Case Reports in Ophthalmology最新文献

{"title":"Bilateral Herpetic Keratitis following Cladribine Immunosuppression: A Case Report.","authors":"Hanna Pawlowski, Cole S Elsner, Sanjana Molleti, Calisa G Lee-Choi, Mina M Sitto, Phillip C Hoopes, Majid Moshirfar","doi":"10.1159/000553454","DOIUrl":"https://doi.org/10.1159/000553454","url":null,"abstract":"<p><strong>Introduction: </strong>Disease-modifying therapies for multiple sclerosis (MS), including cladribine, alter immune function and may increase susceptibility to viral reactivation. While herpesvirus infections have been reported with cladribine, herpetic keratitis has not been previously described. We report a case of bilateral recurrent micro-dendritic keratitis following cladribine therapy in a patient with relapsing-remitting MS (RRMS).</p><p><strong>Case presentation: </strong>A 60-year-old male with RRMS developed progressive leukopenia after completing two cycles of cladribine. Four months after treatment, he presented with decreased vision OD and was found to have a dendritic corneal lesion consistent with herpetic keratitis, confirmed by positive herpesvirus PCR. Despite antiviral therapy, he developed sequential involvement of the left eye and recurrent bilateral episodes characterized by multiple, micro-dendritic lesions, stromal haze, ocular discomfort, and photophobia. Visual acuity declined during flares but improved with oral valacyclovir and ganciclovir gel drops. At peak severity, multiple Thygeson-like lesions with underlying stromal inflammation were present in both eyes. With continued therapy, visual acuity recovered to 20/20 bilaterally, though the disease course fluctuated over several months.</p><p><strong>Conclusion: </strong>This case demonstrates a rare presentation of bilateral, recurrent micro-dendritic herpetic keratitis in the setting of cladribine-induced immunosuppression. The temporal relationship between lymphocyte depletion and symptom onset suggests impaired cell-mediated immunity as a contributing factor. Clinicians should consider atypical herpetic ocular disease in immunosuppressed patients and may need prolonged antiviral therapy and close monitoring to reduce recurrence and preserve vision.</p>","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"17 1","pages":"872-878"},"PeriodicalIF":0.6,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13489615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148788359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late Reposition of a Dislocated Toric Intraocular Lens in a Fibrosed Capsular Bag: A Case Report.","authors":"Mustafa K Hallak, Robin Splawski, Sabine E Buchner, Robert P Finger, Argyrios Chronopoulos","doi":"10.1159/000553211","DOIUrl":"10.1159/000553211","url":null,"abstract":"<p><strong>Introduction: </strong>Toric intraocular lenses (IOLs) are widely used to correct corneal astigmatism during cataract surgery. However, postoperative rotation or decentration may significantly compromise visual outcomes.</p><p><strong>Case presentation: </strong>A 70-year-old patient presented with progressive visual deterioration several years after cataract surgery with toric IOL implantation. Examination revealed a rotated and partially dislocated toric IOL with significant residual astigmatism (-7.50 D). Intraoperatively, the nasal haptic was located in the sulcus and fibrotic adhesions within the capsular bag were present. After careful viscodissection and release of capsular adhesions, the IOL was mobilized and repositioned into the capsular bag using a push-pull technique and aligned to the intended axis.</p><p><strong>Conclusion: </strong>Several years after cataract surgery, a repositioning of a dislocated toric IOL is still possible and can restore visual function avoiding unnecessary complex IOL exchange procedures.</p>","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"17 1","pages":"794-798"},"PeriodicalIF":0.6,"publicationDate":"2026-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13446891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148683472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of High-Dose Steroids in Treatment-Resistant Carotid-Cavernous Fistulas: A Case Report.","authors":"Kennedy Combs, Ian Seddon, Hannah Shuman, Nitya Rao, Jordan Ueberroth, Kyle Fargen, Robert Goodrich","doi":"10.1159/000553387","DOIUrl":"10.1159/000553387","url":null,"abstract":"<p><strong>Introduction: </strong>Carotid-cavernous fistulas (CCFs) are rare arteriovenous communications between the carotid arterial system and the cavernous sinus that can result in vision-threatening and life-threatening complications. Severe cavernous sinus and orbital venous congestion is managed with prompt endovascular intervention to prevent irreversible cranial nerve and ocular pathology. While high-dose corticosteroids have been reported to improve clinical symptoms in a small number of cases of superior ophthalmic vein thrombosis (SOVT) secondary to CCF, their role in the management of severe orbital venous congestion without radiographically confirmed SOVT remains unclear.</p><p><strong>Case presentation: </strong>We report the case of a 67-year-old female who developed a direct CCF following a high-speed motor vehicle collision. Two weeks after the event, she presented with progressive diplopia, right-sided ptosis, and headache. Diagnostic transradial cervical and cerebral angiography revealed a high-flow, direct internal right CCF with bilateral superior ophthalmic vein (SOV) and cavernous sinus opacification. Despite multiple transvenous coil embolizations and subsequent flow diverter stent placements, she continued to develop severe, progressive sequelae of orbital venous congestion without evidence of SOVT on imaging. Following initiation of high-dose oral corticosteroids 5 days prior to additional flow diverter stent placement, the patient experienced symptomatic improvement with subsequent recurrence found clinically following steroid taper and cessation. No changes were noted on her angiograms over this period, and her orbital congestion improved after restarting a high-dose corticosteroid pulse. A final curative trans-orbital direct SOV puncture for coiling was performed, resulting in complete symptom resolution.</p><p><strong>Conclusion: </strong>This case demonstrates that systemic corticosteroid therapy may be a valuable adjunctive treatment for CCF-associated, vision-threatening venous congestion refractory to standard endovascular intervention. Early recognition of progressive orbital venous congestion is critical to prevent permanent vision loss. A multimodal approach combining flow diversion, coil embolization, and corticosteroids may help achieve favorable outcomes in complex cases. This case adds to the limited literature supporting corticosteroid use in this challenging clinical scenario and highlights the importance of aggressive ophthalmologic monitoring following CCF diagnosis.</p>","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"17 1","pages":"814-823"},"PeriodicalIF":0.6,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13461132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148711542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late-Onset Infectious Keratitis over 10 Years after Intracorneal Ring Segment Implantation Treated with Deep Anterior Lamellar Keratoplasty: A Case Report.","authors":"Yasutsugu Akasaki, Toshinari Funaki, Takenori Inomata, Satoru Nakatani, Masahiro Yamaguchi, Shintaro Nakao","doi":"10.1159/000553319","DOIUrl":"10.1159/000553319","url":null,"abstract":"<p><strong>Introduction: </strong>Intracorneal ring segments (ICRS) are employed to manage keratoconus but carry the risk of late-onset complications such as extrusion and infectious keratitis. We report a rare case of infectious keratitis occurring over 10 years following ICRS implantation that was successfully treated with deep anterior lamellar keratoplasty (DALK).</p><p><strong>Case presentation: </strong>A 56-year-old woman with atopic dermatitis and keratoconus presented with severe pain and visual loss in the left eye, where an ICRS had been implanted over 10 years ago. Examination revealed counting-finger vision, dense corneal infiltration around the ICRS, and a hypopyon. Despite intensive antibacterial therapy resolving the active infection, progressive stromal melting resulted in ICRS extrusion. Therapeutic DALK was conducted using the big-bubble method after ICRS explantation. The postoperative course was uneventful, and the graft remained clear after 12 months.</p><p><strong>Conclusion: </strong>Late-onset infectious keratitis can occur even a decade after ICRS implantation, particularly in high-risk patients such as those with atopic dermatitis. In cases of severe stromal thinning or extrusion, DALK offers effective restoration of ocular integrity while minimizing the risk of endothelial rejection. This case highlights that lifelong vigilance is necessary following ICRS implantation, especially in atopic patients, and that DALK may be a valuable alternative to penetrating keratoplasty in advanced cases.</p>","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"17 1","pages":"799-805"},"PeriodicalIF":0.6,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13446893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148683502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nab-Paclitaxel-Induced Cystoid Macular Edema with Minimal Fluorescein Leakage: A Case Report of Two Patients from a Tertiary Referral Center.","authors":"Mariko Kawata, Yuki Saeki, Kazuki Yashiro, Mami Ota, Shuichiro Aoki, Kohdai Kitamoto, Ryo Terao, Keiko Azuma","doi":"10.1159/000553334","DOIUrl":"10.1159/000553334","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of the study was to report 2 cases of nab-paclitaxel (nab-PTX)-induced macular edema and describe its incidence over a 5-year period at a tertiary center.</p><p><strong>Case presentations: </strong>We retrospectively reviewed patients who received nab-PTX between July 2020 and June 2025 across several departments at our institution. Ophthalmic findings, multimodal imaging results, management, and outcomes were analyzed. Among 183 patients treated with nab-PTX, 25 symptomatic patients were referred to ophthalmology, and 2 were adjudicated as definite taxane-induced macular edema (TIME; observed proportion, 2/183; 1.1%). Both patients were men with metastatic pancreatic cancer receiving gemcitabine and nab-PTX. Optical coherence tomography (OCT) demonstrated bilateral cystoid macular edema. In Case 1, fluorescein angiography (FA) showed no macular leakage or vasculitis. Central retinal thickness (CRT) improved from 479/582 µm (right/left) to 175/173 µm after discontinuation of therapy, with macular edema resolving by 11 weeks. In Case 2, FA was not performed because of the patient's poor general condition; OCT angiography showed no microaneurysms or other findings suggestive of alternative causes of macular edema. CRT improved from 659/663 µm to 207/232 µm at 1 month after discontinuation, with complete resolution by 3 months. Best-corrected visual acuity improved in both cases after nab-PTX discontinuation.</p><p><strong>Conclusion: </strong>Nab-PTX can cause bilateral cystoid macular edema, often with minimal or absent FA leakage, and treatment discontinuation can lead to anatomical and functional recovery. Early recognition and prompt interdisciplinary management are important to prevent potentially irreversible visual impairment. Because ophthalmologic evaluation was symptom-driven, asymptomatic, or mildly symptomatic, TIME may have been underdetected; therefore, this observed proportion should not be interpreted as a population-level incidence estimate.</p>","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"17 1","pages":"785-793"},"PeriodicalIF":0.6,"publicationDate":"2026-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13441279/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148677183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent Cerebral Venous Sinus Thrombosis Presenting with Isolated Visual Symptoms: A Case Report.","authors":"Ayham Slimi, Islam Ghassan Awessat, Baraa Nassar","doi":"10.1159/000553117","DOIUrl":"10.1159/000553117","url":null,"abstract":"<p><strong>Introduction: </strong>Cerebral venous sinus thrombosis is a rare but potentially life-threatening cerebrovascular disorder caused by thrombosis of the dural venous sinuses. Clinical manifestations are highly variable and often nonspecific, which may lead to delayed diagnosis. Although headache and focal neurological deficits are common, isolated visual symptoms are uncommon and frequently overlooked. Women of reproductive age are at increased risk due to hormonal and prothrombotic factors such as pregnancy, the postpartum period, assisted reproductive technologies, and endocrine disorders including polycystic ovary syndrome.</p><p><strong>Case presentation: </strong>A 29-year-old woman with polycystic ovary syndrome and primary infertility previously developed cerebral venous sinus thrombosis involving the superior sagittal sinus and right transverse sinus after cesarean delivery following in vitro fertilization. Approximately 1 month after documented radiological recanalization, she represented with recurrent thrombosis; 2 months later, she developed sudden bilateral blurred vision and left-sided floaters. Magnetic resonance imaging with magnetic resonance venography demonstrated recurrent partial thrombosis of the superior sagittal sinus associated with a brief 1-week interruption of anticoagulation therapy. Automated perimetry showed a Glaucoma Hemifield Test within normal limits in the left eye (visual field index: 99%, mean deviation: +0.22 dB) with a superonasal pattern deviation cluster and significant pattern standard deviation (1.94 dB, <i>p</i> < 5%); test reliability was limited by elevated false-positive errors and repeat perimetry was planned. The blurred vision was attributed to transient intracranial venous hypertension without papilledema.</p><p><strong>Conclusion: </strong>Recurrent cerebral venous sinus thrombosis may present with isolated visual symptoms. Early neuroimaging and uninterrupted anticoagulation are essential to prevent recurrence and reduce morbidity.</p>","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"17 1","pages":"652-660"},"PeriodicalIF":0.6,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13349369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148418951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular Bartonellosis with Rapidly Progressive Choroidal Granuloma: Case Report.","authors":"Viridiana Hernandez-Lopez, Elizabeth Rooks, Jennifer Chao, Andrew W Stacey","doi":"10.1159/000552772","DOIUrl":"10.1159/000552772","url":null,"abstract":"<p><strong>Introduction: </strong>Ocular bartonellosis most commonly presents as neuroretinitis, whereas choroidal granulomas are rare and poorly characterized. This case highlights a rapidly progressive, tumor-mimicking choroidal granuloma, expanding the clinical spectrum, and highlighting the importance of early recognition.</p><p><strong>Case presentation: </strong>A 42-year-old woman presented with decreased vision in the left eye and was found to have an elevated chorioretinal lesion with subretinal fluid, concerning for a choroidal neoplasm. Within 1 week, the lesion enlarged with significant visual decline. Serologic testing confirmed <i>Bartonella henselae</i> infection, supported by the presence of cat scratches on the arms and legs, establishing the diagnosis of ocular bartonellosis with choroidal granuloma. The patient was treated with oral doxycycline and a prednisone taper, resulting in rapid visual recovery from 20/200 to 20/20 and complete regression of the lesion.</p><p><strong>Conclusion: </strong><i>Bartonella</i>-associated choroidal granulomas may present as rapidly progressive, tumor-mimicking lesions. Recognition of this rare presentation and early treatment can lead to favorable visual outcomes.</p>","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"17 1","pages":"779-784"},"PeriodicalIF":0.6,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13436935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148673078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Axial Length-Driven Anisometropia in Cornea Plana Spectrum with Alternating Exotropia: A Case Report.","authors":"Emre Subay, C Banu Cosar","doi":"10.1159/000553210","DOIUrl":"10.1159/000553210","url":null,"abstract":"<p><strong>Introduction: </strong>Cornea plana is a rare congenital corneal disorder characterised by marked corneal flattening, often with microcornea and shallow anterior chambers. It is classically associated with high hyperopia and accommodative esotropia.</p><p><strong>Case presentation: </strong>We report a 35-year-old woman with a cornea plana spectrum phenotype in whom cycloplegic refraction revealed marked anisometropia (hyperopic astigmatism in the right eye and myopic astigmatism in the left eye) together with an alternating exotropia. Swept-source optical biometry demonstrated interocular axial length asymmetry, plausibly offsetting reduced corneal power to different degrees between the eyes and explaining the divergent refractive outcomes. This case highlights that axial length can substantially modify refractive expression in cornea plana spectrum phenotypes and that associated strabismus may not be limited to convergence-driven esodeviations.</p><p><strong>Conclusion: </strong>This case provides an educational example of how axial length asymmetry can modify the refractive expression of corneal hypopower in a cornea plana spectrum phenotype. It also illustrates that ocular alignment findings in this setting should be interpreted in the context of refractive development, visual acuity, and sensory status.</p>","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"17 1","pages":"771-778"},"PeriodicalIF":0.6,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13436933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148673138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-Dural Puncture Headache with Abducens Nerve Palsy after Epidural Labor Analgesia: Successful Treatment with CT-Guided Epidural Blood Patch - A Case Report.","authors":"Seraphine Zubel, Nicolas Stiebler, Daniel Behme, Maximilian Thormann","doi":"10.1159/000553081","DOIUrl":"https://doi.org/10.1159/000553081","url":null,"abstract":"<p><strong>Introduction: </strong>Post-dural puncture headache is a well-recognized complication of neuraxial anesthesia caused by cerebrospinal fluid leakage and intracranial hypotension. Although usually self-limiting, persistent post-dural puncture headache may rarely be complicated by cranial nerve palsy.</p><p><strong>Case presentation: </strong>We report the case of a 33-year-old postpartum woman who developed severe orthostatic headache after apparently uncomplicated epidural labor analgesia, followed by neck stiffness, auditory pressure, and horizontal diplopia due to abducens nerve palsy. Initial cranial computed tomography was unremarkable. Because symptoms persisted despite conservative therapy, magnetic resonance imaging of the brain and spine was performed and demonstrated findings consistent with intracranial hypotension and persistent spinal cerebrospinal fluid leakage. On postpartum day 15, a targeted epidural blood patch was performed under computed tomography guidance at the suspected leak site. This resulted in rapid clinical improvement, with complete resolution of symptoms within 2 weeks.</p><p><strong>Conclusion: </strong>This case highlights a rare neurological complication of post-dural puncture headache and supports the use of image-guided epidural blood patch in selected refractory cases.</p>","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"17 1","pages":"837-844"},"PeriodicalIF":0.6,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13472611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148759193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Unilateral NAION following Tirzepatide Therapy: A Case Report.","authors":"Jela Valášková, Dmytro Bondarchuk, Peter Kadlic, Terézia Kaššová, Paulina Plesniková","doi":"10.1159/000552569","DOIUrl":"10.1159/000552569","url":null,"abstract":"<p><strong>Introduction: </strong>Dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonists, such as tirzepatide, have significantly advanced the management of type 2 diabetes mellitus and obesity. However, emerging safety signals have raised concerns regarding rare ocular adverse events.</p><p><strong>Case presentation: </strong>We report a case of an obese patient undergoing treatment with tirzepatide who presented with progressive, painless visual loss in the left eye 2 weeks after symptom onset. Four weeks prior to presentation, she had initiated tirzepatide therapy for weight reduction at a dose of 15 mg once weekly without standard dose titration. Best-corrected visual acuity was 20/20 in the right eye and counting fingers at 1 meter in the left eye. Fundus examination revealed hyperemic optic disc oedema with peripapillary flame-shaped haemorrhages. Automated perimetry demonstrated a central scotoma. MRI of the brain and orbits excluded intracranial pathology and showed no optic nerve enhancement. Intravenous methylprednisolone was administered, after which visual acuity improved to 20/40.</p><p><strong>Conclusion: </strong>Regulatory and pharmacovigilance data suggest that NAION may represent a very rare adverse event associated with GLP-1 receptor agonists, with observational studies indicating a possible association for tirzepatide, although absolute risk appears low and causality remains unproven. While the relationship between dual GIP/GLP-1 receptor agonists and NAION remains controversial, clinicians - particularly ophthalmologists - should remain vigilant and consider this potential risk when evaluating the benefit-risk profile for individual patients.</p>","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"17 1","pages":"806-813"},"PeriodicalIF":0.6,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13450988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148697084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}