Veshesh Patel, Anny M S Cheng, Joby Tsai, Muhammad Shabbir Ijaz, Arash Maleki, Shailesh Gupta
{"title":"A Rare Case of Concurrent Carotid Cavernous Fistula and Orbital Cellulitis: Challenging Diagnosis and Divergent Management.","authors":"Veshesh Patel, Anny M S Cheng, Joby Tsai, Muhammad Shabbir Ijaz, Arash Maleki, Shailesh Gupta","doi":"10.1159/000550431","DOIUrl":"https://doi.org/10.1159/000550431","url":null,"abstract":"<p><strong>Introduction: </strong>Carotid cavernous fistula (CCF) is abnormal vascular connections between the cavernous sinus and the carotid artery or its branches, leading to orbital signs. This rare case report illustrates the diagnostic complexities posed by orbital cellulitis and concomitant CCF.</p><p><strong>Case presentation: </strong>A 52-year-old male with a recent trauma of dehiscent internal carotid artery (ICA) presented initially with bacteremia, fever, tachycardia, and leukocytosis. Based on the orbital symptoms, including proptosis, chemosis, and restricted extraocular in the right eye, the patient was diagnosed with orbital cellulitis. His ocular manifestations deteriorated despite the improvement of systemic symptoms, signs, and laboratory results during systemic antibiotic treatment. A faint bruit and pulsatile proptosis were found in the right eye; thus, neuroimaging was performed. Magnetic resonance venography and computed tomography angiogram demonstrated a direct CCF with arterialized flow in the cavernous sinus, and superior ophthalmic vein dilation. Endovascular coil embolization successfully resolved the CCF, yet the patient experienced permanent vision loss in the affected eye due to an afferent pupillary defect, a neurological sequelae attributed to either orbital cellulitis, CCF or both.</p><p><strong>Conclusion: </strong>The significant overlap in symptoms of orbital cellulitis and CCF complicates diagnosis. When two diseases coexist, the diagnosis becomes more complex. This rare case report highlights that CCF should be considered a potential concurrent pathology in patients with head and neck trauma presenting with orbital cellulitis. In addition, CCF can be considered in trauma patients exhibiting dehiscent ICA, irrespective of orbital symptoms, and prior to performing neuroimaging.</p>","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"17 1","pages":"188-194"},"PeriodicalIF":0.6,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12975148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147431051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ellen Nollet, Nicolas Vandenbussche, Sara Van de Veire
{"title":"When Headache Is Not Just Headache: Two Years of Symptoms and the Value of Ophthalmic Awareness in Undiagnosed Idiopathic Intracranial Hypertension - A Case Report.","authors":"Ellen Nollet, Nicolas Vandenbussche, Sara Van de Veire","doi":"10.1159/000550828","DOIUrl":"10.1159/000550828","url":null,"abstract":"<p><strong>Introduction: </strong>Idiopathic intracranial hypertension (IIH) can present with nonspecific symptoms such as chronic headache and dizziness, making diagnosis challenging and often delayed. Ophthalmologic evaluation plays a crucial role in identifying IIH and preventing irreversible visual damage.</p><p><strong>Case presentation: </strong>We report a case of a young woman with a 2-year history of persistent headache and dizziness of unknown origin. She was subsequently diagnosed with previously unrecognized IIH following ophthalmic evaluation, including optical coherence tomography, fundus examination, and visual field testing. These findings prompted timely shunt placement, which resulted in marked recovery of the visual fields.</p><p><strong>Conclusion: </strong>This case highlights the educational value of ophthalmologic awareness and the importance of integrating ocular findings into clinical decision-making, particularly in patients with chronic unexplained headache. It underscores the relevance of prompt initiation of therapy and, when necessary, invasive surgical intervention to prevent lifelong optic nerve damage and poor visual outcomes in a young population.</p>","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"17 1","pages":"333-344"},"PeriodicalIF":0.6,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13089996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ludovica Gargiulo, Francesco Cutrupi, Francisco Esoin, Lisa Melzi, Benedetta Storti, Nicola Rifino, Anna Bersano, Stefania Bianchi Marzoli
{"title":"Retinal Vasculopathy in Inflammatory Cerebral Amyloid Angiopathy: A Case Report of Peripheral Marker of Treatment Response.","authors":"Ludovica Gargiulo, Francesco Cutrupi, Francisco Esoin, Lisa Melzi, Benedetta Storti, Nicola Rifino, Anna Bersano, Stefania Bianchi Marzoli","doi":"10.1159/000550627","DOIUrl":"10.1159/000550627","url":null,"abstract":"<p><strong>Introduction: </strong>Inflammatory cerebral amyloid angiopathy (CAA-ri) is a rare immune response to vascular amyloid-β. Ocular involvement is exceptional, and the retina may represent an accessible biomarker of disease activity.</p><p><strong>Case presentation: </strong>A 67-year-old woman with probable CAA-ri developed recurrent floaters and transient visual obscurations during steroid tapering, with bilateral optic disc edema and peripapillary hemorrhages. Multimodal retinal imaging supported an inflammatory hemorrhagic retinal arteriolar microangiopathy (normal CSF opening pressure; TREX1 negative). Retinal findings resolved after intensified immunosuppression (steroids plus mycophenolate), recurred during tapering, and resolved again after switching to cyclophosphamide with steroid escalation; brain MRI remained largely unchanged and brain biopsy later confirmed inflammatory CAA.</p><p><strong>Conclusion: </strong>Multimodal retinal imaging may provide a dynamic, sensitive peripheral biomarker to monitor disease activity and treatment response in CAA-ri, even when cerebral MRI appears stable.</p>","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"17 1","pages":"254-262"},"PeriodicalIF":0.6,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13002238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gonococcal Dacryoadenitis: A Case Report.","authors":"Lewis Hains, Clare Quigley, Dinesh Selva","doi":"10.1159/000550844","DOIUrl":"10.1159/000550844","url":null,"abstract":"<p><strong>Introduction: </strong><i>Neisseria gonorrhoeae</i> (NG) causes sexually transmitted hyperacute bacterial conjunctivitis. Involvement of the lacrimal gland is exceedingly rare and has been previously reported in two case reports.</p><p><strong>Case presentation: </strong>This report discusses a 71-year-old male who presented with a painful red left eye. There was notable swelling of the upper eyelid, which was confirmed on CT to be due to lacrimal gland inflammation. Clinical features of dacryoadenitis associated with scleritis were found on ophthalmologic assessment. Conjunctival swabs were sent for culture and returned positive for NG, following which the patient reported a new sexual encounter previously unknown to the treating clinicians. Following IV ceftriaxone and flucloxacillin, topical steroid and chloramphenicol eye drops, the patient saw marked clinical improvement.</p><p><strong>Conclusion: </strong>This case demonstrates that NG may present with unusual features, and clinicians should have a low threshold for conjunctival cultures and promptly explore the sexual and social histories of patients presenting with similar symptomology.</p>","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"17 1","pages":"275-280"},"PeriodicalIF":0.6,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13012776/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147509769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Case of Refractory Panuveitis with Coexisting Spondyloarthritis Successfully Treated with Tofacitinib.","authors":"Ayano Wakabayashi, Kenichi Namba, Daiju Iwata, Kazuomi Mizuuchi, Keitaro Hase, Kayo Suzuki, Yo Ogino, Miki Hiraoka, Nobuyoshi Kitaichi, Shuhei Takeyama, Tatsuya Atsumi, Susumu Ishida","doi":"10.1159/000550660","DOIUrl":"10.1159/000550660","url":null,"abstract":"<p><strong>Introduction: </strong>Non-infectious uveitis is commonly treated with corticosteroids, immunosuppressants, and, recently, TNF inhibitors. However, some patients do not achieve adequate control of uveitis with these drugs. This report presents a case of panuveitis with coexisting spondyloarthritis (SpA) in which both TNF and interleukin-17 (IL-17) inhibitors failed to control uveitis, but tofacitinib, a Janus kinase (JAK) inhibitor, was effective in treating uveitis.</p><p><strong>Case presentation: </strong>A 54-year-old woman visited our hospital with a complaint of blurred vision in her left eye. A small retinal exudate in the inferonasal region in the right eye and 2+ vitreous haze in the left eye were seen. Systemic examinations were performed, but no abnormal findings were detected. The patient subsequently had frequent ocular inflammatory recurrences; thus, Behçet's disease was suspected, although no characteristic extraocular symptoms were noted. In addition to colchicine, adalimumab was administered, but the patient still showed frequent ocular inflammatory attacks. The patient subsequently developed arthritis and was diagnosed with axial SpA. Despite treatment with infliximab (TNF alpha inhibitor) or secukinumab (IL-17 inhibitor), ocular inflammatory attacks persisted, resulting in decreased visual acuity attributed to complicated cataracts. After cataract surgery, oral tofacitinib, a JAK inhibitor, was initiated. Afterward, ocular attacks did not occur for more than 3 years, and her visual acuity remained at 1.0 in both eyes.</p><p><strong>Conclusion: </strong>We examined a case of panuveitis with coexisting SpA refractory to TNF inhibitor and IL-17 inhibitor, in which JAK inhibitor was successfully effective. JAK inhibitors may be useful for some patients with refractory uveitis.</p>","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"17 1","pages":"281-288"},"PeriodicalIF":0.6,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13019177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147572279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ram Cohen, Etti Katzburg, Muhammad Abumanhal, Avi Ohayon, Michaella Goldstein, Adiel Barak, Igal Leibovitch, Efrat Fleissig
{"title":"High-Pressure Water Jet Ocular Injuries during Riot Control: A Case Series.","authors":"Ram Cohen, Etti Katzburg, Muhammad Abumanhal, Avi Ohayon, Michaella Goldstein, Adiel Barak, Igal Leibovitch, Efrat Fleissig","doi":"10.1159/000550815","DOIUrl":"10.1159/000550815","url":null,"abstract":"<p><strong>Introduction: </strong>Eye injuries caused by a high-pressure water jet are rarely reported and mostly occur in sporadic trauma. This study aimed to describe various ocular injuries caused by water jets, with a particular emphasis on injuries inflicted by water cannon vehicles used during riots.</p><p><strong>Case presentations: </strong>This case series presents eleven eyes of 9 patients injured from a direct high-pressure water jet used by the police in Israel as a riot control measure during a demonstration. All patients admitted to the emergency room with blunt ocular trauma had undergone clinical examination by an ophthalmologist. Of which, hyphema was the most common ocular injury observed, affecting 8 out of the 11 eyes examined, followed by traumatic mydriasis and vitreous hemorrhage in 54% and 36% of patients, respectively. In this series, 2 of 9 patients required ocular surgery. Injuries requiring surgical intervention were retinal detachment, lens dislocation, and vitreous hemorrhage.</p><p><strong>Conclusion: </strong>Water jet injuries may inflict severe damage to the globe and orbital structures. Care should be taken in preventing such injuries inflicted by water cannon vehicles used during riots.</p>","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"17 1","pages":"239-247"},"PeriodicalIF":0.6,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13002237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Androniki Syrrou, Maide Gözde İnam, Onur İnam, Sarah Pilson, Tongalp H Tezel
{"title":"A Case of Branch Retinal Arteriole Occlusion and Paracentral Acute Middle Maculopathy after COVID-19 Infection.","authors":"Androniki Syrrou, Maide Gözde İnam, Onur İnam, Sarah Pilson, Tongalp H Tezel","doi":"10.1159/000550630","DOIUrl":"https://doi.org/10.1159/000550630","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to report a case of segmental deep capillary plexus ischemic injury after COVID-19 infection in a vaccinated otherwise healthy male.</p><p><strong>Case presentation: </strong>A healthy 38-year-old male presented with a complaint of not being able to see above his fixation point in the left eye. He had developed a positive scotoma 2 weeks after a COVID-19 infection. Examination showed a branch retinal arteriole occlusion in the inferotemporal quadrant with an area of subtle arcuate retinal whitening inferior to the fovea. Systemic workup was unremarkable. His vision remained 20/20, with a persistent scotoma over 2 months. Severe thinning of the inner nuclear layer and marked attenuation of the outer plexiform layer in an arcuate segment inferior to the fovea were detected with optical coherence tomography (OCT). OCTA revealed a flow void in the deep capillary plexus inferior to the fovea and cessation of the blood flow distal to the occluded retinal arteriole.</p><p><strong>Conclusion: </strong>This case highlights the deep capillary plexus's unique vulnerability to COVID-19-related occlusion, likely due to its high autoregulatory demand and dense vascular architecture. It emphasizes the need for further investigation into retinal microvascular complications of the disease.</p>","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"17 1","pages":"217-223"},"PeriodicalIF":0.6,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147479591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Incidental Discovery of Conjunctival <i>Thelazia callipaeda</i> during Vitrectomy for Diabetic Tractional Retinal Detachment: A Case Report.","authors":"Yiqing Gong, Xiang Cao, Yang Bai","doi":"10.1159/000550668","DOIUrl":"https://doi.org/10.1159/000550668","url":null,"abstract":"<p><strong>Introduction: </strong><i>Thelazia callipaeda</i> is a parasitic nematode that infects the eyes of humans and other mammals. This case highlights its incidental discovery during ocular surgery and underscores the importance of preoperative vigilance.</p><p><strong>Case presentation: </strong>The parasite was identified intraoperatively in a 74-year-old female with a long-standing history of diabetes who was undergoing surgery for diabetic tractional retinal detachment in her right eye. She reported poor hygiene habits but no direct pet contact. The parasite, found within the conjunctival sac, was excised and confirmed by pathological examination. Postoperative care included antibiotic eye drops. At the 3-month follow-up, her best corrected visual acuity had improved to 6/120 with no recurrence.</p><p><strong>Conclusion: </strong>This case emphasizes the critical role of comprehensive preoperative examination for the timely detection of ocular parasites to prevent complications. It also highlights the need for clinician awareness of <i>Thelazia</i> infection, particularly in high-risk individuals, and the importance of appropriate postoperative follow-up to optimize outcomes and minimize recurrence risk.</p>","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"17 1","pages":"195-201"},"PeriodicalIF":0.6,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12975153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147431101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Relapsing Intermediate Uveitis following Resolved Syphilitic Retinitis in an HIV-Positive Patient: A Case Report.","authors":"Anita Sharma, Nikita Dash","doi":"10.1159/000550669","DOIUrl":"10.1159/000550669","url":null,"abstract":"<p><strong>Introduction: </strong>Ocular syphilis has atypical presentation in immunocompromised individuals. We report a case of intermediate uveitis as a delayed immune-mediated relapse following the successful treatment of syphilitic retinitis in an HIV-positive individual.</p><p><strong>Case presentation: </strong>A 30-year-old HIV-positive man presented with decreased vision in his left eye. Examination revealed left eye granulomatous anterior uveitis with vitritis, retinal vasculitis, and optic disc edema. The patient was diagnosed with syphilitic uveitis, reactive for rapid plasma reagin (RPR), and initiated on intravenous penicillin by the internist. Topical corticosteroids were initiated, and oral corticosteroids were added after 1 week. Over 2 months, the lesions resolved clinically with decreasing RPR titers. After 2 months of complete remission and tapering of therapy, the patient presented with renewed disc edema, macular edema, vitreous cells, and snowballs suggestive of intermediate uveitis. The RPR titers showed a decreasing pattern.</p><p><strong>Conclusion: </strong>The patient responded well to oral corticosteroids, indicating a likely immune-mediated relapse rather than reinfection. This case highlights the need for continued surveillance, even after clinical resolution.</p>","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"17 1","pages":"217-222"},"PeriodicalIF":0.6,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12987672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147462667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Simultaneous Branch Retinal Artery and Central Retinal Vein Occlusions following Blood Transfusion in a Young Man: A Case Report.","authors":"Omer Othman Abdullah","doi":"10.1159/000550754","DOIUrl":"10.1159/000550754","url":null,"abstract":"<p><strong>Introduction: </strong>Simultaneous branch retinal artery occlusion (BRAO) and central retinal vein occlusion (CRVO) is an exceptionally rare cause of acute vision loss, particularly in young individuals without systemic vascular risk factors. Blood transfusion has been implicated in rare thromboembolic and hyperviscosity-related complications but is infrequently associated with retinal vascular occlusions.</p><p><strong>Case presentation: </strong>A 20-year-old man presented with sudden painless unilateral vision loss shortly after receiving a packed red blood cell transfusion for severe anemia. Ophthalmic examination revealed optic disc edema, venous engorgement, scattered retinal hemorrhages, and superior hemi-macular whitening in the affected eye. Structural optical coherence tomography demonstrated inner retinal hyperreflectivity and subsequent thinning, consistent with ischemic retinal injury. Fluorescein angiography was contraindicated due to an acute hypersensitivity reaction. Extensive systemic, hematologic, inflammatory, and thrombophilia workup was unremarkable. Despite conservative and supportive management, including hyperbaric oxygen therapy and anticoagulation, visual recovery remained limited at follow-up.</p><p><strong>Conclusion: </strong>This case highlights a rare presentation of concurrent BRAO and CRVO occurring shortly after blood transfusion in a young patient without identifiable systemic risk factors. Although causality cannot be definitively established, the close temporal relationship and exclusion of alternative etiologies suggest transfusion-related rheologic changes as a plausible contributing factor. Clinicians should remain vigilant for acute retinal vascular events following transfusion, even in young patients, and prompt ophthalmic evaluation is essential.</p>","PeriodicalId":9635,"journal":{"name":"Case Reports in Ophthalmology","volume":"17 1","pages":"211-216"},"PeriodicalIF":0.6,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12981899/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147462673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}