Interplay between extracellular vesicles and allergic diseases: Current insights and future perspectives

Interdisciplinary Medicine Pub Date : 2025-01-20 DOI:10.1002/INMD.20240049

Jia Wu, Yan Wang, Yuqing Wang, Jiawei Ribaudo, Shu Li, Shunyan Hu, Maolin Tang, Yongliang Chen, Yan Long

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Abstract

The field of extracellular vesicle (EV) research has rapidly evolved, revealing their significant roles in various biological processes and clinical applications. Allergic diseases are prevalent immunological disorders characterized by exaggerated hypersensitivity reactions to allergens, leading to diverse clinical manifestations that can severely impact quality of life. Recently, studies have underscored the pivotal role of EVs in allergic conditions, including asthma, allergic rhinitis, and atopic dermatitis. In this review, we provide a comprehensive overview of recent advances in the separation and characterization of EVs, their roles in allergic diseases, and their diagnostic value as biomarkers. Additionally, we explore the therapeutic potential of EVs for the treatment and prevention of allergic conditions. Overall, the emerging insights into EVs present promising opportunities for enhancing the diagnosis, treatment, and management of allergic diseases.

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细胞外囊泡与过敏性疾病之间的相互作用：当前的见解和未来的观点

细胞外囊泡（EV）的研究领域迅速发展，揭示了它们在各种生物过程和临床应用中的重要作用。过敏性疾病是一种常见的免疫系统疾病，其特征是对过敏原的过度超敏反应，导致多种临床表现，严重影响生活质量。最近，研究强调了ev在过敏性疾病中的关键作用，包括哮喘、过敏性鼻炎和特应性皮炎。在这篇综述中，我们全面概述了ev的分离和表征，它们在过敏性疾病中的作用，以及它们作为生物标志物的诊断价值的最新进展。此外，我们还探讨了ev在治疗和预防过敏性疾病方面的治疗潜力。总的来说，对ev的新见解为增强过敏性疾病的诊断、治疗和管理提供了有希望的机会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Interdisciplinary Medicine

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