Case Reports in Ophthalmology最新文献_第2页

Cholesterolosis Bulbi in an Eye with Retinal Capillary Hemangioma: A Rare Association with Chemical Analysis. 伴有视网膜毛细血管瘤的眼球胆固醇升高：与化学分析的罕见关联。

IF 0.5

Case Reports in Ophthalmology Pub Date : 2025-04-03 eCollection Date: 2025-01-01 DOI: 10.1159/000545564

Abdelwahab Aleshawi, Rami Al-Dwairi, Mohammad Al Qudah, Abdallah Sharayah, Mahmood Al Nuaimi, Hashem Abu Serhan

{"title":"Cholesterolosis Bulbi in an Eye with Retinal Capillary Hemangioma: A Rare Association with Chemical Analysis.","authors":"Abdelwahab Aleshawi, Rami Al-Dwairi, Mohammad Al Qudah, Abdallah Sharayah, Mahmood Al Nuaimi, Hashem Abu Serhan","doi":"10.1159/000545564","DOIUrl":"https://doi.org/10.1159/000545564","url":null,"abstract":"Introduction: Cholesterolosis bulbi is an ocular condition characterized by the accumulation of cholesterol crystals in the vitreous cavity. This case describes the development of anterior chamber cholesterolosis bulbi secondary to retinal capillary hemangioma.Case presentation: A 26-year-old female, tested negative for von Hippel-Lindau (VHL) syndrome, presented with yellow shinny crystals filling the anterior chamber of the left eye and similar depositions filling the vitreous cavity along with reactivated hemangioma with new feeder vessels. She was diagnosed previously with bilateral capillary retinal hemangiomas. Anterior chamber and vitreous washout and endo-laser photocoagulation for the hemangioma were performed. Analysis of the aqueous sample revealed numerous well-demarcated, rectangular, or polygonal lipid-like crystals on light microscopy. Cholesterolosis bulbi secondary to retinal capillary hemangioma was established.Conclusions: Cholesterolosis bulbi secondary to retinal capillary hemangioma is a rare association and would warrant for extensive tumor or associated complications.","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"16 1","pages":"336-340"},"PeriodicalIF":0.5,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transdermal and Powdered Scopolamine-Induced Anisocoria: A Report of Two Cases. 经皮及粉末状东莨菪碱致异色虫2例报告。

IF 0.5

Case Reports in Ophthalmology Pub Date : 2025-04-02 eCollection Date: 2025-01-01 DOI: 10.1159/000545362

Leyan Li, Lili Lian, Rong Zhou

{"title":"Transdermal and Powdered Scopolamine-Induced Anisocoria: A Report of Two Cases.","authors":"Leyan Li, Lili Lian, Rong Zhou","doi":"10.1159/000545362","DOIUrl":"https://doi.org/10.1159/000545362","url":null,"abstract":"Introduction: In this case report, we present 2 cases of sudden-onset anisocoria caused by accidental exposure to scopolamine in 2 young female patients.Case presentation: Two patients presented with unilateral anisocoria. One patient experienced unilateral mydriasis accompanied by neurological symptoms from a transdermal scopolamine patch, while the other, exposed to powdered scopolamine, presented with unilateral mydriasis without additional neurological symptoms. Both cases showed gradual resolution of symptoms over several days without intervention. Initially, Adie's pupil (tonic pupil) was high in the differential diagnosis, but a comprehensive history taking revealed scopolamine exposure as the more likely cause. In the first case, pilocarpine did not result in miosis, while in the second case, pilocarpine initially induced miosis but was followed by a return to mydriasis. Although current literature suggests that mydriasis caused by an anticholinergic substance presents as pupil dilation unresponsive to pilocarpine, our case series shows its inconsistency in clinical presentation.Conclusion: This report presents 1 case of systemic scopolamine toxicity, alongside unilateral mydriasis, adding confusion to the case given the expected bilateral mydriasis in systemic toxicity, and another case of pharmacological anisocoria secondary to exposure to scopolamine with an atypical reaction to pilocarpine. These cases highlight the importance of thorough history taking and the need to consider pharmacological causes in the differential diagnosis of acute anisocoria.","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"16 1","pages":"341-345"},"PeriodicalIF":0.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077860/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case Report of Successful Cataract Surgery in Theil-Behnke Corneal Dystrophy: A Visual Rehabilitation for the Patient. 角膜营养不良患者白内障手术成功1例：视力康复。

IF 0.5

Case Reports in Ophthalmology Pub Date : 2025-03-28 eCollection Date: 2025-01-01 DOI: 10.1159/000544846

Radhika Paranjpe, Varsha Manade, Preethi Abraham, Khushboo Goyal, Surbhi Chodvadiya

{"title":"A Case Report of Successful Cataract Surgery in Theil-Behnke Corneal Dystrophy: A Visual Rehabilitation for the Patient.","authors":"Radhika Paranjpe, Varsha Manade, Preethi Abraham, Khushboo Goyal, Surbhi Chodvadiya","doi":"10.1159/000544846","DOIUrl":"https://doi.org/10.1159/000544846","url":null,"abstract":"Introduction: Thiel-Behnke corneal dystrophy is a rare inherited condition characterized by symmetrical subepithelial corneal opacities that gradually reduce vision. It is an autosomal dominant inherited epithelial stromal TGFB1 dystrophy that mainly causes visual impairment.Case presentation: This case report describes case of a woman in her early 50s with progressive vision loss in her left eye over the past 3 months with a history of recurrent corneal erosions in childhood. Examination on a slit lamp showed corneal dystrophy affecting both eyes, matching the features of Thiel-Behnke dystrophy. Diagnosis was confirmed with anterior segment-optical coherence tomography, revealing a distinctive sawtooth pattern in Bowman's layer. The patient was managed conservatively for her dystrophy and was also surgically treated for her cataract in the left eye, which showed a significant improvement in her vision.Conclusion: Despite its rarity, Thiel-Behnke dystrophy along with cataract can severely impair vision, making early diagnosis and continuous monitoring crucial for preventing further visual decline.","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"16 1","pages":"308-312"},"PeriodicalIF":0.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mycobacterium chelonae Keratitis following Keratorefractive Lenticule Extraction: Highlighting Diagnostic and Treatment Complexities. 角膜屈光性晶状体提取后的龟分枝杆菌角膜炎：突出诊断和治疗的复杂性。

IF 0.5

Case Reports in Ophthalmology Pub Date : 2025-03-27 eCollection Date: 2025-01-01 DOI: 10.1159/000545563

Natalie Elizabeth Allen, Sarah Sarah, Sally Roberts, Stephen R Ritchie, Alexandra Z Crawford, Bia Kim

{"title":"Mycobacterium chelonae Keratitis following Keratorefractive Lenticule Extraction: Highlighting Diagnostic and Treatment Complexities.","authors":"Natalie Elizabeth Allen, Sarah Sarah, Sally Roberts, Stephen R Ritchie, Alexandra Z Crawford, Bia Kim","doi":"10.1159/000545563","DOIUrl":"https://doi.org/10.1159/000545563","url":null,"abstract":"Introduction: This is a rare case of Mycobacterium chelonae keratitis following keratorefractive lenticule extraction (KLEX).Case presentation: A 35-year-old female presented to the emergency eye clinic with 4 days of eye pain and decreased vision following KLEX surgery. She was using topical tobramycin drops four times per day, which was changed to ciprofloxacin drops. Following initial improvement, the eye deteriorated with further stromal infiltrates. A corneal culture identified M. chelonae. The keratitis required extensive topical and systemic medications, repeat scrapes, and an amniotic membrane over several weeks to reach quiescence. Vision deteriorated to hand movements, but an emergency keratoplasty was avoided.Conclusion: This is the third reported case serving to highlight the diagnostic and treatment challenges associated with postoperative keratitis involving nontuberculous mycobacteria.","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"16 1","pages":"302-307"},"PeriodicalIF":0.5,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12037160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel Pathogenic Variants in IFT140 and IFT172 Genes in Three Patients with Similar Retinal Dystrophy Phenotypes. 三例视网膜营养不良相似表型患者中IFT140和IFT172基因的新致病变异

IF 0.5

Case Reports in Ophthalmology Pub Date : 2025-03-26 eCollection Date: 2025-01-01 DOI: 10.1159/000545390

Jennifer Adeghate, Samantha R Goldburg, Sherry Bass, Joshua Schwimmer, Talia R Kaden

{"title":"Novel Pathogenic Variants in IFT140 and IFT172 Genes in Three Patients with Similar Retinal Dystrophy Phenotypes.","authors":"Jennifer Adeghate, Samantha R Goldburg, Sherry Bass, Joshua Schwimmer, Talia R Kaden","doi":"10.1159/000545390","DOIUrl":"https://doi.org/10.1159/000545390","url":null,"abstract":"Introduction: The intraflagellar transport (IFT) complex plays a key role in protein transport and turnover within photoreceptors. IFT140 and IFT172 gene mutations have been associated with skeletal ciliopathies that occur concurrently with retinal dystrophy. These mutations have also been associated with non-syndromic retinal dystrophies. This phenotypic heterogeneity can make diagnosis challenging. Here, we report novel variants in IFT140 and IFT172 genes in 3 patients with similar retinal dystrophy phenotypes.Case presentations: Two siblings (a 51-year-old male and 46-year-old male) who presented with a similar retinal dystrophy, skeletal abnormalities, and kidney disease were found to have the same novel variant in the IFT140 gene, along with another, previously reported variant. An unrelated individual with a similar retinal phenotype was found to have a novel variant in the IFT172 gene, although this was noted as a variant of uncertain significance. The patients underwent testing with the Blueprint Genetics (Blueprint Genetics Oy, Keilaranta 16 A-B, 02150 Espoo, Finland) \"My Retina Tracker Program Panel Plus\" panel.Conclusion: Novel variants in the IFT140 and IFT172 genes encoding the IFT complex may contribute to similar retinal dystrophy phenotypes, as noted in our case series.","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"16 1","pages":"323-330"},"PeriodicalIF":0.5,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077866/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bilateral Vasoproliferative Tumors in Usher Syndrome. Usher综合征的双侧血管增生性肿瘤。

IF 0.5

Case Reports in Ophthalmology Pub Date : 2025-03-25 eCollection Date: 2025-01-01 DOI: 10.1159/000542415

Francesco Pichi, Federico Rissotto, Khalid N Qadha, Scott D Smith, Arif O Khan

引用次数: 0

Presumed Choroidal Metastasis of Primary Cutaneous Melanoma: A Case Report. 原发性皮肤黑色素瘤的脉络膜转移：1例报告。

IF 0.5

Case Reports in Ophthalmology Pub Date : 2025-03-24 eCollection Date: 2025-01-01 DOI: 10.1159/000544879

Teele Palumaa, Artur Klett

{"title":"Presumed Choroidal Metastasis of Primary Cutaneous Melanoma: A Case Report.","authors":"Teele Palumaa, Artur Klett","doi":"10.1159/000544879","DOIUrl":"https://doi.org/10.1159/000544879","url":null,"abstract":"Introduction: Choroidal metastases most often originate from breast tumors in females and lung cancer in males. Primary cutaneous tumors rarely metastasize to the uveal tract.Case presentation: Here, we present a rare case of a 47-year-old female patient who was clinically diagnosed with a presumed choroidal metastasis of primary cutaneous melanoma. The patient presented with complaints of decreased vision in her right eye. Her best corrected visual acuity (BCVA) was 0.7 decimal in the right eye and 1.0 in the left eye. Examination revealed a pigmented choroidal lesion in the parafoveal region with a prominence of 2.9 mm, orange pigment on the surface, and subretinal fluid in its projection. She had no history of active malignancy, but at the age of 36, a localized stage IB cutaneous melanoma was removed from her back. Yearly follow-up visits at the dermatologist showed no evidence of active disease. Upon diagnosis of a choroidal tumor, the patient underwent brachytherapy with a ruthenium-106 plaque in the right eye. Follow-up at the oncologist revealed a widespread disease with metastases in distant lymph nodes, liver, lung, pancreas, and brain, an uncommon pattern for primary choroidal melanomas, resembling rather the metastasis pattern of primary cutaneous melanoma. The patient was started on systemic therapy against metastatic cutaneous melanoma. At 21 months after brachytherapy and 19 months after the initiation of systemic anticancer therapy, the patient's BCVA in the right eye returned to 1.0 decimal, the choroidal lesion reduced in size, and subretinal fluid receded. Two years after the initial presentation, all metastases were stable or decreased in size.Conclusion: This case highlights the possibility of a choroidal metastasis of cutaneous melanoma more than a decade after the first presentation of the disease and highlights the effectiveness of combined brachytherapy and systemic anticancer therapy in managing the disease.","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"16 1","pages":"267-273"},"PeriodicalIF":0.5,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12002729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Orbital Fracture Resulting in Contralateral Optic Canal Fracture with Traumatic Optic Neuropathy: A Case Report. 眼眶骨折致对侧视神经管骨折伴外伤性视神经病变1例。

IF 0.5

Case Reports in Ophthalmology Pub Date : 2025-03-20 eCollection Date: 2025-01-01 DOI: 10.1159/000545040

Paulina Truong, Saif Aldeen Alryalat, Osama Al Deyabat, Amina Malik, Masayoshi Takashima, Andrew Go Lee

{"title":"Orbital Fracture Resulting in Contralateral Optic Canal Fracture with Traumatic Optic Neuropathy: A Case Report.","authors":"Paulina Truong, Saif Aldeen Alryalat, Osama Al Deyabat, Amina Malik, Masayoshi Takashima, Andrew Go Lee","doi":"10.1159/000545040","DOIUrl":"https://doi.org/10.1159/000545040","url":null,"abstract":"Introduction: Traumatic optic neuropathy (TON) can cause acute vision loss after head trauma, either due to indirect shearing forces or direct trauma, i.e., by a bony fragment of an optic canal fracture (OCF). We present a case of TON due to an isolated OCF with contralateral orbital fracture and injury.Case presentation: A 19-year old male presented with immediate total loss of vision to no light perception in the right eye after being struck on the left cheek by a lawn sign. Computed tomography and magnetic resonance imaging revealed left orbital floor fracture and right optic nerve enhancement. The patient was treated with high-dose intravenous corticosteroids and plasma exchange for a presumed inflammatory or TON. Repeat orbital imaging revealed a right OCF with bony impingement of the optic nerve. The patient underwent endoscopic optic nerve decompression; a 4 × 5 mm bone fragment abutting the optic nerve was removed. 1 month later, vision improved to hand motion.Conclusion: Imaging may fail to detect OCF, and visual prognosis depends on time to surgery and fracture pattern. Therefore, operative management and preoperative intravenous corticosteroids, though controversial, may be considered even in the absence of radiographic findings of bony impingement causing direct TON. Isolated OCF without continuous fractures originating at the injury site is also a rare fracture pattern and potential cause of direct TON.","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"16 1","pages":"290-296"},"PeriodicalIF":0.5,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12021382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fovea Sparing Branch Retinal Artery Occlusions Imaged with Optical Coherence Tomography Angiography: Two Case Reports. 光学相干断层扫描血管造影显示视网膜中央凹保留分支动脉闭塞：2例报告。

IF 0.5

Case Reports in Ophthalmology Pub Date : 2025-03-12 eCollection Date: 2025-01-01 DOI: 10.1159/000543742

Benjamin R Lin, Philip J Rosenfeld, Harry W Flynn

{"title":"Fovea Sparing Branch Retinal Artery Occlusions Imaged with Optical Coherence Tomography Angiography: Two Case Reports.","authors":"Benjamin R Lin, Philip J Rosenfeld, Harry W Flynn","doi":"10.1159/000543742","DOIUrl":"https://doi.org/10.1159/000543742","url":null,"abstract":"Introduction: Central retinal artery occlusions and branch retinal artery occlusions (BRAOs) are ophthalmic emergencies that require workups for systemic risk factors. In the acute setting, BRAOs present with retinal whitening in a sectoral pattern on exam as well as hyperreflectivity and thickening of the inner retinal layers on optical coherence tomography (OCT). In the subacute to chronic phase, the retinal whitening dissipates, which may confound the diagnosis of remote arterial occlusions if there is no clearly visible plaque.Case presentations: A 66-year-old male presented with 20/25 visual acuity (VA) and an inferior visual field defect in the right eye, and a 69-year-old male presented with 20/60 VA and a superior visual field defect in the left eye. Exams of both patients showed ischemic retinal whitening with visible Hollenhorst plaques in the affected eyes. OCT demonstrated inner retinal edema. At follow-up, wide-field OCT angiography (OCTA) showed persistent capillary dropout following the same initial vascular distribution but sparing the fovea and papillomacular bundle. VAs at the most recent follow-up visits were 20/30 and 20/20, respectively.Conclusion: These cases demonstrate the utility of wide-field OCTA in characterizing areas of capillary nonperfusion that can persist for years after the initial ischemic event. Additionally, patients with macula-involving BRAOs can have good VA outcomes if the fovea is spared.","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"16 1","pages":"274-280"},"PeriodicalIF":0.5,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12005688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Topical Losartan Treatment of Herpes Simplex Virus- or Varicella-Zoster Virus-Induced Corneal Scarring: A Case Series. 局部氯沙坦治疗单纯疱疹病毒或水痘带状疱疹病毒引起的角膜瘢痕：病例系列

IF 0.5

Case Reports in Ophthalmology Pub Date : 2025-03-11 eCollection Date: 2025-01-01 DOI: 10.1159/000545215

Barbara A L Dutra, Laura E Drew-Bear, Samantha P Herretes, Danielle Arroyo, Rodrigo Carlos de Oliveira, Lycia Pedral Sampaio, Marcony R Santhiago, Steven E Wilson

{"title":"Topical Losartan Treatment of Herpes Simplex Virus- or Varicella-Zoster Virus-Induced Corneal Scarring: A Case Series.","authors":"Barbara A L Dutra, Laura E Drew-Bear, Samantha P Herretes, Danielle Arroyo, Rodrigo Carlos de Oliveira, Lycia Pedral Sampaio, Marcony R Santhiago, Steven E Wilson","doi":"10.1159/000545215","DOIUrl":"https://doi.org/10.1159/000545215","url":null,"abstract":"Introduction: Topical losartan has emerged as a promising therapeutic option for preventing and treating corneal scarring fibrosis. Its mechanism of action involves the inhibition of ERK-mediated signaling in the noncanonical TGF-beta pathways, promoting apoptosis of myofibroblasts and facilitating a return of corneal transparency. While numerous studies in rabbits and several human case reports have demonstrated its efficacy and safety, published data on its use in clinical scenarios remain limited. This study presents 3 cases where topical losartan successfully treated corneal scarring induced by herpes simplex virus (HSV) or varicella-zoster virus (VZV) keratitis.Case presentations: Three patients (ages 40, 38, 15 years) with corneal scarring and vision loss from HSV or VZV keratitis were treated with topical 0.8 mg/mL losartan 6 times a day for 4-9 months, depending on the clinical response, after failing traditional management with corticosteroids. Best spectacle-corrected vision and slit-lamp corneal opacity improved in each case. Anterior segment OCT documented improved stromal opacity in 1 case.Conclusions: Topical losartan, a known inhibitor of fibrotic TGF-beta signaling, is potentially an effective alternative in the treatment of stromal scarring fibrosis caused by corneal HSV and VZV infections. Patients with HSV- or VZV keratitis-induced corneal scarring may be ideal candidates for planned clinical trials of the efficacy and safety of topical losartan treatment.","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"16 1","pages":"281-289"},"PeriodicalIF":0.5,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12005691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0