Case Reports in Neurology最新文献

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Favorable Outcome with Intravenous Immunoglobulin Therapy in Late-Onset Anti-mGluR1 Encephalitis: A Case Report and Literature Review. 静脉注射免疫球蛋白治疗迟发性抗mglur1脑炎的良好结果:1例报告和文献复习。
IF 0.7
Case Reports in Neurology Pub Date : 2022-09-01 DOI: 10.1159/000526632
Kento Sakashita, Katsuya Nishida, Yu Takenaka, Ichiro Yokota, Hiroshi Yamasaki, Keisuke Nishimoto, Kunihiko Kawamoto, Maki Mitani, Itaru Funakawa, Nobuaki Yoshikura, Akio Kimura, Takayoshi Shimohata, Naonobu Futamura
{"title":"Favorable Outcome with Intravenous Immunoglobulin Therapy in Late-Onset Anti-mGluR1 Encephalitis: A Case Report and Literature Review.","authors":"Kento Sakashita,&nbsp;Katsuya Nishida,&nbsp;Yu Takenaka,&nbsp;Ichiro Yokota,&nbsp;Hiroshi Yamasaki,&nbsp;Keisuke Nishimoto,&nbsp;Kunihiko Kawamoto,&nbsp;Maki Mitani,&nbsp;Itaru Funakawa,&nbsp;Nobuaki Yoshikura,&nbsp;Akio Kimura,&nbsp;Takayoshi Shimohata,&nbsp;Naonobu Futamura","doi":"10.1159/000526632","DOIUrl":"https://doi.org/10.1159/000526632","url":null,"abstract":"<p><p>Anti-metabotropic glutamate receptor 1 (mGluR1) encephalitis is a rare autoimmune disorder manifesting with cerebellar syndrome. Patients with mGluR1 encephalitis have been treated with immunomodulatory therapies; however, little is known about the efficacy of this therapy. A 58-year-old Japanese woman presented with dizziness when walking and standing up. Symptoms persisted and the patient gradually deteriorated. The neurological examination revealed a broad-based gait, horizontal and slightly gaze-evoked nystagmus, noticeable head titubation, and truncal ataxia without limb ataxia. Magnetic resonance imaging was normal. The <sup>123</sup>I-isopropyl-iodoamphetamine single-photon emission-computed tomography scans showed normal cerebellar perfusion. Based on a positive antibody test for anti-mGluR1, the patient was diagnosed with anti-mGluR1 encephalitis. She was treated with intravenous methylprednisolone and intravenous immunoglobulin (IVIg). Symptoms gradually improved over 1 month and almost disappeared after additional IVIg therapy. Anti-mGluR1 encephalitis is a rare disease, and effective treatment is unclear. In this case, a favorable outcome was obtained with immunomodulatory therapy, even though the neurological disability of the disease course is worse. We emphasize the importance of early diagnosis and therapeutic intervention, suspecting the disease on the basis of its characteristic symptoms.</p>","PeriodicalId":9639,"journal":{"name":"Case Reports in Neurology","volume":"14 3","pages":"494-500"},"PeriodicalIF":0.7,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8c/ad/crn-0014-0494.PMC9841793.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9114414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Ischemic Optic Neuropathy Secondary to Varicella-Zoster Vasculitis Mimicking Giant Cell Arteritis: Case Report. 模拟巨细胞动脉炎的水痘带状疱疹血管炎继发缺血性视神经病变1例报告。
IF 0.7
Case Reports in Neurology Pub Date : 2022-09-01 DOI: 10.1159/000527876
Alicia Rodriguez-Pla, Marie F Grill, Geoffrey P Fletcher, Marie A Di Nome
{"title":"Ischemic Optic Neuropathy Secondary to Varicella-Zoster Vasculitis Mimicking Giant Cell Arteritis: Case Report.","authors":"Alicia Rodriguez-Pla,&nbsp;Marie F Grill,&nbsp;Geoffrey P Fletcher,&nbsp;Marie A Di Nome","doi":"10.1159/000527876","DOIUrl":"https://doi.org/10.1159/000527876","url":null,"abstract":"<p><p>Differentiating GCA from its many mimickers remains a challenge in the daily clinical practice, especially in patients presenting with unspecific manifestations. We present the case of an 82-year-old woman who presented with a 3-week history of left eye vision loss secondary to bilateral edema and hemorrhage of the optic discs. Despite negative bilateral temporal artery biopsies, the elevation of the inflammatory markers and brain MRA findings suggestive of temporal arteritis as well as stenosis of the basilar artery led us to initiate treatment with high-dose steroids. Inflammatory markers remained elevated despite high-dose steroids which prompted additional work leading to a diagnosis of varicella-zoster encephalitis. Steroid treatment was quickly tapered off and treatment with acyclovir resulted in the normalization of the acute phase reactants. The persistence of elevated inflammatory markers despite high-dose steroids should prompt additional work up for the search of an alternative diagnosis of GCA mimickers.</p>","PeriodicalId":9639,"journal":{"name":"Case Reports in Neurology","volume":"14 3","pages":"483-490"},"PeriodicalIF":0.7,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e7/7e/crn-0014-0483.PMC9834640.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10590060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multiple Endovascular Treatments for Hemorrhagic Cerebral Proliferative Angiopathy: A Case Report. 出血性脑增生性血管病的多重血管内治疗1例。
IF 0.7
Case Reports in Neurology Pub Date : 2022-09-01 DOI: 10.1159/000527559
Keijiro Shomura, Tomoya Kamide, Kouichi Misaki, Taishi Tsutsui, Iku Nambu, Naoyuki Uchiyama, Mitsutoshi Nakada
{"title":"Multiple Endovascular Treatments for Hemorrhagic Cerebral Proliferative Angiopathy: A Case Report.","authors":"Keijiro Shomura,&nbsp;Tomoya Kamide,&nbsp;Kouichi Misaki,&nbsp;Taishi Tsutsui,&nbsp;Iku Nambu,&nbsp;Naoyuki Uchiyama,&nbsp;Mitsutoshi Nakada","doi":"10.1159/000527559","DOIUrl":"https://doi.org/10.1159/000527559","url":null,"abstract":"<p><p>Cerebral proliferative angiopathy (CPA) is a rare vascular abnormality characterized by transdural supply, stenoses of feeding arteries, and intermingled normal brain parenchyma in abnormal vessels. CPA is often regarded as a separate entity from \"classical\" brain arteriovenous malformations in angioarchitecture, natural history, clinical presentation, and treatment. Bleeding from CPA is uncommon, but once bleeding occurs, the risk of rebleeding is high. Herein, we describe a case of cerebral hemorrhage caused by CPA. We performed two different endovascular treatments: partial embolization with glue for a ruptured aneurysm and coil embolization for an unruptured growing aneurysm. To our knowledge, this is the first report of serial endovascular treatments for hemorrhagic CPA that included a ruptured aneurysm and a growing unruptured aneurysm.</p>","PeriodicalId":9639,"journal":{"name":"Case Reports in Neurology","volume":"14 3","pages":"433-440"},"PeriodicalIF":0.7,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/81/2e/crn-0014-0433.PMC9830309.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10532559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Serial Magnetic Resonance Imaging and Magnetic Resonance Angiographic Findings of Reversible Cerebral Vasoconstriction Syndrome Associated with Postpartum. 产后可逆性脑血管收缩综合征的磁共振成像和磁共振血管造影表现。
IF 0.7
Case Reports in Neurology Pub Date : 2022-09-01 DOI: 10.1159/000527600
Yumiko Nakano, Shunya Fujiwara, Yoshio Omote, Motonori Takamiya, Hisashi Narai, Yasuhiro Manabe
{"title":"Serial Magnetic Resonance Imaging and Magnetic Resonance Angiographic Findings of Reversible Cerebral Vasoconstriction Syndrome Associated with Postpartum.","authors":"Yumiko Nakano,&nbsp;Shunya Fujiwara,&nbsp;Yoshio Omote,&nbsp;Motonori Takamiya,&nbsp;Hisashi Narai,&nbsp;Yasuhiro Manabe","doi":"10.1159/000527600","DOIUrl":"https://doi.org/10.1159/000527600","url":null,"abstract":"<p><p>We report 2 cases of reversible cerebral vasoconstriction syndrome (RCVS) associated with postpartum. In case 1, a 26-year-old woman developed sudden-onset headache, nausea, and vomiting 1 h after an uncomplicated vaginal delivery. In case 2, a 27-year-old woman developed generalized seizures 9 days after an uncomplicated vaginal delivery. In both cases, initial angiographic studies showed no significant vasoconstriction; however, repeat studies revealed reversible vasoconstriction. Serial magnetic resonance imaging (MRI) revealed transient brain lesions during 6 months. RCVS remains poorly characterized, misdiagnosed, and under-recognized. Serial MRI and magnetic resonance angiographic findings may contribute to diagnosis of RCVS.</p>","PeriodicalId":9639,"journal":{"name":"Case Reports in Neurology","volume":"14 3","pages":"413-418"},"PeriodicalIF":0.7,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/de/40/crn-0014-0413.PMC9830283.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10525861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Donepezil-Induced Complex Multimodal Hallucinations: Two Cases and a Review of the Literature. 多奈哌齐致复杂多模态幻觉:两例及文献复习。
IF 0.7
Case Reports in Neurology Pub Date : 2022-09-01 DOI: 10.1159/000526159
Federico Emanuele Pozzi, Lucio Tremolizzo, Carlo Ferrarese, Ildebrando Appollonio
{"title":"Donepezil-Induced Complex Multimodal Hallucinations: Two Cases and a Review of the Literature.","authors":"Federico Emanuele Pozzi,&nbsp;Lucio Tremolizzo,&nbsp;Carlo Ferrarese,&nbsp;Ildebrando Appollonio","doi":"10.1159/000526159","DOIUrl":"https://doi.org/10.1159/000526159","url":null,"abstract":"<p><p>Hallucinations are common in neurodegenerative dementias, being present in a significant proportion of patients. Most of the available studies show that acetylcholinesterase inhibitors may be beneficial in preventing and treating hallucinations in patients with neurodegenerative and even psychiatric disorders, even though there are reports that they might also develop as an adverse effect of such therapy. However, a clear causal relationship for the latter association was not previously established. Here we describe 2 cases of patients treated with donepezil who developed complex multimodal hallucinations, which could be causally linked to the drug by means of a challenge-dechallenge (and rechallenge in one case) paradigm. We also provide a narrative review of the literature regarding donepezil and hallucinations and propose a hypothesis to explain the occurrence of this phenomenon.</p>","PeriodicalId":9639,"journal":{"name":"Case Reports in Neurology","volume":"14 3","pages":"359-365"},"PeriodicalIF":0.7,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ae/63/crn-0014-0359.PMC9941780.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9321537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Vestibular Schwannoma Presenting as Acute Vertigo Mimicking Vestibular Neuritis. 前庭神经鞘瘤表现为急性眩晕模拟前庭神经炎。
IF 0.7
Case Reports in Neurology Pub Date : 2022-09-01 DOI: 10.1159/000527989
Joon Yong Park, Chang-Hee Kim
{"title":"Vestibular Schwannoma Presenting as Acute Vertigo Mimicking Vestibular Neuritis.","authors":"Joon Yong Park,&nbsp;Chang-Hee Kim","doi":"10.1159/000527989","DOIUrl":"https://doi.org/10.1159/000527989","url":null,"abstract":"<p><p>Vestibular schwannoma (VS) is commonly accompanied by hearing loss, tinnitus, and dizziness and tends to be chronically progressive in nature. We report a case of VS presenting as left vestibular neuritis (VN) in a previously healthy 57-year-old patient. Right-beating horizontal-torsional spontaneous nystagmus was observed, and the bedside head impulse test revealed a left catch-up saccade. The bithermal caloric test showed left canal paresis, and pure-tone audiometry revealed an average threshold of 22.5 dB bilaterally. Brain magnetic resonance imaging (MRI) demonstrated a 0.7-cm enhancing mass in the left internal auditory canal, consistent with VS. The patient was administered with high-dose systemic corticosteroids and vestibular suppressants with antiemetic, which relieved acute vertigo. Although dizziness in VS is chronically progressive in nature, VS may present as an acute vestibular syndrome that mimics VN. VS should be considered a potential cause of acute vestibular syndrome, and thorough neurological examination with MRI may be helpful for accurate diagnosis.</p>","PeriodicalId":9639,"journal":{"name":"Case Reports in Neurology","volume":"14 3","pages":"464-468"},"PeriodicalIF":0.7,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/81/cd/crn-0014-0464.PMC9830296.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10527562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Post Stroke Mirror Movements Preventing Performance of Bilateral Movements and Activities of Daily Living. 中风后镜像运动对双侧运动和日常生活活动的影响。
IF 0.7
Case Reports in Neurology Pub Date : 2022-09-01 DOI: 10.1159/000525907
Hokuto Suzuki, Satoshi Yamamoto, Masahiro Wakatabi, Hiroyuki Ohtsuka
{"title":"Post Stroke Mirror Movements Preventing Performance of Bilateral Movements and Activities of Daily Living.","authors":"Hokuto Suzuki,&nbsp;Satoshi Yamamoto,&nbsp;Masahiro Wakatabi,&nbsp;Hiroyuki Ohtsuka","doi":"10.1159/000525907","DOIUrl":"https://doi.org/10.1159/000525907","url":null,"abstract":"<p><p>Mirror movements (MMs) are involuntary synchronous movements of one limb during voluntary movements of the contralateral limb. Generally, MMs after stroke are observed in the unaffected hand during voluntary movements of the affected hand; MMs in the affected hand are comparatively rare. In previous studies, evaluation of MMs in the affected hand was performed using simple unilateral movement tasks, such as tapping or forceful repeated hand closure. However, the impact of MMs of the affected hand on functional tasks, such as activities of daily living (ADLs), has not been reported. We report the rare case of a patient with MMs of the affected hand due to atherothrombotic cerebral infarction of the right postcentral and precentral gyri. An 85-year-old Japanese man presented with left-sided hemiplegia and sensory impairment. MMs were observed in the left (affected) hand during many ADLs and could not be suppressed by the patient's will even when the examiner verbally instructed the patient to move only the unaffected hand. The patient was aware that his hand moved on its own, but he could not control it. The patient was trained on various types of bilateral coordinated motor exercises for 114 days after the MMs were first identified. However, this did not affect MM occurrence, and the MMs remained at the time of discharge. Future research is necessary to plan long-term interventions for MMs of the affected hand.</p>","PeriodicalId":9639,"journal":{"name":"Case Reports in Neurology","volume":"14 3","pages":"389-396"},"PeriodicalIF":0.7,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/21/77/crn-0014-0389.PMC9941781.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9321532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness of Transcranial Direct Current Stimulation in Chronic Daily Headaches: An Experimental Single Case Report with a Novel Protocol. 经颅直流电刺激治疗慢性日常头痛的有效性:一项新方案的单例实验报告。
IF 0.7
Case Reports in Neurology Pub Date : 2022-09-01 DOI: 10.1159/000527021
Mohammad Dawood Rahimi, Hedieh Zargani, Karim Nikkhah
{"title":"Effectiveness of Transcranial Direct Current Stimulation in Chronic Daily Headaches: An Experimental Single Case Report with a Novel Protocol.","authors":"Mohammad Dawood Rahimi,&nbsp;Hedieh Zargani,&nbsp;Karim Nikkhah","doi":"10.1159/000527021","DOIUrl":"https://doi.org/10.1159/000527021","url":null,"abstract":"<p><p>Chronic daily headaches are often refractory to prescribed or non-prescribed medications. Transcranial direct current stimulation (tDCS) is a new technological-based intervention with various modes of applicability. Therefore, we aimed to study the effectiveness of tDCS in an individual with symptoms of chronic daily headaches and the associated comorbidities like depression, anxiety, stress, and RLS or sleepiness, numbness, a sensation of fullness, or ringing in the ears. Based on DASS-21 and Epworth questionnaires, headache diary, and semi-structured interviews, we used repeated measures for assessing the symptoms such as frequency, duration, intensity, or severity of chronic daily headaches and associated comorbidities at baseline, after tDCS-intervention, and at a 12-month follow-up. The results showed that tDCS-intervention reduced the frequency, duration, intensity, or severity of chronic daily headaches and associated symptoms after tDCS-intervention and at a 12-month follow-up.</p>","PeriodicalId":9639,"journal":{"name":"Case Reports in Neurology","volume":"14 3","pages":"381-388"},"PeriodicalIF":0.7,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a7/14/crn-0014-0381.PMC9941777.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9336303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Punctate Enhancement of Bilateral Basal Ganglia in a Case of Epstein-Barr Virus Encephalitis. eb病毒脑炎的双侧基底神经节点状强化1例。
IF 0.7
Case Reports in Neurology Pub Date : 2022-09-01 DOI: 10.1159/000526049
Takafumi Wada, Toru Yamamoto, Akihiko Ozaki
{"title":"Punctate Enhancement of Bilateral Basal Ganglia in a Case of Epstein-Barr Virus Encephalitis.","authors":"Takafumi Wada,&nbsp;Toru Yamamoto,&nbsp;Akihiko Ozaki","doi":"10.1159/000526049","DOIUrl":"https://doi.org/10.1159/000526049","url":null,"abstract":"<p><p>Epstein-Barr virus (EBV) encephalitis is caused by initial infection or reactivation of EBV. In adults, the risk factors of EBV encephalitis include human immunodeficiency virus infection, immunosuppressant drugs, congenital immune deficiencies, post-stem cell transplantation, and post-solid organ transplantation. However, a few cases of adult-onset EBV encephalitis without these risk factors were also reported. The efficacy of steroid or intravenous immunoglobulin remains unclear in the treatment of EBV encephalitis. Herein, we report a case of an 82-year-old man with fever and disturbance of consciousness who was diagnosed as having EBV encephalitis. Gadolinium-enhanced magnetic resonance imaging showed punctate enhancement in the bilateral basal ganglia, which resembled chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS). Symptoms and enhanced lesions improved after immunotherapy. Immunotherapy may be effective in the treatment of EBV encephalitis with CLIPPERS-like lesions.</p>","PeriodicalId":9639,"journal":{"name":"Case Reports in Neurology","volume":"14 3","pages":"397-403"},"PeriodicalIF":0.7,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d5/89/crn-0014-0397.PMC9941769.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9321539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rhabdomyolysis after COVID-19 Comirnaty Vaccination: A Case Report. COVID-19社区疫苗接种后横纹肌溶解1例报告
IF 0.7
Case Reports in Neurology Pub Date : 2022-09-01 DOI: 10.1159/000527599
Veerle J Ruijters, Marjon F G van der Meulen, Michael A van Es, Tessa Smit, Jessica E Hoogendijk
{"title":"Rhabdomyolysis after COVID-19 Comirnaty Vaccination: A Case Report.","authors":"Veerle J Ruijters,&nbsp;Marjon F G van der Meulen,&nbsp;Michael A van Es,&nbsp;Tessa Smit,&nbsp;Jessica E Hoogendijk","doi":"10.1159/000527599","DOIUrl":"https://doi.org/10.1159/000527599","url":null,"abstract":"<p><p>Rhabdomyolysis is an acute disruption in skeletal muscle integrity, leading to the rapid release of 4 muscle contents into the bloodstream, such as creatine kinase (CK). It can have various causes, including infections. Throughout the pandemic, multiple cases of rhabdomyolysis following COVID-19 infections have been reported. However, rhabdomyolysis subsequent to COVID-19 vaccinations appears to be relatively rare. Here, we report such a case after a second COVID-19 Comirnaty (BioNTech/Pfizer) vaccination. Our patient developed rhabdomyolysis 1 day after the second Comirnaty vaccination with high creatine kinase (CK) levels, generalized weakness, and kidney failure. CK levels and muscle weakness resolved after treatment with intravenous fluids, but unfortunately, he remained hemodialysis dependent after discharge. To our knowledge, this is one of the first case reports describing a patient with rhabdomyolysis after a Comirnaty vaccination. However, as millions of people have received the Comirnaty vaccine, it is unclear whether the rhabdomyolysis in our patient is a rare side effect or an unrelated, coincidental event. Large observational studies are needed to elucidate the causality between the Comirnaty vaccination and rhabdomyolysis. Awareness is warranted in patients with myalgia and muscle weakness shortly after COVID-19 vaccination, in order to initiate treatment early and prevent life-threatening complications.</p>","PeriodicalId":9639,"journal":{"name":"Case Reports in Neurology","volume":"14 3","pages":"429-432"},"PeriodicalIF":0.7,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/95/f5/crn-0014-0429.PMC9830288.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10525860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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