Case Reports in Ophthalmology最新文献_第3页

Topical Losartan Treatment of Herpes Simplex Virus- or Varicella-Zoster Virus-Induced Corneal Scarring: A Case Series. 局部氯沙坦治疗单纯疱疹病毒或水痘带状疱疹病毒引起的角膜瘢痕：病例系列

IF 0.5

Case Reports in Ophthalmology Pub Date : 2025-03-11 eCollection Date: 2025-01-01 DOI: 10.1159/000545215

Barbara A L Dutra, Laura E Drew-Bear, Samantha P Herretes, Danielle Arroyo, Rodrigo Carlos de Oliveira, Lycia Pedral Sampaio, Marcony R Santhiago, Steven E Wilson

{"title":"Topical Losartan Treatment of Herpes Simplex Virus- or Varicella-Zoster Virus-Induced Corneal Scarring: A Case Series.","authors":"Barbara A L Dutra, Laura E Drew-Bear, Samantha P Herretes, Danielle Arroyo, Rodrigo Carlos de Oliveira, Lycia Pedral Sampaio, Marcony R Santhiago, Steven E Wilson","doi":"10.1159/000545215","DOIUrl":"https://doi.org/10.1159/000545215","url":null,"abstract":"Introduction: Topical losartan has emerged as a promising therapeutic option for preventing and treating corneal scarring fibrosis. Its mechanism of action involves the inhibition of ERK-mediated signaling in the noncanonical TGF-beta pathways, promoting apoptosis of myofibroblasts and facilitating a return of corneal transparency. While numerous studies in rabbits and several human case reports have demonstrated its efficacy and safety, published data on its use in clinical scenarios remain limited. This study presents 3 cases where topical losartan successfully treated corneal scarring induced by herpes simplex virus (HSV) or varicella-zoster virus (VZV) keratitis.Case presentations: Three patients (ages 40, 38, 15 years) with corneal scarring and vision loss from HSV or VZV keratitis were treated with topical 0.8 mg/mL losartan 6 times a day for 4-9 months, depending on the clinical response, after failing traditional management with corticosteroids. Best spectacle-corrected vision and slit-lamp corneal opacity improved in each case. Anterior segment OCT documented improved stromal opacity in 1 case.Conclusions: Topical losartan, a known inhibitor of fibrotic TGF-beta signaling, is potentially an effective alternative in the treatment of stromal scarring fibrosis caused by corneal HSV and VZV infections. Patients with HSV- or VZV keratitis-induced corneal scarring may be ideal candidates for planned clinical trials of the efficacy and safety of topical losartan treatment.","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"16 1","pages":"281-289"},"PeriodicalIF":0.5,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12005691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrent Subretinal Hemorrhage in a Patient Taking a Turmeric Supplement: Case Report. 服用姜黄补充剂的患者复发性视网膜下出血：病例报告。

IF 0.5

Case Reports in Ophthalmology Pub Date : 2025-03-10 eCollection Date: 2025-01-01 DOI: 10.1159/000545076

Sherry Narang Kalla

{"title":"Recurrent Subretinal Hemorrhage in a Patient Taking a Turmeric Supplement: Case Report.","authors":"Sherry Narang Kalla","doi":"10.1159/000545076","DOIUrl":"https://doi.org/10.1159/000545076","url":null,"abstract":"Introduction: This case report highlights the importance of knowing what nonprescription medications and supplements are being taken by patients in addition to their prescribed medications.Case presentation: A 48-year-old myopic male presented with a 1-day history of hand motion vision. He was found to have an extensive vitreous hemorrhage with no view of the fundus. On follow-up 4 days later, he continued to have a significant vitreous hemorrhage and a B scan that showed a possible retinal tear. Upon having surgery 7 days later, he was found to have a temporal retinal detachment with subretinal fluid and hemorrhage extending to, but not involving, the macula. His postoperative course was complicated by persistent preretinal and subretinal hemorrhages along with recurrent retinal detachments requiring 2 additional surgeries. He was evaluated by his primary care physician and had a normal thrombotic work-up and all his dietary supplements, including turmeric, were discontinued. At post-op month 2, he continued to improve with resolving subretinal hemorrhage and an attached retina.Conclusion: This case report describes the extensive and recurrent subretinal hemorrhage that can develop in those patients taking medications or supplements with anticoagulant and/or antiplatelet properties. These antithrombotic agents are not only limited to prescription medications but can also include dietary supplements such as turmeric. It highlights the importance of knowing both the medications and dietary supplements a patient uses as this can affect the long-term outcome.","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"16 1","pages":"297-301"},"PeriodicalIF":0.5,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12028978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ipsilateral, Multi-Phasic Retinal Vascular Events following Intralesional Triamcinolone Acetonide Injection for Earlobe Keloid: A Case Report. 耳垂瘢痕疙瘩病灶内注射曲安奈德后发生同侧多相视网膜血管事件1例。

IF 0.5

Case Reports in Ophthalmology Pub Date : 2025-03-08 eCollection Date: 2025-01-01 DOI: 10.1159/000543454

Yafeng Li

{"title":"Ipsilateral, Multi-Phasic Retinal Vascular Events following Intralesional Triamcinolone Acetonide Injection for Earlobe Keloid: A Case Report.","authors":"Yafeng Li","doi":"10.1159/000543454","DOIUrl":"10.1159/000543454","url":null,"abstract":"Introduction: Intralesional triamcinolone acetonide is a widely used treatment for scarring skin conditions such as keloid and is known to have retinal vascular complications if administered in the periocular region.Case presentation: A 32-year-old female experienced a prompt onset transient vision decrease and a delayed onset, slow-resolving vison loss in the right eye (OD) following the last of a series of triamcinolone acetonide corticosteroid (TAC) injections in her right earlobe for a disfiguring keloid. Clinically, she developed a branch retinal arterial occlusion accompanied by features of a central retinal vein occlusion. The TAC particles that entered the retinal circulation are implicated in the thrombo-embolic occlusion of the branch retinal artery and subsequent blockage of the central retinal vein.Conclusion: This case should alert clinicians that there is always a potential hazard for retinal vascular occlusion when corticosteroid is injected in the region of the head and face because of the rich anastomoses between the external and internal carotid artery circulations.","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"16 1","pages":"254-260"},"PeriodicalIF":0.5,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DNAJC30 Mutation in a Patient with Coexisting Leber's Hereditary Optic Neuropathy and Multiple Sclerosis (Harding's Syndrome): A Case Report. 合并Leber遗传性视神经病变和多发性硬化症（哈丁综合征）患者的DNAJC30突变：1例报告。

IF 0.5

Case Reports in Ophthalmology Pub Date : 2025-03-07 eCollection Date: 2025-01-01 DOI: 10.1159/000545079

Sara KamaliZonouzi, Jonathan Micieli

{"title":"DNAJC30 Mutation in a Patient with Coexisting Leber's Hereditary Optic Neuropathy and Multiple Sclerosis (Harding's Syndrome): A Case Report.","authors":"Sara KamaliZonouzi, Jonathan Micieli","doi":"10.1159/000545079","DOIUrl":"10.1159/000545079","url":null,"abstract":"Introduction: Patients with Leber's hereditary optic neuropathy (LHON) have a higher risk of developing multiple sclerosis (MS) than the general population. The coexistence of LHON and MS, also known as Harding's syndrome complicates the diagnosis of optic neuropathy, particularly when the underlying genetic mutation is a rare cause of LHON like DNAJC30.Case presentation: We present a 26-year-old woman with progressive, sequential, painless, bilateral visual loss which was unresponsive to steroids, and two temporally distinct episodes of neurological disturbance suggestive of central nervous system demyelination. Thorough investigations including serological tests ruled out other causes, including negative neuromyelitis optica and myelin oligodendrocyte protein (MOG) antibodies and nutritional deficiencies. MRI detected areas of demyelination within the spinal cord and brain (infratentorial and periventricular areas). After genetic analysis revealing c.152A>G (p.Tyr51Cys) mutation at the DNAJC30 gene, LHON was suggested. She was prescribed with idebenone and her visual acuity resolved to normal at 4-year follow-up.Conclusion: This case further expands the clinical presentations of DNAJC30-related LHON and underscores the importance of considering LHON in patients with demyelinating syndrome presenting with severe bilateral visual loss and presumed optic neuritis unresponsive to steroids.","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"16 1","pages":"246-253"},"PeriodicalIF":0.5,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11968095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Macular Morphological Changes in Familial Exudative Vitreoretinopathy with Macular Traction on OCT. 家族性渗出性玻璃体视网膜病变伴黄斑牵引的黄斑形态改变。

IF 0.5

Case Reports in Ophthalmology Pub Date : 2025-03-03 eCollection Date: 2025-01-01 DOI: 10.1159/000545011

Asaki Hirai, Yota Kikuchi, Yuki Ohara, Toshihiko Ohta, Shintaro Nakao

{"title":"Macular Morphological Changes in Familial Exudative Vitreoretinopathy with Macular Traction on OCT.","authors":"Asaki Hirai, Yota Kikuchi, Yuki Ohara, Toshihiko Ohta, Shintaro Nakao","doi":"10.1159/000545011","DOIUrl":"10.1159/000545011","url":null,"abstract":"Introduction: We aimed to report macular morphological changes observed on optical coherence tomography (OCT) in a child with familial exudative vitreoretinopathy (FEVR), experiencing macular traction caused by fibrovascular tissue (FT), who underwent vitrectomy.Case presentation: A 7-year-old girl presented with the chief complaint of decreased visual acuity in the left eye during a school examination. Fundus examination revealed retinal folds with FT extending from the peripheral retina to the posterior pole of the left eye. Despite interventions such as retinal photocoagulation and encircling buckling aimed at reducing the traction on the macula, OCT revealed persistent deep retinal folds and a thickened outer nuclear layer (ONL), indicating gradually increasing macular traction, which contributed to vision loss. A subsequent vitrectomy alleviated the macular traction, enhanced the retinal morphology, and reduced ONL thickening regardless of persistent ectopic inner foveal layers.Conclusions: Macular morphological changes before and after vitrectomy in a pediatric case of FEVR can be observed using OCT. Vitrectomy with FT removal may be effective in partially improving macular morphology in FEVR with macular traction.","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"16 1","pages":"239-245"},"PeriodicalIF":0.5,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11961152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electromagnetic Iontophoresis: A Novel Nonsurgical Method for the Treatment of Dense Vitreous and Retinal Hemorrhages. 电磁离子导入：一种新的非手术治疗玻璃体和视网膜密集出血的方法。

IF 0.5

Case Reports in Ophthalmology Pub Date : 2025-02-27 eCollection Date: 2025-01-01 DOI: 10.1159/000544755

Umut Arslan, Deniz Arslan, Emin Özmert

{"title":"Electromagnetic Iontophoresis: A Novel Nonsurgical Method for the Treatment of Dense Vitreous and Retinal Hemorrhages.","authors":"Umut Arslan, Deniz Arslan, Emin Özmert","doi":"10.1159/000544755","DOIUrl":"10.1159/000544755","url":null,"abstract":"Introduction: Vitreous, retinal, and suprochoroidal hemorrhages might develop secondary to trauma, retinal tear or detachment, neovascularization due to ischemic retina. If the clearance of retinal and vitreous hemorrhages can be accelerated, more effective treatments can be planned for the underlying pathology.Case presentations: We present 6 different cases with dense vitreous, preretinal, and subretinal hemorrhages due to Valsalva retinopathy, polypoid choroidal vasculopathy, diabetic retinopathy, neovascular age-related macular degeneration, retinitis pigmentosa with vasculitis, and myopic choroidal neovascularization. To accelerate the clearance of these dense intraocular hemorrhages, a novel nonsurgical method of electromagnetic iontophoresis (MagnoVision™) was used together with some appropriate medications in an outpatient setting without any complications or side effects. In all cases, liquefaction of the intraocular hemorrhage began by 5 days and mostly resolved by 10 days. This nonsurgical rapid clearance allowed us to diagnose and evaluate the underlying retinal and choroidal pathologies earlier and to treat them appropriately as early as possible.Conclusion: Combined use of electromagnetic iontophoresis, subtenon platelet-rich plasma and bevacizumab injection, and oral bromelain can be considered as an effective and safe new treatment method for vitreous and retinal hemorrhages without any need for surgical intervention.","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"16 1","pages":"221-231"},"PeriodicalIF":0.5,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11936436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case Report of Intravitreal Aflibercept for Iris Metastasis from Small Cell Lung Carcinoma with Neovascular Glaucoma. 小细胞肺癌伴新生血管性青光眼虹膜转移玻璃体内注射阿非利赛普1例。

IF 0.5

Case Reports in Ophthalmology Pub Date : 2025-02-13 eCollection Date: 2025-01-01 DOI: 10.1159/000544159

Hitoshi Goto, Kyrie Hirakata, Kenji Nakamoto, Fumiki Okamoto, Junko Hori

{"title":"A Case Report of Intravitreal Aflibercept for Iris Metastasis from Small Cell Lung Carcinoma with Neovascular Glaucoma.","authors":"Hitoshi Goto, Kyrie Hirakata, Kenji Nakamoto, Fumiki Okamoto, Junko Hori","doi":"10.1159/000544159","DOIUrl":"https://doi.org/10.1159/000544159","url":null,"abstract":"Introduction: Metastatic iris tumors from lung cancer are uncommon and challenging to diagnose. As lung cancer treatments improve, life expectancy increases, potentially leading to more cases of metastasis. These tumors often cause neovascular glaucoma, making intraocular pressure (IOP) management crucial, especially in terminal-stage patients.Case presentation: A 65-year-old man with small cell lung carcinoma (SCLC) presented with right ocular pain and blurred vision. His right IOP was 55 mm Hg, and examination revealed anterior chamber cells, multiple grayish-white iris masses, and right iris neovascularization. Anterior chamber fluid cytology confirmed the diagnosis of metastatic iris tumors from SCLC. Despite treatment with topical eye drops, oral acetazolamide, and intravenous hypertonic mannitol, the IOP remained poorly controlled. Intravitreal aflibercept was subsequently administered into his right eye for neovascular glaucoma. Neovascular glaucoma disappeared rapidly, but IOP did not improve. However, intravenous infusion of hypertonic mannitol was no longer required, and the complaints of nausea associated with IOP decreased. Although this patient died 4 months after the initial visit due to multiple metastases of SCLC, the intravitreal aflibercept was effective in shrinking the iris tumor size and lowering IOP in the terminal phase of the disease.Conclusion: This is the first reported use of intravitreal aflibercept for SCLC metastases to the iris. While the prognosis of patients with metastatic iris tumors remains poor, intravitreal aflibercept injections show potential in reducing iris tumor size and lowering IOP. Although not curative, this therapeutic approach may play a significant role in the symptom management of these patients.","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"16 1","pages":"215-220"},"PeriodicalIF":0.5,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11919313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Choroidal Thickening and Outer Retinal Alterations in Vitamin A Deficiency: A Case Report. 脉络膜增厚和外视网膜改变维生素A缺乏：一个病例报告。

IF 0.5

Case Reports in Ophthalmology Pub Date : 2025-02-13 eCollection Date: 2025-01-01 DOI: 10.1159/000544701

Damian Jaggi, Joel-Benjamin Lincke, Florian M Heussen, Jan D Unterlauft, Martin S Zinkernagel, Lieselotte E Berger

{"title":"Choroidal Thickening and Outer Retinal Alterations in Vitamin A Deficiency: A Case Report.","authors":"Damian Jaggi, Joel-Benjamin Lincke, Florian M Heussen, Jan D Unterlauft, Martin S Zinkernagel, Lieselotte E Berger","doi":"10.1159/000544701","DOIUrl":"10.1159/000544701","url":null,"abstract":"Introduction: Retinal alterations in vitamin A deficiency have been described. The purpose of this study was to report a case of retinal alterations and choroidal thickening due to proven vitamin A deficiency.Case presentation: We report a case of a 39-year-old woman who presented with progressing nyctalopia and mildly reduced visual acuity over a period of 1-2 years, despite being on oral vitamin A supplementation, following a history of gastric bypass and biliopancreatic diversion surgeries many years ago. Vitamin A levels were severely reduced (<0.1 µmol/L, reference range: 1.05-2.08 µmol/L). The outer retinal layers exhibited structural alterations and a reduction in thickness, while choroidal thickness was increased. The electroretinogram showed complete depletion of scotopic responses and a mild reduction in photopic responses. After intravenous vitamin A supplementation, complete resolution of both functional and structural changes was achieved.Conclusion: This case highlights the importance of considering vitamin A deficiency even in patients receiving ongoing oral vitamin A supplementation, particularly if symptoms and clinical findings suggest its presence. Choroidal thickening and outer retinal thinning may provide further insights into the pathophysiology of this condition in future analyses.","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"16 1","pages":"207-214"},"PeriodicalIF":0.5,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12158416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Iatrogenic Cushing Syndrome and Secondary Adrenal Insufficiency in a Child due to Topical Ocular Corticosteroids: A Case Report. 医源性库欣综合征和继发性肾上腺功能不全的儿童由于局部眼皮质类固醇：一个病例报告。

IF 0.5

Case Reports in Ophthalmology Pub Date : 2025-02-12 eCollection Date: 2025-01-01 DOI: 10.1159/000543908

Joana Santos-Oliveira, Luís Torrão, Sónia Torres-Costa, Marta Silva, Ana Catarina Pedrosa, Joana Araújo, Luís Figueira, Cláudia Oliveira-Ferreira

{"title":"Iatrogenic Cushing Syndrome and Secondary Adrenal Insufficiency in a Child due to Topical Ocular Corticosteroids: A Case Report.","authors":"Joana Santos-Oliveira, Luís Torrão, Sónia Torres-Costa, Marta Silva, Ana Catarina Pedrosa, Joana Araújo, Luís Figueira, Cláudia Oliveira-Ferreira","doi":"10.1159/000543908","DOIUrl":"https://doi.org/10.1159/000543908","url":null,"abstract":"Introduction: Iatrogenic Cushing syndrome (ICS) can be caused by synthetic glucocorticoids administered through various routes. ICS caused by corticosteroid eye drops is an exceptional event, being more frequent in pediatric age. Herein, we describe a case of ICS associated with secondary adrenal insufficiency (SAI) caused by ocular topical corticosteroid treatment.Case presentation: An 11-year-old girl was referred to our ocular inflammation department due to idiopathic, chronic, non-hypertensive, non-granulomatous bilateral anterior uveitis, treated with topical dexamethasone (eye drops, 1 mg/mL) for 1 year. During the past year, the child and her mother observed a gradual change in her physical appearance, particularly noting the development of a cushingoid facial appearance. Laboratory data revealed morning serum adrenocorticotropic hormone (ACTH) of 3.6 ng/L (7.2-63.3) and morning serum cortisol of 0.20 μg/dL (6.2-19.4). She was treated with methotrexate (15 mg/week, orally), and the topical corticosteroid regimen was progressively tapered and discontinued after 3 months. Nine months after the patient discontinued corticosteroid eye drops, her cushingoid face disappeared, and her laboratory data improved. Regarding the ophthalmological examination, the uveitis remained in remission with methotrexate, with no new episodes of intraocular inflammation.Conclusion: Although rare, ophthalmologists must be aware of ICS and SAI and prioritize using the least potent corticosteroid for the shortest duration necessary. Additionally, clinicians should avoid abrupt cessation of long-term corticosteroid therapy as this can precipitate an adrenal crisis in the presence of adrenal insufficiency.","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"16 1","pages":"194-201"},"PeriodicalIF":0.5,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11908803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Valsalva-Induced Orbital and Subcutaneous Periorbital Emphysema Secondary to Lamina Papyracea Dehiscence: A Case Report. 缬草诱导的继发于纸莎草膜破裂的眼眶及皮下眼眶周围肺气肿1例。

IF 0.5

Case Reports in Ophthalmology Pub Date : 2025-02-10 eCollection Date: 2025-01-01 DOI: 10.1159/000544098

Stuti Misty Tanya, Merve Kulbay, Femida Kherani, Marc B Mydlarski

{"title":"Valsalva-Induced Orbital and Subcutaneous Periorbital Emphysema Secondary to Lamina Papyracea Dehiscence: A Case Report.","authors":"Stuti Misty Tanya, Merve Kulbay, Femida Kherani, Marc B Mydlarski","doi":"10.1159/000544098","DOIUrl":"https://doi.org/10.1159/000544098","url":null,"abstract":"Introduction: Pneumo-orbit and periorbital subcutaneous emphysema secondary to defects in the sinus wall have been well described in the context of traumatic or surgical sequelae. However, these conditions may rarely occur atraumatically in the setting of an idiopathic or congenital sinus wall dehiscence, with a risk for orbital compartment syndrome and irreversible vision loss. We describe a case of idiopathic lamina papyracea dehiscence with resultant pneumo-orbit and elevated intraocular pressure.Case presentation: A 28-year-old man experienced a sudden onset of unilateral orbital and subcutaneous periorbital emphysema following Valsalva maneuver. He had unilateral subcutaneous emphysema, crepitus, violaceous discoloration of the lids, and chemosis of the palpebral conjunctiva. Visual acuity was intact, and intraocular pressure was mildly elevated. Imaging showed an idiopathic lamina papyracea dehiscence. The patient was advised of sinus precautions with uneventful spontaneous resolution and no visual sequelae.Conclusion: Lamina papyracea dehiscence predisposes to spontaneous Valsalva-induced orbital or periorbital emphysema with a risk of elevated intraocular pressure, optic neuropathy, and vision loss; prompt recognition and early management can prevent vision-threatening sequelae.","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"16 1","pages":"202-206"},"PeriodicalIF":0.5,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11908810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0