Case Reports in Neurology最新文献_第10页

Acute Transient Encephalopathy after Moderna COVID-19 Vaccine 现代COVID-19疫苗接种后急性短暂性脑病

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Case Reports in Neurology Pub Date : 2022-05-09 DOI: 10.1159/000523769

M. Rosso, Y. Anziska, S. Levine

{"title":"Acute Transient Encephalopathy after Moderna COVID-19 Vaccine","authors":"M. Rosso, Y. Anziska, S. Levine","doi":"10.1159/000523769","DOIUrl":"https://doi.org/10.1159/000523769","url":null,"abstract":"Although mRNA vaccine responses following previous coronavirus disease 2019 (COVID-19) infection have not been assessed in trials, it has been shown that serological evidence of previous COVID-19 generates strong humoral and cellular responses to one dose of mRNA vaccine. We describe a patient with prior COVID-19 infection who developed acute transient encephalopathy with elevated inflammatory markers within 24 h of her first injection of Moderna COVID-19 vaccine. A 69-year-old cognitively normal woman presented with intermittent inattention, disorientation, left/right confusion, weakness, gait instability, and decreased speech. Head CT, brain MRI and MRA, complete blood count, liver enzymes, hepatitis B serology, ammonia, thyroid function, vitamin B12, and pulse oximetry were normal. Electroencephalography performed 48 h after symptom onset showed diffuse triphasic waves, diffuse theta and delta slowing, and no posterior dominant rhythm. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgG was positive and inflammatory markers were elevated. On day 5 post-vaccine, she returned to her baseline, without neurological sequelae. The reported patient likely developed a transient inflammatory encephalopathy associated with an abnormal immunologic reaction to one dose of COVID-19 vaccine, in the setting of remote COVID-19 infection (1 year prior), SARS-CoV-2 IgG-positivity, and multiple comorbidities. Physicians should be alert to possible postvaccination reactogenicity in individuals with SARS-CoV-2 IgG-positivity, including risk of neuro-inflammation.","PeriodicalId":9639,"journal":{"name":"Case Reports in Neurology","volume":"14 1","pages":"231 - 236"},"PeriodicalIF":0.7,"publicationDate":"2022-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45395055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Amnesia of Uncertain Etiology in an Adolescent during COVID-19 Pandemic: A Case Report 新冠肺炎大流行期间一名青少年不确定病因失忆症病例报告

IF 0.7

Case Reports in Neurology Pub Date : 2022-05-03 DOI: 10.1159/000523733

Benedetta Basagni, Sonia Martelli, A. Mazzucchi, F. Cecchi

{"title":"Amnesia of Uncertain Etiology in an Adolescent during COVID-19 Pandemic: A Case Report","authors":"Benedetta Basagni, Sonia Martelli, A. Mazzucchi, F. Cecchi","doi":"10.1159/000523733","DOIUrl":"https://doi.org/10.1159/000523733","url":null,"abstract":"Sudden retrograde memory loss, in the absence of neurological causes, is usually referred to as a dissociative symptom. Dissociative amnesia, defined in the DSM-V as an inability to remember important autobiographical experiences, usually of a traumatic or stressful nature, is however a controversial phenomenon. Few cases with this pattern are described in the scientific literature and still fewer regarding adolescents. The objective of this study was to describe the case of an unexplained sudden memory loss that only partially fits with the criteria for dissociative amnesia, in a juvenile patient aged 16 years, which occurred during the COVID-19 lockdown. After the exclusion of any organic disturbances, 10 days after the clinical onset, a series of psychometric (neuropsychological and psychodiagnostics) tests were administered to the patient. Recent distress associated with COVID-19 lockdown was reported, while no previous significant distress or psychiatric history emerged during the clinical interview, conducted with the patient and parents. Severe disturbances in remote memory tests were registered, while no impairments in cognitive or anterograde amnestic functions were found or personality disorders. The disturbance was diagnosed as “amnesia of uncertain etiology.”","PeriodicalId":9639,"journal":{"name":"Case Reports in Neurology","volume":"14 1","pages":"223 - 230"},"PeriodicalIF":0.7,"publicationDate":"2022-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48766796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glioblastoma, IDH-wildtype: A New Association with IgM Paraproteinaemic Neuropathy? 胶质母细胞瘤，idh野生型:与IgM副蛋白贫血性神经病的新关联?

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Case Reports in Neurology Pub Date : 2022-04-22 DOI: 10.1159/000522239

Dana Lewis, N. Colchester, D. Allen, J. Nicoll, H. Katifi, A. Duncombe

{"title":"Glioblastoma, IDH-wildtype: A New Association with IgM Paraproteinaemic Neuropathy?","authors":"Dana Lewis, N. Colchester, D. Allen, J. Nicoll, H. Katifi, A. Duncombe","doi":"10.1159/000522239","DOIUrl":"https://doi.org/10.1159/000522239","url":null,"abstract":"It is well recognized that B-cell clonal disorders such as Waldenstrom’s macroglobulinaemia may affect the central nervous system by direct infiltration of malignant B cells (Bing-Neel syndrome). However, there is no recognition in the current literature of a clear link between paraproteinaemia and primary brain tumours such as glioma. We present 3 cases of classical IgM paraproteinaemic neuropathy who developed glioblastoma in the course of their illness following treatment with chemoimmunotherapy (CIT). Due to the progressive symptomatic nature of their neuropathy, all 3 patients were treated with CIT. The patients presented with glioblastoma, IDH-wildtype at 9 months, 5 years, and 6 years following treatment completion. None of the patients had unequivocal evidence of known predisposing factors for glioblastoma. Both disorders are exceedingly rare and the chance of random association is less than one in a million. Potential common pathogenic mechanisms include the influence of paraproteins and circulating lymphoplasmacytic cells on blood-brain permeability and CNS immune micro-environment as well as raised circulating angiogenic cytokines such as vascular endothelial growth factor. In cases with anti-myelin-associated glycoprotein (MAG) antibodies, surface MAG on glial cells may act as a target releasing cells from growth inhibition. We suggest that all glioblastoma cases be screened at diagnosis for serum paraproteins and that such cases be reported to central registries to establish the frequency of the association more accurately.","PeriodicalId":9639,"journal":{"name":"Case Reports in Neurology","volume":"14 1","pages":"213 - 222"},"PeriodicalIF":0.7,"publicationDate":"2022-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43340926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Small-Fiber Neuropathy Possibly Associated with COVID-19 可能与新冠肺炎相关的小纤维神经病变

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Case Reports in Neurology Pub Date : 2022-04-22 DOI: 10.1159/000524205

A. Burakgazi

引用次数: 7

A Case of Pure Autonomic Failure Initially Presenting with Hemihypohidrosis: Twelve-Year Follow-Up. 一例最初表现为半汗症的单纯自主性失败病例：12年随访

IF 0.6

Case Reports in Neurology Pub Date : 2022-04-19 eCollection Date: 2022-01-01 DOI: 10.1159/000523851

Hiroshi Saito

引用次数: 0

Paramedian Midbrain Infarction Presenting with Bilateral Ptosis and Unilateral Median Longitudinal Fasciculus Syndrome: A Peculiar Midbrain Syndrome 以双侧上睑下垂和单侧正中纵束综合征为表现的副中脑梗死:一种特殊的中脑综合征

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Case Reports in Neurology Pub Date : 2022-04-04 DOI: 10.1159/000523986

Yoshihiro Aoki, T. Hashimoto

引用次数: 0

Wernicke Encephalopathy following Gastric Bypass: A Case Report 胃分流术后韦尼克脑病1例报告

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Case Reports in Neurology Pub Date : 2022-03-29 DOI: 10.1159/000523707

Sarah Glisan, Nazim Khan

引用次数: 2

Isaac Syndrome with Intractable Neuropathic Pain Features: A Case Report 以撒综合征伴顽固性神经性疼痛1例报告

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Case Reports in Neurology Pub Date : 2022-03-29 DOI: 10.1159/000523821

Mustafa Al-Chalabi, Nicholas Delcimmuto, P. Devarasetty, Jayasai Jeyarajan, Blair N. Baumle, N. Pirzada

{"title":"Isaac Syndrome with Intractable Neuropathic Pain Features: A Case Report","authors":"Mustafa Al-Chalabi, Nicholas Delcimmuto, P. Devarasetty, Jayasai Jeyarajan, Blair N. Baumle, N. Pirzada","doi":"10.1159/000523821","DOIUrl":"https://doi.org/10.1159/000523821","url":null,"abstract":"Isaac syndrome (IS) is a peripheral nerve hyperexcitability state associated with voltage-gated potassium channel (VGKC) complex antibodies. Major manifestations are muscle twitching, stiffness, hypertrophy, and dysautonomic features such as hyperhidrosis [Ahmed and Simmons. Muscle Nerve. 2015;52(1):5–12]. Neuropathic pain is a rare manifestation. We describe a case of IS characterized by muscle twitching and intractable neuropathic pain. Diagnostic workup included elevated VGKC complex antibodies and EMG/NC that showed neuromyotonic discharges. Neuropathic pain was initially difficult to relieve even after using multiple medications, including opiates, benzodiazepines, anticonvulsants, and intravenous immunoglobulin (IVIg). Moderate pain control was eventually achieved with long-term use of carbamazepine and subcutaneous immunoglobulin (SCIg). Common manifestations of IS are muscle twitching, stiffness hypertrophy, and dysautonomia [Ahmed and Simmons. Muscle Nerve. 2015;52(1):5–12]. Sensory manifestations such as neuropathic pain are rare, but, as illustrated by our patient, can be the most distressing symptom. In our patient, not only was neuropathic pain disabling but it also showed the least response to IVIg. The use of 200 mg of long-acting carbamazepine twice daily with weekly SCIg demonstrated the best response. This case highlights an uncommon but potentially resistant symptom of IS.","PeriodicalId":9639,"journal":{"name":"Case Reports in Neurology","volume":"14 1","pages":"185 - 190"},"PeriodicalIF":0.7,"publicationDate":"2022-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45020282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Many Faces of Blurry Vision in Parkinson's Disease: An Illustrative Case Series 帕金森病患者模糊视觉的多个方面：一个例证性病例系列

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Case Reports in Neurology Pub Date : 2022-03-29 DOI: 10.1159/000523987

Carlijn Borm, B. Bloem, C. Hoyng, N. D. de Vries, T. Theelen

引用次数: 1

Delayed Visual Loss in a Patient with Snake Bite: Case Report of an Unusual Neuro-Ophthalmic Presentation 蛇咬伤患者的延迟性视力丧失：一例异常神经眼科表现的病例报告

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Case Reports in Neurology Pub Date : 2022-03-24 DOI: 10.1159/000523770

Sandip Kuikel, Suman Rimal, R. Ojha, Sanjeeta Sitaula, R. Karn, B. Gajurel, R. Rajbhandari, N. Gautam, Sunanda Paudel, Aashish Shrestha

引用次数: 0