Platelet-Derived Apoptotic Vesicles Ameliorate Nonalcoholic Fatty Liver Disease by Regulating Lipid Metabolism via APOA2 (1/2025)

Our cover design chooses red as the dominant hue. In the center of the picture is a liver that has partially deteriorated into fatty liver. The purple sphere in the lower left corner are apoptotic vesicles (apoVs), while the cells on the right are platelets, illustrating the process of releasing apoptotic vesicles from platelets. The green substance in apoVs represents APOA2 protein. The embedding of apoVs into fatty liver demonstrates the uptake of apoptotic vesicles into the liver, while the healthy liver on the right shows the amelioration of fatty liver after the uptake of apoptotic vesicles. Overall, the three main elements in the cover design are fatty liver, apoVs and platelets, which are the most significant components in our research. The central idea of our research is that fatty liver has the potential to be ameliorated after uptaking the apoVs released by platelets via APOA2, which can be intuitively comprehended through this cover design.