Case Reports in Ophthalmology最新文献_第3页

Acute Myelin Oligodendrocyte Glycoprotein-IgG Optic Neuritis without Optic Nerve Enhancement. 无视神经强化的急性髓鞘少突胶质细胞糖蛋白igg视神经炎。

IF 0.5

Case Reports in Ophthalmology Pub Date : 2024-12-03 eCollection Date: 2025-01-01 DOI: 10.1159/000542889

Bava Jeyanathan, Jonathan Micieli

{"title":"Acute Myelin Oligodendrocyte Glycoprotein-IgG Optic Neuritis without Optic Nerve Enhancement.","authors":"Bava Jeyanathan, Jonathan Micieli","doi":"10.1159/000542889","DOIUrl":"10.1159/000542889","url":null,"abstract":"Introduction: Optic neuritis (ON) is a common neuro-ophthalmological condition and remains a significant indicator of inflammatory conditions affecting the central nervous system. Varying etiologies exist for ON including multiple sclerosis, NMOSD, and MOGAD. Differential diagnosis is achieved using both radiological and serological testing. MRI characteristics of MOG-ON include T2 hypersensitive lesions, nerve swelling, and gadolinium enhancement of the affected optic nerve. While acute MOG-ON usually presents with optic nerve enhancement, recognizing atypical presentations is critical in accurate diagnosis and effective management.Case presentation: We herein present a case of a 67-year-old woman presenting with sudden decrease in vision in the right eye. The patient underwent a 3T MRI of the orbits and brain 5 days post vision loss which returned normal right optic nerve appearance at presentation (no edema, enhancement or increased T2 signal). Further serological testing of the MOG antibody returned positive (1:100) while APQ4 antibodies were negative. This yielded a diagnosis of MOG-IgG-ON. Subsequently, the patient was treated with IV methylprednisolone 1 g daily for 5 days followed by prednisone 1 mg/kg, resulting in marked improvement in vision.Conclusion: This case highlights the complexity involved in diagnosing ON, especially in the context of MOGAD. Absence of optic nerve enhancement in this patient calls attention to the possibility of subclinical inflammation and/or detectable enhancement later in clinical course. Our findings, along with existing literature, highlight the need for clinicians to consider atypical MRI presentations in MOG-ON cases. Recognizing that normal MRI does not exclude MOG-ON is important for optimizing diagnostic accuracy and effective treatment interventions.","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"16 1","pages":"7-11"},"PeriodicalIF":0.5,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11703545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serendipitous Discovery of Lipemia Retinalis in a Premature Infant: A Case Report. 意外发现早产儿视网膜脂血症1例。

IF 0.5

Case Reports in Ophthalmology Pub Date : 2024-12-03 eCollection Date: 2025-01-01 DOI: 10.1159/000542961

Homayoun Nikkhah, Narges Karrabi, Ehsan Yazdani, Rezvan Nezameslami

{"title":"Serendipitous Discovery of Lipemia Retinalis in a Premature Infant: A Case Report.","authors":"Homayoun Nikkhah, Narges Karrabi, Ehsan Yazdani, Rezvan Nezameslami","doi":"10.1159/000542961","DOIUrl":"10.1159/000542961","url":null,"abstract":"Introduction: Lipemia retinalis (LR) is a rare ocular condition characterized by a creamy white appearance of the retinal vessels, which is indicative of significantly elevated serum triglyceride (TG) levels. This condition is particularly noteworthy in pediatric populations, especially in preterm infants who are at risk for various metabolic disorders.Case presentation: We report a case of LR in a 44-day-old preterm infant identified during routine retinopathy of prematurity (ROP) screening. Unusual retinal findings led to metabolic investigations, revealing elevated TG levels confirming LR. The infant was managed with a dietary regimen including skimmed milk, resulting in a substantial decrease in TG levels and complete resolution of the retinal changes.Conclusion: Fundus examination serves as a portal to the systemic health of an individual, enabling rare identification of LR, indicative of underlying dyslipidemia. This case underscores the necessity for comprehensive metabolic screening in preterm infants, particularly during ROP assessments. Furthermore, it emphasizes the effectiveness of dietary interventions in managing LR. The favorable outcomes stress the significance of early detection of LR in pediatric patients and implementing nutritional strategies to enhance metabolic well-being, thereby averting severe hypertriglyceridemia complications.","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"16 1","pages":"1-6"},"PeriodicalIF":0.5,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11842086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human Amniotic Membrane Graft in the Management of Peripheral Hypertrophic Subepithelial Corneal Degeneration: A Case Report. 人羊膜移植治疗周围性肥厚性角膜上皮下变性1例。

IF 0.5

Case Reports in Ophthalmology Pub Date : 2024-11-21 eCollection Date: 2024-01-01 DOI: 10.1159/000541162

Pietro Rosetta, Bruno Battaglia, Sakshi Watarkar, Alessandro Feo

引用次数: 0

A Case of Aqueductal Stenosis with Bilateral Papilledema and Abducens Nerve Palsies without Headache. 导水管狭窄合并双侧乳头水肿及外展神经麻痹无头痛1例。

IF 0.5

Case Reports in Ophthalmology Pub Date : 2024-11-18 eCollection Date: 2024-01-01 DOI: 10.1159/000542582

Daisuke Nakata, Hiroshi Okada, Takayuki Doi, Yoshiaki Shimada, Atsuhiro Tanikawa, Masayuki Horiguchi, Yasuki Ito

{"title":"A Case of Aqueductal Stenosis with Bilateral Papilledema and Abducens Nerve Palsies without Headache.","authors":"Daisuke Nakata, Hiroshi Okada, Takayuki Doi, Yoshiaki Shimada, Atsuhiro Tanikawa, Masayuki Horiguchi, Yasuki Ito","doi":"10.1159/000542582","DOIUrl":"10.1159/000542582","url":null,"abstract":"Introduction: We report a case of aqueductal stenosis presenting with bilateral papilledema and diplopia, notably without headache.Case presentation: A 16-year-old girl with no relevant medical history presented with a 1-week history of binocular diplopia without any loss of visual acuity in either eye. At the time of her visit, she had no symptoms of headache or vomiting. Examination of eye movements revealed bilateral abduction deficits and fundoscopic examination showed bilateral optic disc swelling. Non-contrast computed tomography of the head indicated hydrocephalus. Contrast-enhanced magnetic resonance imaging of the head revealed significant dilatation of the lateral and third ventricles but not in the fourth ventricle. Sagittal T2-weighted imaging with constructive interference in the steady state showed membranous occlusion of the cerebral aqueduct. The patient underwent an endoscopic third ventriculostomy. Binocular diplopia improved during the early postoperative period.Conclusion: Aqueductal stenosis should be considered in the differential diagnosis for patients presenting with bilateral papilledema and abducens nerve palsies, even in the absence of headache or other neurological findings.","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"15 1","pages":"873-878"},"PeriodicalIF":0.5,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11842021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conservative Management of Intraocular Graphite Foreign Body: A Case Report and Literature Review. 眼内石墨异物保守治疗1例并文献复习。

IF 0.5

Case Reports in Ophthalmology Pub Date : 2024-11-15 eCollection Date: 2024-01-01 DOI: 10.1159/000542584

Mohamed Shadi Nayeb, Lina Okar, Mahran Zeno, Hashem Abu Serhan

引用次数: 0

Conjunctival Phlyctenule and Nodular Scleritis in a Patient with Previous Herpes Simplex Virus-2 Exposure: Causative Agent or Innocent Bystander? 曾接触过单纯疱疹病毒-2 的患者出现结膜疱疹和结节性巩膜炎：致病因子还是无辜的旁观者？

IF 0.5

Case Reports in Ophthalmology Pub Date : 2024-11-14 eCollection Date: 2024-01-01 DOI: 10.1159/000542076

Shawn Khan, Khushi Saigal, Arash Maleki

{"title":"Conjunctival Phlyctenule and Nodular Scleritis in a Patient with Previous Herpes Simplex Virus-2 Exposure: Causative Agent or Innocent Bystander?","authors":"Shawn Khan, Khushi Saigal, Arash Maleki","doi":"10.1159/000542076","DOIUrl":"10.1159/000542076","url":null,"abstract":"Introduction: Phlyctenular keratoconjunctivitis is an inflammatory condition arising from a type IV hypersensitivity reaction, presenting with inflamed nodules on the conjunctiva and cornea. Scleritis is a severe ocular inflammation linked to systemic diseases, potentially vision threatening, and involving immune responses similar to phlyctenular keratoconjunctivitis. This case report discusses a patient with a history of herpes simplex virus (HSV)-2 infection who primarily developed phlyctenular conjunctivitis and later progressed to nodular scleritis.Case presentation: A 66-year-old female presented with pain, redness, and a foreign body sensation in her left eye for 2 days. Initial treatment for epidemic keratoconjunctivitis with tobramycin-dexamethasone improved her symptoms. However, 3 weeks later, she developed a conjunctival phlyctenule. Diagnostic tests, including blood work and conjunctival swabs, were conducted. While most tests were negative, HSV-2 IgG was positive. The patient failed topical corticosteroid monotherapy; however, she responded to oral valacyclovir. Follow-up examinations showed significant improvement, with resolution of the conjunctival phlyctenule and nodular scleritis, and her best-corrected visual acuity returned to 20/20.Conclusion: This case highlights the importance of considering HSV-2 in atypical presentations of phlyctenular conjunctivitis and scleritis. The patient's response to antiviral therapy underscores the potential role of HSV-2 in such ocular inflammation. Thorough infectious workups and alternative treatment approaches are crucial in managing unconventional cases. Experimental treatments based on laboratory findings can be valuable for patients preferring conservative management, emphasizing the need for close follow-up and personalized care in ocular inflammatory diseases.","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"15 1","pages":"777-783"},"PeriodicalIF":0.5,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Asymptomatic Parasitic Worm Thelazia callipaeda Infection Found during Phacoemulsification: A Case Report. 超声乳化术中发现无症状血吸虫感染1例。

IF 0.5

Case Reports in Ophthalmology Pub Date : 2024-11-13 eCollection Date: 2024-01-01 DOI: 10.1159/000541509

Xinzhu Chen, Hanmu Guo, Yanting Li, Peirong Lu

{"title":"Asymptomatic Parasitic Worm Thelazia callipaeda Infection Found during Phacoemulsification: A Case Report.","authors":"Xinzhu Chen, Hanmu Guo, Yanting Li, Peirong Lu","doi":"10.1159/000541509","DOIUrl":"10.1159/000541509","url":null,"abstract":"Introduction: We report a case of asymptomatic Thelazia callipaeda infection discovered incidentally during phacoemulsification cataract surgery in March 2024.Case presentation: A 77-year-old male patient presented with complaints of blurred vision. During a slit-lamp examination, trichiasis was observed, but the patient had no foreign body sensation or itching. He was diagnosed with cataract and underwent phacoemulsification cataract surgery. During the surgery, a white, wriggling worm was discovered in the conjunctival sac and removed. It was later identified as Thelazia callipaeda. The surgical eye was thoroughly washed and received anti-inflammatory medication postoperatively. No recurrence or new symptoms were reported during the 3-month follow-up period.Conclusions: Thelazia callipaeda infection can be asymptomatic and incidentally discovered. A detailed preoperative examination, such as turning over the upper and lower eyelids to check the conjunctival sac, is necessary before the surgery. When a worm is discovered during surgery, it is crucial to remove it completely and thoroughly clean and disinfect the conjunctival sac.","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"15 1","pages":"859-864"},"PeriodicalIF":0.5,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11842018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leber Hereditary Optic Neuropathy "Plus" with the m.14487 T>C Mutation as the Causality of Hemidystonia: A Case Report. Leber遗传性视神经病变+ m.14487tbbb10c基因突变与半肌张力障碍的因果关系：1例报告。

IF 0.5

Case Reports in Ophthalmology Pub Date : 2024-11-13 eCollection Date: 2024-01-01 DOI: 10.1159/000542202

Fumio Takano, Kaori Ueda, Norio Chihara, Mina Arai, Mari Sakamoto, Takuji Kurimoto, Yuko Yamada-Nakanishi, Makoto Nakamura

{"title":"Leber Hereditary Optic Neuropathy \"Plus\" with the m.14487 T>C Mutation as the Causality of Hemidystonia: A Case Report.","authors":"Fumio Takano, Kaori Ueda, Norio Chihara, Mina Arai, Mari Sakamoto, Takuji Kurimoto, Yuko Yamada-Nakanishi, Makoto Nakamura","doi":"10.1159/000542202","DOIUrl":"10.1159/000542202","url":null,"abstract":"Introduction: Leber hereditary optic neuropathy (LHON) complicated with extraocular symptoms is called LHON plus. We describe a case of LHON plus with a rare mutation, which also caused dystonia.Case presentation: An 18-year-old male patient developed symptoms of dystonia at the age of 15 years. Two years later, he noticed decreased visual acuity and central scotoma in the left eye. One month later, the same symptoms occurred in the right eye. Although the optic discs in both eyes revealed mildly redness and edematous change, no abnormal findings were detected on fluorescence fundus angiography and orbital magnetic resonance imaging. Mitochondrial deoxyribonucleic acid (mtDNA) sequencing detected the m.14487 T>C mutation. From clinical course and fundus findings, the case was diagnosed LHON. The optic nerve gradually atrophied and central scotoma remained.Conclusion: The m.14487 T>C mutation is one of the causative mutations in patients with dystonia or Leigh encephalopathy and a minor mutation in patients with LHON. However, in the present case, ocular symptoms were more severe than systematic symptoms and the disease course was consistent with LHON. For the above reasons, this case can be diagnosed as LHON plus. Whole mtDNA sequencing is important in diagnosing LHON if none of the three major mutations are detected.","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"15 1","pages":"852-858"},"PeriodicalIF":0.5,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11842009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Unexpected Response of Orbital Retinoblastoma to Inconsistent Systemic Chemotherapy Alone. 眼眶视网膜母细胞瘤对单用持续性全身化疗的意外反应

IF 0.5

Case Reports in Ophthalmology Pub Date : 2024-10-29 eCollection Date: 2024-01-01 DOI: 10.1159/000541776

Khitam F Alhasseny, Haseeb Mahmud, Mohannad Al-Samarraie

引用次数: 0

Erratum. 勘误表。

IF 0.5

Case Reports in Ophthalmology Pub Date : 2024-10-28 eCollection Date: 2024-01-01 DOI: 10.1159/000542053

引用次数: 0