Wenjun Le, Shuyuan Hu, Pengbo Zhang, Yanqi Wang, Yihui Hu, Zheng Cui, Bingdi Chen

{"title":"Capture of live circulating tumor cells via unique surface charges from cancer patients by a novel nanotechnology (4/2024)","authors":"Wenjun Le, Shuyuan Hu, Pengbo Zhang, Yanqi Wang, Yihui Hu, Zheng Cui, Bingdi Chen","doi":"10.1002/inmd.12138","DOIUrl":"https://doi.org/10.1002/inmd.12138","url":null,"abstract":"<p>The phenomenon of distant metastasis in solid malignancies is attributed to the dissemination of cancer cells from the primary tumor to secondary sites within the body. Circulating tumor cells (CTCs) are tumor cells that detach from the primary tumor mass and subsequently enter the bloodstream, thereby playing a pivotal role in the metastatic cascade of tumors. CTCs have been validated as a biomarker for the evaluation of disease progression, prognostication, and the efficacy of therapeutic interventions in oncological patients. However, the rarity of CTCs in peripheral blood necessitates the development of efficient methodologies for their enrichment and analytical assessment for clinical utility. Herein, we introduce a novel CTC detection assay that exploits the metabolic discrepancies between normal and malignant cells, specifically their glycolytic activity. The heightened glycolysis observed in cancer cells confers a pronounced negative surface charge. Consequently, our self-developed magnetic nanoprobes, engineered with a Permission Request positive surface charge, were capable of specifically identifying the negatively charged CTCs present in the peripheral blood of patients. These probes facilitated the seperation of CTCs through the application of an exogenous magnetic field, thereby enabling the efficient enrichment and isolation of CTCs from the blood. In this study, we have substantiated the efficacy of this methodology in the sequestration of CTCs from clinical blood samples derived from patients with solid tumors and leukemias. This capture technique has exhibited enhanced performance and is anticipated to significantly augment diagnostic precision and the surveillance of therapeutic outcomes in the field of oncology.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"2 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/inmd.12138","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142561652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Table of Content 目录

Interdisciplinary Medicine Pub Date : 2024-10-30 DOI: 10.1002/inmd.12140

引用次数: 0

The Role of long non-coding RNA MEG3 in Cancer-Associated Fibroblasts at Single Cell Pan-cancer Level (4/2024) 长非编码 RNA MEG3 在单细胞泛癌水平上对癌症相关成纤维细胞的作用 (4/2024)

Interdisciplinary Medicine Pub Date : 2024-10-30 DOI: 10.1002/inmd.12137

Tao Zhou, Huayun Yan, Yiqi Deng, Yunfeng Zhu, Xuyang Xia, Wanchun Wu, Wei-Han Zhang, Hai-Ning Chen, Jian-Kun Hu, Zong-Guang Zhou, Yang Shu, Yuan Li, Heng Xu

{"title":"The Role of long non-coding RNA MEG3 in Cancer-Associated Fibroblasts at Single Cell Pan-cancer Level (4/2024)","authors":"Tao Zhou, Huayun Yan, Yiqi Deng, Yunfeng Zhu, Xuyang Xia, Wanchun Wu, Wei-Han Zhang, Hai-Ning Chen, Jian-Kun Hu, Zong-Guang Zhou, Yang Shu, Yuan Li, Heng Xu","doi":"10.1002/inmd.12137","DOIUrl":"https://doi.org/10.1002/inmd.12137","url":null,"abstract":"<p>This cover illustrates the complex interactions between MEG3<sup>+</sup> (Maternally Expressed Gene 3) adipogenic cancer-associated fibroblasts (MACAFs) and tumor cells within the tumor microenvironment. The tumor immune microenvironment is infiltrated by various CAF populations, among which MACAFs engage in unique interplays with tumor cells that profoundly influencing tumor progression. The activation of MEG3 in CAFs is associated with m6A-related post-transcriptional modifications, leading to the downregulation of MEG3 expression in these cells. This activation, aided by tumor cells, facilitates the transformation of CAFs into an adipogenic phenotype. In turn, the emergence of MACAFs creates a feedback loop that enhances the migration and invasiveness of tumor cells. These specific interaction patterns, along with associated genetic and pathway characteristics, have been identified and validated at the single-cell level. These findings not only present deep insights into the molecular mechanisms governing the regulatory functions of MEG3 on CAFs and tumor microenvironmental interactions but also provide potential targets for therapeutic interventions. The elucidation of these mechanisms contributes to the development of immunotherapeutic strategies tailored to the complex dynamics of tumor-stroma interactions.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"2 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/inmd.12137","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142561650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0