CARTILAGE最新文献_第9页

Hyperbaric Oxygen Therapy Improves Subchondral Perfusion and Cartilage Integrity in Established Osteoarthritis: A Pharmacokinetic DCE-MRI and T2* Quantification Study. 高压氧治疗改善骨关节炎软骨下灌注和软骨完整性：药代动力学DCE-MRI和T2*定量研究

IF 2.6 4区医学

CARTILAGE Pub Date : 2026-06-03 DOI: 10.1177/19476035261457601

Guo-Shu Huang, Shih-Wei Chiang, Chiao-Chi Chen, Yi-Jen Peng, Yu-Juei Hsu, Kun-Lun Huang, Yu-Ching Chou, Ming-Huang Lin, Ying-Chun Liu, Chao-Ying Wang

{"title":"Hyperbaric Oxygen Therapy Improves Subchondral Perfusion and Cartilage Integrity in Established Osteoarthritis: A Pharmacokinetic DCE-MRI and T2* Quantification Study.","authors":"Guo-Shu Huang, Shih-Wei Chiang, Chiao-Chi Chen, Yi-Jen Peng, Yu-Juei Hsu, Kun-Lun Huang, Yu-Ching Chou, Ming-Huang Lin, Ying-Chun Liu, Chao-Ying Wang","doi":"10.1177/19476035261457601","DOIUrl":"10.1177/19476035261457601","url":null,"abstract":"ObjectiveThis study investigated whether hyperbaric oxygen (HBO) therapy, initiated after disease establishment, exerts disease-modifying effects in a rat model of anterior cruciate ligament transection (ACLT)-induced post-traumatic osteoarthritis (PTOA).DesignThirty-six Sprague-Dawley rats underwent ACLT surgery. HBO therapy commenced at Week 11 (established OA phase) and continued for 6 weeks. Outcomes were assessed using Von Frey testing, multimodal 7T MRI (T2* quantification and pharmacokinetic DCE-MRI), and histopathology.ResultsBy Week 10, ACLT induced significant mechanical allodynia, T2* prolongation, and SCB perfusion abnormalities (A increase; kep, kel decrease). Following HBO intervention, the ACLT+HBO group exhibited a marked recovery in mechanical withdrawal threshold and significantly lower T2* values compared to the ACLT-only group (p < 0.01). DCE-MRI demonstrated that HBO restored clearance kinetics (kel, kep) and suppressed pathological blood volume (A), effectively remediating subchondral venous congestion. Histologically, HBO reduced OARSI scores and suppressed α-SMA-positive vascular invasion across the tidemark. These findings suggest that HBO therapy may alleviate PTOA by suppressing catabolic activity and normalizing pathological subchondral angiogenesis.ConclusionsHBO therapy, initiated post-pathogenesis, effectively attenuates nociception and preserves cartilage integrity by restoring subchondral microcirculatory homeostasis. These findings establish HBO as a potent, non-invasive disease-modifying strategy for PTOA.","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"19476035261457601"},"PeriodicalIF":2.6,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13233603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the Potential of Multilineage Differentiating Stress-Enduring Cells for Osteochondral Healing. 研究多线性分化应力持久细胞在骨软骨愈合中的潜力

IF 2.6 4区医学

CARTILAGE Pub Date : 2026-06-01 Epub Date: 2024-06-17 DOI: 10.1177/19476035241262020

Shotaro Watanabe, Hiroaki Hosokawa, Takuya Sakamoto, Manato Horii, Yoshimasa Ono, Seiji Kimura, Satoshi Yamaguchi, Seiji Ohtori, Takahisa Sasho

{"title":"Investigating the Potential of Multilineage Differentiating Stress-Enduring Cells for Osteochondral Healing.","authors":"Shotaro Watanabe, Hiroaki Hosokawa, Takuya Sakamoto, Manato Horii, Yoshimasa Ono, Seiji Kimura, Satoshi Yamaguchi, Seiji Ohtori, Takahisa Sasho","doi":"10.1177/19476035241262020","DOIUrl":"10.1177/19476035241262020","url":null,"abstract":"ObjectiveMultilineage differentiating stress-enduring (Muse) cells, a pluripotent stem cell subset of mesenchymal stem cells (MSCs), have shown promise for various tissue repairs due to their stress tolerance and multipotent capabilities. We aimed to investigate the differentiation potential in vitro, the dynamics in vivo, and the reparative contribution of Muse cells to osteochondral lesions.DesignLabeled MSCs were cultured and sorted into Muse and non-Muse (MSCs without Muse cells) groups. These cells were then formed into spheroids, and chondrogenic differentiation was assessed in vitro. Twenty-one immunocompromised mice were used as the in vivo models of osteochondral lesions. Live imaging, macroscopic evaluation, and histological and immunohistochemical analyses were conducted at the 4- and 8-week time points.ResultsMuse cell spheroids were formed, which were larger and stained more intensely with toluidine blue than non-Muse spheroids, indicating better chondrogenic differentiation. Live imaging confirmed luminescence in all 4-week model knees, but only in a few knees at 8 weeks, suggesting cell persistence. Macroscopically and histologically, no significant differences were observed between the Muse and non-Muse groups at 4 and 8 weeks; however, both groups showed better cartilage repair than that of the vehicle group at 8 weeks. No collagen type II generation was observed in the repaired tissues.ConclusionThe implantation of the spheroids of Muse and non-Muse cells resulted in better healing of osteochondral lesions than that of the controls, and Muse cells had a higher chondrogenic differentiation potential in vitro than non-Muse cells.","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"207-219"},"PeriodicalIF":2.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141417908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hsa_circ_0007482 Promotes Proliferation and Differentiation of Chondrocytes in Knee Osteoarthritis. Hsa_circ_0007482 促进膝骨关节炎软骨细胞的增殖和分化

IF 2.6 4区医学

CARTILAGE Pub Date : 2026-06-01 Epub Date: 2024-05-15 DOI: 10.1177/19476035241250198

Dongjie Hou, Ling Lu, Ran Tao

{"title":"Hsa_circ_0007482 Promotes Proliferation and Differentiation of Chondrocytes in Knee Osteoarthritis.","authors":"Dongjie Hou, Ling Lu, Ran Tao","doi":"10.1177/19476035241250198","DOIUrl":"10.1177/19476035241250198","url":null,"abstract":"ObjectiveKnee osteoarthritis (KOA) is a complex degenerative joint disease and a major cause of joint dysfunction. This study aimed to explore the function of hsa_circ_0007482 on inflammation, proliferation, differentiation, and apoptosis in KOA.DesignReal-time quantitative polymerase chain reaction (PCR) was performed to detect the expression of circ_0007482, inflammatory factors, and differentiation-related molecules in KOA chondrocytes and interleukin (IL)-1β-stimulated chondrocytes. The correlation between the circ_0007482 expression and inflammatory factors was analyzed by the Pearson method. KOA cell model was established using IL-1β for 24 hours. The proliferation activity of chondrocytes was evaluated by CCK-8 assay, and cell apoptosis rate was assessed by flow cytometry. The downstream miRNA of circ_0007482 was validated using dual-luciferase reporter assay.ResultsThe circ_0007482 expression was elevated in both KOA cartilage tissues and IL-1β-treated chondrocytes and positively correlated with inflammatory factors expression. In comparison to the control group, IL-1β treatment diminished chondrocyte proliferation abilities and increased cell apoptosis and inflammatory factors IL-6, IL-8, and tumor necrosis factor (TNF)-α mRNA expression. Inhibition of circ_0007482 partially improved IL-1β-induced inflammatory reaction. Circ_0007482 could negatively regulate the expression of miR-558.ConclusionsInterfering of circ_0007482 might partially promote cell proliferation and differentiation, while inhibit cell apoptosis to improve joint injury by regulating miR-558 in IL-1β-treated chondrocyte cell model.","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"233-240"},"PeriodicalIF":2.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140921057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associated Anatomic Abnormalities in Patients Undergoing Rotational Tibial Osteotomies for Patellofemoral Pathology and Implications for the Level of Correction. 髌骨病理行旋转胫骨截骨术患者的相关解剖异常及其对矫正水平的影响。

IF 2.6 4区医学

CARTILAGE Pub Date : 2026-06-01 Epub Date: 2025-01-10 DOI: 10.1177/19476035241311548

Mohammad Haikal, Nishant Singh, Renjit Issac, Gwithyen Silk, Martyn Snow

{"title":"Associated Anatomic Abnormalities in Patients Undergoing Rotational Tibial Osteotomies for Patellofemoral Pathology and Implications for the Level of Correction.","authors":"Mohammad Haikal, Nishant Singh, Renjit Issac, Gwithyen Silk, Martyn Snow","doi":"10.1177/19476035241311548","DOIUrl":"10.1177/19476035241311548","url":null,"abstract":"PurposeTibial rotational deformity is a known risk factor for patellofemoral joint (PFJ) disorders. However, it is commonly associated with other abnormalities which affect the PFJ. The purpose of this study was to describe the prevalence of associated factors known to affect PFJ in patients undergoing rotational tibial osteotomy and their implication for the correction level.MethodsAll patients with PFJ disorder, who underwent rotational tibial osteotomy between July 2009 and February 2020, were included. Patients were excluded if there were no preoperative computed tomography (CT)/magnetic resonance imaging (MRI). Scans were analyzed by 2 observers. Parameters of interest were femoral version, tibial torsion, trochlear dysplasia, lateral trochlear inclination (LTI), tibial tuberosity-trochlear groove (TT-TG) distance, Insall-Salvati (IS), and Caton Deschamps Index (CDI).ResultsThe search resulted in 80 knees, which had a mean femoral version of 21.0 ± 11.7, tibial torsion of 45.9 ± 9.1, TT-TG of 18.3 ± 5.5, and LTI of 11.4 ± 14.7. In total, 42.5% had TT-TG value of ≥ 20 mm. Patella alta/baja was found in 54% based on CDI or IS >1.2 and <0.8. High-grade trochlear dysplasia was found in 25%. In total, 29% had a tibial torsion abnormality but normal TT-TG and patella height. In total, 18% had abnormal TT-TG but normal patellar height.ConclusionBased on the associated abnormalities of patella height and tubercle lateralization, 18% of the population were suitable for supratubercle osteotomy, and 29% of patients were suitable for diaphyseal or distal tibial osteotomy. A tibial tubercle osteotomy was required in 54% of patients, making a through-tubercle approach the most appropriate option for most patients.Level of evidence:Radiological cross-sectional study.","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"142-153"},"PeriodicalIF":2.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11724394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Trends and Gaps in Osteoarthritis Biomarker Research (1999-2024): A Citation Analysis of Top 50 Cited Articles. 探索骨关节炎生物标志物研究的趋势和差距（1999-2024 年）：前 50 篇文章的引用分析》。

IF 2.6 4区医学

CARTILAGE Pub Date : 2026-06-01 Epub Date: 2024-10-18 DOI: 10.1177/19476035241288660

Wenjin Hu, Jiyong Yang, Li Liu, Dongchao Li, Yun Zhao, Aiguo Wang

{"title":"Exploring Trends and Gaps in Osteoarthritis Biomarker Research (1999-2024): A Citation Analysis of Top 50 Cited Articles.","authors":"Wenjin Hu, Jiyong Yang, Li Liu, Dongchao Li, Yun Zhao, Aiguo Wang","doi":"10.1177/19476035241288660","DOIUrl":"10.1177/19476035241288660","url":null,"abstract":"PurposeThis study aimed to comprehensively analyze the landscape of osteoarthritis (OA) biomarker research through the citation analysis of top-cited articles, identifying trends and gaps in this field.MethodsThe Web of Science Core Collection was utilized to retrieve the top 50 cited articles on OA biomarkers. Data extraction included publication characteristics, citation metrics, and biomarker categorization. Statistical analyses were conducted to discern correlations and assess significance.ResultsThe top 50 cited articles spanned the years 1999 to 2020, and collectively cited 4849 articles, accumulating a total of 6177 citations, resulting in an average of 123.5 citations per document. Citations per article varied between 78 and 359, with a citation density ranging from 3.9 to 23.93. Analysis of the top 50 cited articles revealed comparable impact between recent and older publications. Predominant trends included cartilage-related and blood-based biomarkers, while inflammation-related, radiomics, and multi-omics emerged as potential future research directions. In BIPEDS classification, gaps were identified in biomarkers evaluating intervention efficacy and safety.ConclusionDespite significant advancements, there is no universally acknowledged biomarker for OA. Addressing gaps in biomarker exploration is crucial for enhancing OA management strategies. This study provides insights into prevailing trends and future research directions in OA biomarkers, guiding future investigations and therapeutic development.","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"113-122"},"PeriodicalIF":2.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142458766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Etanercept on Experimental Osteoarthritis in Rats: Role of Histone Deacetylases. Etanercept 对大鼠实验性骨关节炎的影响：组蛋白去乙酰化酶的作用

IF 2.6 4区医学

CARTILAGE Pub Date : 2026-06-01 Epub Date: 2024-07-26 DOI: 10.1177/19476035241264012

Zhi-Hong Wen, Chi-Chieh Tang, Yen-You Lin, Zhi-Kang Yao, Shih-Peng Hsieh, Gar-Hwa-Lai, Wu-Fu Chen, Yen-Hsuan Jean

{"title":"Effects of Etanercept on Experimental Osteoarthritis in Rats: Role of Histone Deacetylases.","authors":"Zhi-Hong Wen, Chi-Chieh Tang, Yen-You Lin, Zhi-Kang Yao, Shih-Peng Hsieh, Gar-Hwa-Lai, Wu-Fu Chen, Yen-Hsuan Jean","doi":"10.1177/19476035241264012","DOIUrl":"10.1177/19476035241264012","url":null,"abstract":"ObjectiveMounting evidence suggests that histone deacetylases (HDAC) inhibitors reduce cartilage destruction in animal models of osteoarthritis (OA). Tumor necrosis factor (TNF)-α-blocking treatment for OA may provide effective joint protection by slowing joint damage. To investigate the effects of intraperitoneal administration of etanercept (a TNF-α inhibitor) on OA development in rats and changes in the nociceptive behavior of rats and expression of HDACs, RUNX2, and MMP13 in cartilage.MethodsInduction of OA in Wistar rats was accomplished through anterior cruciate ligament transection (ACLT). One or five milligrams (mg) of etanercept was administered intraperitoneally for 5 consecutive weeks after ACLT to the ACLT + etanercept (1 and 5 mg/kg) groups. Nociceptive behavior and changes in knee joint width were analyzed. Cartilage was evaluated histologically and immunohistochemically.ResultsACLT + etanercept significantly improved mechanical allodynia and weight-bearing distribution compared to ACLT alone. In OA rats treated with etanercept, cartilage degeneration and synovitis were significantly less pronounced than those in ACLT rats. OA-affected cartilage also showed reduced expression of HDAC 6, 7, RUNX-2, and MMP-13 in response to etanercept but increased expression of HDAC4.ConclusionOur study demonstrated that etanercept therapy (1) attenuated the development of OA and synovitis in rats, (2) reduced nociception, and (3) regulated chondrocyte metabolism, possibly by inhibiting cell HDAC6 and HDAC7, RUNX2, and MMP13 and increasing HDAC4 expression. Based on new evidence, etanercept may have therapeutic potential in OA.","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"241-253"},"PeriodicalIF":2.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141757357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Texture Analysis of Cartilage Repair Tissue Maturation: Comparison of Two Cartilage Repair Methods and Correlation with MOCART 2.0. 软骨修复组织成熟的纹理分析：两种软骨修复方法的比较及与MOCART 2.0的相关性。

IF 2.6 4区医学

CARTILAGE Pub Date : 2026-06-01 Epub Date: 2025-01-29 DOI: 10.1177/19476035241313047

Veronika Janacova, Pavol Szomolanyi, Diana Sitarcikova, Alexandra Kirner, Siegfried Trattnig, Vladimir Juras

{"title":"Texture Analysis of Cartilage Repair Tissue Maturation: Comparison of Two Cartilage Repair Methods and Correlation with MOCART 2.0.","authors":"Veronika Janacova, Pavol Szomolanyi, Diana Sitarcikova, Alexandra Kirner, Siegfried Trattnig, Vladimir Juras","doi":"10.1177/19476035241313047","DOIUrl":"10.1177/19476035241313047","url":null,"abstract":"ObjectiveThe objective of this study was to assess the maturation of matrix-associated autologous chondrocyte transplantation (MACT) grafts up to 2 years after the surgery using gray-level co-occurrence matrix (GLCM) texture analysis of quantitative T2 maps, compare the results with the microfracturing technique (MFX) control group, and relate these results to the morphological MOCART 2.0 score.DesignA subcohort of 37 patients from prospective, multi-center study underwent examination on a 3T MR scanner, including a T2 mapping sequence at 3, 12, and 24 months after surgery. Changes between the time-points in the mean T2 values and 20 GLCM features extracted from T2 maps were assessed in repair tissue, tissue adjacent to the repair site, and the reference cartilage for both procedures.ResultsSignificant correlations were found between the MOCART 2.0 and GLCM features for both surgical procedures. There were no significant differences between MACT and MFX. We identified significant intra-group changes in T2 and autocorrelation (3M-12M: P = 0.002; 3M-24M: P = 0.004), dissimilarity (3M-24M: P = 0.01), homogeneity (3M-24M: P = 0.013), and correlation (3M-24M: P = 0.036), sum average (3M-12M: P = 0.001; 3M-24M: P = 0.002), and information measure (3M-24M: P < 0.001) in the MACT repair tissue. MACT models revealed differences in GLCM between all combinations of ROI types at almost all time-points. In the case of MFX, the significant differences were mainly between repair and reference tissue at 12 months.ConclusionTexture analysis provides a useful extension to T2 mapping. Texture features are correlated to the morphological outcome and reveal differences in the process of maturation between MACT and MFX.","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"164-182"},"PeriodicalIF":2.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11780626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical and Cellular Predictors of Outcomes in Autologous Conditioned Plasma Therapy for Knee Osteoarthritis: A Prospective Cohort Study. 自体条件调节血浆疗法治疗膝骨关节炎疗效的临床和细胞预测因素：前瞻性队列研究

IF 2.6 4区医学

CARTILAGE Pub Date : 2026-06-01 Epub Date: 2025-03-19 DOI: 10.1177/19476035251323376

Amr Selim, Tian Lan, Charlotte Hulme, Mike Williams, Jade Perry, Pete Gallacher, Paul Jermin, Karina Wright

{"title":"Clinical and Cellular Predictors of Outcomes in Autologous Conditioned Plasma Therapy for Knee Osteoarthritis: A Prospective Cohort Study.","authors":"Amr Selim, Tian Lan, Charlotte Hulme, Mike Williams, Jade Perry, Pete Gallacher, Paul Jermin, Karina Wright","doi":"10.1177/19476035251323376","DOIUrl":"10.1177/19476035251323376","url":null,"abstract":"IntroductionAutologous conditioned plasma (ACP) is a single-spin, leukocyte-poor platelet-rich plasma (PRP) that provides a plasma with a platelet concentration 2 to 3 times the blood platelet concentration. The objective of this study was to investigate the clinical effectiveness of ACP intra-articular injection in patients with knee osteoarthritis (OA) and to identify any demographic, disease-associated, or biological predictors of outcome.MethodsA prospective cohort study was conducted between 2022 and 2023 in a single high-volume tertiary center, including 42 patients (54 knees) who consented to be enrolled. Patients underwent a series of 3 injections of ACP at weekly intervals, prepared using the Arthrex ACP Double-Syringe System. Lysholm scores were collected at baseline, 3-months, and 6-months post-injection.ResultsForty patients (49 knees) completed the follow-up and were included in the final analysis. The mean age was 53.8 ± 10.16 years (range 35-76 years), and the median body mass index (BMI) was 29 (interquartile range [IQR]: 27-34). There were 22 females and 18 males. Treatment failure occurred in 12 out of 49 cases (24.49%). The mean platelet concentration in the ACP was 588.5 ± 183.2 × 106/ml, with a mean platelet fold increase of 2.14 ± 0.71 compared to the baseline. Multi-linear regression modeling showed that older age and higher mean platelet concentration were predictors of higher post-injection Lysholm scores, with beta coefficients of 0.34 and 0.28, respectively, and p values of 0.013 and 0.036, respectively.ConclusionAutologous conditioned plasma provided clinical benefits in this cohort study of knee OA patients for at least 6 months post-injection. Older age and a higher mean platelet concentration in the ACP were identified as predictors of a higher Lysholm score.","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"123-132"},"PeriodicalIF":2.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11924051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and Associated Factors of Ankle Osteoarthritis in Achondroplasia: A Retrospective Radiographic Assessment of 134 Patients. 软骨发育不全患者踝关节骨关节炎的患病率及相关因素：134例患者的回顾性影像学评估。

IF 2.6 4区医学

CARTILAGE Pub Date : 2026-06-01 Epub Date: 2024-12-20 DOI: 10.1177/19476035241307862

Won Seok Choi, Jung Woo Shin, Sei Wook Son, Hak Jun Kim, Sang Hyeon Hwang, Sang Geon Park, Young Hwan Park

{"title":"Prevalence and Associated Factors of Ankle Osteoarthritis in Achondroplasia: A Retrospective Radiographic Assessment of 134 Patients.","authors":"Won Seok Choi, Jung Woo Shin, Sei Wook Son, Hak Jun Kim, Sang Hyeon Hwang, Sang Geon Park, Young Hwan Park","doi":"10.1177/19476035241307862","DOIUrl":"10.1177/19476035241307862","url":null,"abstract":"ObjectiveThe primary aim of this study is to examine the prevalence of ankle osteoarthritis in patients with achondroplasia and to assess the impact of surgical correction of lower limb alignment on this prevalence. The secondary aim is to identify radiographic parameters associated with ankle osteoarthritis.DesignThis retrospective cohort study included 134 patients (268 ankles) who visited our institution between March 2014 and February 2023. Lower limb alignment was assessed using the mechanical axis deviation, lateral distal tibial angle, anterior distal tibial angle, and talar tilt angle. Ankle osteoarthritis was evaluated using the Van Dijk Osteoarthritis score and modified Kellgren-Lawrence (K-L) scale by 2 experienced orthopedic surgeons.ResultsThe prevalence of ankle osteoarthritis in our study cohort was 29%, and that of advanced ankle osteoarthritis defined by Van Dijk Osteoarthritis scale III or modified K-L grade 4 was 0.8% (aged <40 years, 22%, and 0%; aged ≥40 years, 42% and 2%, respectively). Talar tilt angle was the only radiographic parameter that showed a significant correlation with the degree of ankle osteoarthritis (Van Dijk Osteoarthritis score, rs = 0.403, P < 0.001; modified K-L grade, rs = 0.385, P < 0.001).DiscussionThe prevalence of ankle osteoarthritis in achondroplasia is moderate, but the progression to advanced stages is uncommon. Ankle osteoarthritis in achondroplasia is strongly associated with increased talar tilt angle. This finding emphasizes caution regarding ankle osteoarthritis in achondroplasia with a nonparallel tibiotalar articular surface. Clinicians should, therefore, consider regularly assessing the talar tilt angle in patients with achondroplasia.","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"133-141"},"PeriodicalIF":2.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11660094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of the BMI (<30 kg/m² vs. ≥30 kg/m²) on the Surgical Outcome of Osteochondral Lesions of the Talus: Prospective Data from the German Cartilage Registry (KnorpelRegister DGOU). BMI （2 vs.≥30 kg/m2）对距骨骨软骨病变手术结果的影响：来自德国软骨登记（knnorpelregister DGOU）的前瞻性数据。

IF 2.6 4区医学

CARTILAGE Pub Date : 2026-06-01 Epub Date: 2025-03-12 DOI: 10.1177/19476035241301294

Alena Richter, Anna Altemeier, Christoph Becher, Marco Güllmann, Christian Plaass, Sarah Ettinger

{"title":"Influence of the BMI (<30 kg/m2 vs. ≥30 kg/m2) on the Surgical Outcome of Osteochondral Lesions of the Talus: Prospective Data from the German Cartilage Registry (KnorpelRegister DGOU).","authors":"Alena Richter, Anna Altemeier, Christoph Becher, Marco Güllmann, Christian Plaass, Sarah Ettinger","doi":"10.1177/19476035241301294","DOIUrl":"10.1177/19476035241301294","url":null,"abstract":"ObjectiveAim of this study was to evaluate the 24 months follow-up data of the German Cartilage Registry (KnorpelRegister DGOU, GCR) regarding the influence of body mass index (BMI) on clinical outcomes after surgical osteochondral lesions of the talus (OCT) treatment.DesignA total of 303 patients met the inclusion criteria. Pre- and post-operative Foot and Ankle Outcome Score (FAOS) total scores, subscores, and ΔFAOS were analyzed for most frequent surgical techniques (bone marrow stimulation [BMS], matrix-augmented BMS, matrix-augmented BMS with additional bone grafting) in normal weight group (NW, BMI <30 kg/m2, n = 228) and obese weight group (OW, BMI ≥30 kg/m2, n = 75).ResultsBMI was significantly different in NW and OW (24.6 ± 2.97 [16.9-29.9] kg/m2 vs. 33.7 ± 4.0 [30.0-51.3] kg/m2, P < 0.001). Significant improvement from pre- to post-operative FAOS score and subscales was reached in both groups (NW: 64.2 ± 17.5 vs. 77.7 ± 17.8; OW: 52.3 ± 15.5 vs. 73.5 ± 20.2; P < 0.001) with higher pre- and post-operative scores in NW. No significant difference in ΔFAOS score was detected. Treatment technique did not influence the clinical outcome. OW showed an extended use of bone grafting due to greater defect depth. Age was significantly higher in OW compared to NW (35.7 ± 13.2 [18.0-69.0] years vs. 40.7 ± 13.1 [18.0-77.0] years, P = 0.005).ConclusionsPatients benefit from surgical cartilage therapy regardless of their BMI. OW showed significantly lower pre- and post-operative FAOS scores. In OW, additional bone grafting was required more frequently due to significantly deeper defects.","PeriodicalId":9626,"journal":{"name":"CARTILAGE","volume":" ","pages":"154-163"},"PeriodicalIF":2.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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