Interdisciplinary Medicine最新文献_第4页

Platelet-Derived Apoptotic Vesicles Ameliorate Nonalcoholic Fatty Liver Disease by Regulating Lipid Metabolism via APOA2 (1/2025) 血小板来源的凋亡小泡通过APOA2调节脂质代谢改善非酒精性脂肪肝（1/2025）

Interdisciplinary Medicine Pub Date : 2025-01-25 DOI: 10.1002/inmd.12155

Yuhe Jiang, Yike Liao, Zeying Wang, Lei Zhu, Yunsong Liu, Ping Zhang, Yuan Zhu, Wenyue Li, Yongsheng Zhou, Xiao Zhang

{"title":"Platelet-Derived Apoptotic Vesicles Ameliorate Nonalcoholic Fatty Liver Disease by Regulating Lipid Metabolism via APOA2 (1/2025)","authors":"Yuhe Jiang, Yike Liao, Zeying Wang, Lei Zhu, Yunsong Liu, Ping Zhang, Yuan Zhu, Wenyue Li, Yongsheng Zhou, Xiao Zhang","doi":"10.1002/inmd.12155","DOIUrl":"https://doi.org/10.1002/inmd.12155","url":null,"abstract":"<p>Our cover design chooses red as the dominant hue. In the center of the picture is a liver that has partially deteriorated into fatty liver. The purple sphere in the lower left corner are apoptotic vesicles (apoVs), while the cells on the right are platelets, illustrating the process of releasing apoptotic vesicles from platelets. The green substance in apoVs represents APOA2 protein. The embedding of apoVs into fatty liver demonstrates the uptake of apoptotic vesicles into the liver, while the healthy liver on the right shows the amelioration of fatty liver after the uptake of apoptotic vesicles. Overall, the three main elements in the cover design are fatty liver, apoVs and platelets, which are the most significant components in our research. The central idea of our research is that fatty liver has the potential to be ameliorated after uptaking the apoVs released by platelets via APOA2, which can be intuitively comprehended through this cover design.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/inmd.12155","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143119063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial Intelligence-Driven Change Redefining Radiology Through Interdisciplinary Innovation (1/2025) 人工智能驱动的变革通过跨学科创新重新定义放射学（1/2025）

Interdisciplinary Medicine Pub Date : 2025-01-25 DOI: 10.1002/inmd.12152

Runqiu Huang, Xiaolin Meng, Xiaoxuan Zhang, Zhendong Luo, Lu Cao, Qianjin Feng, Guolin Ma, Di Dong, Yang Wang

{"title":"Artificial Intelligence-Driven Change Redefining Radiology Through Interdisciplinary Innovation (1/2025)","authors":"Runqiu Huang, Xiaolin Meng, Xiaoxuan Zhang, Zhendong Luo, Lu Cao, Qianjin Feng, Guolin Ma, Di Dong, Yang Wang","doi":"10.1002/inmd.12152","DOIUrl":"https://doi.org/10.1002/inmd.12152","url":null,"abstract":"<p>Artificial intelligence (AI) is catalysing a global paradigm shift, yet regulatory frameworks struggle to adapt at a commensurate pace. Drawing parallels to the symbolic apple as the fruit of wisdom in classical mythology, AI represents the epitome of humanity's pursuit of cognitive and technological advancement. This article examines the progressive integration of AI within medicine and radiology, highlighting its transformative potential alongside its inherent risks. As society reaps the benefits of these unprecedented innovations, a comprehensive and vigilant regulatory approach remains imperative to ensure responsible and ethical implementation. Published in the first issue of 2025, this cover piece also extends a heartfelt New Year’s tribute to all scientific innovators whose dedication drives the frontiers of discovery and inspires collective hope for an era defined by ingenuity and responsibility.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/inmd.12152","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143119066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cell death: The underlying mechanisms of photodynamic therapy for skin diseases 细胞死亡：光动力治疗皮肤病的潜在机制

Interdisciplinary Medicine Pub Date : 2025-01-21 DOI: 10.1002/INMD.20240057

Haoxin Li, Jingjie Shen, Chunfu Zheng, Ping Zhu, Hong Yang, Yixiao Huang, Xinru Mao, Zhilu Yang, Guodong Hu, Yinghua Chen

{"title":"Cell death: The underlying mechanisms of photodynamic therapy for skin diseases","authors":"Haoxin Li, Jingjie Shen, Chunfu Zheng, Ping Zhu, Hong Yang, Yixiao Huang, Xinru Mao, Zhilu Yang, Guodong Hu, Yinghua Chen","doi":"10.1002/INMD.20240057","DOIUrl":"https://doi.org/10.1002/INMD.20240057","url":null,"abstract":"<p>Photodynamic therapy (PDT) has significant potential in the treatment of dermatological, oncological, and nonneoplastic conditions through the induction of cell death, immune regulation, antimicrobial effects, etc. However, the response of some patients is unsatisfactory, and there is a lack of an ideal protocol for multiple specific diseases (subtypes) to choose the proper photosensitizer (PS), light source, and dose. A thorough understanding of the underlying mechanism is integral to solving these problems, and cell death has gained much attention. In addition to apoptosis, autophagy, and necrosis, several novel cell death pathways, such as necroptosis, mitotic catastrophe, paraptosis and pyroptosis, have been reported in PDT treatment. The type of induced cell death depends on the dose of PDT, the subcellular location of PSs, and the regulation of signaling pathways. In addition, different types of cell death induced by the same type of PDT, such as apoptosis and autophagy, may interact with each other. Some types of cell death can also trigger immunogenic cell death (ICD), which can ignite an immune response against antigens derived from dying/dead cells and present improved antitumor effects. On the basis of these mechanisms, several strategies, such as targeted PSs, PDT combined with immunotherapy and ICD-based vaccines, have been proposed to improve therapeutic efficacy. Future studies are needed to elucidate the relationship between cell death and therapeutic effects and to shed new light on the exploration of precise PDT for specific patients.</p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20240057","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interplay between extracellular vesicles and allergic diseases: Current insights and future perspectives 细胞外囊泡与过敏性疾病之间的相互作用：当前的见解和未来的观点

Interdisciplinary Medicine Pub Date : 2025-01-20 DOI: 10.1002/INMD.20240049

Jia Wu, Yan Wang, Yuqing Wang, Jiawei Ribaudo, Shu Li, Shunyan Hu, Maolin Tang, Yongliang Chen, Yan Long

{"title":"Interplay between extracellular vesicles and allergic diseases: Current insights and future perspectives","authors":"Jia Wu, Yan Wang, Yuqing Wang, Jiawei Ribaudo, Shu Li, Shunyan Hu, Maolin Tang, Yongliang Chen, Yan Long","doi":"10.1002/INMD.20240049","DOIUrl":"https://doi.org/10.1002/INMD.20240049","url":null,"abstract":"<p>The field of extracellular vesicle (EV) research has rapidly evolved, revealing their significant roles in various biological processes and clinical applications. Allergic diseases are prevalent immunological disorders characterized by exaggerated hypersensitivity reactions to allergens, leading to diverse clinical manifestations that can severely impact quality of life. Recently, studies have underscored the pivotal role of EVs in allergic conditions, including asthma, allergic rhinitis, and atopic dermatitis. In this review, we provide a comprehensive overview of recent advances in the separation and characterization of EVs, their roles in allergic diseases, and their diagnostic value as biomarkers. Additionally, we explore the therapeutic potential of EVs for the treatment and prevention of allergic conditions. Overall, the emerging insights into EVs present promising opportunities for enhancing the diagnosis, treatment, and management of allergic diseases.</p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20240049","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143117040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating pharmacogenetics, multi-omics and machine learning in the novel therapeutic view of pulmonary hypertension 整合药物遗传学，多组学和机器学习在肺动脉高压的新治疗观点

Interdisciplinary Medicine Pub Date : 2025-01-16 DOI: 10.1002/INMD.20240029

Chenxi Li, Jipeng Xue, Dongchen Zhou, Xiaomeng Qi, Ting Chen, Zhoubin Li

引用次数: 0

Platelet-derived apoptotic vesicles ameliorate nonalcoholic fatty liver disease by regulating lipid metabolism via apolipoprotein A-II 血小板来源的凋亡囊泡通过载脂蛋白A-II调节脂质代谢改善非酒精性脂肪肝疾病

Interdisciplinary Medicine Pub Date : 2025-01-16 DOI: 10.1002/INMD.20240059

Yuhe Jiang, Yike Liao, Zeying Wang, Lei Zhu, Yunsong Liu, Ping Zhang, Yuan Zhu, Wenyue Li, Yongsheng Zhou, Xiao Zhang

{"title":"Platelet-derived apoptotic vesicles ameliorate nonalcoholic fatty liver disease by regulating lipid metabolism via apolipoprotein A-II","authors":"Yuhe Jiang, Yike Liao, Zeying Wang, Lei Zhu, Yunsong Liu, Ping Zhang, Yuan Zhu, Wenyue Li, Yongsheng Zhou, Xiao Zhang","doi":"10.1002/INMD.20240059","DOIUrl":"https://doi.org/10.1002/INMD.20240059","url":null,"abstract":"<p>Nonalcoholic fatty liver disease (NAFLD) encompasses a broad range of conditions, commencing with simple steatosis and progressing to non-alcoholic steatohepatitis, with the possibility of further deterioration into fibrosis, cirrhosis, and ultimately, hepatocellular carcinoma. Unfortunately, there is currently no approved medication for treating NAFLD-associated liver steatosis. This underscores the need for improved therapeutic approaches that can modulate lipid metabolism and halt the transition from liver steatosis to chronic liver disease. Our previous studies have demonstrated that apoptotic vesicles (apoVs), which are produced during apoptosis, show great potential in regulating liver homeostasis. However, whether they can ameliorate NAFLD is unknown. In our research, apoVs derived from platelets (PLT-apoVs) as well as apoVs derived from mesenchymal stem cells (MSC-apoVs) were used to treat NAFLD. The results showed that PLT-apoVs exhibited superior effects in diminishing lipid accumulation in liver induced by high-fat diet than MSC-apoVs. Through proteomic analysis, we defined and validated apolipoprotein A-II (APOA2) as a regulator for apoV-mediated MSC adipogenesis, which could be used as a target to enhance apoV therapeutic potential in the lipid metabolism biomedical field. Owing to the higher expression of APOA2, PLT-apoVs showed better therapeutic effects than MSC-apoVs. Our results pave the way to apoV-based therapy for NAFLD.</p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20240059","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143115414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research progress of DNA methylation in the screening of cervical cancer and precancerous lesions DNA甲基化在宫颈癌及癌前病变筛查中的研究进展

Interdisciplinary Medicine Pub Date : 2025-01-12 DOI: 10.1002/INMD.20240043

Yunge Wang, Xueping Ma, Tao Zhang, Lingfei Wang, Yunlong Liu, Guohua Zhou, Haiping Wu

{"title":"Research progress of DNA methylation in the screening of cervical cancer and precancerous lesions","authors":"Yunge Wang, Xueping Ma, Tao Zhang, Lingfei Wang, Yunlong Liu, Guohua Zhou, Haiping Wu","doi":"10.1002/INMD.20240043","DOIUrl":"https://doi.org/10.1002/INMD.20240043","url":null,"abstract":"<p>Cervical cancer is one of the most common malignant tumors that seriously threaten women's health. Persistent infection with high risk human papillomavirus (HPV) is closely related to the progression of cervical cancer. Cervical cancer screening is an effective measure to reduce the incidence and mortality of cervical cancer. The two most common screening strategies are cytology and HPV testing, but they easily lead to missed diagnosis or overdiagnosis. To overcome such limitations, a new triage method needs to be explored. The World Health Organization second edition guideline includes DNA methylation testing as a new method to be evaluated. DNA methylation is a common epigenetic modification and is considered to be closely related to the occurrence and development of tumors. In recent years, many methylated genes have been found to be biomarkers for cervical cancer and precancerous lesions diagnosis. In this paper, we focus on the role and application of host DNA methylation, HPV DNA methylation, as well as combined host and HPV DNA methylation in the screening of cervical cancer and precancerous lesions.</p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20240043","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143114335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In situ detection of piRNA-651 in exosomes and cells for cancer diagnosis by a new gold nanoparticle nucleic acid probe 新型金纳米粒子核酸探针在外泌体和细胞中原位检测piRNA-651用于癌症诊断

Interdisciplinary Medicine Pub Date : 2025-01-09 DOI: 10.1002/INMD.20240058

Qin-Xin Gao, Qian-Qian Wu, Zhi-Ying Dong, Xiao-Yuan Qin, Lin-Yan Zhai, Bao-Ping Xie, Wen-Jun Duan

{"title":"In situ detection of piRNA-651 in exosomes and cells for cancer diagnosis by a new gold nanoparticle nucleic acid probe","authors":"Qin-Xin Gao, Qian-Qian Wu, Zhi-Ying Dong, Xiao-Yuan Qin, Lin-Yan Zhai, Bao-Ping Xie, Wen-Jun Duan","doi":"10.1002/INMD.20240058","DOIUrl":"https://doi.org/10.1002/INMD.20240058","url":null,"abstract":"<p>Increasing studies have demonstrated that PIWI-interacting RNAs (piRNAs) in circulating exosomes can serve as novel molecular biomarkers for tumor liquid biopsy. However, methods for in situ detection of piRNAs encased in exosomes are limited. In this study, we designed a spherical nucleic acid probe named piR-651, which can enter exosomes simply by incubating with them for 2 h and in situ detect piR-651 with a detection limit of 5 × 10<sup>7</sup> particles/μL. Based on this probe, we established a liquid biopsy method for the in situ detection of piR-651 in plasma exosomes. The assay could distinguish the expression levels of piR-651 between 21 breast cancer patients and 22 healthy individuals. The receiver operating characteristic curve shows an area under the curve as 0.9931 and the diagnostic sensitivity and specificity at the best cutoff are 85.7% and 100%, respectively. The probe can also easily perform in situ imaging of piR-651 in living cells. To avoid low sensitivity and kinetics in detecting large-sized PIWI-interacting RNA complexes, we rationally designed the structure and detection scheme of piR-651 probe, which was synthesized by modifying 13-nm gold particles with high-density Anchor-Report DNA duplexes through the butanol dehydration method. The new design of the gold nanoparticle nucleic acid probe can be applied to the fabrication of nucleic acid probes targeting other large-volume nucleic acids for developing more molecular biomarker-based liquid biopsy for cancer diagnosis.</p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20240058","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143113402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive landscape of small non-coding RNAs in large and small extracellular vesicles from human serum and plasma 人类血清和血浆中大小细胞外囊泡中的小非编码rna的综合景观

Interdisciplinary Medicine Pub Date : 2025-01-07 DOI: 10.1002/INMD.20240073

Gui-Yan Xie, Yi-Han Deng, Chun-Jie Liu, An-Yuan Guo, Qian Lei

{"title":"Comprehensive landscape of small non-coding RNAs in large and small extracellular vesicles from human serum and plasma","authors":"Gui-Yan Xie, Yi-Han Deng, Chun-Jie Liu, An-Yuan Guo, Qian Lei","doi":"10.1002/INMD.20240073","DOIUrl":"https://doi.org/10.1002/INMD.20240073","url":null,"abstract":"<p>Small non-coding RNAs (ncRNAs) are functional molecules contained within extracellular vesicles (EVs) that modulate various physiological and pathological processes. This study provides a comprehensive expression profile of seven types of small ncRNAs in serum- and plasma-derived EVs under various conditions. Both large EVs (lEVs) and small EVs (sEVs) contain high proportions of miRNAs (∼28.2% in lEVs and ∼20.8% in sEVs) and ribosomal RNAs (∼24.0% in lEVs and ∼19.1% in sEVs). lEVs are enriched with more transfer RNA (∼38.8%) than sEVs, whereas sEVs have a greater abundance of Y RNA (∼22.5%). Notably, Y RNA is more abundant in sEVs obtained from aged samples (age ≥60 years), a pattern not observed in lEVs. Small ncRNAs are more diverse in serum-derived EVs than plasma-derived EVs. There is also a high degree of overlap (>50%) in the top 100 small ncRNAs identified in lEVs and sEVs. The miRNAs hsa-miR-16-5p, hsa-let-7a-5p, hsa-miR-142-3p, and hsa-miR-103-3p are consistently among the top 10 highly expressed small ncRNAs in plasma- and serum-derived lEVs as well as in peripheral blood mononuclear cells. Serum-derived sEVs in glioblastoma, breast cancer, prostate cancer, and gastric cancer contain specific, highly expressed miRNAs, snoRNAs, small nuclear RNAs, and piRNAs. These results elucidate the patterns of small ncRNA cargoes within lEVs and sEVs derived from serum and plasma under various physiological and pathological conditions and offer valuable insights for future diagnostic and therapeutic applications.</p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"3 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20240073","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial intelligence-driven change redefining radiology through interdisciplinary innovation 人工智能驱动的变革通过跨学科创新重新定义放射学

Interdisciplinary Medicine Pub Date : 2025-01-06 DOI: 10.1002/INMD.20240063

Runqiu Huang, Xiaolin Meng, Xiaoxuan Zhang, Zhendong Luo, Lu Cao, Qianjin Feng, Guolin Ma, Di Dong, Yang Wang

{"title":"Artificial intelligence-driven change redefining radiology through interdisciplinary innovation","authors":"Runqiu Huang, Xiaolin Meng, Xiaoxuan Zhang, Zhendong Luo, Lu Cao, Qianjin Feng, Guolin Ma, Di Dong, Yang Wang","doi":"10.1002/INMD.20240063","DOIUrl":"https://doi.org/10.1002/INMD.20240063","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <p>Artificial intelligence (AI) is rapidly advancing, yet its applications in radiology remain relatively nascent. From a spatiotemporal perspective, this review examines the forces driving AI development and its integration with medicine and radiology, with a particular focus on advancements addressing major diseases that significantly threaten human health. Temporally, the advent of foundational model architectures, combined with the underlying drivers of AI development, is accelerating the progress of AI interventions and their practical applications. Spatially, the discussion explores the potential of evolving AI methodologies to strengthen interdisciplinary applications within medicine, emphasizing the integration of AI with the four critical points of the imaging process, as well as its application in disease management, including the emergence of commercial AI products. Additionally, the current utilization of deep learning is reviewed, and future advancements through multimodal foundation models and Generative Pre-trained Transformer are anticipated.</p>\u0000 </section>\u0000 </div>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/INMD.20240063","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143112453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0