Case Reports in Neurology最新文献_第10页

Clinical Reasoning: Wilbrand's Knee, Scotoma of Traquair, and Normal Tension Glaucoma. 临床推论:Wilbrand’s Knee, Traquair暗点，和Normal Tension青光眼。

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Case Reports in Neurology Pub Date : 2022-08-30 eCollection Date: 2022-05-01 DOI: 10.1159/000525799

Francesco Pellegrini, Alessandra Cuna, Daniele Cirone, Cristina Ciabattoni, Ettore Caruso, Emanuela Interlandi, Antonio Zappacosta

引用次数: 0

Neurosarcoidosis Presenting with Prominent Periventricular White-Matter Lesions during Steroid Treatment for Autoimmune Hepatitis. 自身免疫性肝炎类固醇治疗期间出现显著脑室周围白质病变的神经结节病。

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Case Reports in Neurology Pub Date : 2022-08-19 eCollection Date: 2022-05-01 DOI: 10.1159/000526223

Tomoya Shibahara, Fumitaka Yoshino, Mikiaki Matsuoka, Masaki Tachibana, Kuniyuki Nakamura, Tetsuro Ago, Junya Kuroda, Hiroshi Nakane

{"title":"Neurosarcoidosis Presenting with Prominent Periventricular White-Matter Lesions during Steroid Treatment for Autoimmune Hepatitis.","authors":"Tomoya Shibahara, Fumitaka Yoshino, Mikiaki Matsuoka, Masaki Tachibana, Kuniyuki Nakamura, Tetsuro Ago, Junya Kuroda, Hiroshi Nakane","doi":"10.1159/000526223","DOIUrl":"https://doi.org/10.1159/000526223","url":null,"abstract":"A 63-year-old woman under treatment of autoimmune hepatitis presented with headache, memory loss, and somnolence. Three months before admission, the patient experienced liver inflammation relapse after prednisolone (PSL) cessation. Consequently, PSL was resumed and then tapered. Cerebrospinal fluid (CSF) examination showed lymphocytic pleocytosis with remarkably reduced glucose and elevated angiotensin-converting enzyme and soluble interleukin-2 receptor levels. Magnetic resonance imaging (MRI) revealed prominent bilateral periventricular white-matter lesions, hydrocephalus, ischemic stroke with gadolinium enhancement of frontoparietal and basilar meninges on contrast-enhanced fluid-attenuated inversion recovery. Magnetic resonance angiography (MRA) showed narrowing of the bilateral middle cerebral arteries. Based on these findings, we diagnosed the patient with neurosarcoidosis. Re-increment of PSL improved the neurological symptoms, CSF findings, and abnormalities found on MRI and MRA. This case suggests that neurosarcoidosis may occur as a complication of some autoimmune diseases during immunotherapy administration.","PeriodicalId":9639,"journal":{"name":"Case Reports in Neurology","volume":"14 2","pages":"334-340"},"PeriodicalIF":0.7,"publicationDate":"2022-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/41/d0/crn-0014-0334.PMC9459521.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33486648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunocompetence after SARS-CoV-2 Infection in a Patient with Multiple Sclerosis Treated with Ofatumumab: A Case Report. Ofatumumab治疗多发性硬化症患者感染SARS-CoV-2后的免疫能力:1例报告

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Case Reports in Neurology Pub Date : 2022-08-16 eCollection Date: 2022-05-01 DOI: 10.1159/000524946

Elżbieta Jasińska

{"title":"Immunocompetence after SARS-CoV-2 Infection in a Patient with Multiple Sclerosis Treated with Ofatumumab: A Case Report.","authors":"Elżbieta Jasińska","doi":"10.1159/000524946","DOIUrl":"https://doi.org/10.1159/000524946","url":null,"abstract":"Ofatumumab is the first fully human anti-CD20 monoclonal antibody that, on March 26, 2021, was approved by the EMA to treat patients with relapsing multiple sclerosis. This paper aimed to present a case confirming the ability to produce and maintain anti-SARS-CoV-2 antibodies in a patient treated with ofatumumab for over 4 years. The course of the infection was moderate, and the patient did not require hospitalization. Antibody measurements were performed five times post-COVID-19 infection. The first test was performed in the fourth month (131 days), and the last, over 1 year after the infection. To date, only 2 cases have been published describing the ability of a patient treated with the same drug to produce antibodies against SARS-CoV-2, although the observation was conducted over a shorter period. In our case study, we have 15-month follow-up data. The patient was not vaccinated and additionally received suppressive steroid therapy due to the relapse. We observed an increase in antibodies up to 10 months from the infection. The case under analysis suggests that patients treated with ofatumumab, despite complete peripheral B-cell depletion, can produce and maintain a long-lasting immune response.","PeriodicalId":9639,"journal":{"name":"Case Reports in Neurology","volume":"14 2","pages":"320-325"},"PeriodicalIF":0.7,"publicationDate":"2022-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cc/06/crn-0014-0320.PMC9459643.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33486653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

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Case Reports in Neurology Pub Date : 2022-08-16 eCollection Date: 2022-05-01 DOI: 10.1159/000525908

Monami Tarisawa, Takahiro Kano, Daiki Tanaka, Masanao Yoshino, Hideki Houzen

引用次数: 0

Myasthenia Gravis Complicated by Eosinophilic Granulomatosis with Polyangiitis: A Case Report. 重症肌无力合并嗜酸性肉芽肿病合并多血管炎1例。

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Case Reports in Neurology Pub Date : 2022-07-11 eCollection Date: 2022-05-01 DOI: 10.1159/000525702

Takahumi Uchi, Shingo Konno, Hideo Kihara, Mari Matsushima, Hideki Sugimoto, Toshiaki Oharaseki, Kei Takahashi, Toshiki Fujioka

引用次数: 0

A Case of Perimesencephalic Subarachnoid Hemorrhage with Cerebral Venous Sinus Thrombosis due to Stenosis of the Junction of the Vein of Galen and Rectus Sinus. 脑实质周围蛛网膜下腔出血合并脑静脉窦血栓形成1例，原因是盖伦静脉与直静脉窦交界处狭窄。

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Case Reports in Neurology Pub Date : 2022-07-08 eCollection Date: 2022-05-01 DOI: 10.1159/000525506

Kyoya Sakashita, Kei Miyata, Ryohei Saito, Ryota Sato, Sangnyon Kim, Nobuhiro Mikuni

{"title":"A Case of Perimesencephalic Subarachnoid Hemorrhage with Cerebral Venous Sinus Thrombosis due to Stenosis of the Junction of the Vein of Galen and Rectus Sinus.","authors":"Kyoya Sakashita, Kei Miyata, Ryohei Saito, Ryota Sato, Sangnyon Kim, Nobuhiro Mikuni","doi":"10.1159/000525506","DOIUrl":"https://doi.org/10.1159/000525506","url":null,"abstract":"Perimesencephalic subarachnoid hemorrhage (PMSAH) is a group of diseases characterized by bleeding around the brainstem. In recent years, it has been suggested that PMSAH is associated with the venous system. We report a case of PMSAH caused by stenosis of the junction of the vein of Galen (VG) and the rectus sinus (RS). A 39-year-old man presented with restlessness at work. He was administered diazepam, and a few minutes later, his consciousness became clear. Imaging showed subarachnoid hemorrhage (SAH) around the right midbrain, occlusion of the right sigmoid sinus and the right transverse sinus, stenosis of the junction of the VG and RS, T2 hyperintensity in the right middle temporal gyrus, and obstruction of the right vein of Labbe. The location of the SAH coincided with stenosis of the junction of the VG and RS. PMSAH was diagnosed due to the increase in intracranial venous pressure caused by the patient's sinus obstruction in addition to the stenosis of the junction of the VG and RS. It is necessary to pay attention to venous return when PMSAH is observed.","PeriodicalId":9639,"journal":{"name":"Case Reports in Neurology","volume":"14 2","pages":"307-313"},"PeriodicalIF":0.7,"publicationDate":"2022-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8e/32/crn-0014-0307.PMC9386415.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33486601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute Transient Encephalopathy after Moderna COVID-19 Vaccine 现代COVID-19疫苗接种后急性短暂性脑病

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Case Reports in Neurology Pub Date : 2022-05-09 DOI: 10.1159/000523769

M. Rosso, Y. Anziska, S. Levine

{"title":"Acute Transient Encephalopathy after Moderna COVID-19 Vaccine","authors":"M. Rosso, Y. Anziska, S. Levine","doi":"10.1159/000523769","DOIUrl":"https://doi.org/10.1159/000523769","url":null,"abstract":"Although mRNA vaccine responses following previous coronavirus disease 2019 (COVID-19) infection have not been assessed in trials, it has been shown that serological evidence of previous COVID-19 generates strong humoral and cellular responses to one dose of mRNA vaccine. We describe a patient with prior COVID-19 infection who developed acute transient encephalopathy with elevated inflammatory markers within 24 h of her first injection of Moderna COVID-19 vaccine. A 69-year-old cognitively normal woman presented with intermittent inattention, disorientation, left/right confusion, weakness, gait instability, and decreased speech. Head CT, brain MRI and MRA, complete blood count, liver enzymes, hepatitis B serology, ammonia, thyroid function, vitamin B12, and pulse oximetry were normal. Electroencephalography performed 48 h after symptom onset showed diffuse triphasic waves, diffuse theta and delta slowing, and no posterior dominant rhythm. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgG was positive and inflammatory markers were elevated. On day 5 post-vaccine, she returned to her baseline, without neurological sequelae. The reported patient likely developed a transient inflammatory encephalopathy associated with an abnormal immunologic reaction to one dose of COVID-19 vaccine, in the setting of remote COVID-19 infection (1 year prior), SARS-CoV-2 IgG-positivity, and multiple comorbidities. Physicians should be alert to possible postvaccination reactogenicity in individuals with SARS-CoV-2 IgG-positivity, including risk of neuro-inflammation.","PeriodicalId":9639,"journal":{"name":"Case Reports in Neurology","volume":"14 1","pages":"231 - 236"},"PeriodicalIF":0.7,"publicationDate":"2022-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45395055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Amnesia of Uncertain Etiology in an Adolescent during COVID-19 Pandemic: A Case Report 新冠肺炎大流行期间一名青少年不确定病因失忆症病例报告

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Case Reports in Neurology Pub Date : 2022-05-03 DOI: 10.1159/000523733

Benedetta Basagni, Sonia Martelli, A. Mazzucchi, F. Cecchi

{"title":"Amnesia of Uncertain Etiology in an Adolescent during COVID-19 Pandemic: A Case Report","authors":"Benedetta Basagni, Sonia Martelli, A. Mazzucchi, F. Cecchi","doi":"10.1159/000523733","DOIUrl":"https://doi.org/10.1159/000523733","url":null,"abstract":"Sudden retrograde memory loss, in the absence of neurological causes, is usually referred to as a dissociative symptom. Dissociative amnesia, defined in the DSM-V as an inability to remember important autobiographical experiences, usually of a traumatic or stressful nature, is however a controversial phenomenon. Few cases with this pattern are described in the scientific literature and still fewer regarding adolescents. The objective of this study was to describe the case of an unexplained sudden memory loss that only partially fits with the criteria for dissociative amnesia, in a juvenile patient aged 16 years, which occurred during the COVID-19 lockdown. After the exclusion of any organic disturbances, 10 days after the clinical onset, a series of psychometric (neuropsychological and psychodiagnostics) tests were administered to the patient. Recent distress associated with COVID-19 lockdown was reported, while no previous significant distress or psychiatric history emerged during the clinical interview, conducted with the patient and parents. Severe disturbances in remote memory tests were registered, while no impairments in cognitive or anterograde amnestic functions were found or personality disorders. The disturbance was diagnosed as “amnesia of uncertain etiology.”","PeriodicalId":9639,"journal":{"name":"Case Reports in Neurology","volume":"14 1","pages":"223 - 230"},"PeriodicalIF":0.7,"publicationDate":"2022-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48766796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glioblastoma, IDH-wildtype: A New Association with IgM Paraproteinaemic Neuropathy? 胶质母细胞瘤，idh野生型:与IgM副蛋白贫血性神经病的新关联?

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Case Reports in Neurology Pub Date : 2022-04-22 DOI: 10.1159/000522239

Dana Lewis, N. Colchester, D. Allen, J. Nicoll, H. Katifi, A. Duncombe

{"title":"Glioblastoma, IDH-wildtype: A New Association with IgM Paraproteinaemic Neuropathy?","authors":"Dana Lewis, N. Colchester, D. Allen, J. Nicoll, H. Katifi, A. Duncombe","doi":"10.1159/000522239","DOIUrl":"https://doi.org/10.1159/000522239","url":null,"abstract":"It is well recognized that B-cell clonal disorders such as Waldenstrom’s macroglobulinaemia may affect the central nervous system by direct infiltration of malignant B cells (Bing-Neel syndrome). However, there is no recognition in the current literature of a clear link between paraproteinaemia and primary brain tumours such as glioma. We present 3 cases of classical IgM paraproteinaemic neuropathy who developed glioblastoma in the course of their illness following treatment with chemoimmunotherapy (CIT). Due to the progressive symptomatic nature of their neuropathy, all 3 patients were treated with CIT. The patients presented with glioblastoma, IDH-wildtype at 9 months, 5 years, and 6 years following treatment completion. None of the patients had unequivocal evidence of known predisposing factors for glioblastoma. Both disorders are exceedingly rare and the chance of random association is less than one in a million. Potential common pathogenic mechanisms include the influence of paraproteins and circulating lymphoplasmacytic cells on blood-brain permeability and CNS immune micro-environment as well as raised circulating angiogenic cytokines such as vascular endothelial growth factor. In cases with anti-myelin-associated glycoprotein (MAG) antibodies, surface MAG on glial cells may act as a target releasing cells from growth inhibition. We suggest that all glioblastoma cases be screened at diagnosis for serum paraproteins and that such cases be reported to central registries to establish the frequency of the association more accurately.","PeriodicalId":9639,"journal":{"name":"Case Reports in Neurology","volume":"14 1","pages":"213 - 222"},"PeriodicalIF":0.7,"publicationDate":"2022-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43340926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Small-Fiber Neuropathy Possibly Associated with COVID-19 可能与新冠肺炎相关的小纤维神经病变

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Case Reports in Neurology Pub Date : 2022-04-22 DOI: 10.1159/000524205

A. Burakgazi

引用次数: 7