PDE5 Inhibitors Against Cancer Via Mediating Immune Cells in Tumor Microenvironment: AI-Based Approach for Future Drug Repurposing Exploration (3/2024)
{"title":"PDE5 Inhibitors Against Cancer Via Mediating Immune Cells in Tumor Microenvironment: AI-Based Approach for Future Drug Repurposing Exploration (3/2024)","authors":"Zhenzhan Zhang, Donghua Huang, Junjie Feng, Wangji Li, Zhe Wang, Mengting Lu, Yangyang Luo, Weihao Yang, Zhou Xu, Qingfeng Xie, Wenfu Ding, Xin Tan, Wenjun He, Guoxin Li, Hao Liu, Shangtong Lei","doi":"10.1002/inmd.12116","DOIUrl":null,"url":null,"abstract":"<p>This review summarized the effects of PDE5 inhibitors on immune cells in the tumor microenvironment (TME). By combining new methods of artificial intelligence (AI), it proposes that AI can explore the drug targets of PDE5 inhibitors on immune cells in the TME and predict pharmacodynamic targets and responses, has significant scientific implications.\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":100686,"journal":{"name":"Interdisciplinary Medicine","volume":"2 3","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/inmd.12116","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Interdisciplinary Medicine","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/inmd.12116","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
This review summarized the effects of PDE5 inhibitors on immune cells in the tumor microenvironment (TME). By combining new methods of artificial intelligence (AI), it proposes that AI can explore the drug targets of PDE5 inhibitors on immune cells in the TME and predict pharmacodynamic targets and responses, has significant scientific implications.