Case Reports in Neurology最新文献_第2页

Spinal Teratoma with Recurrent Epileptic Episodes in Adults: A Case Report. 脊柱畸胎瘤伴成人癫痫反复发作：病例报告。

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Case Reports in Neurology Pub Date : 2024-09-18 eCollection Date: 2024-01-01 DOI: 10.1159/000541522

Jinlong Wang, Bo Cao

{"title":"Spinal Teratoma with Recurrent Epileptic Episodes in Adults: A Case Report.","authors":"Jinlong Wang, Bo Cao","doi":"10.1159/000541522","DOIUrl":"https://doi.org/10.1159/000541522","url":null,"abstract":"Introduction: Spinal teratomas are rare, accounting for nearly 0.2-0.5% of all spinal tumors and 2% of all teratomas. Teratomas at the conus medullaris location do not inherently lead to epilepsy. However, potential epileptic seizures are caused when teratoma ruptures and the chemical stimulation of teratoma components enter the dural sac.Case presentation: A 31-year-old Asian male patient suffering from epileptic onset and poor antiepileptic treatment was demonstrated. The spinal imaging examination was performed, and the patient suffered a space-occupying lesion within the conus medullaris related to spinal deformity, spinal embolism, etc. The autoimmune encephalitis spectrum revealed mGluR5 antibody IgG (+) 1:10 response. The patient stabilized after treatment with hormones and human immunoglobulin. Some hair and lipid droplets could be observed in the dural sac intraoperatively, and more hair and lipid-like material were present in the spinal cord. Postoperative pathology established the diagnosis as a conus medullaris teratoma in adults. Epileptic seizures stopped after surgery, and no additional seizures were reported during the 33-month follow-up period.Conclusions: Conus medullaris teratoma rupture in adults rarely causes epileptic seizures. For spinal deformity patients with unexplained epileptic symptoms, spinal MRI can be helpful in early diagnosis, and more appropriate treatment improves disease prognosis.","PeriodicalId":9639,"journal":{"name":"Case Reports in Neurology","volume":"16 1","pages":"249-255"},"PeriodicalIF":0.6,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11521525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Head-Up Tilt Sleeping to Treat Orthostatic Intolerance in a Patient with Advanced Parkinson's Disease: A Case Report. 用仰卧睡眠法治疗晚期帕金森病患者的直立性不耐受：病例报告。

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Case Reports in Neurology Pub Date : 2024-09-17 eCollection Date: 2024-01-01 DOI: 10.1159/000541424

Amber H van der Stam, Sharon Shmuely, Nienke M de Vries, Roland D Thijs, Mirjam van Kesteren-Biegstraaten, Bastiaan R Bloem

{"title":"Head-Up Tilt Sleeping to Treat Orthostatic Intolerance in a Patient with Advanced Parkinson's Disease: A Case Report.","authors":"Amber H van der Stam, Sharon Shmuely, Nienke M de Vries, Roland D Thijs, Mirjam van Kesteren-Biegstraaten, Bastiaan R Bloem","doi":"10.1159/000541424","DOIUrl":"https://doi.org/10.1159/000541424","url":null,"abstract":"Introduction: Orthostatic hypotension is common in people with Parkinson's disease (PD) due to autonomic dysfunction and medication use and can have a significant negative impact on quality of life. Pharmacological treatment is often complicated due to complex blood pressure regulation problems. This case report presents a patient whose symptoms of orthostatic intolerance were successfully treated with the non-pharmacological method of head-up tilt sleeping (HUTS).Case presentation: A 69-year-old man with PD and prominent autonomic failure received recommendation from the neurologist to use HUTS to battle orthostatic intolerance, of which complaints were worst in the early morning. The patient noted a marked improvement of the orthostatic intolerance after a period in which he slowly step-by-step inclined the bed to an angle just over 10°. When ceasing HUTS for a brief period, complaints of orthostatic intolerance immediately returned and the patient returned to tilted sleeping right away. After a follow-up of 3 months, the patient did not report orthostatic intolerance during a standing test.Conclusion: This case illuminates that, despite difficulties intrinsic to this method, whole-body HUTS can ameliorate orthostatic intolerance and improve the daily life of people with advanced movement disorders.","PeriodicalId":9639,"journal":{"name":"Case Reports in Neurology","volume":"16 1","pages":"256-261"},"PeriodicalIF":0.6,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11521494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effective Management of Chronic Intestinal Pseudo-Obstruction in MELAS Using Acotiamide: A Case Report. 使用阿考替酰胺有效治疗 MELAS 的慢性假性肠梗阻：病例报告。

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Case Reports in Neurology Pub Date : 2024-09-14 eCollection Date: 2024-01-01 DOI: 10.1159/000541012

Yuri Kawano, Akira Taniguchi, Yugo Narita, Ken Kagawa, Tetsuro Harada, Akihiro Shindo

{"title":"Effective Management of Chronic Intestinal Pseudo-Obstruction in MELAS Using Acotiamide: A Case Report.","authors":"Yuri Kawano, Akira Taniguchi, Yugo Narita, Ken Kagawa, Tetsuro Harada, Akihiro Shindo","doi":"10.1159/000541012","DOIUrl":"10.1159/000541012","url":null,"abstract":"Introduction: Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) is reported to be a secondary cause of chronic intestinal pseudo-obstruction (CIPO). Although few case reports have described CIPO in MELAS, effective treatment for CIPO has not been established. Here, we present a case report of amelioration of CIPO symptoms using acotiamide in a patient with MELAS.Case presentation: A 51-year-old Japanese female with a mitochondrial disorder with m.3243A>G mutation and a history of anorexia for 2 years presented to our hospital with a left temporal headache and acute paraphasia. A stroke-like episode of MELAS was suspected and combined therapy with arginine, edaravone, and levetiracetam was initiated. Although her symptoms improved, she presented with nausea and vomiting and abdominal distension 6 days following admission. Abdominal contrast-enhanced computed tomography revealed dilatation from the stomach to the intestine, particularly marked the stomach, with neither obstruction nor impaired blood flow in the intestine. CIPO exacerbation with MELAS was suspected, and the patient's symptoms gradually improved with acotiamide.Conclusion: Patients with MELAS could possibly experience stroke-like episodes during CIPO. Since acetylcholine possibly plays an important role in the pathophysiology of CIPO and acotiamide possesses prokinetic activity by inhibiting acetylcholinesterase, acotiamide could possibly improve CIPO symptoms.","PeriodicalId":9639,"journal":{"name":"Case Reports in Neurology","volume":"16 1","pages":"288-293"},"PeriodicalIF":0.6,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiphasic Acute Disseminated Encephalomyelitis with a Temporal Gap of 26 Years: A Case Report with Novel Presentation. 时隔 26 年的多相急性播散性脑脊髓炎：一个表现新颖的病例报告

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Case Reports in Neurology Pub Date : 2024-08-19 eCollection Date: 2024-01-01 DOI: 10.1159/000540951

Muhammad Hamza Asif, Armeen Butt, Khadija Riaz, Faizan Shahzad, Maimoonah Asif, Muhammad Farhan, Waqas Ahmed, Besher Shami

{"title":"Multiphasic Acute Disseminated Encephalomyelitis with a Temporal Gap of 26 Years: A Case Report with Novel Presentation.","authors":"Muhammad Hamza Asif, Armeen Butt, Khadija Riaz, Faizan Shahzad, Maimoonah Asif, Muhammad Farhan, Waqas Ahmed, Besher Shami","doi":"10.1159/000540951","DOIUrl":"https://doi.org/10.1159/000540951","url":null,"abstract":"Introduction: Acute disseminated encephalomyelitis (ADEM) is an acute autoimmune demyelinating disease of the central nervous system that typically follows an acute viral infection or post-vaccination. It is more common in children than in adults and is characterized by widespread demyelination of the white matter of the brain and spinal cord. ADEM typically presents as a monophasic illness. Multiphasic ADEM has been an emerging topic with case reports highlighting the importance of the need for further investigation and literature on this topic. Multiphasic ADEM in adults is a rare presentation with an atypical course that can cause a delay in diagnosis leading to disability in patients.Case presentation: Multiple case reports have shown the presence of multiphasic ADEM without an established cause, emphasizing the importance of additional insight and data in this context. This is a unique case of multiphasic ADEM in a 59-year-old male with a temporal gap of 26 years with an idiopathic cause. He was suffering from many neurologic symptoms involving his upper and lower extremities and level of consciousness, and after he was diagnosed with ADEM, he was commenced on steroids and achieved a marked improvement in his clinical status.Conclusion: Rarely, ADEM can present with recurrence or multiple phases, which requires prompt diagnosis and treatment. These phases may or may not be preceded by an identifiable trigger. Most patients respond well to steroids. However, further studies are required to achieve a good understanding and guidelines when dealing with such cases.","PeriodicalId":9639,"journal":{"name":"Case Reports in Neurology","volume":"16 1","pages":"242-248"},"PeriodicalIF":0.6,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11521480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolated Respiratory Failure as the Presenting Symptom of Muscle-Specific Kinase Myasthenia Gravis: A Case Report and Literature Review. 以孤立性呼吸衰竭为主要症状的肌肉特异性激酶性肌萎缩症：病例报告与文献综述》（Isolated Respiratory Failure as the Presenting Symptom of Muscle-Specific Kinase Myasthenia Gravis: A Case Report and Literature Review.

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Case Reports in Neurology Pub Date : 2024-08-14 eCollection Date: 2024-01-01 DOI: 10.1159/000540916

Hassan Doumiati, Ali Ezzeddine

{"title":"Isolated Respiratory Failure as the Presenting Symptom of Muscle-Specific Kinase Myasthenia Gravis: A Case Report and Literature Review.","authors":"Hassan Doumiati, Ali Ezzeddine","doi":"10.1159/000540916","DOIUrl":"https://doi.org/10.1159/000540916","url":null,"abstract":"Introduction: Anti-MuSK antibodies obstruct MuSK binding sites, leading to acetylcholine receptor (AChR) displacement within the postsynaptic membrane. MuSK MG patients often exhibit bulbar involvement and respiratory crises, setting them apart from other MG subtypes.Case presentation: A case of a 51-year-old male with MuSK MG that presented as isolated respiratory failure was compared to similar cases in the literature. The objectives were to explore the varied clinical presentations, treatment approaches, and outcomes, and to better understand the management of this subgroup of MG. The patient responded well to treatment with pyridostigmine, steroids, and intravenous immunoglobulins and immunosuppressive therapy.Conclusion: A review of the literature revealed varied clinical presentations and treatment approaches among reported cases. Long-term prognosis appears favorable, requiring ongoing immunosuppressive management. Although the reported outcomes of MuSK MG patients with respiratory insufficiency show substantial heterogeneity, long-term prognosis appears favorable.","PeriodicalId":9639,"journal":{"name":"Case Reports in Neurology","volume":"16 1","pages":"233-241"},"PeriodicalIF":0.6,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11521485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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Case Reports in Neurology Pub Date : 2024-08-13 eCollection Date: 2024-01-01 DOI: 10.1159/000539899

Bonifacio Pedregosa, Mark Ramos, Steven Villaraza

引用次数: 0

Cerebrospinal Fluid Leak and Idiopathic Intracranial Hypertension in a Transgender Male: Is Intracranial Hypertension Hormonally Mediated? 一名变性男性的脑脊液漏和特发性颅内高压：颅内高压由激素介导吗？

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Case Reports in Neurology Pub Date : 2024-07-25 eCollection Date: 2024-01-01 DOI: 10.1159/000540259

Isaac Smith, Raissa Aoun, Rebecca Lalchan

{"title":"Cerebrospinal Fluid Leak and Idiopathic Intracranial Hypertension in a Transgender Male: Is Intracranial Hypertension Hormonally Mediated?","authors":"Isaac Smith, Raissa Aoun, Rebecca Lalchan","doi":"10.1159/000540259","DOIUrl":"https://doi.org/10.1159/000540259","url":null,"abstract":"Introduction: The pathophysiology of idiopathic intracranial hypertension (IIH) is not fully characterized, and less is known about its development in transgender patients. Several cases of IIH in transgender patients have been reported, but fewer cases have been published that identify a cerebrospinal fluid (CSF) leak as a complication of IIH in this population. These patients can serve as an important study population, as an association between exogenous testosterone use in karyotypical females and development of IIH may support a hormonally mediated mechanism of development of this disease.Case presentation: We describe the case of a 33-year-old obese (BMI: 30.58 kg/m2) female-to-male transgender patient on exogenous testosterone for 15 years who presented with 1 month of acute or chronic headache with profuse rhinorrhea. Fundoscopic exam revealed disk pallor and edema consistent with a Frisen grade 3 papilledema. Nasal secretion was positive for beta-2 transferrin, consistent with CSF. Computed tomography head demonstrated a 5-mm defect in the medial left middle cranial fossa, bilateral optic nerve prominence and tortuosity, and abnormal arachnoid granulations concerning for IIH. After a successful endoscopic endonasal repair of the left lateral sphenoid recess leak, our patient continued to report headaches, was started on acetazolamide, and noted improvement in symptoms.Conclusion: The case described herein further supports the growing body of evidence that implicates a hormonal mechanism of action in the development of IIH. Importantly, it also addresses the need for increased study and conversation about rare neurologic diseases in transgender patients.","PeriodicalId":9639,"journal":{"name":"Case Reports in Neurology","volume":"16 1","pages":"213-220"},"PeriodicalIF":0.6,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11521422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Status Epilepticus and Low-Grade Glioma in the Pregnant State: Case Report and Ethical Considerations. 孕妇癫痫状态和低级别胶质瘤：病例报告与伦理考虑。

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Case Reports in Neurology Pub Date : 2024-07-17 eCollection Date: 2024-01-01 DOI: 10.1159/000539510

Andrew L Waack, Vito M Lucarelli, Amulya Marellapudi, Alisa Gega, Andrew J Zillgitt, Michael D Staudt

{"title":"Status Epilepticus and Low-Grade Glioma in the Pregnant State: Case Report and Ethical Considerations.","authors":"Andrew L Waack, Vito M Lucarelli, Amulya Marellapudi, Alisa Gega, Andrew J Zillgitt, Michael D Staudt","doi":"10.1159/000539510","DOIUrl":"10.1159/000539510","url":null,"abstract":"Introduction: The pregnant state may cause or exacerbate existing neurological disease. Gliomas appear to be influenced by the physiological changes that occur during pregnancy. The pregnant state may also cause seizures, including status epilepticus. There are currently no defined treatment guidelines to direct clinical decision making, and many of the commonly employed therapies are contraindicated during pregnancy.Case presentation: The current article describes the case of a 40-year-old G3P1101 female at 10 weeks' gestation, who sought medical care for recurrent left hemifacial twitching, eventually leading to nonconvulsive status epilepticus. Intubation and sedation were required to achieve seizure cessation. Imaging revealed a lobulated cystic mass in the right parietal lobe, suspicious for low-grade glioma. Despite thorough explanation of the potential risks, the patient adamantly wished to pursue surgical intervention. An uneventful craniotomy was performed for resection of a low-grade glioma. No patient or fetal complications were encountered, and the patient has not had any reported seizures since surgery.Discussion: Managing complex neurosurgical diseases in pregnant patients provides both clinical and ethical quandaries. We describe the successful management of a patient presenting with status epilepticus caused by an underlying glioma during pregnancy. Although challenging, favorable neurosurgical outcomes are possible during pregnancy.","PeriodicalId":9639,"journal":{"name":"Case Reports in Neurology","volume":"16 1","pages":"196-203"},"PeriodicalIF":0.6,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11324210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141981811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endovascular Mechanical Thrombectomy for Ischemic Stroke Treatment in the Setting of Aortic Dissection: Case Report. 治疗主动脉夹层缺血性脑卒中的血管内机械取栓术：病例报告。

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Case Reports in Neurology Pub Date : 2024-06-21 eCollection Date: 2024-01-01 DOI: 10.1159/000539441

Luis Alberto Cruz-Saavedra, Jeet Patel, Daniel Siragusa, Scott L Silliman

{"title":"Endovascular Mechanical Thrombectomy for Ischemic Stroke Treatment in the Setting of Aortic Dissection: Case Report.","authors":"Luis Alberto Cruz-Saavedra, Jeet Patel, Daniel Siragusa, Scott L Silliman","doi":"10.1159/000539441","DOIUrl":"10.1159/000539441","url":null,"abstract":"Introduction: Acute ischemic stroke can occur in the setting of aortic dissection. Information concerning the utility of endovascular mechanical thrombectomy as an intervention for patients with aortic dissection who are experiencing an acute stroke due to large vessel occlusion is limited to a few case reports. Case series of patients presenting with this clinical situation are needed to further investigate the potential utility of this procedure when patients with acute ischemic stroke and aortic dissection are encountered.Case presentation: We report a patient with a chronic Stanford type A aortic dissection with dissection extension into the left common carotid artery and left internal carotid artery who had a good clinical outcome following mechanical thrombectomy for a symptomatic middle cerebral artery occlusion. We also review other cases in which endovascular mechanical thrombectomy was conducted in patients with aortic dissection and acute ischemic stroke and discuss the potential risks and benefits of carotid artery stenting in this clinical situation.Conclusion: The rate of successful arterial recanalization in patients with aortic dissection, large vessel occlusion, and acute ischemic stroke treated with mechanical thrombectomy is high. The intervention has been associated with good neurological outcomes and a low rate of procedure-related complications. Additional case series are needed to help discern if our observations are present in a broader array of patients in order to identify which patients are most likely to benefit from mechanical thrombectomy.","PeriodicalId":9639,"journal":{"name":"Case Reports in Neurology","volume":"16 1","pages":"159-170"},"PeriodicalIF":0.6,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11249457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141626173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Case of Coronavirus Disease 2019 Encephalitis Mimicking Creutzfeldt-Jacob Disease in an Immunocompromised Patient: A Case Report. 一例罕见的模仿克雅氏症的冠状病毒病 2019 年脑炎病例：病例报告。

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Case Reports in Neurology Pub Date : 2024-06-13 eCollection Date: 2024-01-01 DOI: 10.1159/000539741

Naveenkumar Nallathambi, Shriganesh P Naidu, Yogesh S, Balamanikandan P, Adithyan C, Navvin S, Hariharan Seshadri, Mohanapriya N, Suriya Prakash

{"title":"A Rare Case of Coronavirus Disease 2019 Encephalitis Mimicking Creutzfeldt-Jacob Disease in an Immunocompromised Patient: A Case Report.","authors":"Naveenkumar Nallathambi, Shriganesh P Naidu, Yogesh S, Balamanikandan P, Adithyan C, Navvin S, Hariharan Seshadri, Mohanapriya N, Suriya Prakash","doi":"10.1159/000539741","DOIUrl":"10.1159/000539741","url":null,"abstract":"Introduction: Coronavirus disease 2019 (COVID-19) encephalitis is characterized by viral entry into the brain, resulting in inflammation and a cascade of neuronal damage. Clinical manifestations include headaches, seizures, and movement disorders. A mortality rate of 20% and infrequent presentation make COVID-19 encephalitis a diagnostic challenge.Case presentation: We hereby present the case of a 55-year-old man with a history of diabetes mellitus (potential impact on COVID-19 severity discussed in the supplementary material) presenting with altered sensorium, swelling in the left eye, and involuntary jerky limb movements. Neurological examination revealed neck rigidity, myoclonic jerks, and an extensor plantar response. Brain magnetic resonance imaging (MRI) was performed, which revealed cortical enhancement in the bifrontal, temporal, and occipital lobes. Rapid progression of myoclonus, altered sensorium, and cortical enhancement on MRI suggested Creutzfeldt-Jacob disease. After a thorough workup, the diagnosis was COVID-19 encephalitis with rhino-orbital mucormycosis. The treatment regimen consisted of adequate glycemic control, remdesivir injection, intravenous and retroorbital liposomal amphotericin, and levetiracetam. The patient's condition improved, and he was eventually discharged.Conclusion: This case illustrates the uncommon presentation of COVID-19 with neurological involvement and emphasizes the value of history-taking, neuroimaging, and cerebrospinal fluid analysis. A high index of suspicion is critical for a prompt diagnosis and initiating therapy.","PeriodicalId":9639,"journal":{"name":"Case Reports in Neurology","volume":"16 1","pages":"180-187"},"PeriodicalIF":0.6,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11249769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141626170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0