Punctate Enhancement of Bilateral Basal Ganglia in a Case of Epstein-Barr Virus Encephalitis.

IF 0.6 Q4 CLINICAL NEUROLOGY

Case Reports in Neurology Pub Date : 2022-09-01 DOI:10.1159/000526049

Takafumi Wada, Toru Yamamoto, Akihiko Ozaki

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Abstract

Epstein-Barr virus (EBV) encephalitis is caused by initial infection or reactivation of EBV. In adults, the risk factors of EBV encephalitis include human immunodeficiency virus infection, immunosuppressant drugs, congenital immune deficiencies, post-stem cell transplantation, and post-solid organ transplantation. However, a few cases of adult-onset EBV encephalitis without these risk factors were also reported. The efficacy of steroid or intravenous immunoglobulin remains unclear in the treatment of EBV encephalitis. Herein, we report a case of an 82-year-old man with fever and disturbance of consciousness who was diagnosed as having EBV encephalitis. Gadolinium-enhanced magnetic resonance imaging showed punctate enhancement in the bilateral basal ganglia, which resembled chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS). Symptoms and enhanced lesions improved after immunotherapy. Immunotherapy may be effective in the treatment of EBV encephalitis with CLIPPERS-like lesions.

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eb病毒脑炎的双侧基底神经节点状强化1例。

eb病毒(EBV)脑炎是由EBV的初次感染或再激活引起的。在成人中，EBV脑炎的危险因素包括人类免疫缺陷病毒感染、免疫抑制药物、先天性免疫缺陷、干细胞移植后和实体器官移植后。然而，也报道了少数没有这些危险因素的成人发作的EBV脑炎病例。类固醇或静脉注射免疫球蛋白治疗EBV脑炎的疗效尚不清楚。在此，我们报告一个82岁男性发烧和意识障碍的病例，他被诊断为EBV脑炎。钆增强磁共振成像显示双侧基底节区点状强化，与慢性淋巴细胞炎症相似，脑桥周围血管增强对类固醇有反应(CLIPPERS)。免疫治疗后症状和强化病变得到改善。免疫疗法可能是有效的治疗EBV脑炎与clipps样病变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Case Reports in Neurology Medicine-Neurology (clinical)

CiteScore

1.50

自引率

0.00%

发文量

审稿时长

14 weeks

期刊介绍： This new peer-reviewed online-only journal publishes original case reports covering the entire spectrum of neurology. Clinicians and researchers are given a tool to disseminate their personal experience to a wider public as well as to review interesting cases encountered by colleagues all over the world. To complement the contributions supplementary material is welcomed. The reports are searchable according to the key words supplied by the authors; it will thus be possible to search across the entire growing collection of case reports with universally used terms, further facilitating the retrieval of specific information. Following the open access principle, the entire contents can be retrieved at no charge, guaranteeing easy access to this valuable source of anecdotal information at all times.