Case Reports in Neurology最新文献_第3页

Paradoxical Kinesia Induced by Nightmare: Unique Case Report and Insights regarding the Neural Mechanism Based on Human and Rat Studies. 梦魇诱发的反常运动：独特的病例报告以及基于人类和大鼠研究的神经机制启示。

IF 0.6

Case Reports in Neurology Pub Date : 2024-05-30 eCollection Date: 2024-01-01 DOI: 10.1159/000539548

Jorge Gelvane Tostes, Mateus Dal Fabbro, David J Pedrosa, Norberto Cysne Coimbra, Rainer Schwarting, Liana Melo-Thomas

{"title":"Paradoxical Kinesia Induced by Nightmare: Unique Case Report and Insights regarding the Neural Mechanism Based on Human and Rat Studies.","authors":"Jorge Gelvane Tostes, Mateus Dal Fabbro, David J Pedrosa, Norberto Cysne Coimbra, Rainer Schwarting, Liana Melo-Thomas","doi":"10.1159/000539548","DOIUrl":"10.1159/000539548","url":null,"abstract":"Introduction: Bradykinesia, characterized by slowed movement, stands out as a primary symptom observed in individuals with Parkinson's disease (PD). Nonetheless, there are instances where PD patients exhibit sudden and effective movements despite the presence of bradykinesia. This phenomenon, referred to as paradoxical kinesia, has remained a subject of interest for neuroscientists, who have struggled to unravel its underlying neural mechanisms for decades.Case presentation: We describe a patient who is suffering from advanced PD. The patient has severe motor limitations, including difficulty rising from bed and walking, as well as cognitive decline and visual impairment. However, an interesting occurrence took place during a nightmare episode. Surprisingly, the patient was able to get out of bed and quickly run away from the perceived threat within the nightmare, without any assistance.Conclusion: This report presents the first documented case of paradoxical kinesia induced by nightmares in a patient with PD. This phenomenon raises questions about the neurological mechanisms involved, which are still not fully understood. Based on existing research conducted on both animal and human subjects, we propose that after processing the emotion of fear, the brain aversive system activates motor outputs to generate appropriate behavior. Thus, the brain aversive system converts the emotion of fear into action through projections from the inferior colliculus to motor-related areas such as the mesencephalic locomotor region, pontine nuclei, and substantia nigra.","PeriodicalId":9639,"journal":{"name":"Case Reports in Neurology","volume":"16 1","pages":"154-158"},"PeriodicalIF":0.6,"publicationDate":"2024-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11249461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141626174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case Report: Treatment of Akinetic Mutism after Unilateral Anterior Cerebral Artery Infarction with Methylphenidate and Levodopa/Benserazide. 病例报告：用哌醋甲酯和左旋多巴/苄丝肼治疗单侧大脑前动脉梗塞后的动眼神经障碍。

IF 0.6

Case Reports in Neurology Pub Date : 2024-05-28 eCollection Date: 2024-01-01 DOI: 10.1159/000539033

Julia Zibold, Moritz Luigi Schmidbauer, Johannes Wischmann, Konstantinos Dimitriadis

{"title":"Case Report: Treatment of Akinetic Mutism after Unilateral Anterior Cerebral Artery Infarction with Methylphenidate and Levodopa/Benserazide.","authors":"Julia Zibold, Moritz Luigi Schmidbauer, Johannes Wischmann, Konstantinos Dimitriadis","doi":"10.1159/000539033","DOIUrl":"10.1159/000539033","url":null,"abstract":"Introduction: Akinetic mutism is a severe state of impaired volition that can result from a stroke. Its therapeutic evidence relies on single case reports that used atomoxetine or levodopa with variable latency and efficacy.Case presentation: We present the case of a 54-year-old woman who developed akinetic mutism after infarction in the territory of the right anterior cerebral artery, successfully treated with methylphenidate and levodopa/benserazide. Clinical examination showed a patient lacking any spontaneous speech and movement while opening her eyes and fixating. Suspecting akinetic mutism after a comprehensive diagnostic work-up, we started an individual therapy attempt with methylphenidate 10 mg and levodopa/benserazide 100/25 mg twice daily. Both drugs affect the dopaminergic and noradrenergic transmission in the frontal-subcortical circuit, compromised in akinetic mutism. We saw rapid and sustained improvement in her volitional actions, devoid of side effects. Finally, the patient was actively communicating and moving her limbs.Conclusion: We discuss the patient's favorable clinical course in response to the synergistic combination of methylphenidate and levodopa/benserazide, emerging as a promising treatment strategy, and provide a brief literature review of treatment options in akinetic mutism following stroke.","PeriodicalId":9639,"journal":{"name":"Case Reports in Neurology","volume":"16 1","pages":"136-141"},"PeriodicalIF":0.6,"publicationDate":"2024-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11250274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141626172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute Leriche Syndrome Mimicking Spinal Cord Infarction: A Case Report. 模仿脊髓梗死的急性莱里切综合征：病例报告

IF 0.6

Case Reports in Neurology Pub Date : 2024-05-24 eCollection Date: 2024-01-01 DOI: 10.1159/000539456

Takamichi Kanbayashi, Sonoko Tanaka, Kiyoshi Matsukura, Masahiro Sonoo, Shunsuke Kobayashi

{"title":"Acute Leriche Syndrome Mimicking Spinal Cord Infarction: A Case Report.","authors":"Takamichi Kanbayashi, Sonoko Tanaka, Kiyoshi Matsukura, Masahiro Sonoo, Shunsuke Kobayashi","doi":"10.1159/000539456","DOIUrl":"10.1159/000539456","url":null,"abstract":"Introduction: Acute Leriche syndrome is a rare but potentially life-threatening condition. Pain, pallor, and coldness of the lower extremities serve as clues for suspecting Leriche syndrome. However, the absence of these findings may pose a diagnostic challenge.Case presentation: An 83-year-old man presented at our emergency department with a complaint of sudden-onset paraparesis. Initially, spinal cord infarction was suspected due to clinical course and neurological findings, but thoracolumbar MRI showed normal findings. On admission, symptoms associated with aortoiliac occlusion were not present, except for muscle atrophy in the thigh. CT angiography revealed aortoiliac occlusion, leading to a diagnosis of Leriche syndrome.Conclusion: Leriche syndrome should be considered as a potential differential diagnosis in patients with acute paraparesis. Muscle atrophy of the lower limbs disproportionate to the clinical course may be the clue for suspecting acute Leriche syndrome with symptoms related to atherosclerotic occlusion which are inconspicuous.","PeriodicalId":9639,"journal":{"name":"Case Reports in Neurology","volume":"16 1","pages":"148-153"},"PeriodicalIF":0.6,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11250112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141626171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unilateral Anterior Spinal Artery Syndrome following Spinal Anesthesia for Cesarian Section: A Case Report. 剖腹产脊髓麻醉后单侧脊髓前动脉综合征：病例报告。

IF 0.6

Case Reports in Neurology Pub Date : 2024-05-22 eCollection Date: 2024-01-01 DOI: 10.1159/000539405

Matthew J Kraus, Joseph Nguyen

{"title":"Unilateral Anterior Spinal Artery Syndrome following Spinal Anesthesia for Cesarian Section: A Case Report.","authors":"Matthew J Kraus, Joseph Nguyen","doi":"10.1159/000539405","DOIUrl":"10.1159/000539405","url":null,"abstract":"Introduction: Spinal cord infarction is a rare but serious neurologic complication of spinal anesthesia. Direct vessel injury, intra-arterial anesthetic injection, and anesthetic-induced local hypotension are potential mechanisms of infarction during this procedure. The proximity of the artery of Adamkiewicz to the spinal levels used for spinal anesthesia may also play a role. This case of unilateral anterior spinal artery syndrome highlights the potential for an atypical pattern of injury and deficits due to the complexity of the spinal cord's anterior circulation.Case presentation: We present a 38-year-old female patient who presented with left lower extremity weakness, loss of temperature sensation, and urinary retention following spinal anesthesia for cesarian section. Magnetic resonance imaging of the spine demonstrated T2 hyperintensities in the left central spinal cord from T8 to the conus medullaris. A diagnosis of spinal cord infarction was made after lumbar puncture testing showed no evidence of inflammatory myelitis. The patient was treated with steroids empirically until lumbar puncture testing showed no inflammation. The patient was discharged on daily aspirin with persistent left lower extremity weakness and loss of temperature sensation. A plan for outpatient physical therapy was made for rehabilitation.Conclusion: Awareness of the potential for spinal cord infarction secondary to spinal anesthesia must increase among anesthesiologists, obstetricians, and neurologists. The risk of systemic hypotension during and after spinal anesthesia is important to recognize for both primary and secondary prevention of this complication. The hyperacute onset of myelopathic symptoms should point neurologists to investigate an ischemic etiology in the proper clinical context.","PeriodicalId":9639,"journal":{"name":"Case Reports in Neurology","volume":"16 1","pages":"142-147"},"PeriodicalIF":0.6,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11250075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141626175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

No Efficacy with Noninvasive Brain Stimulation for Painful Legs and Moving Toes: A Case Report. 无创脑电刺激治疗疼痛腿和移动脚趾无效：病例报告。

IF 0.7

Case Reports in Neurology Pub Date : 2024-02-28 eCollection Date: 2024-01-01 DOI: 10.1159/000536467

Anna Brück, Jaakko Pullinen, Janne Nummelin, Saara Lehto, Juho Joutsa

引用次数: 0

Repetitive Transcranial Magnetic Stimulation for Major Depressive Disorder in Huntington Disease Patient with Improvement in Neuropsychiatric and Movement Symptoms: A Case Report. 重复经颅磁刺激治疗亨廷顿病患者的重度抑郁症并改善其神经精神和运动症状：病例报告。

IF 0.7

Case Reports in Neurology Pub Date : 2024-02-14 eCollection Date: 2024-01-01 DOI: 10.1159/000537750

Cheyenne Rahn, Kris Peterson, Elizabeth Lamb

引用次数: 0

Disseminated Aspergillosis with Mediastinal Invasion Causing Fatal Stroke in an Immunocompetent Young Man. 一名免疫功能正常的年轻男子因弥散性曲霉菌病并发纵隔侵犯而导致致命中风

IF 0.7

Case Reports in Neurology Pub Date : 2024-02-05 eCollection Date: 2024-01-01 DOI: 10.1159/000536594

Robert Yarham, Rudy Goh, Eamon P Raith, Krishnaswamy Sundararajan, Timothy Kleinig

引用次数: 0

Migraine Symptoms Induced by an Auricular Piercing in a 27-Year-Old Female: A Case Report. 一名 27 岁女性因耳廓穿刺引发偏头痛症状：病例报告。

IF 0.7

Case Reports in Neurology Pub Date : 2024-01-31 eCollection Date: 2024-01-01 DOI: 10.1159/000536132

Sophia Uddin, Jordan Terry

{"title":"Migraine Symptoms Induced by an Auricular Piercing in a 27-Year-Old Female: A Case Report.","authors":"Sophia Uddin, Jordan Terry","doi":"10.1159/000536132","DOIUrl":"10.1159/000536132","url":null,"abstract":"Introduction: Migraines are common and debilitating, and have high direct and indirect costs. They can be difficult to treat, and many patients make use of alternative medicine techniques. One of these is acupuncture applied to locations on the auricle thought to modulate migraine symptoms. Some patients obtain piercings in these locations in hopes of relieving their symptoms; however, the literature does not address the possibility of migraine symptoms being worsened or even induced by such piercings.Case presentation: We present a case of a 27-year-old female with a history of transient hemiplegia without headaches who developed headaches, visual disturbances, and nausea after a piercing of the inferior crus of her left antihelix (known as a rook piercing). No abnormalities were found on workup, and symptoms were treated with supportive care. After removing the piercing 9 months later, the patient's symptoms resolved.Conclusion: The mechanism linking the piercing with the migraine symptoms is unclear, but may involve modulation of trigeminal or vagal pain pathways, as both of these cranial nerves innervate this area of the auricle. Regardless, in patients presenting with migraine symptoms, history and physical exam should not overlook piercings as potential contributory factors.","PeriodicalId":9639,"journal":{"name":"Case Reports in Neurology","volume":"16 1","pages":"36-40"},"PeriodicalIF":0.7,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10849747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139701948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A First Case of Acute Flaccid Myelitis Related to Enterovirus D68 in Belgium: Case Report. 比利时首例与肠道病毒 D68 相关的急性弛缓性脊髓炎病例：病例报告。

IF 0.7

Case Reports in Neurology Pub Date : 2024-01-31 eCollection Date: 2024-01-01 DOI: 10.1159/000535316

Marine Rodesch, Claudine Sculier, Valentina Lolli, Gauthier Remiche, Iris Delpire, Christophe Fricx, Françoise Vermeulen, Florence Christiaens

{"title":"A First Case of Acute Flaccid Myelitis Related to Enterovirus D68 in Belgium: Case Report.","authors":"Marine Rodesch, Claudine Sculier, Valentina Lolli, Gauthier Remiche, Iris Delpire, Christophe Fricx, Françoise Vermeulen, Florence Christiaens","doi":"10.1159/000535316","DOIUrl":"https://doi.org/10.1159/000535316","url":null,"abstract":"Introduction: We describe the first case of acute flaccid myelitis (AFM) related to enterovirus D68 (EV-D68) infection in Belgium. The clinical and radiological presentation of AFM associated with EV-D68 although well described currently remains a challenging diagnosis. Through this interesting clinical case, we aimed to review the differential diagnosis of acute flaccid palsy in a child and discuss the specific point of interest related to AFM.Case presentation: We present the case of a 4-year-old girl with a torticollis associated with an acute palsy of the right upper limb. The magnetic resonance imaging revealed an increased T2 signal intensity of the entire central gray matter of the cervical cord with involvement of the posterior brainstem. A polymerase chain reaction (PCR) conducted on a nasopharyngeal swab was found positive for EV-D68. The definition of AFM proposed by the Center for Disease Control and Prevention (CDC) is an acute-onset flaccid weakness of one or more limbs in the absence of a clear alternative diagnosis and the radiological evidence of gray matter involvement on an MRI picture, and our case fits these two criteria. A prompt and detailed workup is required to distinguish this emergent disease from other forms of acute flaccid palsy. The functional prognosis of AFM is poor, and there are no evidence-based treatment guidelines so far.Conclusion: AFM is an emerging pathology that requires the attention of pediatricians to quickly rule out differential diagnoses and adequately manage the patient. Further research is needed to optimize treatments, improve outcomes, and provide scientifically based guidelines.","PeriodicalId":9639,"journal":{"name":"Case Reports in Neurology","volume":"16 1","pages":"41-47"},"PeriodicalIF":0.7,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10890805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139971089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highly Active Relapsing-Remitting Multiple Sclerosis with Neurofibromatosis Type 1: Radiological Aspects and Therapeutic Challenges - Case Report. 神经纤维瘤病 1 型高活性复发性多发性硬化症：放射学方面和治疗挑战--病例报告。

IF 0.7

Case Reports in Neurology Pub Date : 2024-01-24 eCollection Date: 2024-01-01 DOI: 10.1159/000536463

Marios Lemonaris, Kleopas A Kleopa

{"title":"Highly Active Relapsing-Remitting Multiple Sclerosis with Neurofibromatosis Type 1: Radiological Aspects and Therapeutic Challenges - Case Report.","authors":"Marios Lemonaris, Kleopas A Kleopa","doi":"10.1159/000536463","DOIUrl":"https://doi.org/10.1159/000536463","url":null,"abstract":"Introduction: Multiple sclerosis (MS) is an autoimmune neurodegenerative disease which can rarely co-exist with neurofibromatosis 1 (NF1), a neurocutaneous inherited disorder that predisposes to oncogenesis. Patients who suffer from both conditions can be challenging cases for clinicians, as clinical symptoms and radiological findings may overlap, while MS immune-modifying treatments could further increase the risk of oncogenesis.Case presentation: In this study, we describe the case of a 27-year-old woman who presented with signs and symptoms of optic neuritis and was then diagnosed with both MS and NF1. As the patient continued to experience MS relapses despite initial interferon-beta treatment, she was subsequently switched to natalizumab and responded well.Conclusion: This case illustrates how MRI lesion differentiation with the co-existence of MS and NF1 can be difficult due to overlaps in lesion characteristics, while treatment decisions can be challenging mainly due to scarce data on the oncogenic risk of MS immunomodulary therapies. Therefore, clinicians need to balance out the risk of malignancy development with the risk of progressive neurological disability when treating such patients.","PeriodicalId":9639,"journal":{"name":"Case Reports in Neurology","volume":"16 1","pages":"48-54"},"PeriodicalIF":0.7,"publicationDate":"2024-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10890804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139975486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0